EVI2A (ecotropic viral integration site 2A)

Gene: EVI2A (ecotropic viral integration site 2A) Sus scrofa

Analyze

Symbol:

EVI2A

Name:

ecotropic viral integration site 2A

RGD ID:

14155917

Description:

ASSOCIATED WITH cerebral palsy (ortholog); Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

EV12A protein; protein EVI2A

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	43,543,214 - 43,549,498 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	43,543,020 - 43,548,586 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	45,370,507 - 45,375,912 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebral palsy (ISO)

Developmental Disabilities (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

neurofibromatosis 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

membrane (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

EVI2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	43,543,214 - 43,549,498 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	43,543,020 - 43,548,586 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	45,370,507 - 45,375,912 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EVI2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	31,316,410 - 31,321,622 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	31,316,410 - 31,321,749 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	29,643,428 - 29,648,640 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	26,668,801 - 26,672,843 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	26,668,801 - 26,672,843	NCBI
Celera	17	26,564,149 - 26,569,490 (-)	NCBI		Celera
Cytogenetic Map	17	q11.2	NCBI
HuRef	17	25,854,030 - 25,859,366 (-)	NCBI		HuRef
CHM1_1	17	29,706,611 - 29,711,950 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	32,262,087 - 32,267,297 (-)	NCBI		T2T-CHM13v2.0

Evi2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	79,417,386 - 79,421,435 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	79,417,386 - 79,421,435 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	79,526,560 - 79,530,609 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	79,526,560 - 79,530,609 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	79,340,062 - 79,344,111 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	79,342,755 - 79,346,804 (-)	NCBI		MGSCv36	mm8
Celera	11	89,159,242 - 89,163,291 (-)	NCBI		Celera
Cytogenetic Map	11	B5	NCBI
cM Map	11	46.81	NCBI

Evi2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	64,983,727 - 64,987,627 (-)	NCBI		GRCr8
mRatBN7.2	10	64,485,760 - 64,489,660 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	64,485,200 - 64,489,843 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	69,112,101 - 69,116,004 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	68,617,477 - 68,621,380 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	64,087,079 - 64,090,983 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	66,870,048 - 66,873,948 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	66,870,067 - 66,873,948 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	64,774,687 - 64,778,587 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	65,713,406 - 65,717,306 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	63,456,573 - 63,460,473 (-)	NCBI		Celera
Cytogenetic Map	10	q25	NCBI

Evi2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	6,346,024 - 6,350,216 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	6,346,024 - 6,350,216 (-)	NCBI	ChiLan1.0	ChiLan1.0

EVI2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	33,147,981 - 33,164,302 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	35,037,089 - 35,043,076 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	25,476,668 - 25,482,394 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	26,212,899 - 26,216,994 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	26,215,638 - 26,216,348 (+)	Ensembl	panpan1.1		panPan2

EVI2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	41,520,000 - 41,524,103 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	40,681,816 - 40,686,505 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	42,340,792 - 42,345,490 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	42,340,925 - 42,345,477 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	41,124,130 - 41,128,845 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	41,419,002 - 41,423,694 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	41,495,175 - 41,499,853 (+)	NCBI		UU_Cfam_GSD_1.0

Evi2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	40,570,842 - 40,575,289 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936538	3,448,784 - 3,453,369 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EVI2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	24,779,056 - 24,784,018 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666075	5,292,272 - 5,296,494 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Evi2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624875	3,900,109 - 3,903,592 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624875	3,899,550 - 3,903,664 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in EVI2A
130 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	4	2		5		20		1	3
Low	6	2	3		2	3	2	2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003131752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF027381	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK231142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK391432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU469262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01054196	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000019318 ⟹ ENSSSCP00000018805

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	12	43,543,214 - 43,549,498 (+)	Ensembl

RefSeq Acc Id:

XM_003131752 ⟹ XP_003131800

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	12	43,543,020 - 43,548,586 (+)	NCBI

