DLD (dihydrolipoamide dehydrogenase) - Rat Genome Database

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Gene: DLD (dihydrolipoamide dehydrogenase) Sus scrofa
Analyze
Symbol: DLD
Name: dihydrolipoamide dehydrogenase
RGD ID: 14110839
Description: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, the protein can function as a protease. [provided by RefSeq, Jan 2014]
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dihydrolipoyl dehydrogenase, mitochondrial; DLDH; lipoamide dehydrogenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9107,642,095 - 107,673,583 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19107,642,129 - 107,668,443 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29118,410,873 - 118,437,344 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
2-aminoadipic 2-oxoadipic aciduria pathway  (ISO)
3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway  (ISO)
3-hydroxyisobutyric aciduria pathway  (ISO)
3-methylcrotonyl CoA carboxylase 1 deficiency pathway  (ISO)
3-methylglutaconic aciduria type 1 pathway  (ISO)
3-methylglutaconic aciduria type 3 pathway  (ISO)
citric acid cycle pathway  (ISO)
dihydropyrimidine dehydrogenase deficiency pathway  (ISO)
dimethylglycine dehydrogenase deficiency pathway  (ISO)
folate cycle metabolic pathway  (ISO)
fumaric aciduria pathway  (ISO)
glutaric aciduria type I pathway  (ISO)
hyperlysinemia pathway  (ISO)
isobutyryl-CoA dehydrogenase deficiency pathway  (ISO)
isovaleric acidemia pathway  (ISO)
Leigh disease pathway  (ISO)
lysine degradation pathway  (ISO)
malonic aciduria pathway  (ISO)
maple syrup urine disease pathway  (ISO)
methylmalonate semialdehyde dehydrogenase deficiency pathway  (ISO)
methylmalonic acidemia pathway  (ISO)
methylmalonic aciduria, cobalamin-related pathway  (ISO)
mitochondrial complex II deficiency pathway  (ISO)
nonketotic hyperglycinemia pathway  (ISO)
primary hyperoxaluria type 2 pathway  (ISO)
propanoate metabolic pathway  (ISO)
propionic acidemia pathway  (ISO)
pyruvate decarboxylase deficiency pathway  (ISO)
pyruvate dehydrogenase E1 deficiency pathway  (ISO)
pyruvate dehydrogenase E2 deficiency pathway  (ISO)
pyruvate dehydrogenase E3 deficiency pathway  (ISO)
pyruvate kinase deficiency of red cells pathway  (ISO)
pyruvate metabolic pathway  (ISO)
saccharopinuria pathway  (ISO)
sarcosinemia pathway  (ISO)
valine, leucine and isoleucine degradation pathway  (ISO)

References
Additional References at PubMed
PMID:3693355   PMID:6954534   PMID:14681463   PMID:15196936   PMID:17404228   PMID:20097961  


