NUAK1 (NUAK family kinase 1) - Rat Genome Database

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Gene: NUAK1 (NUAK family kinase 1) Sus scrofa
Analyze
Symbol: NUAK1
Name: NUAK family kinase 1
RGD ID: 14093674
Description: ENCODES a protein that exhibits ATP binding (inferred); nucleotide binding (inferred); p53 binding (inferred); INVOLVED IN intracellular signal transduction (inferred); regulation of cell adhesion (inferred); regulation of cellular senescence (inferred); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); multiple myeloma (ortholog); FOUND IN cytoplasm (inferred); fibrillar center (inferred); microtubule cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NUAK family SNF1-like kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,102,006 - 14,177,584 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,089,584 - 14,177,584 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2514,165,755 - 14,290,617 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NUAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,102,006 - 14,177,584 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,089,584 - 14,177,584 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2514,165,755 - 14,290,617 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NUAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812106,063,345 - 106,138,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12106,063,345 - 106,138,954 (-)EnsemblGRCh38hg38GRCh38
GRCh3712106,457,123 - 106,532,732 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,981,255 - 105,057,941 (-)NCBINCBI36Build 36hg18NCBI36
Celera12106,122,505 - 106,199,131 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12103,517,880 - 103,594,537 (-)NCBIHuRef
CHM1_112106,422,717 - 106,499,407 (-)NCBICHM1_1
T2T-CHM13v2.012106,026,098 - 106,101,716 (-)NCBIT2T-CHM13v2.0
Nuak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391084,206,764 - 84,282,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1084,206,769 - 84,276,461 (-)EnsemblGRCm39 Ensembl
GRCm381084,370,900 - 84,440,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1084,370,905 - 84,440,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv371083,834,056 - 83,903,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361083,801,110 - 83,870,270 (-)NCBIMGSCv36mm8
Celera1086,350,008 - 86,419,314 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.42NCBI
Nuak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8721,217,729 - 21,289,608 (+)NCBIGRCr8
mRatBN7.2719,330,034 - 19,401,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl719,329,933 - 19,401,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx721,290,632 - 21,360,457 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0723,453,310 - 23,523,126 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0723,230,282 - 23,300,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0725,039,336 - 25,111,118 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl725,039,335 - 25,113,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0725,184,054 - 25,253,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4721,461,413 - 21,529,068 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1721,481,448 - 21,548,614 (+)NCBI
Celera716,538,758 - 16,608,089 (+)NCBICelera
Cytogenetic Map7q13NCBI
Nuak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540540,153,747 - 40,188,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540540,156,316 - 40,188,144 (-)NCBIChiLan1.0ChiLan1.0
NUAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210114,130,583 - 114,206,322 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112114,126,980 - 114,202,690 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012103,642,744 - 103,720,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112107,037,632 - 107,113,163 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12107,037,627 - 107,113,163 (-)Ensemblpanpan1.1panPan2
NUAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11032,463,845 - 32,537,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1032,464,123 - 32,536,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1032,383,951 - 32,457,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01033,305,053 - 33,378,753 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1033,306,774 - 33,378,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11033,041,000 - 33,114,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01033,329,739 - 33,403,411 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01033,517,685 - 33,591,445 (+)NCBIUU_Cfam_GSD_1.0
Nuak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494515,699,625 - 15,764,456 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364928,710,039 - 8,775,112 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364928,710,039 - 8,774,870 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111101,282,483 - 101,362,618 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11101,282,347 - 101,360,602 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037143,676,111 - 143,753,398 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nuak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247503,141,441 - 3,197,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247503,141,442 - 3,197,821 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NUAK1
2950 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 13
Low 10 4 3 5 2 10 2 3 1
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000060131   ⟹   ENSSSCP00000043266
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl514,102,006 - 14,177,584 (+)Ensembl
RefSeq Acc Id: XM_003126093   ⟹   XP_003126141
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1514,101,978 - 14,177,480 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013988236   ⟹   XP_013843690
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1514,089,584 - 14,177,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013988237   ⟹   XP_013843691
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1514,102,327 - 14,177,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091582   ⟹   XP_020947241
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1514,120,984 - 14,177,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091583   ⟹   XP_020947242
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1514,089,584 - 14,177,584 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020947242   ⟸   XM_021091583
- Peptide Label: isoform X2
- UniProtKB: A0A8D0IFM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013843690   ⟸   XM_013988236
- Peptide Label: isoform X2
- UniProtKB: A0A8D0IFM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003126141   ⟸   XM_003126093
- Peptide Label: isoform X1
- UniProtKB: A0A287AGV4 (UniProtKB/TrEMBL),   A0A8D1ABV5 (UniProtKB/TrEMBL),   A0A4X1WCU1 (UniProtKB/TrEMBL),   A0A8D0UL51 (UniProtKB/TrEMBL),   A0A8D1QX02 (UniProtKB/TrEMBL),   A0A8D1XCQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013843691   ⟸   XM_013988237
- Peptide Label: isoform X2
- UniProtKB: A0A8D0IFM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020947241   ⟸   XM_021091582
- Peptide Label: isoform X2
- UniProtKB: A0A8D0IFM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043266   ⟸   ENSSSCT00000060131
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032861 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005010555 UniProtKB/TrEMBL
  ENSSSCG00025020960 UniProtKB/TrEMBL
  ENSSSCG00030021137 UniProtKB/TrEMBL
  ENSSSCG00035055325 UniProtKB/TrEMBL
  ENSSSCG00040044631 UniProtKB/TrEMBL
  ENSSSCG00045022835 UniProtKB/TrEMBL
  ENSSSCG00050058458 UniProtKB/TrEMBL
  ENSSSCG00055018099 UniProtKB/TrEMBL
  ENSSSCG00060031495 UniProtKB/TrEMBL
  ENSSSCG00065006883 UniProtKB/TrEMBL
  ENSSSCG00070030528 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000060131 ENTREZGENE
  ENSSSCT00000060131.3 UniProtKB/TrEMBL
  ENSSSCT00005016354.1 UniProtKB/TrEMBL
  ENSSSCT00025028442.1 UniProtKB/TrEMBL
  ENSSSCT00030029308.1 UniProtKB/TrEMBL
  ENSSSCT00035073799.1 UniProtKB/TrEMBL
  ENSSSCT00040059878.1 UniProtKB/TrEMBL
  ENSSSCT00045038944.1 UniProtKB/TrEMBL
  ENSSSCT00050079684.1 UniProtKB/TrEMBL
  ENSSSCT00055035532.1 UniProtKB/TrEMBL
  ENSSSCT00060042616.1 UniProtKB/TrEMBL
  ENSSSCT00065009230.1 UniProtKB/TrEMBL
  ENSSSCT00070061451.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100523669 UniProtKB/TrEMBL
NCBI Gene NUAK1 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NUAK FAMILY SNF1-LIKE KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287AGV4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WCU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0IFM4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0UL51 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0VZ15_PIG UniProtKB/TrEMBL
  A0A8D1ABV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QX02 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1TKJ0_PIG UniProtKB/TrEMBL
  A0A8D1XCQ5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90940 ENTREZGENE