NECAB1 (N-terminal EF-hand calcium binding protein 1) - Rat Genome Database

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Gene: NECAB1 (N-terminal EF-hand calcium binding protein 1) Sus scrofa
Analyze
Symbol: NECAB1
Name: N-terminal EF-hand calcium binding protein 1
RGD ID: 14113973
Description: ENCODES a protein that exhibits calcium ion binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN blastocyst hatching (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: N-terminal EF-hand calcium-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl445,982,106 - 46,239,654 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1445,981,777 - 46,239,673 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2449,754,887 - 49,826,195 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NECAB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl445,982,106 - 46,239,654 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1445,981,777 - 46,239,673 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2449,754,887 - 49,826,195 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NECAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38890,791,775 - 90,959,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl890,791,741 - 90,959,393 (+)EnsemblGRCh38hg38GRCh38
GRCh37891,804,003 - 91,971,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36891,872,954 - 92,040,806 (+)NCBINCBI36Build 36hg18NCBI36
Build 34891,872,953 - 92,040,806NCBI
Celera887,998,620 - 88,166,361 (+)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef887,013,523 - 87,181,552 (+)NCBIHuRef
CHM1_1891,844,508 - 92,012,293 (+)NCBICHM1_1
T2T-CHM13v2.0891,916,601 - 92,084,316 (+)NCBIT2T-CHM13v2.0
Necab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39414,952,245 - 15,149,804 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl414,952,245 - 15,149,794 (-)EnsemblGRCm39 Ensembl
GRCm38414,952,245 - 15,149,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl414,952,245 - 15,149,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv37414,879,392 - 15,076,278 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36414,879,395 - 15,076,261 (-)NCBIMGSCv36mm8
Celera414,753,853 - 14,952,324 (-)NCBICelera
Cytogenetic Map4A2NCBI
cM Map46.45NCBI
Necab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8533,155,078 - 33,375,707 (-)NCBIGRCr8
mRatBN7.2528,357,859 - 28,578,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl528,357,859 - 28,578,642 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl528,330,206 - 28,357,152 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx530,518,914 - 30,720,223 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0532,111,591 - 32,312,896 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0532,071,758 - 32,273,057 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0528,507,596 - 28,737,556 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl528,504,558 - 28,737,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0533,184,793 - 33,414,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4529,427,273 - 29,664,037 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1529,427,272 - 29,664,037 (-)NCBI
Celera527,607,138 - 27,808,811 (-)NCBICelera
Cytogenetic Map5q13NCBI
Necab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554177,573,861 - 7,737,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554177,573,861 - 7,737,920 (+)NCBIChiLan1.0ChiLan1.0
NECAB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27108,160,887 - 108,330,181 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1883,699,385 - 83,868,688 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0887,453,523 - 87,622,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1889,405,495 - 89,573,788 (+)NCBIpanpan1.1PanPan1.1panPan2
NECAB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12936,154,555 - 36,332,111 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2936,154,510 - 36,329,460 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2936,299,409 - 36,484,455 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02936,348,024 - 36,533,389 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2936,348,046 - 36,533,385 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12936,346,899 - 36,553,590 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02936,349,439 - 36,535,346 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02936,788,023 - 36,973,627 (+)NCBIUU_Cfam_GSD_1.0
Necab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530343,201,181 - 43,352,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365444,439,900 - 4,583,885 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365444,439,739 - 4,589,060 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NECAB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1885,851,899 - 86,027,993 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603954,835,703 - 55,012,088 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Necab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247441,021,089 - 1,211,694 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247441,021,362 - 1,211,739 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NECAB1
3276 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 9 1
Low 1 12
Below cutoff 3 2 3 1 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000040864   ⟹   ENSSSCP00000050813
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl445,982,106 - 46,239,654 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000078735   ⟹   ENSSSCP00000070080
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl445,982,115 - 46,239,729 (-)Ensembl
RefSeq Acc Id: XM_021089131   ⟹   XP_020944790
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1445,981,777 - 46,239,673 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020944790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000050813
  ENSSSCP00000050813.2
  ENSSSCP00070025842.1
Reference Protein Sequences
RefSeq Acc Id: XP_020944790   ⟸   XM_021089131
- UniProtKB: A0A4X1UD70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000070080   ⟸   ENSSSCT00000078735
RefSeq Acc Id: ENSSSCP00000050813   ⟸   ENSSSCT00000040864
Protein Domains
ABM   EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031424 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070015772 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040864 ENTREZGENE
  ENSSSCT00000040864.3 UniProtKB/TrEMBL
  ENSSSCT00070030985.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.100 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro ABM_dom UniProtKB/TrEMBL
  Dimeric_a/b-barrel UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  NECAB1/2/3 UniProtKB/TrEMBL
NCBI Gene NECAB1 ENTREZGENE
PANTHER N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 1 UniProtKB/TrEMBL
  PTHR12178 UniProtKB/TrEMBL
Pfam ABM UniProtKB/TrEMBL
PROSITE ABM UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF54909 UniProtKB/TrEMBL
UniProt A0A287B321_PIG UniProtKB/TrEMBL
  A0A4X1UD70 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90659 ENTREZGENE