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Gene: CYTL1 (cytokine like 1) Sus scrofa

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Symbol:

CYTL1

Name:

cytokine like 1

RGD ID:

14144462

Description:

INVOLVED IN cartilage homeostasis (ortholog); chondrocyte differentiation (ortholog); chondroitin sulfate proteoglycan biosynthetic process (ortholog); ASSOCIATED WITH Ellis-Van Creveld syndrome (ortholog); tooth and nail syndrome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytokine-like protein 1

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYTL1 (cytokine like 1)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Cytl1 (cytokine-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cytl1 (cytokine like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cytl1 (cytokine like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CYTL1 (cytokine like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYTL1 (cytokine like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cytl1 (cytokine like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CYTL1 (cytokine like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cytl1 (cytokine like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	5,455,671 - 5,460,861 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	5,455,576 - 5,460,861 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	5,266,914 - 5,272,133 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ellis-Van Creveld syndrome (ISO)

tooth and nail syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cartilage homeostasis (IEA,ISO)

chondrocyte differentiation (IEA,ISO)

chondroitin sulfate proteoglycan biosynthetic process (IEA,ISO)

inner ear development (IEA,ISO)

positive regulation of DNA-binding transcription factor activity (ISO)

positive regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

transcription by RNA polymerase II (IEA,ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CYTL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	5,455,671 - 5,460,861 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	5,455,576 - 5,460,861 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	5,266,914 - 5,272,133 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYTL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	5,014,586 - 5,019,458 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	5,014,586 - 5,019,458 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	5,016,313 - 5,021,185 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	5,067,214 - 5,072,098 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	5,134,387 - 5,139,269	NCBI
Celera	4	4,913,525 - 4,918,414 (-)	NCBI		Celera
Cytogenetic Map	4	p16.2	NCBI
HuRef	4	4,952,728 - 4,957,617 (-)	NCBI		HuRef
CHM1_1	4	5,014,307 - 5,019,195 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	4,984,228 - 4,989,105 (-)	NCBI		T2T-CHM13v2.0

Cytl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	37,892,863 - 37,897,164 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	37,892,863 - 37,897,164 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	37,735,519 - 37,739,820 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	37,735,519 - 37,739,820 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	38,126,758 - 38,131,059 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	38,023,768 - 38,028,069 (+)	NCBI		MGSCv36	mm8
Celera	5	35,191,397 - 35,195,691 (+)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI
cM Map	5	20.21	NCBI

Cytl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	77,278,635 - 77,283,645 (-)	NCBI		GRCr8
mRatBN7.2	14	73,053,876 - 73,058,886 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	73,053,877 - 73,058,886 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	77,508,028 - 77,513,034 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	78,748,888 - 78,753,890 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	75,189,427 - 75,194,462 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	77,805,137 - 77,810,147 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	77,805,130 - 77,810,147 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	77,783,865 - 77,788,875 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	78,349,878 - 78,354,888 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	72,016,197 - 72,021,228 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Cytl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	4,826,755 - 4,831,951 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	4,826,792 - 4,831,424 (+)	NCBI	ChiLan1.0	ChiLan1.0

CYTL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	5,280,955 - 5,286,058 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	5,214,116 - 5,219,213 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	4	5,092,567 - 5,097,456 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	5,092,144 - 5,098,092 (-)	Ensembl	panpan1.1		panPan2

CYTL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	70,354,099 - 70,358,521 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	70,354,090 - 70,359,128 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	72,904,811 - 72,909,240 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	71,113,282 - 71,117,712 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	71,113,283 - 71,117,907 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	70,384,321 - 70,388,747 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	70,544,734 - 70,549,165 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	70,929,545 - 70,933,976 (-)	NCBI		UU_Cfam_GSD_1.0

Cytl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	63,807,132 - 63,813,091 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	17,508,823 - 17,512,663 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	17,508,833 - 17,512,608 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYTL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	41,187,925 - 41,192,768 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	41,187,828 - 41,192,690 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	87,982,211 - 87,987,014 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cytl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	21,968,570 - 21,973,397 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	21,968,360 - 21,972,986 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CYTL1
288 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

circulatory system	ectoderm	hemolymphoid system	mesoderm	nervous system
1	19	1	1	19

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003356855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU915529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01061208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000009545 ⟹ ENSSSCP00000009300

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	5,455,671 - 5,460,861 (+)	Ensembl

RefSeq Acc Id:

XM_003356855 ⟹ XP_003356903

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	8	5,455,576 - 5,460,861 (+)	NCBI

