PDE4C (phosphodiesterase 4C) - Rat Genome Database

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Gene: PDE4C (phosphodiesterase 4C) Sus scrofa
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Symbol: PDE4C
Name: phosphodiesterase 4C
RGD ID: 14138755
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; FOUND IN cilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1259,567,644 - 59,598,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,129,446 - 59,137,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PDE4C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1259,567,644 - 59,598,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,129,446 - 59,137,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE4C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,208,652 - 18,248,200 (-)EnsemblGRCh38hg38GRCh38
GRCh381918,207,965 - 18,248,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,318,775 - 18,359,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,179,771 - 18,220,010 (-)NCBINCBI36hg18NCBI36
Build 341918,181,514 - 18,205,015NCBI
Celera1918,220,510 - 18,260,722 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,882,418 - 17,922,774 (-)NCBIHuRef
CHM1_11918,318,324 - 18,358,516 (-)NCBICHM1_1
Pde4c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,176,485 - 71,203,835 (+)NCBIGRCm39mm39
GRCm39 Ensembl871,176,369 - 71,203,835 (+)Ensembl
GRCm38870,723,835 - 70,751,186 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,723,720 - 70,751,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,247,963 - 73,275,085 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,653,053 - 73,680,175 (+)NCBImm8
Celera873,280,734 - 73,312,488 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Pde4c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21618,690,727 - 18,711,555 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1618,691,700 - 18,710,640 (-)Ensembl
Rnor_6.01620,442,305 - 20,466,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,442,609 - 20,460,959 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,462,609 - 20,466,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,298,910 - 20,318,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,197,277 - 19,215,627 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,197,497 - 19,200,188 (-)NCBI
Celera1618,883,915 - 18,902,144 (-)NCBICelera
Celera1618,903,793 - 18,907,574 (-)NCBICelera
Cytogenetic Map16p14NCBI
Pde4c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555243,199,534 - 3,218,013 (+)NCBIChiLan1.0ChiLan1.0
PDE4C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11918,663,378 - 18,686,194 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01917,683,455 - 17,709,936 (-)NCBIMhudiblu_PPA_v0panPan3
PDE4C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,767,187 - 44,792,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,742,161 - 44,791,053 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,689,267 - 44,706,455 (+)NCBI
ROS_Cfam_1.02045,261,030 - 45,278,277 (+)NCBI
UMICH_Zoey_3.12044,498,073 - 44,515,446 (+)NCBI
UNSW_CanFamBas_1.02044,908,785 - 44,925,897 (+)NCBI
UU_Cfam_GSD_1.02045,184,206 - 45,201,379 (+)NCBI
Pde4c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,425,746 - 203,437,639 (+)NCBI
SpeTri2.0NW_0049365962,962,671 - 2,984,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE4C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,684,622 - 16,707,412 (-)NCBI
Vero_WHO_p1.0NW_0236660742,669,399 - 2,693,322 (+)NCBI
Pde4c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,539,934 - 1,551,001 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 9 4 3 5 1 18 2 3 3
Below cutoff 1 5

Sequence


Reference Sequences
RefSeq Acc Id: XM_021083501   ⟹   XP_020939160
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1259,568,078 - 59,598,398 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083502   ⟹   XP_020939161
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1259,567,644 - 59,598,398 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083503   ⟹   XP_020939162
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1259,583,940 - 59,598,398 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083504   ⟹   XP_020939163
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1259,584,007 - 59,598,398 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083505   ⟹   XP_020939164
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1259,583,965 - 59,598,398 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020939161   ⟸   XM_021083502
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020939160   ⟸   XM_021083501
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020939162   ⟸   XM_021083503
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020939164   ⟸   XM_021083505
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020939163   ⟸   XM_021083504
- Peptide Label: isoform X4
- Sequence:
Protein Domains
PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000036363 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070015238 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014778 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000051677 UniProtKB/TrEMBL
  ENSSSCP00000056562 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070025031 UniProtKB/TrEMBL
  ENSSSCP00070025038 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015184 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000045396 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000059096 UniProtKB/TrEMBL
  ENSSSCT00070030008 UniProtKB/TrEMBL
  ENSSSCT00070030016 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PDE4_UCR UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene PDE4C ENTREZGENE
Pfam PDE4_UCR UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
UniProt A0A287B5B4_PIG UniProtKB/TrEMBL
  A0A287BKG1_PIG UniProtKB/TrEMBL
  A0A4X1U823_PIG UniProtKB/TrEMBL
  A0A4X1UAL9_PIG UniProtKB/TrEMBL
  F1S918_PIG UniProtKB/TrEMBL
VGNC ID VGNC:100320 ENTREZGENE