CASP10 (caspase 10) - Rat Genome Database

Name: CASP10
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: CASP10 (caspase 10) Sus scrofa

Analyze

Symbol:

CASP10

Name:

caspase 10

RGD ID:

14104857

Description:

ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); INVOLVED IN apoptotic signaling pathway (inferred); execution phase of apoptosis (inferred); positive regulation of I-kappaB kinase/NF-kappaB signaling (inferred); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; ASSOCIATED WITH autoimmune lymphoproliferative syndrome (ortholog); autoimmune lymphoproliferative syndrome type 2A (ortholog); autoimmune lymphoproliferative syndrome type 2B (ortholog); FOUND IN CD95 death-inducing signaling complex (inferred); ripoptosome (inferred); INTERACTS WITH fumonisin B1

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

caspase 10, apoptosis-related cysteine peptidase; caspase-10

RGD Orthologs

Human

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CASP10 (caspase 10)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Pan paniscus (bonobo/pygmy chimpanzee):	CASP10 (caspase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CASP10 (caspase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Casp10 (caspase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	CASP10 (caspase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Casp10 (caspase 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	104,858,100 - 104,894,933 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	104,858,082 - 104,895,941 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	116,127,433 - 116,215,682 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune lymphoproliferative syndrome (ISO)

autoimmune lymphoproliferative syndrome type 2A (ISO)

autoimmune lymphoproliferative syndrome type 2B (ISO)

hypomyelinating leukodystrophy 5 (ISO)

melanoma (ISO)

Neurodevelopmental Disorders (ISO)

non-Hodgkin lymphoma (ISO)

Pulmonary Arterial Hypertension (ISO)

Skin Neoplasms (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

fumonisin B1 (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of cysteine-type endopeptidase activity involved in apoptotic process (IBA)

apoptotic process (IBA)

apoptotic signaling pathway (IEA)

execution phase of apoptosis (IEA)

positive regulation of I-kappaB kinase/NF-kappaB signaling (IEA)

proteolysis (IEA)

regulation of apoptotic process (IEA)

Cellular Component

CD95 death-inducing signaling complex (IEA)

cytoplasm (IBA)

ripoptosome (IEA)

Molecular Function

cysteine-type endopeptidase activity (ISO)

cysteine-type endopeptidase activity involved in apoptotic process (IBA)

cysteine-type endopeptidase activity involved in apoptotic signaling pathway (IBA,IEA)

cysteine-type endopeptidase activity involved in execution phase of apoptosis (IBA)

death effector domain binding (IBA)

protein binding (ISO)

ubiquitin protein ligase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

extrinsic apoptotic pathway (ISO)

FasL mediated signaling pathway (ISO)

Trail mediated signaling pathway (ISO)

References

Additional References at PubMed

PMID:14681463

Genomics

Comparative Map Data

CASP10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	104,858,100 - 104,894,933 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	104,858,082 - 104,895,941 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	116,127,433 - 116,215,682 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CASP10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	201,182,881 - 201,229,406 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	2	201,182,898 - 201,229,406 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	201,182,885 - 201,229,406 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	202,047,621 - 202,094,129 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	2	202,047,864 - 202,094,129 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	201,755,866 - 201,802,355 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	201,873,360 - 201,910,373	NCBI
Celera	2	195,802,231 - 195,848,720 (+)	NCBI
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	193,898,993 - 193,945,498 (+)	NCBI		HuRef
CHM1_1	2	202,053,583 - 202,100,108 (+)	NCBI		CHM1_1

CASP10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	206,595,776 - 206,641,775 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	206,595,776 - 206,641,775 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	88,440,199 - 88,479,277 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

CASP10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	10,315,867 - 10,350,585 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Casp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936726	460,556 - 489,550 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CASP10
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	86,830,101 - 86,884,729 (+)	NCBI
ChlSab1.1 Ensembl	10	86,830,589 - 86,871,200 (+)	Ensembl

Casp10
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624889	31,132 - 63,774 (-)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	8	2		5				1	2
Low	2	2	3		2	22	2	2	1
Below cutoff						1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001161640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021074526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB499815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AEMK02000100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK232925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK393009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU607103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01105412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000025501 ⟹ ENSSSCP00000026681

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	15	104,858,100 - 104,889,437 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000053464 ⟹ ENSSSCP00000035915