Sequence:

show sequence

GTGCTCTTGGCCTTGGCTGGGACCCACAGGAAATGGAGGCGTGGAGGACCACCCCCAAGCCCCT
GCTTAAAGGGGCGGCCGGCGCCGGGATGCAGTCAGGCTGCTGTCAGGCTGCCTTTGCACCATGA
CACCCCGGCTGCTCCCTCTGCTGCTGCTGCTCCTGGCCCGGCCTCCCGCCGCGCAGCCGACTCC
CCCGACGTGCTACTCCAGGATGCTGGCCCTGAGCCGGGAGATCACCGCTGACTTCCAGAGGCTG
CAGGCCACGGAGCCCTCGGAGCCTTGTGTGAGATACCTGCCCAGGCTGTACCTGGATATACACA
ACTACTGTGTGTTGGACAAGCTGCGGGACTTCGTGGCGTCACCCCAGTGTTGGAGAGTGGCCCA
GGTAGACGCCCTGAAGGACAAGGTGCGGAAACTGTACACCATCATGAACTCGTTCTGCCGGAGA
GACCTGGTGTTCCTATCAGATGACTGCAATGCCTTGGAATACCCCATCCCAGTGACCACTGTCC
GGCCGGATCCTCAGAGGCGGGACCCCGCAGCTCAGACCAGAGACAGAACCCGAGGGCACTGAAG
CTCTCTCAGTGCCCAGACACAGTGGGCTGAAGCCACGGCCCCCACCGGTCTTCCTCTGTGTGTC
CCTGCATCTTCTGGAAAGCGGTTGCCTCTGTTCCTCTCCTGGGGCTGGTTTTGAACATAGAAGC
CTTGCCTCTGCTTCCCCCGGTTGTGTCTTGCCAGGTCGGTTAGATACACGAGCATGTTGATTTG
ATCGCTGAGAAGCAAAGCAACTTCTCTTTTATGAACAATTAGCTTGAGAAGGAGCAAACGAGTG
TGTTTGTAGTACTGCTTTAACGGAGGGGTGGGACCGTTTTTCGTGATGGATAGAAACCTGCTTA
TATTTAATCAAGCTTCTATTTTATACCCTCCACCGCCAACTCTGCTCCTTACAGATATCTTCCA
TTTTTAAAGAAATGCCCCTGCCTCTAAGATGCATTGCAAGGTTCCTGATTACACAGTGCTGACG
GAAACCACTCTTTCAGTGAAAGGTGATGAAAATCAAATAAAGGCTATCTTTAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003356903	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000009300
	ENSSSCP00000009300.3
	ENSSSCP00030003660.1
	ENSSSCP00035005031.1
	ENSSSCP00040028088.1
	ENSSSCP00045028667.1
	ENSSSCP00050033146.1
	ENSSSCP00055001300.1
	ENSSSCP00065004241.1

RefSeq Acc Id:	XP_003356903 ⟸ XM_003356855
- UniProtKB:	F1S5H0 (UniProtKB/TrEMBL), A0A8D1N1E0 (UniProtKB/TrEMBL), A0A8D0K7Q8 (UniProtKB/TrEMBL), A0A8D1TSY0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTPRLLPLLLLLLARPPAAQPTPPTCYSRMLALSREITADFQRLQATEPSEPCVRYLPRLYLDI HNYCVLDKLRDFVASPQCWRVAQVDALKDKVRKLYTIMNSFCRRDLVFLSDDCNALEYPIPVTT VRPDPQRRDPAAQTRDRTRGH hide sequence

Ensembl Acc Id:

ENSSSCP00000009300 ⟸ ENSSSCT00000009545

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000008725	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00030006265	UniProtKB/TrEMBL
	ENSSSCG00035011749	UniProtKB/TrEMBL
	ENSSSCG00040049160	UniProtKB/TrEMBL
	ENSSSCG00045024230	UniProtKB/TrEMBL
	ENSSSCG00050056439	UniProtKB/TrEMBL
	ENSSSCG00055000977	UniProtKB/TrEMBL
	ENSSSCG00065007576	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000009545	ENTREZGENE
	ENSSSCT00000009545.5	UniProtKB/TrEMBL
	ENSSSCT00030008434.1	UniProtKB/TrEMBL
	ENSSSCT00035014753.1	UniProtKB/TrEMBL
	ENSSSCT00040066256.1	UniProtKB/TrEMBL
	ENSSSCT00045041306.1	UniProtKB/TrEMBL
	ENSSSCT00050076963.1	UniProtKB/TrEMBL
	ENSSSCT00055001722.1	UniProtKB/TrEMBL
	ENSSSCT00065010170.1	UniProtKB/TrEMBL
InterPro	CYTL1	UniProtKB/TrEMBL
KEGG Report	ssc:100624008	UniProtKB/TrEMBL
NCBI Gene	CYTL1	ENTREZGENE
PANTHER	CYTOKINE-LIKE PROTEIN 1	UniProtKB/TrEMBL
	PTHR15974	UniProtKB/TrEMBL
Pfam	CYTL1	UniProtKB/TrEMBL
UniProt	A0A8D0K7Q8	ENTREZGENE
	A0A8D0YRW0_PIG	UniProtKB/TrEMBL
	A0A8D1N1E0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1TSY0	ENTREZGENE, UniProtKB/TrEMBL
	F1S5H0	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:87138	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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