Sequence:

show sequence

TCAATCTCAGGGAAAATGCCATTTCACCTTCTTCTGAATGATATACTAATAAAAATATACAATA
AAAATAAGGTCAAAGGCATTAAGCAGAACCCCCTCCCCTCCCTGGAGGCGGGGATTTGTTCTAC
AAAGCCTTCTGTCATGCCAGTGGCCAACTAGAGTTTTTTTTTTCCCCTGTGACATGGGCTTTAG
TTGCAGTGGAAAGGAAATGTGTCATCTGTGGTTAGTGGAAAGCTAGTTGTACATATCCTTTTTT
ACTGAAGATTTACTTTTAGGTTCATATTCTACAAGTCTATTCTGCTTTGAATTACTTGGAAACT
GTGCTTCAAGACAAGAAAAGAAGTGGCTTATTAAAATCAGTTAATAATAAGATTGTGACCAAGC
ATTTTGTAAGATTACCAGCACACTCACGGACATGGACCACACGGGGCACTACCTGCATCTTGCC
TTTCTGATGACAACAGTTCTTCCTTTGTCTCCTGGAACAAAAGTAAACTACACCCATCTGTGGG
CTAATAATACTACTGTCTGGGATCCAGATACTGAGAATAAGACGGGCAGAAGCCAAGATGAAAA
CATTAACACAAACCCTACAGTTCCTGAAGTAGATAAAGAAGGTAATTCTACAAACATTCCTGAA
ATAGCAACATCATCTCCCATCGTGTCTGTAACTCCTAAATCTGAACAGGAGCTTTATACTTCCG
TTGTCAGGAAGAGTTCTCCAACAGTACAGAGCATTGAAAACACAAGCAAAAGTCACAGTGATAT
TTTCAAAAAAGATATCTGTGAGGAAAACAACAACAAAATGGCTATGCTAGTTTGCTTAATTATA
ATTGCAGTGCTCTTCCTTATCTGTACCATTTTATTTCTATCAACTGTGGTTCTGGCAAACAAAG
TCTCATCTCTCAGACGATCAAAACAAGTAGGCAAGCGTCAGCCTAGAAGCAATGGTGATTTTCT
GGCAAGCAGTGGTCTATGGCCTGCTGAATCAGACACTTGGAAAAGAGCAAAACAGGTCACAGGG
CCCAACCTAATGATGCAATCCACTGGAGTGCTCACAGTTACCAGGGAAAGAAAAGACGAAGGAA
CTGAAAAACTCACTAACTAACAGATGCTTTAGTGAAGCAAGATGCAAAACAGTACTGAGAAAGT
TCTTGGAAAAAATGAAGTCAGTCTGATATTTAATGCCAGTATGTTGATCTGATGGTCTAAAAGT
TGACATGGCAGGCCTTGCAATTTAGAGTCAAGCAGGTAAGAAGGAGAGAAGTTTGCCTGCTTAA
TTACTTAAACCATGCACTTTTGTTCTGACGCCAACTATTTAAAAGGCAAATAACAAAACAACCA
AACATTTGAAGAAGTTTTGAAAGAGGAGTTGAAGGAAATGACTAACAGAGGTAGAAAGGGACAA
TAAATATTTCCTGTTCAGCAACAGGAGTTAGATGATCTCCGTTCGGATGTAATTATACTCTGAA
GAGTGTAATTCTACTTTGAAGTGTGTCGTCAGAGAAAAGTATATGCTTTAACATCTAACAGAAG
TCACATTCCTAATGCATCGAGTGGGAACTGTATAGTTAAATGGTACTTTCTTTGCTGAATGTGA
CAGAATCCATACCAGCTCATACATCAACACAGCTATGCTATCTTATGCTAGATGTTTTCATCCT
TACATATGGCACACAGAAGAAAGTGTTTTTCTACTATAAATATTTAATTAAAACTTTAAAATTT
GTATAATAAATTATGACTCGTTAGAATAAAACTATGTATATGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_003131800	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC77494	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000018805
	ENSSSCP00000018805.3
	ENSSSCP00005025520.1
	ENSSSCP00015040631.1
	ENSSSCP00025044324.1
	ENSSSCP00030041851.1
	ENSSSCP00035043497.1
	ENSSSCP00040036499.1
	ENSSSCP00045027367.1
	ENSSSCP00050043581.1
	ENSSSCP00055005965.1
	ENSSSCP00065032840.1
	ENSSSCP00070016358.1

