ALDH18A1 (aldehyde dehydrogenase 18 family member A1) - Rat Genome Database
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Gene: ALDH18A1 (aldehyde dehydrogenase 18 family member A1) Sus scrofa
Analyze
Symbol: ALDH18A1
Name: aldehyde dehydrogenase 18 family member A1
RGD ID: 14100531
Description: ENCODES a protein that exhibits ATP binding (inferred); glutamate 5-kinase activity (inferred); identical protein binding (inferred); INVOLVED IN proline biosynthetic process (ortholog); response to temperature stimulus (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); aphasia (ortholog); autosomal dominant cutis laxa (ortholog); FOUND IN mitochondrial membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: delta-1-pyrroline-5-carboxylate synthase
Orthologs:
Homo sapiens (human) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)  HGNC  Alliance
Mus musculus (house mouse) : Aldh18a1 (aldehyde dehydrogenase 18 family, member A1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aldh18a1 (aldehyde dehydrogenase 18 family, member A1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh18a1 (aldehyde dehydrogenase 18 family member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Canis lupus familiaris (dog) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101975532 (delta-1-pyrroline-5-carboxylate synthase)
Chlorocebus sabaeus (African green monkey) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Heterocephalus glaber (naked mole-rat) : Aldh18a1 (aldehyde dehydrogenase 18 family member A1)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14107,170,689 - 107,221,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114107,174,062 - 107,221,373 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214116,807,918 - 116,855,192 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
ALDH18A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14107,170,689 - 107,221,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114107,174,062 - 107,221,373 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214116,807,918 - 116,855,192 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH18A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1095,605,941 - 95,656,711 (-)EnsemblGRCh38hg38GRCh38
GRCh381095,605,938 - 95,656,901 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371097,365,686 - 97,416,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361097,355,676 - 97,406,557 (-)NCBINCBI36hg18NCBI36
Build 341097,355,691 - 97,406,372NCBI
Celera1091,106,883 - 91,157,764 (-)NCBI
Cytogenetic Map10q24.1NCBI
HuRef1090,993,396 - 91,044,247 (-)NCBIHuRef
CHM1_11097,647,547 - 97,698,414 (-)NCBICHM1_1
Aldh18a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391940,538,701 - 40,576,907 (-)NCBI
GRCm381940,550,257 - 40,588,463 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1940,550,257 - 40,588,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv371940,624,747 - 40,662,953 (-)NCBIGRCm37mm9NCBIm37
MGSCv361940,603,568 - 40,641,680 (-)NCBImm8
Celera1941,354,703 - 41,390,340 (-)NCBICelera
Cytogenetic Map19C3NCBI
Aldh18a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01259,641,673 - 259,674,521 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1259,641,676 - 259,674,425 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1259,057,402 - 259,089,642 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01266,505,493 - 266,537,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01267,085,392 - 267,117,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,685,979 - 245,718,198 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11245,796,065 - 245,825,127 (-)NCBI
Celera1235,221,086 - 235,253,280 (-)NCBICelera
Cytogenetic Map1q54NCBI
Aldh18a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555071,892,061 - 1,946,703 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555071,892,087 - 1,946,526 (-)NCBIChiLan1.0ChiLan1.0
ALDH18A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11095,723,099 - 95,774,095 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1095,723,099 - 95,774,095 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01092,216,639 - 92,267,525 (-)NCBIMhudiblu_PPA_v0panPan3
ALDH18A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl289,102,282 - 9,147,992 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1289,101,578 - 9,148,063 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101975532
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366363,779,259 - 3,800,846 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH18A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1988,773,493 - 88,823,438 (-)NCBI
Aldh18a1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247376,921,619 - 6,970,113 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 3 4 20 2 2
Low 1 2 1 2 3 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011483   ⟹   ENSSSCP00000011182
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14107,170,689 - 107,221,215 (-)Ensembl
RefSeq Acc Id: XM_001927529   ⟹   XP_001927564
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114107,174,062 - 107,221,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005671336   ⟹   XP_005671393
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114107,174,062 - 107,221,348 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001927564 (Get FASTA)   NCBI Sequence Viewer  
  XP_005671393 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001927564   ⟸   XM_001927529
- Peptide Label: isoform X1
- UniProtKB: F1SC47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005671393   ⟸   XM_005671336
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000011182   ⟸   ENSSSCT00000011483
Protein Domains
AA_kinase   Aldedh


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010495 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070017062 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011182 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070028124 UniProtKB/TrEMBL
  ENSSSCP00070028138 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011483 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070033697 UniProtKB/TrEMBL
  ENSSSCT00070033711 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1160.10 UniProtKB/TrEMBL
  3.40.309.10 UniProtKB/TrEMBL
  3.40.605.10 UniProtKB/TrEMBL
InterPro AceGlu_kinase-like_sf UniProtKB/TrEMBL
  Ald_DH/histidinol_DH UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/TrEMBL
  Asp/Glu/Uridylate_kinase UniProtKB/TrEMBL
  G-glutamylP_reductase_CS UniProtKB/TrEMBL
  G5K_ProBA UniProtKB/TrEMBL
  Glu/AcGlu_kinase UniProtKB/TrEMBL
  Glu_5kinase/COase_Synthase UniProtKB/TrEMBL
  Glutamate_5-kinase_CS UniProtKB/TrEMBL
  GPR_dom UniProtKB/TrEMBL
  P5_carboxy_syn UniProtKB/TrEMBL
KEGG Report ssc:100151977 UniProtKB/TrEMBL
NCBI Gene ALDH18A1 ENTREZGENE
Pfam AA_kinase UniProtKB/TrEMBL
  Aldedh UniProtKB/TrEMBL
PIRSF P5C_syn UniProtKB/TrEMBL
PRINTS GLU5KINASE UniProtKB/TrEMBL
PROSITE GLUTAMATE_5_KINASE UniProtKB/TrEMBL
  PROA UniProtKB/TrEMBL
Superfamily-SCOP SSF53633 UniProtKB/TrEMBL
  SSF53720 UniProtKB/TrEMBL
TIGRFAMs P5CS UniProtKB/TrEMBL
  proA UniProtKB/TrEMBL
  proB UniProtKB/TrEMBL
UniGene Ssc.3321 ENTREZGENE
UniProt A0A4X1UHT2_PIG UniProtKB/TrEMBL
  A0A4X1UJ55_PIG UniProtKB/TrEMBL
  F1SC47 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85237 ENTREZGENE