TOP2B (DNA topoisomerase II beta) - Rat Genome Database

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Gene: TOP2B (DNA topoisomerase II beta) Sus scrofa
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Symbol: TOP2B
Name: DNA topoisomerase II beta
RGD ID: 14115307
Description: ENCODES a protein that exhibits ribonucleoprotein complex binding (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to ATP (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN doxorubicin pharmacodynamics pathway; doxorubicin response pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); B-Cell Immunodeficiency, Distal Limb Anomalies, and Urogenital Malformations (ortholog); congenital disorder of deglycosylation (ortholog); FOUND IN chromosome (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA topoisomerase 2-beta; topoisomerase (DNA) II beta 180kDa
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1312,507,138 - 12,575,583 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11312,507,738 - 12,575,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21314,119,707 - 14,187,251 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8889548   PMID:17407547   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TOP2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1312,507,138 - 12,575,583 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11312,507,738 - 12,575,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21314,119,707 - 14,187,251 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOP2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38325,597,905 - 25,664,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl325,597,978 - 25,664,909 (-)EnsemblGRCh38hg38GRCh38
GRCh37325,639,396 - 25,706,398 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36325,614,479 - 25,680,792 (-)NCBINCBI36Build 36hg18NCBI36
Build 34325,614,478 - 25,680,792NCBI
Celera325,576,353 - 25,642,666 (-)NCBICelera
Cytogenetic Map3p24.2NCBI
HuRef325,584,872 - 25,651,422 (-)NCBIHuRef
CHM1_1325,589,386 - 25,655,854 (-)NCBICHM1_1
T2T-CHM13v2.0325,600,752 - 25,667,754 (-)NCBIT2T-CHM13v2.0
Top2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39146,038,976 - 6,104,585 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl146,034,301 - 6,104,584 (-)EnsemblGRCm39 Ensembl
GRCm381416,365,206 - 16,430,787 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1416,365,179 - 16,435,462 (+)EnsemblGRCm38mm10GRCm38
MGSCv371417,197,720 - 17,263,301 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361415,158,473 - 15,224,054 (+)NCBIMGSCv36mm8
Celera1412,058,636 - 12,125,106 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
Top2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81511,482,089 - 11,542,464 (-)NCBIGRCr8
mRatBN7.2159,051,340 - 9,111,721 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl159,051,341 - 9,112,085 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1511,194,159 - 11,253,909 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01512,106,947 - 12,166,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01510,407,427 - 10,467,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01510,262,972 - 10,319,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1510,262,651 - 10,320,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01514,308,369 - 14,366,373 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera159,095,127 - 9,153,091 (-)NCBICelera
Cytogenetic Map15p16NCBI
Top2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543017,457,603 - 17,507,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543017,457,603 - 17,523,115 (-)NCBIChiLan1.0ChiLan1.0
TOP2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2225,558,594 - 25,625,391 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1325,563,361 - 25,630,147 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0325,499,239 - 25,566,029 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1325,830,424 - 25,877,870 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl325,828,879 - 25,896,912 (-)Ensemblpanpan1.1panPan2
TOP2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12318,159,521 - 18,206,413 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2318,146,095 - 18,206,287 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2318,145,151 - 18,204,187 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02318,450,639 - 18,509,671 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2318,462,741 - 18,509,662 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12318,269,373 - 18,328,309 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02318,372,171 - 18,431,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02318,486,061 - 18,545,078 (+)NCBIUU_Cfam_GSD_1.0
