CASP10 (caspase 10) - Rat Genome Database
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Gene: CASP10 (caspase 10) Sus scrofa
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Symbol: CASP10
Name: caspase 10
RGD ID: 14104857
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); INVOLVED IN apoptotic signaling pathway (inferred); execution phase of apoptosis (inferred); positive regulation of I-kappaB kinase/NF-kappaB signaling (inferred); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; Trail mediated signaling pathway; ASSOCIATED WITH autoimmune lymphoproliferative syndrome (ortholog); autoimmune lymphoproliferative syndrome type 2A (ortholog); autoimmune lymphoproliferative syndrome type 2B (ortholog); FOUND IN CD95 death-inducing signaling complex (inferred); ripoptosome (inferred); INTERACTS WITH fumonisin B1
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: caspase 10, apoptosis-related cysteine peptidase; caspase-10
RGD Orthologs
Human
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,858,100 - 104,894,933 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,858,082 - 104,895,941 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,127,433 - 116,215,682 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
fumonisin B1  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
CASP10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,858,100 - 104,894,933 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,858,082 - 104,895,941 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,127,433 - 116,215,682 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2201,182,881 - 201,229,406 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2201,182,898 - 201,229,406 (+)EnsemblGRCh38hg38GRCh38
GRCh382201,182,885 - 201,229,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372202,047,621 - 202,094,129 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh372202,047,864 - 202,094,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,755,866 - 201,802,355 (+)NCBINCBI36hg18NCBI36
Build 342201,873,360 - 201,910,373NCBI
Celera2195,802,231 - 195,848,720 (+)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2193,898,993 - 193,945,498 (+)NCBIHuRef
CHM1_12202,053,583 - 202,100,108 (+)NCBICHM1_1
CASP10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B206,595,776 - 206,641,775 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,595,776 - 206,641,775 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B88,440,199 - 88,479,277 (+)NCBIMhudiblu_PPA_v0panPan3
CASP10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,315,867 - 10,350,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Casp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936726460,556 - 489,550 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,830,101 - 86,884,729 (+)NCBI
ChlSab1.1 Ensembl1086,830,589 - 86,871,200 (+)Ensembl
Casp10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462488931,132 - 63,774 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 1 2
Low 2 2 3 2 22 2 2 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025501   ⟹   ENSSSCP00000026681
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15104,858,100 - 104,889,437 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053464   ⟹   ENSSSCP00000035915
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15104,858,100 - 104,894,933 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000086180   ⟹   ENSSSCP00000073448
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15104,858,100 - 104,883,333 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000087784   ⟹   ENSSSCP00000061317
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15104,858,100 - 104,889,424 (+)Ensembl
RefSeq Acc Id: NM_001161640   ⟹   NP_001155112
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115104,858,101 - 104,894,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021074526   ⟹   XP_020930185
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115104,858,082 - 104,895,941 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001155112 (Get FASTA)   NCBI Sequence Viewer  
  XP_020930185 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAH57972 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020930185   ⟸   XM_021074526
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001155112   ⟸   NM_001161640
- UniProtKB: C1PIJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000026681   ⟸   ENSSSCT00000025501
RefSeq Acc Id: ENSSSCP00000073448   ⟸   ENSSSCT00000086180
RefSeq Acc Id: ENSSSCP00000035915   ⟸   ENSSSCT00000053464
RefSeq Acc Id: ENSSSCP00000061317   ⟸   ENSSSCT00000087784
Protein Domains
CASPASE_P10   CASPASE_P20   DED


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026940 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022979 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000026681 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000035915 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000061317 UniProtKB/TrEMBL
  ENSSSCP00000073448 UniProtKB/TrEMBL
  ENSSSCP00070038534 UniProtKB/TrEMBL
  ENSSSCP00070038536 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025501 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053464 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000086180 UniProtKB/TrEMBL
  ENSSSCT00000087784 UniProtKB/TrEMBL
  ENSSSCT00070045723 UniProtKB/TrEMBL
  ENSSSCT00070045725 UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_10 UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  DED_dom UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
KEGG Report ssc:100154896 UniProtKB/TrEMBL
NCBI Gene CASP10 ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
  PTHR10454:SF26 UniProtKB/TrEMBL
Pfam DED UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A286ZWN2_PIG UniProtKB/TrEMBL
  A0A4X1V6T1_PIG UniProtKB/TrEMBL
  A0A4X1VA45_PIG UniProtKB/TrEMBL
  A0A5G2QAC0_PIG UniProtKB/TrEMBL
  A0A5G2R848_PIG UniProtKB/TrEMBL
  C1PIJ2 ENTREZGENE, UniProtKB/TrEMBL
  I3LRE7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:95638 ENTREZGENE