RefSeq Acc Id:

XP_003131800 ⟸ XM_003131752

- UniProtKB:

F1RJ57 (UniProtKB/TrEMBL), A0A4X1TML2 (UniProtKB/TrEMBL), A0A8D0PXE6 (UniProtKB/TrEMBL), A0A8D1ZDC1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDHTGHYLHLAFLMTTVLPLSPGTKVNYTHLWANNTTVWDPDTENKTGRSQDENINTNPTVPEV
DKEGNSTNIPEIATSSPIVSVTPKSEQELYTSVVRKSSPTVQSIENTSKSHSDIFKKDICEENN
NKMAMLVCLIIIAVLFLICTILFLSTVVLANKVSSLRRSKQVGKRQPRSNGDFLASSGLWPAES
DTWKRAKQVTGPNLMMQSTGVLTVTRERKDEGTEKLTN

hide sequence

RefSeq Acc Id:

ENSSSCP00000018805 ⟸ ENSSSCT00000019318

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000017749	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005026410	UniProtKB/TrEMBL
	ENSSSCG00015073380	UniProtKB/TrEMBL
	ENSSSCG00025073006	UniProtKB/TrEMBL
	ENSSSCG00030065078	UniProtKB/TrEMBL
	ENSSSCG00035075109	UniProtKB/TrEMBL
	ENSSSCG00040061590	UniProtKB/TrEMBL
	ENSSSCG00045023051	UniProtKB/TrEMBL
	ENSSSCG00050073461	UniProtKB/TrEMBL
	ENSSSCG00055003849	UniProtKB/TrEMBL
	ENSSSCG00065055120	UniProtKB/TrEMBL
	ENSSSCG00070010130	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000019318	ENTREZGENE
	ENSSSCT00000019318.5	UniProtKB/TrEMBL
	ENSSSCT00005041736.1	UniProtKB/TrEMBL
	ENSSSCT00015098576.1	UniProtKB/TrEMBL
	ENSSSCT00025100417.1	UniProtKB/TrEMBL
	ENSSSCT00030090919.1	UniProtKB/TrEMBL
	ENSSSCT00035102049.1	UniProtKB/TrEMBL
	ENSSSCT00040083775.1	UniProtKB/TrEMBL
	ENSSSCT00045039339.1	UniProtKB/TrEMBL
	ENSSSCT00050100433.1	UniProtKB/TrEMBL
	ENSSSCT00055007536.1	UniProtKB/TrEMBL
	ENSSSCT00065075451.1	UniProtKB/TrEMBL
	ENSSSCT00070019680.1	UniProtKB/TrEMBL
InterPro	Ectropic_vir_integratn_site_2A	UniProtKB/TrEMBL
NCBI Gene	EVI2A	ENTREZGENE
PANTHER	PROTEIN EVI2A	UniProtKB/TrEMBL
	PTHR15568	UniProtKB/TrEMBL
Pfam	EVI2A	UniProtKB/TrEMBL
PIRSF	EVI_S2A	UniProtKB/TrEMBL
UniProt	A0A4X1TML2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0PXE6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1ZDC1	ENTREZGENE, UniProtKB/TrEMBL
	F1RJ57	ENTREZGENE
UniProt Secondary	F1RJ57	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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