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	15	104,858,100 - 104,894,933 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000086180 ⟹ ENSSSCP00000073448

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	15	104,858,100 - 104,883,333 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000087784 ⟹ ENSSSCP00000061317

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	15	104,858,100 - 104,889,424 (+)	Ensembl

RefSeq Acc Id:

NM_001161640 ⟹ NP_001155112

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	15	104,858,101 - 104,894,956 (+)	NCBI

Sequence:

show sequence

CTTGCCTGGGCTGCACCAAGTTGAGTTCCCTTCCTGAACAAATGGGAGCTTCTTTGGAACGTGG
AGGACGCAGAGGATTATAATTGTTTTCAAGGTGTGTTTCCAGGAAATTTCCCTGAGAACTTTAA
CCTCCAGAAGATCAGTGGAATTTGATCTGAAGCACTTCTAGAAAAGTCTAAGGCCTGGAACAGA
GGCGACCAGGACGGAGGAAGGGCCTGGGACGTTGGGGTGCCCCGTCTCCTTAGTCTCTAACCCA
CGGCCCCCACCTGCTGTCTCAGGCCGGCCATGACAGCGCAAGGCCAAAGTCTGAGTTCAGATGA
TTACCGTCAAATGGACTTTCGAGGGAAGCTTCTGATTATAGATTCGAACCTCGGAGATCAAGAT
GTGGAGCGCTTGAAGTTTCTCTGCCGAGACCACATCTCCTCCAGGAGCCTGGAGAGGTCCAACT
CGGCCGTGGATATTTTTGATCAGCTGATGACAGAGGAGCTGCTGAGTGAAGAAGACACTTTCTT
CCTAGCGGAGCTTCTGTACACCATCAAGCAGAATTCCCTGCTAAGGCACCTCCACTACACCAAG
GAGCAGGTGGCATGCTTGCTGCCCACCCGCCGGAAGGTCTCCCTGTTCAGAAACCTGCTGTATG
AACTGTCAGAAAACATCAGCTCCGAAAACTTAAAGGGGATGACCTTCCTTCTGAGGGAGTCCAT
TCCTAGAGTCCAGATGACCTCTCTAAGTTTGCTGTCATATCTGGAGAAACAAGATCAAATAGAT
GAAGATAATCTGACGTTACTGGAGGATGTCTGCAAAAAAATTGCACCTAACCTTATGAGAAAGA
TAGAAAAATATAAAAGAGAGAAAGCCTCCCAGGTGGTGACCCCTCCCTCAGCCGAGGAAACTGA
GTCATTGCCTCAAGGAAAGGAGGAACTATTTTCCCCATCGGACATTAAACATCTCCTTGGAAGC
TTACAGGAGGGGTCCCAGCAAGATGAACATGCAGGGAGTAACGGTGAGACAGCAACTCCGGTCT
CCGTGGAGCTGTTGGGAGCATCTGTTGAGACTCTAACTTCTAAATCCAGCACAAAGGAGACAGC
TGTGTACAGGATGGACCGGAATCACAGGGGGTTTTGTGTTGTTGTCAACAACCACAGATTCACC
TCGATGTCAGAAAGACCAGGAACCCATAAGGATGCTGAATGTCTGAGGCGCGTGTTTGAGTGGC
TGGGGTTCAGCGTCCATGTGTATGTCGATGTGACTAAAGTCCACCTCATGCAGGTTCTGCAGAA
ATATCAGAGTCACCCAGGCCATGCTGATGGAGACTGCTTTGTGTTCTGTGTGCTGACCCACGGG
GAATTTGGAGCCATCTACTCCTCTGATGGGGACCTCATTCCCATTCGGGAGATCCTGTCTCATT
TCACAGCCCAGCAGTGCCCCGGTCTGGCGCACAAACCCAAACTCTTTTTCATCCAAGCCTGTCA
AGGTGAAGAGATACAACCCTCCGTATCCATTGAAGCAGATGCTGTAAATCCTGAGCTCAAGGCC
CCTCTCCTTAAGGACAGCATTCCTGTCGAGGCGGATTTCCTTCTTGGCCTGGCCACTGTCCCTG
GCTACGTGTCATTTCGGCATGTGAAGGAAGGTAGCTGGTATATCCAGTCTCTTTACAATCATCT
GAAGGACTTGGTCCCAAGACGCGAAGATATCTTATCCATTCTCACCGCCGTCAACAATGATGTG
AGCCGACAAGTGGACAAACGTGGAAGCAAAAAACAGATGCCTCAGCCTGCTTTCACACTACGTA
AAAAGTCGTATTCCCTGTGCCACAGGAAGAGCTTTTATTGTAGCAGCGAATTCTGATCGACTTA
AGACTTGAGAGGATCCTTTGGCCATCGCTCCAACTTCCCCACTCATCATAGAAATTAGTGACAG
ATGGTGAGCTGGCCTCCGACTGTCATTCTAATAATAGAAAAGGTCCTATTTTCTGCCACAACAA
ATTCTGTTTTTTTTTTTTTTTCTTTTCTTCTTTTTGATATGCCACACATATGGCTCAAATCTGC
TGTTTCTGTGGCTGTGGTGATTCACCCCCAACCTGGGAACTTCCTTTTTCTTTTCTTTCTTTCT
TTTTTTTTCTGTCTTTTCAGGGCCATATGCCGCGGGAGCGGCCCAAGAAATAGCAACAACAACA
ACAACAAAAAGACAAAAGACAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_021074526 ⟹ XP_020930185

