C4A (complement C4A (Rodgers blood group)) - Rat Genome Database

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Gene: C4A (complement C4A (Rodgers blood group)) Sus scrofa
Analyze
Symbol: C4A
Name: complement C4A (Rodgers blood group)
RGD ID: 14130271
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); complement binding (ortholog); complement component C1q complex binding (ortholog); INVOLVED IN complement activation (ortholog); detection of molecule of bacterial origin (ortholog); immunoglobulin mediated immune response (ortholog); ASSOCIATED WITH autistic disorder (ortholog); autoimmune disease (ortholog); complement component 4B deficiency (ortholog); FOUND IN classical-complement-pathway C3/C5 convertase complex (ortholog); extracellular space (ortholog); neuronal cell body (ortholog); INTERACTS WITH zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C4; complement C4; complement C4-A
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,068,019 - 24,083,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,068,019 - 24,083,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,729,081 - 27,744,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
zearalenone  (EXP)

References
Additional References at PubMed
PMID:2890688   PMID:2988374   PMID:8661725   PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
C4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,068,019 - 24,083,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,068,019 - 24,083,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,729,081 - 27,744,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,014,795 - 32,035,418 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl632,014,795 - 32,035,418 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,982,572 - 32,003,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,057,813 - 32,078,435 (+)NCBINCBI36Build 36hg18NCBI36
Celera633,549,596 - 33,570,219 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
CHM1_1631,984,848 - 32,005,386 (+)NCBICHM1_1
T2T-CHM13v2.0631,868,001 - 31,888,625 (+)NCBIT2T-CHM13v2.0
C4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,947,249 - 34,962,876 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,947,354 - 34,962,856 (-)EnsemblGRCm39 Ensembl
GRCm381734,728,139 - 34,743,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,728,380 - 34,743,882 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,865,325 - 34,880,842 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,336,443 - 34,351,939 (-)NCBIMGSCv36mm8
Celera1737,826,575 - 37,840,058 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.29NCBI
C4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,197,371 - 4,211,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,197,366 - 4,211,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,903,172 - 4,917,487 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0204,264,923 - 4,279,238 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0204,799,242 - 4,813,541 (+)NCBIRnor_WKY
Rnor_6.0204,302,344 - 4,316,752 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,302,344 - 4,316,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,381,700 - 6,396,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,300,687 - 4,315,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera203,819,383 - 3,833,684 (-)NCBICelera
Cytogenetic Map20p12NCBI
LOC481722
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,433,185 - 1,448,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,568,269 - 1,582,800 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,575,361 - 1,589,884 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1121,433,082 - 1,447,359 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,501,274 - 1,515,547 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,567,611 - 1,582,146 (+)NCBIUU_Cfam_GSD_1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 1 5 2 2 3 1
Low 2 2 2 21
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001570   ⟹   ENSSSCP00000001528
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,068,019 - 24,083,058 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000079853   ⟹   ENSSSCP00000061845
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,068,019 - 24,083,058 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000102168   ⟹   ENSSSCP00000080009
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,068,019 - 24,083,061 (+)Ensembl
RefSeq Acc Id: NM_001123089   ⟹   NP_001116561
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1724,068,019 - 24,083,060 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116561 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR20891 (Get FASTA)   NCBI Sequence Viewer  
  ABW73320 (Get FASTA)   NCBI Sequence Viewer  
  CAN59660 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001116561   ⟸   NM_001123089
- Peptide Label: precursor
- UniProtKB: B0LFE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001528   ⟸   ENSSSCT00000001570
RefSeq Acc Id: ENSSSCP00000061845   ⟸   ENSSSCT00000079853
RefSeq Acc Id: ENSSSCP00000080009   ⟸   ENSSSCT00000102168
Protein Domains
Anaphylatoxin-like   NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001427 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022994 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001528.3 UniProtKB/TrEMBL
  ENSSSCP00000061845 ENTREZGENE
  ENSSSCP00000061845.1 UniProtKB/TrEMBL
  ENSSSCP00070038633.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001570.5 UniProtKB/TrEMBL
  ENSSSCT00000079853 ENTREZGENE
  ENSSSCT00000079853.1 UniProtKB/TrEMBL
  ENSSSCT00070045832.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/TrEMBL
  Anaphylatoxin_comp_syst UniProtKB/TrEMBL
  Complement_C4A UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/TrEMBL
  MG2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
KEGG Report ssc:445467 UniProtKB/TrEMBL
NCBI Gene C4A ENTREZGENE
PANTHER PTHR11412:SF86 UniProtKB/TrEMBL
Pfam A2M UniProtKB/TrEMBL
  A2M_BRD UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  ANATO UniProtKB/TrEMBL
  MG2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
  TED_complement UniProtKB/TrEMBL
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/TrEMBL
  ANAPHYLATOXIN_1 UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
SMART A2M UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  ANATO UniProtKB/TrEMBL
  C345C UniProtKB/TrEMBL
Superfamily-SCOP SSF47686 UniProtKB/TrEMBL
  SSF48239 UniProtKB/TrEMBL
  SSF49410 UniProtKB/TrEMBL
  SSF50242 UniProtKB/TrEMBL
UniProt A0A4X1VBD2_PIG UniProtKB/TrEMBL
  A0A5G2QCL1_PIG UniProtKB/TrEMBL
  A5A8W8_PIG UniProtKB/TrEMBL
  B0LFE9 ENTREZGENE, UniProtKB/TrEMBL
  F1RQW2_PIG UniProtKB/TrEMBL