TNNC1 (troponin C1, slow skeletal and cardiac type) - Rat Genome Database

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Pathways
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Gene: TNNC1 (troponin C1, slow skeletal and cardiac type) Sus scrofa
Analyze
Symbol: TNNC1
Name: troponin C1, slow skeletal and cardiac type
RGD ID: 14106128
Description: ENCODES a protein that exhibits actin filament binding (ortholog); calcium ion binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); diaphragm contraction (ortholog); regulation of muscle contraction (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH cardiomyopathy (ortholog); congenital disorder of glycosylation In (ortholog); dilated cardiomyopathy (ortholog); FOUND IN contractile muscle fiber (ortholog); troponin complex (ortholog); INTERACTS WITH deoxynivalenol; zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: TN-C; TNNC; troponin C, slow skeletal and cardiac muscles
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,591,386 - 34,594,337 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,591,571 - 34,594,320 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,805,313 - 37,808,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:2777752   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TNNC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,591,386 - 34,594,337 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,591,571 - 34,594,320 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,805,313 - 37,808,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNNC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,451,100 - 52,454,041 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,451,100 - 52,454,041 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,485,116 - 52,488,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,460,158 - 52,463,098 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,460,157 - 52,463,098NCBI
Celera352,464,352 - 52,467,302 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,547,765 - 52,550,715 (-)NCBIHuRef
CHM1_1352,437,484 - 52,440,434 (-)NCBICHM1_1
T2T-CHM13v2.0352,484,001 - 52,486,942 (-)NCBIT2T-CHM13v2.0
Tnnc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,930,274 - 30,933,671 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,930,269 - 30,933,686 (+)EnsemblGRCm39 Ensembl
GRCm381431,208,312 - 31,211,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,208,312 - 31,211,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv371432,021,498 - 32,024,897 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,037,321 - 30,040,720 (+)NCBIMGSCv36mm8
Celera1427,466,935 - 27,470,320 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Tnnc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,408,607 - 6,412,070 (+)NCBIGRCr8
mRatBN7.2166,400,801 - 6,405,634 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,402,171 - 6,405,634 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,414,415 - 6,417,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,559,640 - 7,562,670 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,421,423 - 6,424,453 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,292,207 - 7,295,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,292,096 - 7,295,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,220,777 - 7,223,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,639,357 - 6,642,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,639,312 - 6,642,502 (+)NCBI
Celera168,783,769 - 8,786,737 (-)NCBICelera
Cytogenetic Map16p16NCBI
Tnnc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,434,874 - 2,441,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,438,644 - 2,441,596 (-)NCBIChiLan1.0ChiLan1.0
TNNC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,446,169 - 52,449,158 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,450,941 - 52,453,930 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,393,106 - 52,396,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,621,749 - 53,624,726 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,621,749 - 53,624,726 (-)Ensemblpanpan1.1panPan2
TNNC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,313,983 - 37,317,288 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,311,966 - 37,317,321 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,295,437 - 37,298,748 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,664,003 - 37,667,314 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,664,083 - 37,667,311 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,027,955 - 37,031,266 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,436,607 - 37,439,918 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,721,202 - 37,724,515 (+)NCBIUU_Cfam_GSD_1.0
Tnnc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,152,389 - 170,155,387 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,290,913 - 3,294,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,290,961 - 3,293,920 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,816,603 - 13,819,572 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,816,222 - 13,819,518 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041153,080,316 - 153,083,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnnc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,764,742 - 4,770,293 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,763,285 - 4,767,810 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TNNC1
45 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system nervous system renal system reproductive system
High 2 2
Medium 1
Low 3 1 1 2 1
Below cutoff 1 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000012521   ⟹   ENSSSCP00000012193
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1334,591,386 - 34,594,337 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000050122   ⟹   ENSSSCP00000043815
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1334,591,210 - 34,594,339 (-)Ensembl
RefSeq Acc Id: NM_001130243   ⟹   NP_001123715
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11334,591,571 - 34,594,320 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001123715   ⟸   NM_001130243
- UniProtKB: Q4G1M5 (UniProtKB/Swiss-Prot),   P63317 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043815   ⟸   ENSSSCT00000050122
RefSeq Acc Id: ENSSSCP00000012193   ⟸   ENSSSCT00000012521
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011441 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005016411 UniProtKB/Swiss-Prot
  ENSSSCG00015079078 UniProtKB/Swiss-Prot
  ENSSSCG00025015750 UniProtKB/Swiss-Prot
  ENSSSCG00030073168 UniProtKB/Swiss-Prot
  ENSSSCG00035072554 UniProtKB/Swiss-Prot
  ENSSSCG00040038293 UniProtKB/Swiss-Prot
  ENSSSCG00045014719 UniProtKB/Swiss-Prot
  ENSSSCG00050075504 UniProtKB/Swiss-Prot
  ENSSSCG00055017398 UniProtKB/Swiss-Prot
  ENSSSCG00060028932 UniProtKB/Swiss-Prot
  ENSSSCG00065034718 UniProtKB/Swiss-Prot
  ENSSSCG00070025573 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012521 ENTREZGENE
  ENSSSCT00000012521.4 UniProtKB/Swiss-Prot
  ENSSSCT00005025801.1 UniProtKB/Swiss-Prot
  ENSSSCT00015107220.1 UniProtKB/Swiss-Prot
  ENSSSCT00025021119.1 UniProtKB/Swiss-Prot
  ENSSSCT00030102516.1 UniProtKB/Swiss-Prot
  ENSSSCT00035098214.1 UniProtKB/Swiss-Prot
  ENSSSCT00040051401.1 UniProtKB/Swiss-Prot
  ENSSSCT00045025066.1 UniProtKB/Swiss-Prot
  ENSSSCT00050103559.1 UniProtKB/Swiss-Prot
  ENSSSCT00055034141.1 UniProtKB/Swiss-Prot
  ENSSSCT00060039098.1 UniProtKB/Swiss-Prot
  ENSSSCT00065047256.1 UniProtKB/Swiss-Prot
  ENSSSCT00070051140.1 UniProtKB/Swiss-Prot
  ENSSSCT00070051143.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100156435 UniProtKB/Swiss-Prot
NCBI Gene TNNC1 ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN 1, 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TROPONIN C1, SLOW SKELETAL AND CARDIAC TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS RECOVERIN UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1VN52_PIG UniProtKB/TrEMBL
  P63317 ENTREZGENE
  Q4G1M5 ENTREZGENE
  TNNC1_PIG UniProtKB/Swiss-Prot
UniProt Secondary O14800 UniProtKB/Swiss-Prot
  P02590 UniProtKB/Swiss-Prot
  P04463 UniProtKB/Swiss-Prot
  Q4G1M5 UniProtKB/Swiss-Prot
VGNC ID VGNC:94282 ENTREZGENE