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	15	104,858,082 - 104,895,941 (+)	NCBI

Sequence:

show sequence

AAACTCAGAGACAGTTTCACTTGCCTGGGCTGCACCAAGTTGAGTTCCCTTCCTGAACAAATGG
GAGCTTCCTTGGAACGTGGAGGACGCAGAGGATTATAATTGTTTTCAAGGTGTGTTTCCAGGAA
ATTTCCCTGAGAACTTTAACCTCCAGAAGATCAGTGGAATTTGATCTGAAGCACTTCTAGAAAA
GTCTAAGGCCTGGAACAGAGGCGACCAGGACGGAGGAAGGGCCTGGGACGTTGGGGTGCCCCGT
CTCCTTAGTCTCTAACCCACGGCCCCCACCTGCTGTCTCAGGCCGGCCATGACAGCGCAAGGCC
AAAGTCTGAGTTCAGATGATTACTGTCAAATGGACTTTCGAGGGAAGCTTCTGATTATAGATTC
GAACCTCGGAGATCAAGATGTGGAGCGCTTGAAGTTTCTCTGCCGAGACCACATCTCCTCCAGG
AGCCTGGAGAGGTCCAACTCGGCCGTGGATATTTTTGATCAGCTGATGACAGAGGAGCTGCTGA
GTGAAGAAGACACTTTCTTCCTAGCGGAGCTTCTGTACACCATCAAGCAGAATTCCCTGCTAAG
GCACCTCCACTACACCAAGGAGCAGGTGGCATGCTTGCTGCCCACCCGCCGGAAGGTCTCCCTG
TTCAGAAACCTGCTGTATGAACTGTCAGAAGACATCAGCTCCGAAAACTTAAAGGGGATGACCT
TCCTTCTGAGGGAGTCCATTCCTAGAGTCCAGATGACCTCTCTAAGTTTGCTGTCATATCTGGA
GAAACAAGATCAAATAGATGAAGATAATCTGACGTTACTGGAGGATGTCTGCAAAAAAATTGCA
CCTAACCTTATGAGAAAGATAGAAAAATATAAAAGAGAGAAAGCCTCCCAGGTGGTGACCCCTC
CCTCAGCCGAGGAAACTGAGTCATTGCCTCAAGGAAAGGAGGAACTATTTTCCCCATCGGACAT
TAAACATCTCCTTGGAAGCTTACAGGAGGGGTCCCAGCAAGATGAACATGCAGGGAGTAACGGT
GAGACAGCAACTCCGGTCTCCGTGGAGCTGTTGGGAGCATCTGTTGAGACTCTAACTTCTAAAT
CCAGCACAAAGGAGACAGCTGTGTACAGGATGGACCGGAATCACAGGGGGTTTTGTGTTGTTGT
CAACAACCACAGATTCACCTCGATGTCAGAAAGACCAGGAACCCATAAAGATGCTGAATGTCTG
AGGCGCGTGTTTGAGTGGCTGGGGTTCAGCGTCCATGTGTATGTCGATGTGACTAAAGTCCACC
TCATGCAGGTTCTGCAGAAATATCAGAGTCACCCAGGCCATGCTGATGGAGACTGCTTTGTGTT
CTGTGTGCTGACCCACGGGGAATTTGGAGCCATCTACTCCTCTGATGGGGACCTCATTCCCATT
CGGGAGATCCTGTCTCATTTCACAGCCCAGCAGTGCCCCGGTCTGGCGCACAAACCCAAACTCT
TTTTCATCCAAGCCTGTCAAGGTGAAGAGATACAACCCTCCGTATCCATTGAAGCAGATGCTGT
AAATCCTGAGCTCAAGGCCCCTCTCCTTAAGGACAGCATTCCTGTCGAGGCGGATTTCCTTCTT
GGCCTGGCCACTGTCCCTGGCTACGTGTCATTTCGGCATGTGAAGGAAGGTAGCTGGTATATCC
AGTCTCTTTACAATCATCTGAAGGACTTGGTCCCAAGACGCGAAGATATCTTATCCATTCTCAC
CGCCGTCAACAATGATGTGAGCCGACAAGTGGACAAACGTGGAAGCAAAAAACAGATGCCTCAG
CCTGCTTTCACACTACGTAAAAAAGTCGTATTCCCTGTGCCACAGGAAGAGCTTTTATTGTAGC
AGCGAATTCTGATCGACTTAAGACTTGAGAGGATCCTTTGGCCATCGCTCCAACTTCCCCACTC
ATCATAGAAATTAGTGACAGATGGTGAGCTGGCCTCCGACTGTCATTCTAATAATAGAAAAGGT
CCTATTTTCTGCCACAACAAATTCTGTTTTTTTTTTTTTTTCTTTTCTTCTTTTTGATATGCCA
