FGF8 (fibroblast growth factor 8) - Rat Genome Database

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Gene: FGF8 (fibroblast growth factor 8) Sus scrofa
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Symbol: FGF8
Name: fibroblast growth factor 8
RGD ID: 14100969
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); INVOLVED IN aorta morphogenesis (ortholog); apoptotic process (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH 22q11 Deletion Syndrome (ortholog); breast cancer (ortholog); Cardiovascular Abnormalities (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); INTERACTS WITH hydrogen peroxide; oleanolic acid
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,808,162 - 112,814,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114112,808,215 - 112,814,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214122,661,225 - 122,666,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IBA)
aorta morphogenesis  (IEA,ISO)
apoptotic process  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
bone development  (IEA)
branching involved in blood vessel morphogenesis  (IEA,ISO)
branching involved in salivary gland morphogenesis  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cell migration involved in mesendoderm migration  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell proliferation in forebrain  (IEA,ISO)
central nervous system neuron development  (ISO)
corticotropin hormone secreting cell differentiation  (IEA,ISO)
determination of left/right symmetry  (IEA,ISO)
dopaminergic neuron differentiation  (IEA)
dorsal/ventral axon guidance  (ISO)
dorsal/ventral pattern formation  (IBA)
embryo development ending in birth or egg hatching  (IEA,ISO)
embryonic heart tube development  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic neurocranium morphogenesis  (IEA,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IBA,IEA,ISO)
forebrain dorsal/ventral pattern formation  (IEA,ISO)
forebrain morphogenesis  (IEA,ISO)
forebrain neuron development  (ISO)
generation of neurons  (IEA,ISO)
gonad development  (IEA)
heart development  (IEA,ISO)
heart looping  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
inner ear morphogenesis  (IEA,ISO)
kidney development  (IEA,ISO)
larynx morphogenesis  (IEA,ISO)
limb morphogenesis  (IEA,ISO)
lung development  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
male genitalia development  (IEA,ISO)
MAPK cascade  (IEA,ISO)
mesodermal cell migration  (IEA,ISO)
mesonephros development  (IEA)
metanephros development  (IEA)
midbrain-hindbrain boundary development  (IEA,ISO)
mitotic nuclear division  (IEA,ISO)
motor neuron axon guidance  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cardiac muscle tissue development  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
neural plate morphogenesis  (IEA,ISO)
neuroepithelial cell differentiation  (IEA)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (IBA)
odontogenesis  (IEA)
organ growth  (IEA,ISO)
organ induction  (IEA,ISO)
otic vesicle formation  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
outflow tract septum morphogenesis  (IEA)
pallium development  (IEA,ISO)
pharyngeal system development  (IEA,ISO)
positive regulation of cell population proliferation  (IBA,IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of gene expression  (IBA,IEA,ISO)
positive regulation of MAPK cascade  (IBA)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of organ growth  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of stem cell proliferation  (IEA,ISO)
regulation of cell migration  (IBA)
regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
signal transduction involved in regulation of gene expression  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
subpallium development  (IEA,ISO)
telencephalon development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
thyroid-stimulating hormone-secreting cell differentiation  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,808,162 - 112,814,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114112,808,215 - 112,814,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214122,661,225 - 122,666,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810101,770,109 - 101,780,369 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10101,770,109 - 101,780,371 (-)EnsemblGRCh38hg38GRCh38
GRCh3710103,529,866 - 103,540,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,519,877 - 103,525,817 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410103,519,876 - 103,525,817NCBI
Celera1097,268,628 - 97,274,500 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,160,317 - 97,170,664 (-)NCBIHuRef
CHM1_110103,813,541 - 103,823,715 (-)NCBICHM1_1
T2T-CHM13v2.010102,653,607 - 102,663,864 (-)NCBIT2T-CHM13v2.0
Fgf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391945,724,930 - 45,731,380 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1945,725,237 - 45,731,354 (-)EnsemblGRCm39 Ensembl
GRCm381945,736,491 - 45,742,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1945,736,798 - 45,742,915 (-)EnsemblGRCm38mm10GRCm38
MGSCv371945,811,288 - 45,817,374 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361945,790,129 - 45,796,184 (-)NCBIMGSCv36mm8
Celera1946,499,127 - 46,505,223 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
Fgf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,533,504 - 254,539,605 (-)NCBIGRCr8
mRatBN7.21244,584,477 - 244,590,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,584,652 - 244,590,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1252,726,050 - 252,731,769 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,424,173 - 259,429,872 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,076,241 - 252,081,969 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,492,949 - 265,498,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,493,124 - 265,498,831 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01272,923,589 - 272,929,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41250,951,023 - 250,956,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,211,591 - 251,217,299 (-)NCBI
Celera1240,393,901 - 240,399,608 (-)NCBICelera
Cytogenetic Map1q54NCBI
Fgf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,517,412 - 8,521,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554858,517,412 - 8,521,732 (+)NCBIChiLan1.0ChiLan1.0
FGF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28113,656,283 - 113,662,837 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110113,661,598 - 113,668,156 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,372,251 - 98,378,811 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110101,844,792 - 101,849,873 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,844,792 - 101,853,916 (-)Ensemblpanpan1.1panPan2
FGF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,362,407 - 14,367,109 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,362,109 - 14,367,468 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2814,530,980 - 14,536,626 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02814,830,423 - 14,836,072 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2814,829,998 - 14,836,143 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,376,915 - 14,382,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,416,494 - 14,421,136 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,548,787 - 14,554,435 (-)NCBIUU_Cfam_GSD_1.0
Fgf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,401,605 - 32,407,401 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,004,824 - 4,010,689 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366004,004,847 - 4,010,626 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1994,797,157 - 94,803,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl994,798,088 - 94,803,629 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604855,874,226 - 55,880,198 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,253,044 - 1,257,741 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248311,251,991 - 1,259,247 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF8
21 total Variants

Expression

RNA-SEQ Expression

ectoderm
mesoderm
nervous system
2 1 2

Sequence


Ensembl Acc Id: ENSSSCT00000044394   ⟹   ENSSSCP00000049563
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14112,808,210 - 112,813,870 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000069658   ⟹   ENSSSCP00000062179
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14112,808,167 - 112,814,248 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000071754   ⟹   ENSSSCP00000066541
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14112,808,162 - 112,814,248 (-)Ensembl
RefSeq Acc Id: XM_021073392   ⟹   XP_020929051
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114112,808,215 - 112,814,225 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020929051 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000062179.1
  ENSSSCP00000066541.1
RefSeq Acc Id: XP_020929051   ⟸   XM_021073392
- Sequence:
Ensembl Acc Id: ENSSSCP00000049563   ⟸   ENSSSCT00000044394
Ensembl Acc Id: ENSSSCP00000062179   ⟸   ENSSSCT00000069658
Ensembl Acc Id: ENSSSCP00000066541   ⟸   ENSSSCT00000071754


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000036146 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000069658.2 UniProtKB/TrEMBL
  ENSSSCT00000071754.2 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
NCBI Gene FGF8 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF3 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PRINTS IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A5G2QC91_PIG UniProtKB/TrEMBL
  A0A5G2R7G2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88116 ENTREZGENE