CYP2S1 (cytochrome P450 family 2 subfamily S member 1) - Rat Genome Database

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Gene: CYP2S1 (cytochrome P450 family 2 subfamily S member 1) Sus scrofa
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Symbol: CYP2S1
Name: cytochrome P450 family 2 subfamily S member 1
RGD ID: 14124244
Description: ENCODES a protein that exhibits heme binding (inferred); hydro-lyase activity (inferred); iron ion binding (inferred); INVOLVED IN icosanoid metabolic process (inferred); prostaglandin metabolic process (inferred); retinoic acid metabolic process (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytochrome P450 2S1; cytochrome P450, family 2, subfamily S, polypeptide 1; LOC106510546
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,221,763 - 49,235,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,221,361 - 49,235,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,925,122 - 44,935,474 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYP2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,221,763 - 49,235,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,221,361 - 49,235,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,925,122 - 44,935,474 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,193,219 - 41,207,539 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,193,210 - 41,207,539 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,699,124 - 41,713,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,390,955 - 46,405,284 (+)NCBINCBI36Build 36hg18NCBI36
Build 341946,390,954 - 46,405,283NCBI
Celera1938,499,270 - 38,513,599 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,131,135 - 38,145,468 (+)NCBIHuRef
CHM1_11941,698,871 - 41,713,172 (+)NCBICHM1_1
T2T-CHM13v2.01944,013,177 - 44,028,420 (+)NCBIT2T-CHM13v2.0
Cyp2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,501,894 - 25,515,950 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,501,900 - 25,516,338 (-)EnsemblGRCm39 Ensembl
GRCm38725,802,469 - 25,816,525 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,802,475 - 25,816,913 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,587,495 - 26,601,549 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,511,236 - 25,525,290 (-)NCBIMGSCv36mm8
Celera720,411,576 - 20,425,630 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.05NCBI
Cyp2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,437,741 - 90,453,073 (-)NCBIGRCr8
mRatBN7.2181,309,948 - 81,325,303 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,310,451 - 81,325,303 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,702,625 - 86,717,474 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,253,992 - 95,269,028 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,458,434 - 88,473,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,595,211 - 82,610,350 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,595,211 - 82,610,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,854,677 - 83,868,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,008,464 - 81,023,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,087,648 - 81,101,775 (-)NCBI
Celera175,748,428 - 75,763,207 (-)NCBICelera
Cytogenetic Map1q21NCBI
LOC102010839
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555168,139 - 182,196 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555167,634 - 183,572 (+)NCBIChiLan1.0ChiLan1.0
CYP2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,403,087 - 47,417,496 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,271,326 - 49,285,734 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,185,893 - 38,200,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,692,906 - 46,707,004 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,693,025 - 46,705,950 (+)Ensemblpanpan1.1panPan2
CYP2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,735,586 - 112,747,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,736,706 - 112,747,555 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,138,862 - 112,150,468 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,333,336 - 113,344,950 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11112,894,082 - 112,905,643 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,526,640 - 112,538,235 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,519,846 - 113,531,479 (-)NCBIUU_Cfam_GSD_1.0
CYP2S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,512,559 - 35,521,775 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607313,709,718 - 13,726,006 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101700677
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462490757,276 - 67,275 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462490757,749 - 67,274 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CYP2S1
163 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 2 10 3 2 5 12 10 10 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000039237   ⟹   ENSSSCP00000040026
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl649,221,763 - 49,235,330 (+)Ensembl
RefSeq Acc Id: XM_021094414   ⟹   XP_020950073
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1649,221,361 - 49,235,335 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020950073   ⟸   XM_021094414
- UniProtKB: A0A4X1SLR7 (UniProtKB/TrEMBL),   A0A287A8C0 (UniProtKB/TrEMBL),   M3VK37 (UniProtKB/TrEMBL),   A0A8D0ZN08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000040026   ⟸   ENSSSCT00000039237


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032803 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015080720 UniProtKB/TrEMBL
  ENSSSCG00025018476 UniProtKB/TrEMBL
  ENSSSCG00030021377 UniProtKB/TrEMBL
  ENSSSCG00035036431 UniProtKB/TrEMBL
  ENSSSCG00040065927 UniProtKB/TrEMBL
  ENSSSCG00055010667 UniProtKB/TrEMBL
  ENSSSCG00060063701 UniProtKB/TrEMBL
  ENSSSCG00065008215 UniProtKB/TrEMBL
  ENSSSCG00070002248 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039237 ENTREZGENE
  ENSSSCT00000039237.3 UniProtKB/TrEMBL
  ENSSSCT00015109850.1 UniProtKB/TrEMBL
  ENSSSCT00025025052.1 UniProtKB/TrEMBL
  ENSSSCT00030029658.1 UniProtKB/TrEMBL
  ENSSSCT00035048288.1 UniProtKB/TrEMBL
  ENSSSCT00040089995.1 UniProtKB/TrEMBL
  ENSSSCT00055020934.1 UniProtKB/TrEMBL
  ENSSSCT00060086907.1 UniProtKB/TrEMBL
  ENSSSCT00065011017.1 UniProtKB/TrEMBL
  ENSSSCT00070004183.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2A-like UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
NCBI Gene LOC106510546 ENTREZGENE
PANTHER CYTOCHROME P450 2S1 UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP2A UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A287A8C0 ENTREZGENE
  A0A4X1SLR7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ZN08 ENTREZGENE, UniProtKB/TrEMBL
  M3VK37 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287A8C0 UniProtKB/TrEMBL
VGNC ID VGNC:103351 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-21 CYP2S1  cytochrome P450 family 2 subfamily S member 1  LOC106510546  cytochrome P450 2S1  Symbol and/or name change 19259463 PROVISIONAL