FRAS1 (Fraser extracellular matrix complex subunit 1) - Rat Genome Database

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Gene: FRAS1 (Fraser extracellular matrix complex subunit 1) Sus scrofa
Analyze
Symbol: FRAS1
Name: Fraser extracellular matrix complex subunit 1
RGD ID: 14108784
Description: INVOLVED IN embryonic limb morphogenesis (ortholog); metanephros morphogenesis (ortholog); morphogenesis of an epithelium (ortholog); ASSOCIATED WITH Axenfeld-Rieger syndrome (ortholog); CAKUT (ortholog); clubfoot (ortholog); FOUND IN basement membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: extracellular matrix protein FRAS1; Fraser syndrome 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl873,502,717 - 73,957,375 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1873,502,368 - 73,959,454 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2877,753,520 - 78,204,495 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
FRAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl873,502,717 - 73,957,375 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1873,502,368 - 73,959,454 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2877,753,520 - 78,204,495 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FRAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38478,057,323 - 78,544,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl478,057,323 - 78,544,269 (+)EnsemblGRCh38hg38GRCh38
GRCh37478,978,477 - 79,465,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36479,198,120 - 79,684,447 (+)NCBINCBI36Build 36hg18NCBI36
Build 34479,336,312 - 79,724,964NCBI
Celera476,280,569 - 76,761,461 (+)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef474,729,839 - 75,211,820 (+)NCBIHuRef
CHM1_1478,955,468 - 79,441,921 (+)NCBICHM1_1
T2T-CHM13v2.0481,398,139 - 81,879,833 (+)NCBIT2T-CHM13v2.0
Fras1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39596,518,622 - 96,932,592 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl596,521,814 - 96,932,587 (+)EnsemblGRCm39 Ensembl
GRCm38596,373,777 - 96,784,733 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl596,373,955 - 96,784,728 (+)EnsemblGRCm38mm10GRCm38
MGSCv37596,802,974 - 97,213,747 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36596,614,257 - 97,025,030 (+)NCBIMGSCv36mm8
Celera593,713,114 - 94,117,836 (+)NCBICelera
Cytogenetic Map5E3NCBI
cM Map547.29NCBI
Fras1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81413,095,370 - 13,506,895 (-)NCBIGRCr8
mRatBN7.21412,791,407 - 13,200,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,793,599 - 13,200,726 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1412,762,032 - 13,168,346 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01414,061,884 - 14,468,203 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,778,367 - 13,184,674 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01414,438,392 - 14,853,016 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1414,439,082 - 14,689,554 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01414,380,117 - 14,795,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41414,309,668 - 14,574,022 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11414,340,005 - 14,589,252 (-)NCBI
Celera1412,851,004 - 13,251,138 (-)NCBICelera
Cytogenetic Map14p22NCBI
Fras1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554332,547,323 - 2,957,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554332,547,228 - 2,957,294 (+)NCBIChiLan1.0ChiLan1.0
FRAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2351,518,280 - 52,008,877 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1451,707,425 - 52,195,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0445,650,346 - 46,138,222 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1451,497,242 - 51,983,161 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl451,500,396 - 51,981,476 (-)Ensemblpanpan1.1panPan2
FRAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1322,558,442 - 2,993,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl322,558,354 - 2,991,063 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3238,900,653 - 39,334,034 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0322,585,113 - 3,019,145 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl322,585,107 - 3,017,320 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1322,573,250 - 3,006,733 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0322,521,646 - 2,954,866 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03237,216,085 - 37,650,773 (-)NCBIUU_Cfam_GSD_1.0
Fras1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052859,368,402 - 9,787,973 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366761,870,814 - 2,135,823 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366761,870,856 - 2,138,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1726,545,048 - 26,992,346 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl726,700,869 - 26,954,352 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660374,899,779 - 5,375,874 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fras1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475712,532,466 - 12,972,918 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475712,529,475 - 12,973,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FRAS1
