RACK1 (receptor for activated C kinase 1) - Rat Genome Database

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Gene: RACK1 (receptor for activated C kinase 1) Sus scrofa
Analyze
Symbol: RACK1
Name: receptor for activated C kinase 1
RGD ID: 14154908
Description: ENCODES a protein that exhibits enzyme binding (ortholog); ion channel inhibitor activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to growth factor stimulus (ortholog); negative regulation of cell growth (ortholog); negative regulation of phagocytosis (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; insulin-like growth factor signaling pathway; protein kinase C (PKC) signaling pathway; ASSOCIATED WITH Mouth Neoplasms (ortholog); squamous cell carcinoma (ortholog); transient cerebral ischemia (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: G-beta like protein; guanine nucleotide-binding protein subunit beta-2-like 1; receptor of activated protein C kinase 1; receptor of activated protein kinase C 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl257,279,857 - 57,284,855 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1257,280,192 - 57,284,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
apoptotic process  (IEA)
cellular response to glucose stimulus  (IEA)
cellular response to growth factor stimulus  (ISS)
gastrulation  (IEA)
negative regulation of cell growth  (ISS)
negative regulation of gene expression  (IEA)
negative regulation of hydrogen peroxide-induced neuron death  (IEA)
negative regulation of peptidyl-serine phosphorylation  (IEA)
negative regulation of phagocytosis  (ISS)
negative regulation of protein binding  (IEA)
negative regulation of protein kinase B signaling  (IEA)
negative regulation of protein tyrosine kinase activity  (IEA)
negative regulation of smoothened signaling pathway  (IEA)
negative regulation of translation  (ISO)
negative regulation of Wnt signaling pathway  (ISS)
pigmentation  (ISO)
positive regulation of apoptotic process  (ISS)
positive regulation of cell migration  (ISS)
positive regulation of cyclic-nucleotide phosphodiesterase activity  (IEA)
positive regulation of gastrulation  (ISS)
positive regulation of Golgi to plasma membrane protein transport  (ISS)
positive regulation of GTPase activity  (ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IEA)
positive regulation of mitochondrial depolarization  (IEA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISS)
positive regulation of protein phosphorylation  (IBA,ISS)
positive regulation of protein-containing complex assembly  (ISS)
protein ubiquitination  (ISS)
regulation of cell cycle  (ISS)
regulation of cell division  (ISS)
regulation of establishment of cell polarity  (ISS)
regulation of protein localization  (ISS)
regulation of protein localization to plasma membrane  (ISO)
rescue of stalled ribosome  (IBA,ISS)
rhythmic process  (IEA)
translation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:10673032   PMID:14681463   PMID:17145712   PMID:32605753  


Genomics

Comparative Map Data
RACK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl257,279,857 - 57,284,855 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1257,280,192 - 57,284,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RACK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5181,236,897 - 181,248,096 (-)EnsemblGRCh38hg38GRCh38
GRCh385181,236,897 - 181,243,906 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375180,663,897 - 180,670,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365180,596,534 - 180,603,512 (-)NCBINCBI36hg18NCBI36
Build 345180,596,556 - 180,603,502NCBI
Celera5176,291,782 - 176,298,759 (-)NCBI
Cytogenetic Map5q35.3NCBI
HuRef5175,390,873 - 175,397,848 (-)NCBIHuRef
CHM1_15180,096,332 - 180,103,310 (-)NCBICHM1_1
Rack1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391148,691,187 - 48,697,068 (+)NCBIGRCm39mm39
GRCm39 Ensembl1148,691,159 - 48,697,261 (+)Ensembl
GRCm381148,800,360 - 48,806,241 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1148,800,332 - 48,806,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371148,613,862 - 48,619,743 (+)NCBIGRCm37mm9NCBIm37
MGSCv361148,643,783 - 48,649,664 (+)NCBImm8
Celera1153,382,599 - 53,388,480 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
Rack1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21033,169,415 - 33,174,896 (+)NCBI
Rnor_6.0 Ensembl1235,905,358 - 35,906,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,149,717 - 34,155,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01034,149,717 - 34,155,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01033,920,259 - 33,939,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41034,067,237 - 34,072,593 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11034,068,286 - 34,073,642 (+)NCBI
Celera1032,555,573 - 32,561,054 (+)NCBICelera
Cytogenetic Map10q21NCBI
Rack1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553078,426 - 83,297 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495553078,488 - 83,297 (+)NCBIChiLan1.0ChiLan1.0
RACK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15183,712,665 - 183,720,128 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5183,712,665 - 183,720,128 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05176,462,991 - 176,470,153 (-)NCBIMhudiblu_PPA_v0panPan3
RACK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.111426,734 - 431,087 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl11426,215 - 431,089 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha11485,398 - 489,759 (-)NCBI
ROS_Cfam_1.011388,903 - 393,264 (-)NCBI
UMICH_Zoey_3.111361,070 - 365,431 (-)NCBI
UNSW_CanFamBas_1.011448,653 - 453,014 (-)NCBI
UU_Cfam_GSD_1.011610,070 - 614,431 (-)NCBI
Rack1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213117,852,090 - 117,857,037 (+)NCBI
SpeTri2.0NW_004936826748,256 - 753,460 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RACK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12382,800,211 - 82,805,769 (-)NCBI
ChlSab1.1 Ensembl2382,798,085 - 82,805,936 (-)Ensembl
Vero_WHO_p1.0NW_02366607514,238,895 - 14,245,606 (+)NCBI
Rack1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624958181,325 - 185,620 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_214332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF146043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK237420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK237743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK239515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK239567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK239961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK345704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK351147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK397800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK401007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK401013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK401019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK401023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01100905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z33879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000022602   ⟹   ENSSSCP00000023723
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl257,279,857 - 57,284,853 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000052824   ⟹   ENSSSCP00000032331
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl257,279,857 - 57,284,853 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000074602   ⟹   ENSSSCP00000066654
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl257,280,279 - 57,284,855 (+)Ensembl
RefSeq Acc Id: NM_214332   ⟹   NP_999497
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1257,280,192 - 57,284,846 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999497 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD37978 (Get FASTA)   NCBI Sequence Viewer  
  CAA83944 (Get FASTA)   NCBI Sequence Viewer  
  P63246 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999497   ⟸   NM_214332
- UniProtKB: P63246 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000066654   ⟸   ENSSSCT00000074602
RefSeq Acc Id: ENSSSCP00000032331   ⟸   ENSSSCT00000052824
RefSeq Acc Id: ENSSSCP00000023723   ⟸   ENSSSCT00000022602
Protein Domains
WD_REPEATS_REGION


