PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha) - Rat Genome Database

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Gene: PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha) Sus scrofa
Analyze
Symbol: PPP2R3A
Name: protein phosphatase 2 regulatory subunit B''alpha
RGD ID: 14123661
Description: ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); INVOLVED IN eye photoreceptor cell differentiation (ortholog); negative regulation of canonical Wnt signaling pathway (ortholog); positive regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway; ASSOCIATED WITH atrial fibrillation (ortholog); genetic disease (ortholog); Primary Lymphedema with Myelodysplasia (ortholog); FOUND IN protein phosphatase type 2A complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1376,945,395 - 77,147,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11376,945,318 - 77,148,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21384,435,243 - 84,445,841 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPP2R3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1376,945,395 - 77,147,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11376,945,318 - 77,148,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21384,435,243 - 84,445,841 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2R3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383135,965,728 - 136,147,894 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3135,965,728 - 136,147,894 (+)EnsemblGRCh38hg38GRCh38
GRCh373135,684,570 - 135,866,736 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363137,167,257 - 137,349,423 (+)NCBINCBI36Build 36hg18NCBI36
Build 343137,224,279 - 137,349,431NCBI
Celera3134,110,687 - 134,292,965 (+)NCBICelera
Cytogenetic Map3q22.2-q22.3NCBI
HuRef3133,061,996 - 133,244,183 (+)NCBIHuRef
CHM1_13135,647,730 - 135,830,019 (+)NCBICHM1_1
T2T-CHM13v2.03138,711,499 - 138,893,700 (+)NCBIT2T-CHM13v2.0
Ppp2r3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,982,188 - 101,129,031 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9100,982,283 - 101,128,994 (-)EnsemblGRCm39 Ensembl
GRCm389101,104,989 - 101,251,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9101,105,084 - 101,251,795 (-)EnsemblGRCm38mm10GRCm38
MGSCv379101,007,319 - 101,154,162 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369100,956,921 - 101,108,095 (-)NCBIMGSCv36mm8
Celera9100,640,744 - 100,786,778 (-)NCBICelera
Cytogenetic Map9E4NCBI
cM Map953.19NCBI
Ppp2r3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88110,582,479 - 110,720,516 (-)NCBIGRCr8
mRatBN7.28101,703,512 - 101,841,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8101,704,778 - 101,841,502 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8107,366,598 - 107,462,469 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08105,565,916 - 105,661,788 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08103,408,435 - 103,504,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08109,481,352 - 109,621,462 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8109,482,614 - 109,621,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08108,898,749 - 109,038,840 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48106,061,334 - 106,155,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18106,081,385 - 106,158,939 (-)NCBI
Celera8101,095,388 - 101,189,142 (-)NCBICelera
Cytogenetic Map8q31NCBI
Ppp2r3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555012,648,017 - 2,752,057 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555012,648,017 - 2,751,999 (-)NCBIChiLan1.0ChiLan1.0
PPP2R3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22133,896,877 - 134,079,058 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13133,901,614 - 134,083,788 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03133,017,166 - 133,202,163 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13140,485,926 - 140,666,592 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3140,485,925 - 140,666,592 (+)Ensemblpanpan1.1panPan2