Genomics

Comparative Map Data
DLD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9107,642,095 - 107,673,583 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19107,642,129 - 107,668,443 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29118,410,873 - 118,437,344 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7107,891,162 - 107,931,730 (+)EnsemblGRCh38hg38GRCh38
GRCh387107,891,107 - 107,921,198 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377107,531,552 - 107,561,643 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367107,318,822 - 107,348,879 (+)NCBINCBI36hg18NCBI36
Build 347107,125,561 - 107,154,360NCBI
Celera7102,338,571 - 102,368,626 (+)NCBI
Cytogenetic Map7q31.1NCBI
HuRef7101,894,030 - 101,924,084 (+)NCBIHuRef
CHM1_17107,465,307 - 107,495,360 (+)NCBICHM1_1
CRA_TCAGchr7v27106,892,712 - 106,922,768 (+)NCBI
Dld
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391231,381,561 - 31,401,470 (-)NCBIGRCm39mm39
GRCm39 Ensembl1231,381,276 - 31,401,452 (-)Ensembl
GRCm381231,331,562 - 31,351,471 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1231,331,277 - 31,351,453 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,016,427 - 32,036,302 (-)NCBIGRCm37mm9NCBIm37
MGSCv361231,917,620 - 31,937,454 (-)NCBImm8
Celera1232,779,653 - 32,799,528 (-)NCBICelera
Cytogenetic Map12A2NCBI
cM Map1213.43NCBI
Dld
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2647,904,153 - 47,924,814 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl647,903,914 - 47,924,795 (-)Ensembl
Rnor_6.0650,597,677 - 50,618,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl650,597,677 - 50,618,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0659,273,427 - 59,293,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4649,185,188 - 49,205,894 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1649,188,314 - 49,209,020 (-)NCBI
Celera647,106,161 - 47,126,575 (-)NCBICelera
Cytogenetic Map6q16NCBI
Dld
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541012,212,963 - 12,238,561 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541012,212,981 - 12,238,561 (+)NCBIChiLan1.0ChiLan1.0
DLD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17112,593,934 - 112,623,629 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7112,593,934 - 112,623,629 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0799,872,020 - 99,901,884 (+)NCBIMhudiblu_PPA_v0panPan3
DLD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11812,703,340 - 12,734,408 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1812,703,341 - 12,734,479 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1812,347,573 - 12,378,642 (-)NCBI
ROS_Cfam_1.01812,974,872 - 13,005,942 (-)NCBI
UMICH_Zoey_3.11812,791,797 - 12,823,078 (-)NCBI
UNSW_CanFamBas_1.01812,712,079 - 12,743,105 (-)NCBI
UU_Cfam_GSD_1.01812,939,857 - 12,971,151 (-)NCBI
Dld
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,123,461 - 55,147,834 (-)NCBI
SpeTri2.0NW_00493647916,247,230 - 16,271,597 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12176,795,573 - 76,825,504 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2176,795,592 - 76,824,923 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604227,037,869 - 27,067,933 (-)NCBIVero_WHO_p1.0
Dld
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473921,842,897 - 21,873,334 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000016824   ⟹   ENSSSCP00000016374
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9107,642,095 - 107,668,720 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000073075   ⟹   ENSSSCP00000063057
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9107,642,095 - 107,668,720 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000079736   ⟹   ENSSSCP00000061323
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9107,642,138 - 107,670,051 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000084040   ⟹   ENSSSCP00000063389
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9107,642,095 - 107,668,720 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000089601   ⟹   ENSSSCP00000066635
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9107,642,944 - 107,668,720 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000090517   ⟹   ENSSSCP00000062140
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9107,642,124 - 107,673,583 (+)Ensembl
RefSeq Acc Id: NM_214062   ⟹   NP_999227
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19107,642,129 - 107,668,443 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999227 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA31069 (Get FASTA)   NCBI Sequence Viewer  
  BAI47781 (Get FASTA)   NCBI Sequence Viewer  
  JAA74189 (Get FASTA)   NCBI Sequence Viewer  
  P09623 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999227   ⟸   NM_214062
- Peptide Label: precursor
- UniProtKB: P09623 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000063389   ⟸   ENSSSCT00000084040
RefSeq Acc Id: ENSSSCP00000061323   ⟸   ENSSSCT00000079736
RefSeq Acc Id: ENSSSCP00000062140   ⟸   ENSSSCT00000090517
RefSeq Acc Id: ENSSSCP00000066635   ⟸   ENSSSCT00000089601
RefSeq Acc Id: ENSSSCP00000016374   ⟸   ENSSSCT00000016824
RefSeq Acc Id: ENSSSCP00000063057   ⟸   ENSSSCT00000073075
Protein Domains
Pyr_redox_2   Pyr_redox_dim


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015443 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070021583 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000016374 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000061323 UniProtKB/TrEMBL
  ENSSSCP00000062140 UniProtKB/TrEMBL
  ENSSSCP00000063057 UniProtKB/TrEMBL
  ENSSSCP00000063389 UniProtKB/TrEMBL
  ENSSSCP00000066635 UniProtKB/TrEMBL
  ENSSSCP00070036104 UniProtKB/TrEMBL
  ENSSSCP00070036115 UniProtKB/TrEMBL
  ENSSSCP00070036119 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000016824 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000073075 UniProtKB/TrEMBL
  ENSSSCT00000079736 UniProtKB/TrEMBL
  ENSSSCT00000084040 UniProtKB/TrEMBL
  ENSSSCT00000089601 UniProtKB/TrEMBL
  ENSSSCT00000090517 UniProtKB/TrEMBL
  ENSSSCT00070042918 UniProtKB/TrEMBL
  ENSSSCT00070042929 UniProtKB/TrEMBL
  ENSSSCT00070042933 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipoamide_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nuc-diS_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_OxRdtase_I_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397129 UniProtKB/Swiss-Prot
NCBI Gene DLD ENTREZGENE
Pfam Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_dim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Mercury_reductase_MerA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PYRIDINE_REDOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs lipoamide_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480N1D9_PIG UniProtKB/TrEMBL
  A0A4X1V436_PIG UniProtKB/TrEMBL
  A0A4X1V5N5_PIG UniProtKB/TrEMBL
  A0A4X1V5Q2_PIG UniProtKB/TrEMBL
  A0A5G2QGG6_PIG UniProtKB/TrEMBL
  A0A5G2QH34_PIG UniProtKB/TrEMBL
  A0A5G2QPK6_PIG UniProtKB/TrEMBL
  A0A5G2QXX6_PIG UniProtKB/TrEMBL
  D0G6S3_PIG UniProtKB/TrEMBL
  DLDH_PIG UniProtKB/Swiss-Prot
  F1SAF0_PIG UniProtKB/TrEMBL
  P09623 ENTREZGENE