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029724 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005041028 UniProtKB/Swiss-Prot
  ENSSSCG00015067931 UniProtKB/Swiss-Prot
  ENSSSCG00025061587 UniProtKB/Swiss-Prot
  ENSSSCG00030032752 UniProtKB/Swiss-Prot
  ENSSSCG00035076782 UniProtKB/Swiss-Prot
  ENSSSCG00040046413 UniProtKB/Swiss-Prot
  ENSSSCG00045005934 UniProtKB/Swiss-Prot
  ENSSSCG00050071078 UniProtKB/Swiss-Prot
  ENSSSCG00055022149 UniProtKB/Swiss-Prot
  ENSSSCG00060004937 UniProtKB/Swiss-Prot
  ENSSSCG00065060348 UniProtKB/Swiss-Prot
  ENSSSCG00070013602 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000023723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000032331 UniProtKB/TrEMBL
  ENSSSCP00000066654 UniProtKB/TrEMBL
  ENSSSCP00005040753 UniProtKB/Swiss-Prot
  ENSSSCP00015037908 UniProtKB/Swiss-Prot
  ENSSSCP00025036753 UniProtKB/Swiss-Prot
  ENSSSCP00030020404 UniProtKB/Swiss-Prot
  ENSSSCP00035045285 UniProtKB/Swiss-Prot
  ENSSSCP00040026390 UniProtKB/Swiss-Prot
  ENSSSCP00045006795 UniProtKB/Swiss-Prot
  ENSSSCP00050041781 UniProtKB/Swiss-Prot
  ENSSSCP00055034861 UniProtKB/Swiss-Prot
  ENSSSCP00060002097 UniProtKB/Swiss-Prot
  ENSSSCP00065036048 UniProtKB/Swiss-Prot
  ENSSSCP00070022062 UniProtKB/TrEMBL
  ENSSSCP00070022091 UniProtKB/Swiss-Prot
  ENSSSCP00070022099 UniProtKB/TrEMBL
  ENSSSCP00070022110 UniProtKB/TrEMBL
  ENSSSCP00070022114 UniProtKB/TrEMBL
  ENSSSCP00070022115 UniProtKB/TrEMBL
  ENSSSCP00070022126 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000022602 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000052824 UniProtKB/TrEMBL
  ENSSSCT00000074602 UniProtKB/TrEMBL
  ENSSSCT00005065854 UniProtKB/Swiss-Prot
  ENSSSCT00015092717 UniProtKB/Swiss-Prot
  ENSSSCT00025084487 UniProtKB/Swiss-Prot
  ENSSSCT00030045369 UniProtKB/Swiss-Prot
  ENSSSCT00035105457 UniProtKB/Swiss-Prot
  ENSSSCT00040062588 UniProtKB/Swiss-Prot
  ENSSSCT00045009969 UniProtKB/Swiss-Prot
  ENSSSCT00050096955 UniProtKB/Swiss-Prot
  ENSSSCT00055043778 UniProtKB/Swiss-Prot
  ENSSSCT00060006171 UniProtKB/Swiss-Prot
  ENSSSCT00065082735 UniProtKB/Swiss-Prot
  ENSSSCT00070026550 UniProtKB/TrEMBL
  ENSSSCT00070026581 UniProtKB/Swiss-Prot
  ENSSSCT00070026589 UniProtKB/TrEMBL
  ENSSSCT00070026605 UniProtKB/TrEMBL
  ENSSSCT00070026608 UniProtKB/TrEMBL
  ENSSSCT00070026609 UniProtKB/TrEMBL
  ENSSSCT00070026620 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397605 UniProtKB/Swiss-Prot
NCBI Gene RACK1 ENTREZGENE
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZLL3_PIG UniProtKB/TrEMBL
  A0A4X1TXG2_PIG UniProtKB/TrEMBL
  A0A4X1TXG8_PIG UniProtKB/TrEMBL
  A0A4X1TXH7_PIG UniProtKB/TrEMBL
  A0A4X1U2L8_PIG UniProtKB/TrEMBL
  A0A4X1U2X6_PIG UniProtKB/TrEMBL
  A0A4X1U2Z0_PIG UniProtKB/TrEMBL
  A0A5G2QXJ1_PIG UniProtKB/TrEMBL
  P63246 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P25388 UniProtKB/Swiss-Prot
  P99049 UniProtKB/Swiss-Prot
VGNC ID VGNC:100848 ENTREZGENE