PARP11 (poly(ADP-ribose) polymerase family member 11) - Rat Genome Database

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Pathways
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Gene: PARP11 (poly(ADP-ribose) polymerase family member 11) Sus scrofa
Analyze
Symbol: PARP11
Name: poly(ADP-ribose) polymerase family member 11
RGD ID: 14145958
Description: ENCODES a protein that exhibits glycosyltransferase activity (inferred); NAD+ ADP-ribosyltransferase activity (inferred); NAD+-protein ADP-ribosyltransferase activity (inferred); INVOLVED IN nuclear envelope organization (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH genetic disease (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); FOUND IN cytosol (inferred); nuclear body (inferred); nuclear envelope (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: poly [ADP-ribose] polymerase 11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,443,494 - 66,483,626 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1566,443,483 - 66,483,630 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,750,914 - 68,791,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nuclear body  (IEA)
nuclear envelope  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
PARP11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,443,494 - 66,483,626 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1566,443,483 - 66,483,630 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,750,914 - 68,791,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PARP11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,808,861 - 3,873,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl123,791,047 - 3,873,448 (-)EnsemblGRCh38hg38GRCh38
GRCh37123,918,027 - 3,982,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,788,288 - 3,852,863 (-)NCBINCBI36Build 36hg18NCBI36
Build 34123,791,397 - 3,852,801NCBI
Celera125,540,003 - 5,604,577 (-)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef123,774,077 - 3,838,651 (-)NCBIHuRef
CHM1_1123,917,467 - 3,982,056 (-)NCBICHM1_1
T2T-CHM13v2.0123,815,532 - 3,880,061 (-)NCBIT2T-CHM13v2.0
Parp11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,423,803 - 127,491,200 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,423,803 - 127,471,224 (+)EnsemblGRCm39 Ensembl
GRCm386127,446,830 - 127,514,233 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,446,840 - 127,494,261 (+)EnsemblGRCm38mm10GRCm38
MGSCv376127,403,741 - 127,444,257 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366127,419,342 - 127,459,858 (+)NCBIMGSCv36mm8
Celera6129,128,692 - 129,169,408 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map662.39NCBI
Parp11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,984,192 - 162,030,550 (+)NCBIGRCr8
mRatBN7.24160,298,040 - 160,344,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4160,304,905 - 160,341,946 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.04160,013,968 - 160,059,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4160,020,472 - 160,058,729 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04231,551,302 - 231,590,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,866,313 - 163,937,904 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4149,016,105 - 149,058,242 (+)NCBICelera
Cytogenetic Map4q42NCBI
Parp11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554131,615,304 - 1,682,410 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554131,549,572 - 1,682,395 (-)NCBIChiLan1.0ChiLan1.0
PARP11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2109,361,911 - 9,423,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,328,236 - 9,420,322 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0123,928,474 - 3,992,713 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,854,338 - 3,916,318 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,857,256 - 3,879,242 (-)Ensemblpanpan1.1panPan2
PARP11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,982,462 - 41,029,264 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,943,824 - 41,026,800 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,652,608 - 5,699,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02741,340,525 - 41,387,051 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2741,299,505 - 41,387,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12741,277,910 - 41,324,618 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02741,252,812 - 41,299,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,014,976 - 5,061,763 (-)NCBIUU_Cfam_GSD_1.0
Parp11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945105,063,793 - 105,121,086 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,063,171 - 4,120,397 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366064,062,301 - 4,120,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1113,855,701 - 3,909,368 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl113,858,993 - 3,909,340 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660634,332,985 - 4,390,932 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Parp11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624860987,260 - 1,042,618 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624860987,266 - 1,042,559 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PARP11