PPP2R3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12332,441,130 - 32,628,588 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2332,471,921 - 32,626,548 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2332,426,057 - 32,613,965 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02332,969,746 - 33,157,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2332,969,747 - 33,157,639 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12332,652,811 - 32,840,709 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02332,720,304 - 32,908,185 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02332,960,890 - 33,151,864 (+)NCBIUU_Cfam_GSD_1.0
Ppp2r3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560272,106,796 - 72,271,369 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365298,920,243 - 9,033,865 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365298,885,803 - 9,034,217 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2R3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11554,291,843 - 54,480,733 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604127,352,064 - 27,547,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2r3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473012,429,902 - 12,567,683 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473012,384,691 - 12,568,115 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP2R3A
3857 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 2 2 9 2 3
Low 8 4 2 3 14 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000041882   ⟹   ENSSSCP00000058883
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1376,945,370 - 77,122,246 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042471   ⟹   ENSSSCP00000059146
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1377,013,312 - 77,146,929 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045079   ⟹   ENSSSCP00000040837
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1376,945,395 - 77,147,072 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000052789   ⟹   ENSSSCP00000055782
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1376,945,384 - 77,147,531 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053754   ⟹   ENSSSCP00000039718
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1376,945,384 - 77,147,531 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064406   ⟹   ENSSSCP00000047972
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1376,992,581 - 77,146,946 (+)Ensembl
RefSeq Acc Id: XM_021069482   ⟹   XP_020925141
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11376,945,318 - 77,147,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021069483   ⟹   XP_020925142
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11376,945,652 - 77,147,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021069484   ⟹   XP_020925143
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11376,992,577 - 77,147,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021069485   ⟹   XP_020925144
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11376,945,346 - 77,120,147 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021069486   ⟹   XP_020925145
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11377,013,223 - 77,148,521 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020925141   ⟸   XM_021069482
- Peptide Label: isoform X1
- UniProtKB: A0A4X1TP04 (UniProtKB/TrEMBL),   A0A287BGR4 (UniProtKB/TrEMBL),   A0A287AAK4 (UniProtKB/TrEMBL),   A0A8D0N9R5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020925144   ⟸   XM_021069485
- Peptide Label: isoform X2
- UniProtKB: A0A8D0Z169 (UniProtKB/TrEMBL),   A0A8D1GBA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020925142   ⟸   XM_021069483
- Peptide Label: isoform X1
- UniProtKB: A0A4X1TP04 (UniProtKB/TrEMBL),   A0A287BGR4 (UniProtKB/TrEMBL),   A0A287AAK4 (UniProtKB/TrEMBL),   A0A8D0N9R5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020925143   ⟸   XM_021069484
- Peptide Label: isoform X1
