RLN2 (relaxin 2) - Rat Genome Database

Name: RLN2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: RLN2 (relaxin 2) Sus scrofa

Analyze

Symbol:

RLN2

Name:

relaxin 2

RGD ID:

14148888

Description:

ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN blastocyst growth; flagellated sperm motility; oocyte maturation; ASSOCIATED WITH chromosome 9p deletion syndrome (ortholog); genetic disease (ortholog); Prostatic Neoplasms (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

preprorelaxin; prorelaxin; RLN

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RLN2 (relaxin 2)	HGNC	EggNOG, Ensembl, OMA, OrthoDB, Panther, Treefam
Pan paniscus (bonobo/pygmy chimpanzee):	RLN2 (relaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RLN2 (relaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RLN2 (relaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rln2 (relaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RLN1 (relaxin 1)	HGNC	Ensembl, OMA, OrthoDB, Panther, Treefam
Homo sapiens (human):	INSL4 (insulin like 4)	HGNC	Ensembl, Panther, Treefam

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	216,763,546 - 216,769,802 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	242,497,113 - 242,503,501 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 9p deletion syndrome (ISO)

genetic disease (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst growth (IDA)

flagellated sperm motility (IDA)

oocyte maturation (IDA)

positive regulation of acrosome reaction (IDA)

positive regulation of angiogenesis (ISO)

positive regulation of epithelial cell proliferation (IDA)

positive regulation of gene expression (ISO)

positive regulation of glucose import (IDA)

signal transduction (IEA)

Cellular Component

extracellular region (IEA)

Molecular Function

hormone activity (IEA)

References

Additional References at PubMed

PMID:622170	PMID:843375	PMID:851452	PMID:876374	PMID:887933	PMID:938497	PMID:2442155	PMID:6897721	PMID:7904801	PMID:8145201	PMID:15956696	PMID:15956715
PMID:16926527	PMID:16956745	PMID:17851698	PMID:17979884	PMID:20807724	PMID:21177955	PMID:21251292	PMID:21272344	PMID:21317299	PMID:22301074	PMID:23946288	PMID:24640560

Genomics

Comparative Map Data

RLN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	216,763,546 - 216,769,802 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	242,497,113 - 242,503,501 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RLN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	5,299,864 - 5,339,326 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	5,299,864 - 5,304,716 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	5,299,864 - 5,304,716 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	5,289,868 - 5,294,580 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	5,289,867 - 5,294,580	NCBI
Celera	9	5,225,495 - 5,230,205 (-)	NCBI		Celera
Cytogenetic Map	9	p24.1	NCBI
HuRef	9	5,255,310 - 5,260,104 (-)	NCBI		HuRef
CHM1_1	9	5,300,035 - 5,304,782 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	5,304,955 - 5,344,419 (-)	NCBI		T2T-CHM13v2.0

RLN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	119,221,186 - 119,254,178 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	119,227,131 - 119,260,125 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	5,138,882 - 5,167,037 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	5,324,368 - 5,330,184 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	5,324,368 - 5,329,081 (-)	Ensembl	panpan1.1		panPan2

RLN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	93,500,682 - 93,505,098 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	93,500,682 - 93,505,098 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	93,908,885 - 93,913,301 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	94,054,224 - 94,066,013 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	94,054,123 - 94,066,884 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	93,686,709 - 93,691,124 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	93,411,281 - 93,415,697 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	94,175,653 - 94,180,069 (-)	NCBI		UU_Cfam_GSD_1.0

RLN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	74,184,516 - 74,191,364 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	74,186,116 - 74,190,540 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	62,577,681 - 62,582,677 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rln2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	9,886,148 - 9,891,191 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	9,886,285 - 9,891,887 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in RLN2
145 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system
High
Medium
Low	1	1	2	1		4		1
Below cutoff	3	3	1	2	2	11	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_213872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021082276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	A06852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	A16593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AEMK02000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK395920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU302244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU861563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01001719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J02792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	K01088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_213872 ⟹ NP_999037

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	1	216,763,546 - 216,769,802 (+)	NCBI

Sequence:

show sequence

ATGCCGCGCCTGTTCTCCTACCTCCTAGGTGTCTGGCTGCTCCTGAGCCAACTTCCCAGAGAAA
TCCCAGGCCAGAGTACGAACGATTTTATTAAGGCATGCGGCCGAGAATTAGTCCGTCTGTGGGT
GGAGATCTGTGGCTCCGTCTCCTGGGGAAGAACTGCTCTCAGCCTGGAAGAGCCTCAGCTGGAA
ACTGGACCCCCGGCAGAAACCATGCCATCCTCCATCACCAAAGATGCAGAAATCTTAAAGATGA
TGTTGGAATTTGTTCCTAATTTGCCACAGGAGCTGAAGGCAACATTGTCTGAGAGGCAACCATC
ACTGAGAGAGCTACAACAATCTGCATCAAAGGATTCGAATCTTAACTTTGAAGAATTTAAGAAA
ATTATTCTTAACAGACAAAATGAAGCAGAAGACAAAAGTCTTTTAGAATTAAAAAACTTAGGTT
TAGATAAACATTCCAGAAAAAAGAGACTGTTCCGTATGACACTGAGCGAGAAATGTTGTCAAGT
AGGTTGTATCAGAAAAGATATTGCTAGATTATGCTGAAAAGGAGCTAATGATATATTTTATATA
ATGTTCACATGTATTCTCAGTGACATATTCACTTATGCCTCTGTCACCCACTGATTATTAGCAC
TGTTTAGTGTTTAGGTTTTTCATTTTATGTGTAAGAAAATGTCCCTTGCATTAATGTAGTTTCT
GCTAATAATATTTTTTTAAACTAAAAGGT

hide sequence

RefSeq Acc Id:

XM_021082276 ⟹ XP_020937935

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	1	216,763,895 - 216,769,799 (+)	NCBI

Sequence:

show sequence

TGCCTCGTAACTTGCTTTCTAGCGAGTATTTCATGGGGGATTTCACCAGAAAGAGGGAAAGCAT
CAGGAACAGCAAATAGCTTCACTTAAGAGGTCCGGCGCCCTTCACCTCCTGGCAGTCAGAAAGA
AGGGGGAAACCACAGAAGTGAAACCATGCCATCCTCCATCACCAAAGATGCAGAAATCTTAAAG
ATGATGTTGGAATTTGTTCCTAATTTGCCACAGGAGCTGAAGGCAACATTGTCTGAGAGGCAAC
CATCACTGAGAGAGCTACAACAATCTGCATTAAAGGATTCGAATCTTAACTTTGAAGAATTTAA
GAAAATTATTCTTAACAGACAAAATGAAGCAGAAGACAAAAGTCTTTTAGAATTAAAAAACTTA
GGTTTAGATAAACATTCCAGAAAAAAGAGACTGTTCCGTATGACACTGAGCGAGAAATGTTGTC
AAGTAGGTTGTATCAGAAAAGATATTGCTAGATTATGCTGAAAAGGAGCTAATGATATATTTTA
TATAATGTTCACATGTATTCTCAGTGACATATTCACTTATGCCTCTGTCACCCACTGATTATTA
GCACTGTTTAGTGTTTAGGTTTTTCATTTTATGTGTAAGAAAATGTCCCTTGCATTAATGTAGT
TTCTGCTAATAATATTTTTTTAAACTAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_999037	(Get FASTA)	NCBI Sequence Viewer
	XP_020937935	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA31114	(Get FASTA)	NCBI Sequence Viewer
	AAA31115	(Get FASTA)	NCBI Sequence Viewer
	CAA00600	(Get FASTA)	NCBI Sequence Viewer
	CAA01295	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000005607
	ENSSSCP00000005607.3
	ENSSSCP00005028391.1
	ENSSSCP00070050314.1
GenBank Protein	P01348	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_999037 ⟸ NM_213872
- Peptide Label:	precursor
- UniProtKB:	P01348 (UniProtKB/Swiss-Prot), A0A4X1W973 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPRLFSYLLGVWLLLSQLPREIPGQSTNDFIKACGRELVRLWVEICGSVSWGRTALSLEEPQLE TGPPAETMPSSITKDAEILKMMLEFVPNLPQELKATLSERQPSLRELQQSASKDSNLNFEEFKK IILNRQNEAEDKSLLELKNLGLDKHSRKKRLFRMTLSEKCCQVGCIRKDIARLC hide sequence

RefSeq Acc Id:	XP_020937935 ⟸ XM_021082276
- Peptide Label:	isoform X1
- Sequence:	show sequence MPSSITKDAEILKMMLEFVPNLPQELKATLSERQPSLRELQQSALKDSNLNFEEFKKIILNRQN EAEDKSLLELKNLGLDKHSRKKRLFRMTLSEKCCQVGCIRKDIARLC hide sequence

Protein Domains

Insulin-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000005216	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005029075	UniProtKB/TrEMBL
	ENSSSCG00070029422	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000005749	ENTREZGENE
	ENSSSCT00000005749.4	UniProtKB/TrEMBL
	ENSSSCT00005046181.1	UniProtKB/TrEMBL
	ENSSSCT00070059107.1	UniProtKB/TrEMBL
InterPro	Insulin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Insulin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Relaxin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:396891	UniProtKB/Swiss-Prot
NCBI Gene	RLN2	ENTREZGENE
PANTHER	PRORELAXIN H2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RELAXIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Insulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	RELAXIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	INSULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	IlGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56994	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A4X1W973	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1L5W4_PIG	UniProtKB/TrEMBL
	P01348	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	J9JIL0	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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