PTPN6 (protein tyrosine phosphatase non-receptor type 6) - Rat Genome Database

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Gene: PTPN6 (protein tyrosine phosphatase non-receptor type 6) Sus scrofa
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Symbol: PTPN6
Name: protein tyrosine phosphatase non-receptor type 6
RGD ID: 14091225
Description: ENCODES a protein that exhibits natural killer cell lectin-like receptor binding (ortholog); INVOLVED IN abortive mitotic cell cycle (ortholog); B cell receptor signaling pathway (ortholog); hematopoietic progenitor cell differentiation (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH anogenital venereal wart (ortholog); calcinosis (ortholog); cervical cancer (ortholog); FOUND IN alpha-beta T cell receptor complex (inferred); cell-cell junction (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: non-receptor type protein tyrosine phosphatase SHP1; tyrosine-protein phosphatase non-receptor type 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,762,112 - 63,808,350 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,762,109 - 63,779,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,198,250 - 66,215,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
abortive mitotic cell cycle  (IEA,ISO)
B cell receptor signaling pathway  (IEA,ISO)
cell differentiation  (IEA)
dephosphorylation  (IEA)
epididymis development  (IEA)
hematopoietic progenitor cell differentiation  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
megakaryocyte development  (IEA,ISO)
natural killer cell mediated cytotoxicity  (IEA,ISO)
negative regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA)
negative regulation of MAP kinase activity  (IEA,ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of mast cell activation involved in immune response  (IEA)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of T cell receptor signaling pathway  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA)
peptidyl-tyrosine dephosphorylation  (IEA)
peptidyl-tyrosine phosphorylation  (IEA)
platelet aggregation  (IEA,ISO)
platelet formation  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA)
protein dephosphorylation  (IEA,ISO)
regulation of B cell differentiation  (IEA,ISO)
regulation of ERK1 and ERK2 cascade  (IEA)
regulation of G1/S transition of mitotic cell cycle  (IEA)
regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
response to wounding  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
PTPN6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,762,112 - 63,808,350 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,762,109 - 63,779,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,198,250 - 66,215,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl126,946,468 - 6,961,316 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,946,577 - 6,961,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,055,740 - 7,070,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,926,001 - 6,940,740 (+)NCBINCBI36hg18NCBI36
Build 34126,930,762 - 6,940,740NCBI
Celera128,674,361 - 8,691,497 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,911,844 - 6,928,943 (+)NCBIHuRef
CHM1_1127,054,727 - 7,069,431 (+)NCBICHM1_1
Ptpn6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,697,670 - 124,715,672 (-)NCBIGRCm39mm39
GRCm39 Ensembl6124,697,670 - 124,715,677 (-)Ensembl
GRCm386124,720,707 - 124,738,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,720,707 - 124,738,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,670,736 - 124,688,727 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,686,336 - 124,698,725 (-)NCBImm8
Celera6126,402,447 - 126,420,442 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Ptpn6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,526,034 - 157,550,783 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4157,526,035 - 157,550,984 (-)Ensembl
Rnor_6.04157,239,141 - 157,263,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,239,142 - 157,263,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,256,737 - 224,281,486 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,843,699 - 160,868,856 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,088,634 - 161,113,792 (-)NCBI
Celera4146,264,696 - 146,289,049 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ptpn6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,525,954 - 4,547,177 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,525,954 - 4,547,177 (+)NCBIChiLan1.0ChiLan1.0
PTPN6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1126,991,099 - 7,008,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,991,099 - 7,008,830 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0127,075,879 - 7,093,041 (+)NCBIMhudiblu_PPA_v0panPan3
