SPNS3 (SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)) - Rat Genome Database

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Gene: SPNS3 (SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)) Sus scrofa
Analyze
Symbol: SPNS3
Name: SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)
RGD ID: 14100696
Description: ENCODES a protein that exhibits transmembrane transporter activity (inferred); INVOLVED IN transmembrane transport (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sphingolipid transporter 3 (putative)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,388,897 - 50,443,324 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11250,388,973 - 50,445,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,389,047 - 52,445,102 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SPNS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,388,897 - 50,443,324 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11250,388,973 - 50,445,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,389,047 - 52,445,102 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPNS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,433,940 - 4,488,204 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,433,940 - 4,488,208 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,337,235 - 4,391,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,283,968 - 4,338,248 (+)NCBINCBI36Build 36hg18NCBI36
Celera174,349,747 - 4,403,640 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,227,024 - 4,280,745 (+)NCBIHuRef
CHM1_1174,345,971 - 4,400,060 (+)NCBICHM1_1
T2T-CHM13v2.0174,323,199 - 4,378,061 (+)NCBIT2T-CHM13v2.0
Spns3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,388,979 - 72,441,334 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,385,745 - 72,441,332 (-)EnsemblGRCm39 Ensembl
GRCm381172,498,153 - 72,550,509 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,494,919 - 72,550,506 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,311,658 - 72,363,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,314,351 - 72,366,441 (-)NCBIMGSCv36mm8
Celera1180,018,322 - 80,070,509 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1144.34NCBI
Spns3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81057,612,796 - 57,667,601 (-)NCBIGRCr8
mRatBN7.21057,114,247 - 57,169,056 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1057,114,266 - 57,168,951 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1061,777,459 - 61,831,959 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,265,935 - 61,320,439 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01056,765,017 - 56,819,520 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01059,056,460 - 59,113,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,057,789 - 59,112,788 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01058,792,618 - 58,851,321 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41059,382,792 - 59,438,400 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1056,241,019 - 56,293,466 (-)NCBICelera
Cytogenetic Map10q24NCBI
Spns3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546712,447,232 - 12,496,874 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546712,447,232 - 12,496,874 (-)NCBIChiLan1.0ChiLan1.0
SPNS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,048,779 - 12,107,022 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,017,209 - 14,075,454 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,488,490 - 4,543,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,482,672 - 4,536,703 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,482,672 - 4,536,393 (+)Ensemblpanpan1.1panPan2
SPNS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1530,464,288 - 30,493,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl530,464,513 - 30,526,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha530,661,158 - 30,690,425 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0530,565,760 - 30,595,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl530,565,374 - 30,628,766 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1530,531,902 - 30,561,159 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0530,490,436 - 30,519,684 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0530,663,827 - 30,693,102 (+)NCBIUU_Cfam_GSD_1.0
Spns3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560254,850,064 - 54,897,603 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366771,003,394 - 1,050,655 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366771,007,776 - 1,050,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPNS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,914,020 - 3,967,595 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605917,693,981 - 17,749,498 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spns3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247867,010,585 - 7,057,256 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247867,010,136 - 7,060,442 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SPNS3
2346 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 8 2 5 1 2 2 1
Below cutoff 2 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000019457   ⟹   ENSSSCP00000018940
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1250,389,197 - 50,443,324 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000055547   ⟹   ENSSSCP00000039727
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1250,389,237 - 50,446,297 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071462   ⟹   ENSSSCP00000069913
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1250,388,897 - 50,443,324 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000078316   ⟹   ENSSSCP00000062383
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1250,399,650 - 50,443,324 (+)Ensembl
RefSeq Acc Id: XM_003131886   ⟹   XP_003131934
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11250,388,973 - 50,445,297 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003131934   ⟸   XM_003131886
- UniProtKB: A0A8D1EH53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000062383   ⟸   ENSSSCT00000078316
RefSeq Acc Id: ENSSSCP00000018940   ⟸   ENSSSCT00000019457
RefSeq Acc Id: ENSSSCP00000039727   ⟸   ENSSSCT00000055547
RefSeq Acc Id: ENSSSCP00000069913   ⟸   ENSSSCT00000071462
Protein Domains
Major facilitator superfamily (MFS) profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017880 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00015058497 UniProtKB/TrEMBL
  ENSSSCG00025028819 UniProtKB/TrEMBL
  ENSSSCG00030033493 UniProtKB/TrEMBL
  ENSSSCG00035064468 UniProtKB/TrEMBL
  ENSSSCG00040037191 UniProtKB/TrEMBL
  ENSSSCG00045027918 UniProtKB/TrEMBL
  ENSSSCG00055029368 UniProtKB/TrEMBL
  ENSSSCG00065047246 UniProtKB/TrEMBL
  ENSSSCG00070017759 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019457.5 UniProtKB/TrEMBL
  ENSSSCT00000071462.1 UniProtKB/TrEMBL
  ENSSSCT00015078589.1 UniProtKB/TrEMBL
  ENSSSCT00015078676.1 UniProtKB/TrEMBL
  ENSSSCT00025039264.1 UniProtKB/TrEMBL
  ENSSSCT00025039353.1 UniProtKB/TrEMBL
  ENSSSCT00030046410.1 UniProtKB/TrEMBL
  ENSSSCT00030046440.1 UniProtKB/TrEMBL
  ENSSSCT00035086784.1 UniProtKB/TrEMBL
  ENSSSCT00035086791.1 UniProtKB/TrEMBL
  ENSSSCT00040049881.1 UniProtKB/TrEMBL
  ENSSSCT00040049977.1 UniProtKB/TrEMBL
  ENSSSCT00045047735.1 UniProtKB/TrEMBL
  ENSSSCT00045047842.1 UniProtKB/TrEMBL
  ENSSSCT00055058336.1 UniProtKB/TrEMBL
  ENSSSCT00055058365.1 UniProtKB/TrEMBL
  ENSSSCT00065064633.1 UniProtKB/TrEMBL
  ENSSSCT00065064650.1 UniProtKB/TrEMBL
  ENSSSCT00070035049.1 UniProtKB/TrEMBL
  ENSSSCT00070035074.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_spinster-like UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
KEGG Report ssc:100523208 UniProtKB/TrEMBL
NCBI Gene SPNS3 ENTREZGENE
PANTHER PROTEIN SPINSTER HOMOLOG 3 UniProtKB/TrEMBL
  PTHR23505 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PROSITE MFS UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A4X1UMA0_PIG UniProtKB/TrEMBL
  A0A4X1UMB9_PIG UniProtKB/TrEMBL
  A0A5G2QYF5_PIG UniProtKB/TrEMBL
  A0A8D0RH70_PIG UniProtKB/TrEMBL
  A0A8D0WHV0_PIG UniProtKB/TrEMBL
  A0A8D0WHV3_PIG UniProtKB/TrEMBL
  A0A8D1D139_PIG UniProtKB/TrEMBL
  A0A8D1EH53 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IF07_PIG UniProtKB/TrEMBL
  F1RGP3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:99079 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-17 SPNS3  SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)  SPNS3  sphingolipid transporter 3 (putative)  Symbol and/or name change 19259463 PROVISIONAL