CACATATGGCTCAAATCTGCTGTTTCTGTGGCTGTGGTGATTCACCCCCAACCTGGGAACTTCC
TTTTTCTTTTCTTTCTTTCTTTTTTTTTCTGTCTTTTCAGGGCCATACCAGCGGCATATGGAGG
TTCCCAGGCTAGGGGTCTAATTGGAGCTGTAGCTGCCTGCCCACGCCACAGCCACAGCAACAGC
AACACCAGATCCGAGCTGCATCTGCGACCTACACCACAGCTCATGACAACGCCCGGATCCTTAA
CCTATTGAGCGAGGCCAGGGATTGAACCCACAACCTCATGGTTCTTAGTTGGATTCATTTCTGC
TGCCCCAGGACGGGAACTCCCCAACCTGGGAACTTCCATGTGCCACAGACGCAGCTATAAAACA
ACAACAACAACAAAAAGTTAGAAAACTTTCTTTATTGAAGCCTTGGATTGTTGTTTGTTTGTTT
GTTTAGTGCTGCATCTGTTGTAAATGGAAGTTTCCAGGTCCCCAGGTGAGGGGTCACATCAGAG
CTGCAGCTGGGGCCACAGCCACATGGGATCTGAGCCACATCTGAGACCTACACTGGCAGCTCGC
AGCAACACCGGATCCTTAATCCACCGATCGAGGCCAGGGATTGAATCTGCATCCTCATGGGAAC
AATACCATGCCCTTAACCCATTGAGCCACAACAGGAGCTCCAGCCTTGGATTGTGGTCTTGAAT
TTAGTTGTGTACCCTGAGAAAAAAGTAATTGTTCTTTGTTTGTGGATCTGTGAAGGAAGTGGTG
GAACAGGTATATTTTAAGGTTCCTTTTAGCTCAGAACCACTGTTCATGGCCTTGACTGAGCTTA
GGTGTCCTTTCTATATGCCCATCCCTTGGTATAATTTTGTATCCTCTCTGCGCCTTGTTTTAGA
CACTGGATGGTGGCATAGTCATGGTTCACCGACTCTGCCCTCCCTAAAATGTGGTTTGTGCCAT
GCCCTTGTCCTGCTTTAGTGGCAGGAATGGGCTCCTCAGGAGCTGTTTCTCTTGGGCTGAGAAC
AGGGTTGGCTCTAGGAAGATGACAGCTCGATGTGAAGAGAGACCCTCAGCTCCTCTGGGGACAG
ACGTTTTGACAAATTTGCATTAAATTCCATGTTGTGTTAAATTCCACCAGCTTCAGATACCCGT
GACACAACAACCCATCTCAAACCGCCTAAAGCTCAGAAGCAAATTAATTGCCTCTTTCCCTTGA
AAACACATCAACAGGAGACTGGCTTCATGTGAGGCTTGAATCAGGACTAAATCTGCCAAACAGC
ATCTCTCAGCCAGCGTCCTCCGGGTTGGCAGCCGACTGGCGTCAGTACCTCGCCTTAACGCCAC
ACTCTCTGCTTCTCTGGCCCAAAGTGTTGAAGAGAGAGGCAGCCTCAGGTACCAGGGCTGTTCA
CAGGGCTCATTGCTCCCTCTTTAGCCAGAGCAGTGTCTGACTATGCCTTTGGTGGCTCTGTATG
GAAGCCTTGATACTTGAAGGTTTTGAACACTTCTATGTACTGAACTTTTTTTTTTTTTTTTAAT
TTCAAGAGGAATTTTTAATTCTTGGAAGGAATTAGATGTTAATTCCTGGAAAGAGGGGAGATTA
AAAATCCCGTGGTTAAGGATGCATTTGCAGACCAAGAAGCCGAAACTCAAGGAGACAGAGTGAT
TTTGCTACAGCCTCCAGGCAATTATTGTTTACAGCATTTTATTTCCTACTTAACTGAACTGGAA
TGTCATGAGTCATAAGAGGACTCTGAATGCTTCTTGGAAACGCATGCCCTCATGAAAGATGTCA
AGGAGTGATGAAGAAAAATAACTCAGTGATGCTTGATGTCTGACAAATTTGCAATGAGAGATAT
TCCTAAGAACATTGTTATAATGTAGCCAGTTATCATATGGATTTGAATGTAGGTGGTCCAAGGA
AGCAAATCTCATATATATGTCAGGATAATCTTCCAGAACCATGTTTATACAAGTCAAAGCTAAC
TACTAGTGGGTATAGTCTTTGCCCAGGTGGGTATACACAGGACTGTTGGCCATTTAACAGTCCT
TTGCAAATGAAGGATGGTTTGGAACAAAAGAAGGAGCAAAGGATCCAGAGAGAGAAGCTTTAGG
TTTCTGTTGTACATATGCTGTGACCTTCTTGCTCTGAGACACTAAATCTAGGTTTTTTTTTTTT
GTCTTTTTAGGGCTGTACCCATAGCTTATGGAGATGCCCAGGTTAGGGGTCGAATCAGAGCTGC
