THRA (thyroid hormone receptor alpha) - Rat Genome Database
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Gene: THRA (thyroid hormone receptor alpha) Sus scrofa
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Symbol: THRA
Name: thyroid hormone receptor alpha
RGD ID: 14128460
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); intronic transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN adrenal gland development (ortholog); animal organ morphogenesis (ortholog); brain development (ortholog); ASSOCIATED WITH breast cancer (ortholog); congenital nongoitrous hypothyroidism 6 (ortholog); Diaphragmatic Hernia (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH clofibrate
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: c-erbA-1; C-ERBA-ALPHA; NR1A1; nuclear receptor subfamily 1 group A member 1; thyroid hormone receptor alpha 2; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,270,062 - 22,296,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,270,506 - 22,296,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,488,984 - 22,497,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
clofibrate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
animal organ morphogenesis  (ISO)
brain development  (ISO)
cartilage condensation  (IEA)
cell differentiation  (IBA)
cytoplasmic sequestering of transcription factor  (ISO)
digestive tract development  (ISO)
embryonic organ development  (ISO)
erythrocyte differentiation  (IEA)
female courtship behavior  (IEA)
hormone-mediated signaling pathway  (IBA,IEA)
intracellular receptor signaling pathway  (IEA)
kidney development  (ISO)
learning or memory  (IEA)
liver development  (ISO)
lung development  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription, initiation  (ISO)
negative regulation of RNA polymerase II transcription preinitiation complex assembly  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA)
negative regulation of transcription, DNA-templated  (ISO)
ossification  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of female receptivity  (IEA)
positive regulation of myotube differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA)
regulation of heart contraction  (IEA)
regulation of lipid catabolic process  (IEA)
regulation of myeloid cell apoptotic process  (IEA)
regulation of thyroid hormone mediated signaling pathway  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IEA)
response to cold  (IEA)
response to drug  (ISO)
response to nutrient levels  (ISO)
thyroid gland development  (IEA)
thyroid hormone mediated signaling pathway  (IBA)
transcription by RNA polymerase II  (IEA)
type I pneumocyte differentiation  (IEA)

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
mitochondrion  (ISO)
nucleus  (IEA)

References
Additional References at PubMed
PMID:10514561   PMID:21751158   PMID:28972010  


