MTO1 (mitochondrial tRNA translation optimization 1) - Rat Genome Database

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Gene: MTO1 (mitochondrial tRNA translation optimization 1) Sus scrofa
Analyze
Symbol: MTO1
Name: mitochondrial tRNA translation optimization 1
RGD ID: 14107937
Description: ENCODES a protein that exhibits flavin adenine dinucleotide binding (inferred); INVOLVED IN mitochondrial tRNA wobble uridine modification (ortholog); tRNA wobble uridine modification (ortholog); ASSOCIATED WITH combined oxidative phosphorylation deficiency (ortholog); combined oxidative phosphorylation deficiency 10 (ortholog); Developmental Disabilities (ortholog); FOUND IN cytosol (inferred); mitochondrion (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein MTO1 homolog, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl192,447,164 - 92,483,236 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1192,447,156 - 92,472,488 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21103,499,924 - 103,525,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA)
mitochondrion  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MTO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl192,447,164 - 92,483,236 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1192,447,156 - 92,472,488 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21103,499,924 - 103,525,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38673,461,737 - 73,509,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl673,461,578 - 73,509,236 (+)EnsemblGRCh38hg38GRCh38
GRCh37674,171,460 - 74,218,959 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36674,228,209 - 74,267,896 (+)NCBINCBI36Build 36hg18NCBI36
Celera674,565,658 - 74,605,390 (+)NCBICelera
Cytogenetic Map6q13NCBI
HuRef671,369,741 - 71,410,063 (+)NCBIHuRef
CHM1_1674,338,243 - 74,377,999 (+)NCBICHM1_1
T2T-CHM13v2.0674,638,132 - 74,686,339 (+)NCBIT2T-CHM13v2.0
Mto1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,355,372 - 78,381,447 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl978,355,490 - 78,382,630 (+)EnsemblGRCm39 Ensembl
GRCm38978,443,479 - 78,474,165 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,448,208 - 78,475,348 (+)EnsemblGRCm38mm10GRCm38
MGSCv37978,296,017 - 78,321,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36978,233,904 - 78,259,836 (+)NCBIMGSCv36mm8
Celera975,626,365 - 75,652,703 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
Mto1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8888,188,918 - 88,215,516 (+)NCBIGRCr8
mRatBN7.2879,309,681 - 79,335,231 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,309,982 - 79,335,231 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,839,709 - 84,865,096 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0883,116,858 - 83,142,241 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,939,545 - 80,964,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,807,703 - 85,832,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,808,125 - 85,831,937 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,357,705 - 85,381,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,444,213 - 83,457,260 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1883,372,221 - 83,476,311 (+)NCBI
Celera879,057,065 - 79,081,337 (+)NCBICelera
Cytogenetic Map8q31NCBI
Mto1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554938,636,110 - 8,649,721 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554938,636,093 - 8,655,090 (+)NCBIChiLan1.0ChiLan1.0
MTO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2593,435,896 - 93,477,979 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1691,361,600 - 91,403,718 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0671,282,988 - 71,325,075 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1674,570,849 - 74,612,567 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl674,570,890 - 74,612,567 (+)Ensemblpanpan1.1panPan2
MTO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11235,533,766 - 35,563,058 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1235,533,808 - 35,560,593 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1235,405,010 - 35,434,313 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01236,090,861 - 36,120,181 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1236,090,892 - 36,122,136 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11235,630,018 - 35,657,430 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01235,651,760 - 35,680,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01235,775,710 - 35,805,208 (+)NCBIUU_Cfam_GSD_1.0