AGCCGCCAGCCTACACCACAGCCACAGCCACAGCCATGCCAGATCCAAGCTGCATCTGCGACCT
ATACCACGGCAATACCGGATCCTTAACCCACTGAGCGAGGCCAGGGATCCAACCTGCATCCTCA
TGGATACTAGTCAGATTCGTTTCCGTTGAGCCACGACGGGAACTCCCTCAAGTTAGTTTTTTTG
AACCTTATCTATAAAGCAGAGAAAGCATTATCTGTTGGGAGGATTAAGTTTTGAACTTAATTGT
GCAGCACTGAATATAAGGCTTATGTTAGCAGAGTCTTCTGGTAGTAACCTAAATGGAAATTGCA
TTGCTTTGCATCTAATTCCATCTGACTTTTAGCCTCAAATCAACACTAGCAGCACCCACTGACA
TTCTCTGAATGAGGAACTACAGGGCCAGCTCTTGGCTTGGAGTCCACTGGACAAAATACTGTTG
GGGACTCCTGAATCAGAAGCGTGTGGGGCTTGATGTCGAAGTCCTGGTCTATTTTATATTTCTG
TTTTACTGGAACTTAGTGCTTGTGCAAGGTTAAATTCTGGAATCAGGAAACTTTCCATGAATTT
TCTTTCCAGAGGCCTCCAGGAAGGGCTAGAGGAACCACTAGACATTTATGTCTGTGTGTCATGG
GTCTGTACAGACACCAGGGGTGCAATCATTCTGACTCATTTTTCCTAAATGGAGCATGTACACA
CTTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTGTGAATTTAGAGTCCAGAGATGAGAGG
ATGTGATTTGGTCACAGCTACTTGACAGCTGGTACAGCCATTGTCTATGCAGACATTTATGATG
AAAGTGGGTGGATGGAGGAAAGTGTCTGTATATTTTGCCCCAGTTTTGCTCACCTTTCTAGAGC
TGTAATTAATTTTTTCTTTCTTTTCTTTTTTTTTTTCTCCCCCAAAAGTTTGGCTTCTCCCAAG
CAAAATGAAGGATATGGAAACTTTGATGTTGGATATGCACATGTTGGTTATTTAATAATGATGC
TTCTGGTGTTTATCATTATTAGAAATATTAATCACTACAATGTCCTACTGGCTCTACTTCAGAT
TCTCACCGAGGTGATGGGCGTGGGGTGATAGCATGGTATTTCCTTTGGTAATATGTTAGATTCT
CCCAGTGCTCAGGTAATTTAAACTTAGAAGCAACTGTGACATTGCGGTTACTGACCAATTAGAA
GAGGCACTGATCAGTTTAACACAACAGTGAATGAGGCTGAATAGCAGCCCTTTATTAAAAGTCA
AATCTCCACTGAGGTGAACCAAATTAGACATTTACCTCCTTTTCTTTTTTCTTTTTCCTTTTTT
TTCCATACTCTTAATTTTATAACGTTTGCAGTTCTACAACAATCATCATAACCCAATTTTATAG
CATTTCCATCCCAAACCCCCAGCCCATCCCCCCACCCCTAGCCTGTCTCCTTTGGAAACTGTAA
GTTTTTCAAAGTCTGTGGGTCAGTATCTGTTCTGCAAAGAAATTCATTGTGTCCTTTTTTTAGA
TTTCACATGTAAGCAATAGCATATGATGTTGGTGTCTCACTGTCTGATTAACTTCACGTAGCGT
GATCATTTCTAGGTCCATCCGTGTTGCTTCAGATGCTGTTATTTCTTTCCTTTTAATGGCTGAG
TAATATTCCATTGTGTATATGTACCATATTTTCTTGATCCACTCCTCTGTCGATGGGCATTTAG
GTGGTTTCCATGTCTTGGCTGTTGTATACAGTGCTGCAGTGAACACTGGAGTACATATATCTTT
CCGAGTCGTGGTTTCCTCTGGATAGACGCCCAGGAGTGGGATTGTTGGAATAGACATTTACATC
ATTTTATAGAAAGCCTGTGTACTATATCTGAGTCGCAAAATTTTCTAGGTCGGATACTTGCTGA
ATGATCTAGTCAAGTTGTCTTCAACCTGGAATTTTTTGGCCCTTAGGTTTTTGTGGATTTATTC
TCAGGGGCTGGGAGTCCTCTATCTTCATTTTTAAATATTTTCATTCCTTTGGGTGCTTATCTTT
AAAAATTAATATAAGTGCACTTCTCTGTTGTATGATTGCTTCATATGTGAGCATTACCGCATAA