Genomics

Comparative Map Data
THRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,270,062 - 22,296,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,270,506 - 22,296,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,488,984 - 22,497,735 (+)NCBISscrofa10.2Sscrofa10.2susScr3
THRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1740,058,290 - 40,093,867 (+)EnsemblGRCh38hg38GRCh38
GRCh381740,062,193 - 40,093,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371738,218,446 - 38,250,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,472,589 - 35,503,646 (+)NCBINCBI36hg18NCBI36
Build 341735,472,588 - 35,499,815NCBI
Celera1734,878,512 - 34,910,230 (+)NCBI
Cytogenetic Map17q21.1NCBI
HuRef1734,012,227 - 34,043,856 (+)NCBIHuRef
CHM1_11738,454,163 - 38,485,823 (+)NCBICHM1_1
Thra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,631,539 - 98,659,832 (+)NCBIGRCm39mm39
GRCm381198,740,776 - 98,769,006 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,740,638 - 98,769,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,603,187 - 98,626,425 (+)NCBIGRCm37mm9NCBIm37
MGSCv361198,557,963 - 98,581,201 (+)NCBImm8
Celera11108,407,991 - 108,419,811 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.58NCBI
Thra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01086,657,285 - 86,684,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,657,285 - 86,684,933 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,453,436 - 86,480,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,514,443 - 87,542,306 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,540,629 - 87,556,674 (+)NCBI
Celera1082,449,971 - 82,477,615 (+)NCBICelera
Cytogenetic Map10q31NCBI
RH 3.4 Map10839.79RGD
Thra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,731,746 - 14,744,367 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,731,746 - 14,743,545 (+)NCBIChiLan1.0ChiLan1.0
THRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11717,420,186 - 17,448,502 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01717,196,459 - 17,226,263 (-)NCBIMhudiblu_PPA_v0panPan3
THRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl922,468,594 - 22,493,445 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1922,469,466 - 22,493,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Thra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649015,188,341 - 15,206,032 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,087,071 - 66,118,137 (-)NCBI
Thra
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247953,109,663 - 3,132,494 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 5 2 22 2 3 1
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000047067   ⟹   ENSSSCP00000036874
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,271,872 - 22,286,595 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000049618   ⟹   ENSSSCP00000041664
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,271,045 - 22,290,353 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000060832   ⟹   ENSSSCP00000032431
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,270,062 - 22,290,130 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000067484   ⟹   ENSSSCP00000066040
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,271,045 - 22,290,353 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000075382   ⟹   ENSSSCP00000071017
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,270,506 - 22,296,618 (-)Ensembl
RefSeq Acc Id: NM_214190   ⟹   NP_999355
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,274,542 - 22,285,160 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021066243   ⟹   XP_020921902
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,270,506 - 22,296,684 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021066244   ⟹   XP_020921903
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,270,506 - 22,286,585 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021066245   ⟹   XP_020921904
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,270,506 - 22,291,032 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020921902   ⟸   XM_021066243
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020921904   ⟸   XM_021066245
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020921903   ⟸   XM_021066244
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999355   ⟸   NM_214190
- UniProtKB: O97716 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000041664   ⟸   ENSSSCT00000049618
RefSeq Acc Id: ENSSSCP00000071017   ⟸   ENSSSCT00000075382
RefSeq Acc Id: ENSSSCP00000032431   ⟸   ENSSSCT00000060832
RefSeq Acc Id: ENSSSCP00000036874   ⟸   ENSSSCT00000047067
RefSeq Acc Id: ENSSSCP00000066040   ⟸   ENSSSCT00000067484
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035969 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00015019223 UniProtKB/Swiss-Prot
  ENSSSCG00025066098 UniProtKB/Swiss-Prot
  ENSSSCG00030035812 UniProtKB/Swiss-Prot
  ENSSSCG00035049912 UniProtKB/Swiss-Prot
  ENSSSCG00040004192 UniProtKB/Swiss-Prot
  ENSSSCG00045035402 UniProtKB/Swiss-Prot
  ENSSSCG00050073891 UniProtKB/Swiss-Prot
  ENSSSCG00055002444 UniProtKB/Swiss-Prot
  ENSSSCG00060074529 UniProtKB/Swiss-Prot
  ENSSSCG00065004151 UniProtKB/Swiss-Prot
  ENSSSCG00070016193 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000032431 UniProtKB/Swiss-Prot
  ENSSSCP00000036874 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000041664 UniProtKB/TrEMBL
  ENSSSCP00000066040 UniProtKB/TrEMBL
  ENSSSCP00000071017 UniProtKB/TrEMBL
  ENSSSCP00015009958 UniProtKB/Swiss-Prot
  ENSSSCP00015009979 UniProtKB/Swiss-Prot
  ENSSSCP00025039926 UniProtKB/Swiss-Prot
  ENSSSCP00030022664 UniProtKB/Swiss-Prot
  ENSSSCP00030022679 UniProtKB/Swiss-Prot
  ENSSSCP00030022726 UniProtKB/Swiss-Prot
  ENSSSCP00035026974 UniProtKB/Swiss-Prot
  ENSSSCP00040001975 UniProtKB/Swiss-Prot
  ENSSSCP00045042736 UniProtKB/Swiss-Prot
  ENSSSCP00050043930 UniProtKB/Swiss-Prot
  ENSSSCP00055003578 UniProtKB/Swiss-Prot
  ENSSSCP00060044427 UniProtKB/Swiss-Prot
  ENSSSCP00065002539 UniProtKB/Swiss-Prot
  ENSSSCP00065002540 UniProtKB/Swiss-Prot
  ENSSSCP00065002544 UniProtKB/Swiss-Prot
  ENSSSCP00070026538 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000047067 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000049618 UniProtKB/TrEMBL
  ENSSSCT00000060832 UniProtKB/Swiss-Prot
  ENSSSCT00000067484 UniProtKB/TrEMBL
  ENSSSCT00000075382 UniProtKB/TrEMBL
  ENSSSCT00015025497 UniProtKB/Swiss-Prot
  ENSSSCT00015025551 UniProtKB/Swiss-Prot
  ENSSSCT00025091091 UniProtKB/Swiss-Prot
  ENSSSCT00030049889 UniProtKB/Swiss-Prot
  ENSSSCT00030049909 UniProtKB/Swiss-Prot
  ENSSSCT00030049980 UniProtKB/Swiss-Prot
  ENSSSCT00035066516 UniProtKB/Swiss-Prot
  ENSSSCT00040005431 UniProtKB/Swiss-Prot
  ENSSSCT00045060844 UniProtKB/Swiss-Prot
  ENSSSCT00050101093 UniProtKB/Swiss-Prot
  ENSSSCT00055004638 UniProtKB/Swiss-Prot
  ENSSSCT00060102103 UniProtKB/Swiss-Prot
  ENSSSCT00065005721 UniProtKB/Swiss-Prot
  ENSSSCT00065005724 UniProtKB/Swiss-Prot
  ENSSSCT00065005735 UniProtKB/Swiss-Prot
  ENSSSCT00070031832 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThyrH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397387 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene THRA ENTREZGENE
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROIDHORMR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480Q663_PIG UniProtKB/TrEMBL
  A0A5G2R623_PIG UniProtKB/TrEMBL
  A0A5G2RHV6_PIG UniProtKB/TrEMBL
  A0A5S6HJG4_PIG UniProtKB/TrEMBL
  O97716 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O97715 UniProtKB/Swiss-Prot
VGNC ID VGNC:93963 ENTREZGENE