Mto1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494670,822,149 - 70,852,299 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936859740,281 - 788,435 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936859757,977 - 788,073 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1171,650,818 - 1,688,362 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl171,651,011 - 1,688,321 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660587,556,648 - 7,600,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mto1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624819687,050 - 722,993 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624819686,759 - 729,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MTO1
373 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 8
Low 10 4 3 4 2 15 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004958   ⟹   ENSSSCP00000004841
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl192,447,164 - 92,483,236 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000103433   ⟹   ENSSSCP00000079251
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl192,447,708 - 92,483,236 (-)Ensembl
RefSeq Acc Id: XM_003121409   ⟹   XP_003121457
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1192,447,157 - 92,472,488 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092413   ⟹   XP_020948072
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1192,447,156 - 92,472,487 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020948072   ⟸   XM_021092413
- Peptide Label: isoform X2
- UniProtKB: A0A8D0I0Y4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003121457   ⟸   XM_003121409
- Peptide Label: isoform X1
- UniProtKB: F1RQG8 (UniProtKB/TrEMBL),   A0A4X1U0H2 (UniProtKB/TrEMBL),   A0A8D0I0Y4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000004841   ⟸   ENSSSCT00000004958
RefSeq Acc Id: ENSSSCP00000079251   ⟸   ENSSSCT00000103433
Protein Domains
MnmG N-terminal   tRNA uridine 5-carboxymethylaminomethyl modification


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004487 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005008120 UniProtKB/TrEMBL
  ENSSSCG00015021565 UniProtKB/TrEMBL
  ENSSSCG00025027635 UniProtKB/TrEMBL
  ENSSSCG00030061747 UniProtKB/TrEMBL
  ENSSSCG00035047775 UniProtKB/TrEMBL
  ENSSSCG00040064962 UniProtKB/TrEMBL
  ENSSSCG00045031354 UniProtKB/TrEMBL
  ENSSSCG00050009940 UniProtKB/TrEMBL
  ENSSSCG00055027175 UniProtKB/TrEMBL
  ENSSSCG00060027746 UniProtKB/TrEMBL
  ENSSSCG00065041839 UniProtKB/TrEMBL
  ENSSSCG00070013160 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004958 ENTREZGENE
  ENSSSCT00000004958.4 UniProtKB/TrEMBL
  ENSSSCT00000103433.1 UniProtKB/TrEMBL
  ENSSSCT00005012316.1 UniProtKB/TrEMBL
  ENSSSCT00015028466.1 UniProtKB/TrEMBL
  ENSSSCT00025037455.1 UniProtKB/TrEMBL
  ENSSSCT00030086307.1 UniProtKB/TrEMBL
  ENSSSCT00035063613.1 UniProtKB/TrEMBL
  ENSSSCT00040088710.1 UniProtKB/TrEMBL
  ENSSSCT00045053550.1 UniProtKB/TrEMBL
  ENSSSCT00050013382.1 UniProtKB/TrEMBL
  ENSSSCT00055053705.1 UniProtKB/TrEMBL
  ENSSSCT00060037550.1 UniProtKB/TrEMBL
  ENSSSCT00065057234.1 UniProtKB/TrEMBL
  ENSSSCT00070025664.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.570 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  GidA-assoc_3 UniProtKB/TrEMBL
  GIDA_C_N UniProtKB/TrEMBL
  MnmG UniProtKB/TrEMBL
  MnmG-rel UniProtKB/TrEMBL
  MnmG-rel_CS UniProtKB/TrEMBL
  MnmG_C_subdom UniProtKB/TrEMBL
  MnmG_C_subdom UniProtKB/TrEMBL
  MnmG_N UniProtKB/TrEMBL
KEGG Report ssc:100515594 UniProtKB/TrEMBL
NCBI Gene MTO1 ENTREZGENE
PANTHER PTHR11806 UniProtKB/TrEMBL
  PTHR11806:SF0 UniProtKB/TrEMBL
Pfam GIDA UniProtKB/TrEMBL
  GIDA_assoc UniProtKB/TrEMBL
  GIDA_C_1st UniProtKB/TrEMBL
PRINTS FADPNR UniProtKB/TrEMBL
PROSITE GIDA_1 UniProtKB/TrEMBL
  GIDA_2 UniProtKB/TrEMBL
SMART GIDA_assoc_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt A0A4X1U0H2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0I0Y4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FIU3_PIG UniProtKB/TrEMBL
  F1RQG8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90465 ENTREZGENE