CTTCCGTGCTCACATCTAGGAGCCCACAGAAAGCGATTAACTTTACATTGCACTTTTAATGTAG
CATGGATTAGAGTCCATGGCTGGGGGGGCCTTCGGTTTACTGTCGGGTATCAGGGGTTAAACTG
TTTGAAACCTATTCCAACCATCCTCTTATTTATGACAGATCCCTTCTTTACCATCCCTCCCCGC
TGCTTACGTCTTCCAACAGGGAACTTACAGCACACGCAGACTCGTGGATTTGGGTGTTTATGTC
ATGAATTTGAGAGACCCTGTGGTCCTTCAGAGGGTTAAACTTATCCAAATCTCACAGCTGTAGC
GGAGGATTTGCAATCCTGTGTCTCTCTTGCTCTGCAATCCTGCCACCTGGTTTCACCTGTGAAC
CACTTTAATTATCTTTTTCTCTGTTGGACTTGAATCTGCCCCTCTGAATGTACTTTAAGCCACT
GAGGCTCATTCTAACTCTGAAGCCATACCAAACAAGTCTAACAATTGTCTGGTGACGGATATGT
CATATGTAACAAGTTTTTGTTTGTTTGTTTATTTGTTTTAACTTTTTTATCTGATAGGCGCTGG
ATCTTGTCAAAAGTCTATAATTTGCTCTTAAGGATGTAGTAAGAATATAGTGACAGATTTGTAT
CTTTAAACAGAAACTAAGTTTCTGAAAGTGAAACCCTTTTAAAAAAGGCACTAATGGAGTTCCT
GTCGTGGCGCAGTGGTTAATGAATCCGACTACGAACCATGAGGTTGCGGGTTCGGTCCCTGCCC
TTGCTCAGTGGGTTAACGATCCGGCGTTGCCGTGAGCTGTGGTGTAGGCTGCAGACGCGGCTCG
GATCCTGCGTTGCTGTGGCTCTGGCGTAGGCCCGTGGCTGCAGCTCCGATTCAACCCCTAGCCT
GGGAATCTCCATATGCCGCGGGAGCGGCCCAAGAAATAGCAACAACAACAACAACAAAAAGACA
AAAGACAAAAAAAAAAAAAAAAAAAAAGGCACTAAGGAGGAGTTCCCTCGTAGGGCAGGGGGGT
AAGGACCTTGTGTCATCACTGCAGTGTCTTGGGTTGCCGCTGTTGCATGGGTTCAGTCCCTGGC
CTGGGAACTTCCACATGCCATGGGCATGGCCAAAAGAAATACAAACAACCATTTTTTTTTTTTT
TCTTTTTTAAAGTGTTTGGCTGCACCCGCAGCATGTAGAAGCTCCAGGGCCAGGGATCAAACCA
GAGCAGAAATAGCACCTAGGCCACAGGGGAAGTCCATAGACAATTATTTCTTGACACAACTTTT
GCATATATGAAATTTTAAAAGAGTTTTTCTAGTAAAATTTTTTACTAGTATTATTATTTTTTCT
TTTTCTTTTTAGGGCTACACTCGAGGCATATGGAAGTTCCTAGGCCAGGGGTCTAATCGGAACA
GCAGCTGCTGGCCTACACCACAGACACAGCAACCTGAGATCCGAGCCGCGTCTTCAACCTACAC
CACAGCTCAGGGCAATGCCAGATCCTTCACCCACTGAGTGAGGCCAGGGATAGAACTCATATCC
TCATGGATCCTAGCTGGGTTTGTTAACGAAGAGAACTCCCTAAATTTTACTTTTTAAACTTATT
TTTGAATAGGTACTATATTTACATTGTTCAAAGATAAGAAGATATGAAAAGATGTTTAGGAAAT
GTCTTGCCCTCATTTCTGTCCACTGCACATTCGGTCCTCCCTCCTCCTCATCCCACAGATGATC
TCAGGGTTTCCTAATGCAAGTGCAGACACCGAATACAAACTCTGTGCCTTTTAAAATATGTATC
TCTTGAAACAAATTCCATACACTGTGAAGTTCACATCTCATTTGGTCTTATTTAAGATGATTCT
GTTCAATTCTATACAGTTCGAGAATGGGAATAACTACGAGCTTTGTGGACTGAGTGCTTGTGCA
TAGTAGTGATTGCCTTACCAATAAATATATTTTTTCTCCTTTTTACCTTTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001155112	(Get FASTA)	NCBI Sequence Viewer
	XP_020930185	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAH57972	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_020930185 ⟸ XM_021074526

