NKRF (NFKB repressing factor) - Rat Genome Database

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Gene: NKRF (NFKB repressing factor) Sus scrofa
Analyze
Symbol: NKRF
Name: NFKB repressing factor
RGD ID: 14152215
Description: ENCODES a protein that exhibits ATPase activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); syndromic X-linked intellectual disability 14 (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH cadmium dichloride; deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NF-kappa-B-repressing factor; NKRF_tv2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX98,007,910 - 98,025,373 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,008,870 - 98,025,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X113,639,511 - 113,654,411 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleolus  (IBA,IEA)
nucleoplasm  (IBA,IEA)
nucleus  (ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NKRF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX98,007,910 - 98,025,373 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,008,870 - 98,025,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X113,639,511 - 113,654,411 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NKRF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X119,588,337 - 119,606,424 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX119,588,337 - 119,606,443 (-)EnsemblGRCh38hg38GRCh38
GRCh37X118,722,300 - 118,740,387 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,606,334 - 118,623,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X118,504,181 - 118,508,995NCBI
CeleraX119,177,007 - 119,194,549 (-)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX108,215,568 - 108,232,838 (-)NCBIHuRef
CHM1_1X118,633,590 - 118,651,487 (-)NCBICHM1_1
T2T-CHM13v2.0X117,966,055 - 117,984,174 (-)NCBIT2T-CHM13v2.0
Nkrf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X36,149,644 - 36,167,118 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX36,151,193 - 36,167,166 (-)EnsemblGRCm39 Ensembl
GRCm38X36,885,991 - 36,903,465 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX36,887,540 - 36,902,899 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 EnsemblX36,887,540 - 36,903,513 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X34,427,535 - 34,442,894 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X33,318,985 - 33,334,344 (-)NCBIMGSCv36mm8
CeleraX23,611,185 - 23,626,544 (-)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX21.3NCBI
Nkrf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X120,992,038 - 121,010,251 (-)NCBIGRCr8
mRatBN7.2X116,126,341 - 116,144,554 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,128,798 - 116,144,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX118,229,719 - 118,247,947 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X121,798,854 - 121,817,082 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,345,012 - 119,363,238 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,502,074 - 123,516,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,502,096 - 123,515,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,647,015 - 123,661,225 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX115,356,571 - 115,374,775 (-)NCBICelera
Cytogenetic MapXq34NCBI
Nkrf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955534393,963 - 408,636 (+)NCBIChiLan1.0ChiLan1.0
NKRF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X118,969,901 - 118,988,049 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X118,973,510 - 118,991,658 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X108,620,903 - 108,639,027 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X119,047,826 - 119,065,090 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX119,047,826 - 119,065,090 (-)Ensemblpanpan1.1panPan2
NKRF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X91,621,255 - 91,639,202 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX91,621,258 - 91,638,775 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX77,696,043 - 77,713,939 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X93,360,374 - 93,378,277 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX93,360,374 - 93,378,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X90,813,057 - 90,830,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X92,571,793 - 92,589,681 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X92,300,973 - 92,318,870 (-)NCBIUU_Cfam_GSD_1.0
Nkrf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X90,659,525 - 90,675,427 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647910,311,996 - 10,328,393 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647910,312,061 - 10,327,970 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKRF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606532,341,256 - 32,359,478 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkrf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248953,556,730 - 3,571,183 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248953,556,730 - 3,571,916 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NKRF
156 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 3 3 5 2 23 2 3 3
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000013799   ⟹   ENSSSCP00000013418
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX98,007,910 - 98,025,373 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000069958   ⟹   ENSSSCP00000072521
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX98,007,910 - 98,022,773 (-)Ensembl
RefSeq Acc Id: XM_001927183   ⟹   XP_001927218
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X98,008,870 - 98,025,423 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_001927218   ⟸   XM_001927183
- UniProtKB: F1RUA0 (UniProtKB/TrEMBL),   A0A8D1L7Q1 (UniProtKB/TrEMBL),   A0A8D1EEB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000072521   ⟸   ENSSSCT00000069958
RefSeq Acc Id: ENSSSCP00000013418   ⟸   ENSSSCT00000013799
Protein Domains
G-patch   R3H   XRN2-binding (XTBD)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012620 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025071762 UniProtKB/TrEMBL
  ENSSSCG00030037046 UniProtKB/TrEMBL
  ENSSSCG00035075622 UniProtKB/TrEMBL
  ENSSSCG00040035957 UniProtKB/TrEMBL
  ENSSSCG00045035249 UniProtKB/TrEMBL
  ENSSSCG00050053354 UniProtKB/TrEMBL
  ENSSSCG00055027454 UniProtKB/TrEMBL
  ENSSSCG00060038992 UniProtKB/TrEMBL
  ENSSSCG00065035978 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013799 ENTREZGENE
  ENSSSCT00000013799.5 UniProtKB/TrEMBL
  ENSSSCT00000069958.2 UniProtKB/TrEMBL
  ENSSSCT00025098636.1 UniProtKB/TrEMBL
  ENSSSCT00030051552.1 UniProtKB/TrEMBL
  ENSSSCT00035102808.1 UniProtKB/TrEMBL
  ENSSSCT00040048350.1 UniProtKB/TrEMBL
  ENSSSCT00045060542.1 UniProtKB/TrEMBL
  ENSSSCT00050072682.1 UniProtKB/TrEMBL
  ENSSSCT00055054335.1 UniProtKB/TrEMBL
  ENSSSCT00060052730.1 UniProtKB/TrEMBL
  ENSSSCT00065049037.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.50 UniProtKB/TrEMBL
  3.30.160.20 UniProtKB/TrEMBL
InterPro dsRBD_dom UniProtKB/TrEMBL
  G_patch_dom UniProtKB/TrEMBL
  R3H_dom UniProtKB/TrEMBL
  R3H_dom_sf UniProtKB/TrEMBL
  R3H_NRF UniProtKB/TrEMBL
  XTBD UniProtKB/TrEMBL
KEGG Report ssc:100155370 UniProtKB/TrEMBL
NCBI Gene NKRF ENTREZGENE
PANTHER NF-KAPPA-B-REPRESSING FACTOR UniProtKB/TrEMBL
  NF-KAPPA-B-REPRESSING FACTOR-RELATED UniProtKB/TrEMBL
Pfam G-patch UniProtKB/TrEMBL
  R3H UniProtKB/TrEMBL
  XTBD UniProtKB/TrEMBL
PROSITE G_PATCH UniProtKB/TrEMBL
  R3H UniProtKB/TrEMBL
  XTBD UniProtKB/TrEMBL
SMART DSRM UniProtKB/TrEMBL
  G_patch UniProtKB/TrEMBL
  R3H UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
  SSF82708 UniProtKB/TrEMBL
UniProt A0A5G2R5K3_PIG UniProtKB/TrEMBL
  A0A8D1EEB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1L7Q1 ENTREZGENE, UniProtKB/TrEMBL
  F1RUA0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90764 ENTREZGENE