15508 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 3 2 3 4 2 23 1 3 1
Below cutoff 6 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009848   ⟹   ENSSSCP00000009595
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl873,502,664 - 73,958,083 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000033980   ⟹   ENSSSCP00000028747
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl873,503,295 - 73,957,375 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000034559   ⟹   ENSSSCP00000030152
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl873,502,664 - 73,958,083 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000065756   ⟹   ENSSSCP00000044572
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl873,502,664 - 73,958,083 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000072143   ⟹   ENSSSCP00000067597
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl873,502,664 - 73,958,083 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000075282   ⟹   ENSSSCP00000064903
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl873,502,664 - 73,958,083 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000080511   ⟹   ENSSSCP00000071538
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl873,502,664 - 73,958,083 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000084016   ⟹   ENSSSCP00000061113
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl873,502,717 - 73,760,589 (+)Ensembl
RefSeq Acc Id: XM_013978814   ⟹   XP_013834268
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1873,503,709 - 73,959,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100604   ⟹   XP_020956263
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1873,502,368 - 73,959,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100605   ⟹   XP_020956264
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1873,502,369 - 73,959,442 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020956263   ⟸   XM_021100604
- Peptide Label: isoform X2
- UniProtKB: A0A8D1QPB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020956264   ⟸   XM_021100605
- Peptide Label: isoform X3
- UniProtKB: A0A8D0TR79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013834268   ⟸   XM_013978814
- Peptide Label: isoform X1
- UniProtKB: A0A5G2QS27 (UniProtKB/TrEMBL),   K7GLL6 (UniProtKB/TrEMBL),   A0A8D1QPB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000030152   ⟸   ENSSSCT00000034559
RefSeq Acc Id: ENSSSCP00000009595   ⟸   ENSSSCT00000009848
RefSeq Acc Id: ENSSSCP00000044572   ⟸   ENSSSCT00000065756
RefSeq Acc Id: ENSSSCP00000064903   ⟸   ENSSSCT00000075282
RefSeq Acc Id: ENSSSCP00000071538   ⟸   ENSSSCT00000080511
RefSeq Acc Id: ENSSSCP00000067597   ⟸   ENSSSCT00000072143
RefSeq Acc Id: ENSSSCP00000028747   ⟸   ENSSSCT00000033980
RefSeq Acc Id: ENSSSCP00000061113   ⟸   ENSSSCT00000084016
Protein Domains
VWFC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008991 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005044399 UniProtKB/TrEMBL
  ENSSSCG00015040196 UniProtKB/TrEMBL
  ENSSSCG00045001381 UniProtKB/TrEMBL
  ENSSSCG00055015838 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000033980 ENTREZGENE
  ENSSSCT00000033980.4 UniProtKB/TrEMBL
  ENSSSCT00000084016.2 UniProtKB/TrEMBL
  ENSSSCT00005071784.1 UniProtKB/TrEMBL
  ENSSSCT00015053769.1 UniProtKB/TrEMBL
  ENSSSCT00015054109.1 UniProtKB/TrEMBL
  ENSSSCT00045002250.1 UniProtKB/TrEMBL
  ENSSSCT00055031277.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2030 UniProtKB/TrEMBL
  6.20.200.20 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro CalX-like_sf UniProtKB/TrEMBL
  Calx_beta UniProtKB/TrEMBL
  CSPG_rpt UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
NCBI Gene FRAS1 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1 UniProtKB/TrEMBL
  MATRIX PROTEIN, PUTATIVE-RELATED UniProtKB/TrEMBL
Pfam Cadherin_3 UniProtKB/TrEMBL
  Calx-beta UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
PROSITE CSPG UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
SMART Calx_beta UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  SM00261 UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/TrEMBL
  SSF141072 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A5G2QS27 ENTREZGENE
  A0A5G2QSE3_PIG UniProtKB/TrEMBL
  A0A8D0NPN7_PIG UniProtKB/TrEMBL
  A0A8D0NV02_PIG UniProtKB/TrEMBL
  A0A8D0TR79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1GCM8_PIG UniProtKB/TrEMBL
  A0A8D1QPB9 ENTREZGENE, UniProtKB/TrEMBL
  K7GLL6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A5G2QS27 UniProtKB/TrEMBL
VGNC ID VGNC:88232 ENTREZGENE