PTPN6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,084,976 - 38,101,552 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,084,980 - 38,101,937 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,519,708 - 8,531,714 (+)NCBI
ROS_Cfam_1.02738,437,567 - 38,449,584 (-)NCBI
ROS_Cfam_1.0 Ensembl2738,437,569 - 38,453,615 (-)Ensembl
UMICH_Zoey_3.12738,312,457 - 38,324,047 (-)NCBI
UNSW_CanFamBas_1.02738,353,429 - 38,365,020 (-)NCBI
UU_Cfam_GSD_1.0277,998,465 - 8,010,486 (+)NCBI
Ptpn6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,196,659 - 102,217,158 (-)NCBI
SpeTri2.0NW_004936709864,206 - 884,630 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,977,480 - 6,994,525 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl116,984,710 - 6,994,545 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660631,223,213 - 1,240,430 (-)NCBIVero_WHO_p1.0
Ptpn6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248603,580,225 - 3,595,403 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 2 5 3
Low 5 2 3 2 23 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000031587   ⟹   ENSSSCP00000024517
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl563,762,112 - 63,808,350 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000040579   ⟹   ENSSSCP00000036336
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl563,762,113 - 63,779,033 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000054519   ⟹   ENSSSCP00000045365
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl563,762,117 - 63,779,033 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000078320   ⟹   ENSSSCP00000071829
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl563,762,112 - 63,772,747 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089024   ⟹   ENSSSCP00000069263
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl563,762,504 - 63,772,747 (-)Ensembl
RefSeq Acc Id: XM_003355590   ⟹   XP_003355638
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1563,762,109 - 63,772,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005652593   ⟹   XP_005652650
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1563,762,109 - 63,779,086 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003355638 (Get FASTA)   NCBI Sequence Viewer  
  XP_005652650 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACE79216 (Get FASTA)   NCBI Sequence Viewer  
  JAA53760 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005652650   ⟸   XM_005652593
- Peptide Label: isoform X1
- UniProtKB: A0A286ZXH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003355638   ⟸   XM_003355590
- Peptide Label: isoform X2
- UniProtKB: I3LKA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000071829   ⟸   ENSSSCT00000078320
RefSeq Acc Id: ENSSSCP00000045365   ⟸   ENSSSCT00000054519
RefSeq Acc Id: ENSSSCP00000036336   ⟸   ENSSSCT00000040579
RefSeq Acc Id: ENSSSCP00000069263   ⟸   ENSSSCT00000089024
RefSeq Acc Id: ENSSSCP00000024517   ⟸   ENSSSCT00000031587

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000025537 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070020564 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024517 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000036336 UniProtKB/TrEMBL
  ENSSSCP00000045365 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000069263 UniProtKB/TrEMBL
  ENSSSCP00000071829 UniProtKB/TrEMBL
  ENSSSCP00070034315 UniProtKB/TrEMBL
  ENSSSCP00070034320 UniProtKB/TrEMBL
  ENSSSCP00070034326 UniProtKB/TrEMBL
  ENSSSCP00070034333 UniProtKB/TrEMBL
  ENSSSCP00070034336 UniProtKB/TrEMBL
  ENSSSCP00070034350 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031587 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000040579 UniProtKB/TrEMBL
  ENSSSCT00000054519 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000078320 UniProtKB/TrEMBL
  ENSSSCT00000089024 UniProtKB/TrEMBL
  ENSSSCT00070040885 UniProtKB/TrEMBL
  ENSSSCT00070040890 UniProtKB/TrEMBL
  ENSSSCT00070040897 UniProtKB/TrEMBL
  ENSSSCT00070040908 UniProtKB/TrEMBL
  ENSSSCT00070040911 UniProtKB/TrEMBL
  ENSSSCT00070040926 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-6/11 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
KEGG Report ssc:100171389 UniProtKB/TrEMBL
NCBI Gene PTPN6 ENTREZGENE
Pfam SH2 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF Tyr-Ptase_nr_6 UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A286ZXH2 ENTREZGENE, UniProtKB/TrEMBL
  A0A480TLF2_PIG UniProtKB/TrEMBL
  A0A4X1UW03_PIG UniProtKB/TrEMBL
  A0A4X1UYC7_PIG UniProtKB/TrEMBL
  A0A4X1UZH9_PIG UniProtKB/TrEMBL
  A0A4X1UZI4_PIG UniProtKB/TrEMBL
  A0A4X1UZL5_PIG UniProtKB/TrEMBL
  A0A5G2QYP2_PIG UniProtKB/TrEMBL
  A0A5G2RJ70_PIG UniProtKB/TrEMBL
  B3VK30_PIG UniProtKB/TrEMBL
  I3LKA3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91982 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN6  protein tyrosine phosphatase non-receptor type 6    protein tyrosine phosphatase, non-receptor type 6  Symbol and/or name change 5135510 APPROVED