Top2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118184,007,995 - 184,050,993 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647317,143,894 - 17,189,605 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647317,146,576 - 17,189,589 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11570,266,267 - 70,332,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1570,266,601 - 70,332,824 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604143,404,940 - 43,471,152 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247883,493,188 - 3,590,138 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TOP2B
2013 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000012279   ⟹   ENSSSCP00000011962
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1312,507,138 - 12,575,583 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000068656   ⟹   ENSSSCP00000072509
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1312,507,138 - 12,575,583 (-)Ensembl
RefSeq Acc Id: NM_001258386   ⟹   NP_001245315
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11312,507,738 - 12,575,042 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001245315   ⟸   NM_001258386
- UniProtKB: A0A8D1TV73 (UniProtKB/TrEMBL),   A0A8D0VMC8 (UniProtKB/TrEMBL),   A0A8D1H7M8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000072509   ⟸   ENSSSCT00000068656
Ensembl Acc Id: ENSSSCP00000011962   ⟸   ENSSSCT00000012279
Protein Domains
Toprim


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011213 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015059675 UniProtKB/TrEMBL
  ENSSSCG00030012997 UniProtKB/TrEMBL
  ENSSSCG00035039113 UniProtKB/TrEMBL
  ENSSSCG00040067583 UniProtKB/TrEMBL
  ENSSSCG00045011534 UniProtKB/TrEMBL
  ENSSSCG00050047993 UniProtKB/TrEMBL
  ENSSSCG00055003951 UniProtKB/TrEMBL
  ENSSSCG00065067196 UniProtKB/TrEMBL
  ENSSSCG00070017617 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012279.5 UniProtKB/TrEMBL
  ENSSSCT00000068656 ENTREZGENE
  ENSSSCT00000068656.2 UniProtKB/TrEMBL
  ENSSSCT00015080370.1 UniProtKB/TrEMBL
  ENSSSCT00030017882.1 UniProtKB/TrEMBL
  ENSSSCT00035051956.1 UniProtKB/TrEMBL
  ENSSSCT00035051967.1 UniProtKB/TrEMBL
  ENSSSCT00040092559.1 UniProtKB/TrEMBL
  ENSSSCT00040092932.1 UniProtKB/TrEMBL
  ENSSSCT00045019601.1 UniProtKB/TrEMBL
  ENSSSCT00045019686.1 UniProtKB/TrEMBL
  ENSSSCT00045019767.1 UniProtKB/TrEMBL
  ENSSSCT00050065396.1 UniProtKB/TrEMBL
  ENSSSCT00050065406.1 UniProtKB/TrEMBL
  ENSSSCT00055007772.1 UniProtKB/TrEMBL
  ENSSSCT00055007782.1 UniProtKB/TrEMBL
  ENSSSCT00065092256.1 UniProtKB/TrEMBL
  ENSSSCT00065092294.1 UniProtKB/TrEMBL
  ENSSSCT00070034906.1 UniProtKB/TrEMBL
  ENSSSCT00070034910.1 UniProtKB/TrEMBL
  ENSSSCT00070034932.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.268.10 UniProtKB/TrEMBL
  3.30.1360.40 UniProtKB/TrEMBL
  3.30.1490.30 UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
  3.40.50.670 UniProtKB/TrEMBL
  3.90.199.10 UniProtKB/TrEMBL
InterPro DNA_Topoisomerase_II UniProtKB/TrEMBL
  DTHCT UniProtKB/TrEMBL
  HATPase_C UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
  Topo_IIA UniProtKB/TrEMBL
  Topo_IIA-like_dom_sf UniProtKB/TrEMBL
  Topo_IIA_A/C UniProtKB/TrEMBL
  Topo_IIA_A/C_ab UniProtKB/TrEMBL
  Topo_IIA_A_a_sf UniProtKB/TrEMBL
  Topo_IIA_B_C UniProtKB/TrEMBL
  Topo_IIA_bsu_dom2 UniProtKB/TrEMBL
  TopoII_euk UniProtKB/TrEMBL
  TopoIIA_CS UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/TrEMBL
  TOPRIM_domain UniProtKB/TrEMBL
  TOPRIM_TopoII UniProtKB/TrEMBL
KEGG Report ssc:100156319 UniProtKB/TrEMBL
NCBI Gene TOP2B ENTREZGENE
PANTHER DNA TOPOISOMERASE/GYRASE UniProtKB/TrEMBL
  PTHR10169:SF36 UniProtKB/TrEMBL
Pfam DNA_gyraseB UniProtKB/TrEMBL
  DNA_topoisoIV UniProtKB/TrEMBL
  DTHCT UniProtKB/TrEMBL
  HATPase_c UniProtKB/TrEMBL
  Toprim UniProtKB/TrEMBL
  TOPRIM_C UniProtKB/TrEMBL
PRINTS TOPISMRASEII UniProtKB/TrEMBL
  TPI2FAMILY UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_II UniProtKB/TrEMBL
  TOPRIM UniProtKB/TrEMBL
SMART TOP2c UniProtKB/TrEMBL
  TOP4c UniProtKB/TrEMBL
Superfamily-SCOP SSF54211 UniProtKB/TrEMBL
  SSF55874 UniProtKB/TrEMBL
  SSF56719 UniProtKB/TrEMBL
UniProt A0A4X1UIY2_PIG UniProtKB/TrEMBL
  A0A4X1UKM7_PIG UniProtKB/TrEMBL
  A0A4X1UKP8_PIG UniProtKB/TrEMBL
  A0A5G2R5Z1_PIG UniProtKB/TrEMBL
  A0A8D0PDZ0_PIG UniProtKB/TrEMBL
  A0A8D0VMC8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1H7M8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KJC7_PIG UniProtKB/TrEMBL
  A0A8D1TV73 ENTREZGENE, UniProtKB/TrEMBL
  F1RS45_PIG UniProtKB/TrEMBL
  Q9GKI9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:94311 ENTREZGENE