1516 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 4 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000000791   ⟹   ENSSSCP00000000775
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl566,443,548 - 66,482,346 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000032426   ⟹   ENSSSCP00000020998
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl566,458,653 - 66,483,626 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000036895   ⟹   ENSSSCP00000035345
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl566,448,716 - 66,481,474 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000102847   ⟹   ENSSSCP00000080513
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl566,443,494 - 66,482,085 (+)Ensembl
RefSeq Acc Id: XM_003126559   ⟹   XP_003126607
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1566,443,483 - 66,483,630 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005664071   ⟹   XP_005664128
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1566,443,593 - 66,483,630 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013997828   ⟹   XP_013853282
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1566,443,536 - 66,483,630 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003126607   ⟸   XM_003126559
- Peptide Label: isoform X1
- UniProtKB: A0A286ZV63 (UniProtKB/TrEMBL),   A0A4X1UMS3 (UniProtKB/TrEMBL),   A0A8D1PYL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013853282   ⟸   XM_013997828
- Peptide Label: isoform X2
- UniProtKB: F1SKY8 (UniProtKB/TrEMBL),   A0A4X1UQW7 (UniProtKB/TrEMBL),   A0A8D0UH90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005664128   ⟸   XM_005664071
- Peptide Label: isoform X3
- UniProtKB: A0A4X1UQZ1 (UniProtKB/TrEMBL),   I3LAD0 (UniProtKB/TrEMBL),   A0A8D0I2H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000000775   ⟸   ENSSSCT00000000791
RefSeq Acc Id: ENSSSCP00000035345   ⟸   ENSSSCT00000036895
RefSeq Acc Id: ENSSSCP00000020998   ⟸   ENSSSCT00000032426
RefSeq Acc Id: ENSSSCP00000080513   ⟸   ENSSSCT00000102847
Protein Domains
PARP catalytic   WWE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005008693 UniProtKB/TrEMBL
  ENSSSCG00015047109 UniProtKB/TrEMBL
  ENSSSCG00025006881 UniProtKB/TrEMBL
  ENSSSCG00030005910 UniProtKB/TrEMBL
  ENSSSCG00035009853 UniProtKB/TrEMBL
  ENSSSCG00040024607 UniProtKB/TrEMBL
  ENSSSCG00045026339 UniProtKB/TrEMBL
  ENSSSCG00055006640 UniProtKB/TrEMBL
  ENSSSCG00060067530 UniProtKB/TrEMBL
  ENSSSCG00065042512 UniProtKB/TrEMBL
  ENSSSCG00070018516 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000791 ENTREZGENE
  ENSSSCT00000000791.5 UniProtKB/TrEMBL
  ENSSSCT00000032426 ENTREZGENE
  ENSSSCT00000032426.4 UniProtKB/TrEMBL
  ENSSSCT00000036895 ENTREZGENE
  ENSSSCT00000036895.3 UniProtKB/TrEMBL
  ENSSSCT00000102847.1 UniProtKB/TrEMBL
  ENSSSCT00005013305.1 UniProtKB/TrEMBL
  ENSSSCT00005013326.1 UniProtKB/TrEMBL
  ENSSSCT00005013347.1 UniProtKB/TrEMBL
  ENSSSCT00015062785.1 UniProtKB/TrEMBL
  ENSSSCT00015063046.1 UniProtKB/TrEMBL
  ENSSSCT00025009141.1 UniProtKB/TrEMBL
  ENSSSCT00025009151.1 UniProtKB/TrEMBL
  ENSSSCT00030008015.1 UniProtKB/TrEMBL
  ENSSSCT00030008027.1 UniProtKB/TrEMBL
  ENSSSCT00035012328.1 UniProtKB/TrEMBL
  ENSSSCT00035012331.1 UniProtKB/TrEMBL
  ENSSSCT00035012339.1 UniProtKB/TrEMBL
  ENSSSCT00040032862.1 UniProtKB/TrEMBL
  ENSSSCT00040032904.1 UniProtKB/TrEMBL
  ENSSSCT00045044814.1 UniProtKB/TrEMBL
  ENSSSCT00045044949.1 UniProtKB/TrEMBL
  ENSSSCT00045045048.1 UniProtKB/TrEMBL
  ENSSSCT00055012827.1 UniProtKB/TrEMBL
  ENSSSCT00055012881.1 UniProtKB/TrEMBL
  ENSSSCT00060092150.1 UniProtKB/TrEMBL
  ENSSSCT00060092162.1 UniProtKB/TrEMBL
  ENSSSCT00065058111.1 UniProtKB/TrEMBL
  ENSSSCT00065058123.1 UniProtKB/TrEMBL
  ENSSSCT00065058124.1 UniProtKB/TrEMBL
  ENSSSCT00070036572.1 UniProtKB/TrEMBL
  ENSSSCT00070036587.1 UniProtKB/TrEMBL
  ENSSSCT00070036598.1 UniProtKB/TrEMBL
  ENSSSCT00070036604.1 UniProtKB/TrEMBL
  ENSSSCT00070036618.1 UniProtKB/TrEMBL
  ENSSSCT00070036638.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.720.50 UniProtKB/TrEMBL
  3.90.228.10 UniProtKB/TrEMBL
InterPro Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
  WWE-dom UniProtKB/TrEMBL
  WWE_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100524437 UniProtKB/TrEMBL
NCBI Gene PARP11 ENTREZGENE
PANTHER POLY [ADP-RIBOSE] POLYMERASE UniProtKB/TrEMBL
  PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP11 UniProtKB/TrEMBL
Pfam PARP UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
PROSITE PARP_CATALYTIC UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
Superfamily-SCOP ADP-ribosylation UniProtKB/TrEMBL
  SSF117839 UniProtKB/TrEMBL
UniProt A0A286ZV63 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UMS3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UQV7_PIG UniProtKB/TrEMBL
  A0A4X1UQW7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UQZ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0I2H1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0IF79_PIG UniProtKB/TrEMBL
  A0A8D0UH90 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1PYL9 ENTREZGENE, UniProtKB/TrEMBL
  F1SKY8 ENTREZGENE, UniProtKB/TrEMBL
  I3LAD0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8W4FMT9 UniProtKB/TrEMBL
VGNC ID VGNC:103308 ENTREZGENE