- Peptide Label:

isoform X1

- Sequence:

show sequence

MTAQGQSLSSDDYCQMDFRGKLLIIDSNLGDQDVERLKFLCRDHISSRSLERSNSAVDIFDQLM
TEELLSEEDTFFLAELLYTIKQNSLLRHLHYTKEQVACLLPTRRKVSLFRNLLYELSEDISSEN
LKGMTFLLRESIPRVQMTSLSLLSYLEKQDQIDEDNLTLLEDVCKKIAPNLMRKIEKYKREKAS
QVVTPPSAEETESLPQGKEELFSPSDIKHLLGSLQEGSQQDEHAGSNGETATPVSVELLGASVE
TLTSKSSTKETAVYRMDRNHRGFCVVVNNHRFTSMSERPGTHKDAECLRRVFEWLGFSVHVYVD
VTKVHLMQVLQKYQSHPGHADGDCFVFCVLTHGEFGAIYSSDGDLIPIREILSHFTAQQCPGLA
HKPKLFFIQACQGEEIQPSVSIEADAVNPELKAPLLKDSIPVEADFLLGLATVPGYVSFRHVKE
GSWYIQSLYNHLKDLVPRREDILSILTAVNNDVSRQVDKRGSKKQMPQPAFTLRKKVVFPVPQE
ELLL

hide sequence

RefSeq Acc Id:

NP_001155112 ⟸ NM_001161640

- UniProtKB:

C1PIJ2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTAQGQSLSSDDYRQMDFRGKLLIIDSNLGDQDVERLKFLCRDHISSRSLERSNSAVDIFDQLM
TEELLSEEDTFFLAELLYTIKQNSLLRHLHYTKEQVACLLPTRRKVSLFRNLLYELSENISSEN
LKGMTFLLRESIPRVQMTSLSLLSYLEKQDQIDEDNLTLLEDVCKKIAPNLMRKIEKYKREKAS
QVVTPPSAEETESLPQGKEELFSPSDIKHLLGSLQEGSQQDEHAGSNGETATPVSVELLGASVE
TLTSKSSTKETAVYRMDRNHRGFCVVVNNHRFTSMSERPGTHKDAECLRRVFEWLGFSVHVYVD
VTKVHLMQVLQKYQSHPGHADGDCFVFCVLTHGEFGAIYSSDGDLIPIREILSHFTAQQCPGLA
HKPKLFFIQACQGEEIQPSVSIEADAVNPELKAPLLKDSIPVEADFLLGLATVPGYVSFRHVKE
GSWYIQSLYNHLKDLVPRREDILSILTAVNNDVSRQVDKRGSKKQMPQPAFTLRKKSYSLCHRK
SFYCSSEF

hide sequence

RefSeq Acc Id:

ENSSSCP00000026681 ⟸ ENSSSCT00000025501

RefSeq Acc Id:

ENSSSCP00000073448 ⟸ ENSSSCT00000086180

RefSeq Acc Id:

ENSSSCP00000035915 ⟸ ENSSSCT00000053464

RefSeq Acc Id:

ENSSSCP00000061317 ⟸ ENSSSCT00000087784

Protein Domains

CASPASE_P10 CASPASE_P20 DED

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000026940	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00070022979	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000026681	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCP00000035915	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCP00000061317	UniProtKB/TrEMBL
	ENSSSCP00000073448	UniProtKB/TrEMBL
	ENSSSCP00070038534	UniProtKB/TrEMBL
	ENSSSCP00070038536	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000025501	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCT00000053464	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCT00000086180	UniProtKB/TrEMBL
	ENSSSCT00000087784	UniProtKB/TrEMBL
	ENSSSCT00070045723	UniProtKB/TrEMBL
	ENSSSCT00070045725	UniProtKB/TrEMBL
InterPro	Caspase-like_dom_sf	UniProtKB/TrEMBL
	Caspase_10	UniProtKB/TrEMBL
	Caspase_cys_AS	UniProtKB/TrEMBL
	Caspase_his_AS	UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/TrEMBL
	DED_dom	UniProtKB/TrEMBL
	Pept_C14	UniProtKB/TrEMBL
	Pept_C14_p10	UniProtKB/TrEMBL
	Pept_C14_p20	UniProtKB/TrEMBL
	Pept_C14A	UniProtKB/TrEMBL
KEGG Report	ssc:100154896	UniProtKB/TrEMBL
NCBI Gene	CASP10	ENTREZGENE
PANTHER	PTHR10454	UniProtKB/TrEMBL
	PTHR10454:SF26	UniProtKB/TrEMBL
Pfam	DED	UniProtKB/TrEMBL
PRINTS	IL1BCENZYME	UniProtKB/TrEMBL
PROSITE	CASPASE_CYS	UniProtKB/TrEMBL
	CASPASE_HIS	UniProtKB/TrEMBL
	CASPASE_P10	UniProtKB/TrEMBL
	CASPASE_P20	UniProtKB/TrEMBL
	DED	UniProtKB/TrEMBL
SMART	CASc	UniProtKB/TrEMBL
	DED	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47986	UniProtKB/TrEMBL
	SSF52129	UniProtKB/TrEMBL
UniProt	A0A286ZWN2_PIG	UniProtKB/TrEMBL
	A0A4X1V6T1_PIG	UniProtKB/TrEMBL
	A0A4X1VA45_PIG	UniProtKB/TrEMBL
	A0A5G2QAC0_PIG	UniProtKB/TrEMBL
	A0A5G2R848_PIG	UniProtKB/TrEMBL
	C1PIJ2	ENTREZGENE, UniProtKB/TrEMBL
	I3LRE7_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:95638	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)