- UniProtKB: A0A4X1TP04 (UniProtKB/TrEMBL),   A0A287BGR4 (UniProtKB/TrEMBL),   A0A287AAK4 (UniProtKB/TrEMBL),   A0A8D0N9R5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020925145   ⟸   XM_021069486
- Peptide Label: isoform X3
- UniProtKB: A0A287BSN7 (UniProtKB/TrEMBL),   A0A4X1TRS4 (UniProtKB/TrEMBL),   A0A8D0NAK5 (UniProtKB/TrEMBL),   A0A8D0K6M1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047972   ⟸   ENSSSCT00000064406
RefSeq Acc Id: ENSSSCP00000058883   ⟸   ENSSSCT00000041882
RefSeq Acc Id: ENSSSCP00000040837   ⟸   ENSSSCT00000045079
RefSeq Acc Id: ENSSSCP00000059146   ⟸   ENSSSCT00000042471
RefSeq Acc Id: ENSSSCP00000055782   ⟸   ENSSSCT00000052789
RefSeq Acc Id: ENSSSCP00000039718   ⟸   ENSSSCT00000053754
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033185 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005035348 UniProtKB/TrEMBL
  ENSSSCG00015026041 UniProtKB/TrEMBL
  ENSSSCG00025003426 UniProtKB/TrEMBL
  ENSSSCG00030059503 UniProtKB/TrEMBL
  ENSSSCG00035017905 UniProtKB/TrEMBL
  ENSSSCG00040044031 UniProtKB/TrEMBL
  ENSSSCG00045001449 UniProtKB/TrEMBL
  ENSSSCG00050035292 UniProtKB/TrEMBL
  ENSSSCG00055017496 UniProtKB/TrEMBL
  ENSSSCG00060058894 UniProtKB/TrEMBL
  ENSSSCG00070011101 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000042471 ENTREZGENE
  ENSSSCT00000042471.3 UniProtKB/TrEMBL
  ENSSSCT00000045079 ENTREZGENE
  ENSSSCT00000045079.3 UniProtKB/TrEMBL
  ENSSSCT00000064406 ENTREZGENE
  ENSSSCT00000064406.3 UniProtKB/TrEMBL
  ENSSSCT00005056959.1 UniProtKB/TrEMBL
  ENSSSCT00005057005.1 UniProtKB/TrEMBL
  ENSSSCT00005057035.1 UniProtKB/TrEMBL
  ENSSSCT00005057055.1 UniProtKB/TrEMBL
  ENSSSCT00005057079.1 UniProtKB/TrEMBL
  ENSSSCT00005057129.1 UniProtKB/TrEMBL
  ENSSSCT00015034507.1 UniProtKB/TrEMBL
  ENSSSCT00015034635.1 UniProtKB/TrEMBL
  ENSSSCT00015034758.1 UniProtKB/TrEMBL
  ENSSSCT00025004529.1 UniProtKB/TrEMBL
  ENSSSCT00025004539.1 UniProtKB/TrEMBL
  ENSSSCT00025004579.1 UniProtKB/TrEMBL
  ENSSSCT00025004594.1 UniProtKB/TrEMBL
  ENSSSCT00030083293.1 UniProtKB/TrEMBL
  ENSSSCT00035023072.1 UniProtKB/TrEMBL
  ENSSSCT00035023074.1 UniProtKB/TrEMBL
  ENSSSCT00035023080.1 UniProtKB/TrEMBL
  ENSSSCT00035023085.1 UniProtKB/TrEMBL
  ENSSSCT00040059705.1 UniProtKB/TrEMBL
  ENSSSCT00045002344.1 UniProtKB/TrEMBL
  ENSSSCT00045002376.1 UniProtKB/TrEMBL
  ENSSSCT00045002449.1 UniProtKB/TrEMBL
  ENSSSCT00050047470.1 UniProtKB/TrEMBL
  ENSSSCT00055034320.1 UniProtKB/TrEMBL
  ENSSSCT00055034450.1 UniProtKB/TrEMBL
  ENSSSCT00055034580.1 UniProtKB/TrEMBL
  ENSSSCT00055034670.1 UniProtKB/TrEMBL
  ENSSSCT00055034773.1 UniProtKB/TrEMBL
  ENSSSCT00060080418.1 UniProtKB/TrEMBL
  ENSSSCT00070021625.1 UniProtKB/TrEMBL
  ENSSSCT00070021640.1 UniProtKB/TrEMBL
  ENSSSCT00070021650.1 UniProtKB/TrEMBL
  ENSSSCT00070021663.1 UniProtKB/TrEMBL
  ENSSSCT00070021670.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.238.220 UniProtKB/TrEMBL
  1.10.238.230 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF-hand_13 UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  P2R3A_B_D_EF-hand UniProtKB/TrEMBL
NCBI Gene PPP2R3A ENTREZGENE
PANTHER PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam EF-hand_13 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
  P2R3B_EF-hand UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A287AAK4 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AV38_PIG UniProtKB/TrEMBL
  A0A287BGR4 ENTREZGENE
  A0A287BSN7 ENTREZGENE
  A0A4X1TP04 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TRI1_PIG UniProtKB/TrEMBL
  A0A4X1TRS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0K5S8_PIG UniProtKB/TrEMBL
  A0A8D0K6M1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0K8B6_PIG UniProtKB/TrEMBL
  A0A8D0K8Y4_PIG UniProtKB/TrEMBL
  A0A8D0LUU7_PIG UniProtKB/TrEMBL
  A0A8D0N9R5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NAK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Z169 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1GBA9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287BGR4 UniProtKB/TrEMBL
  A0A287BSN7 UniProtKB/TrEMBL
VGNC ID VGNC:108686 ENTREZGENE