MAEA (macrophage erythroblast attacher, E3 ubiquitin ligase) - Rat Genome Database

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Gene: MAEA (macrophage erythroblast attacher, E3 ubiquitin ligase) Sus scrofa
Analyze
Symbol: MAEA
Name: macrophage erythroblast attacher, E3 ubiquitin ligase
RGD ID: 14090575
Description: ENCODES a protein that exhibits actin binding (inferred); metal ion binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN cytoskeleton organization (ortholog); enucleate erythrocyte development (ortholog); erythrocyte development (ortholog); ASSOCIATED WITH cherubism (ortholog); genetic disease (ortholog); type 2 diabetes mellitus (ortholog); FOUND IN actin cytoskeleton (inferred); actomyosin contractile ring (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: macrophage erythroblast attacher
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8543,291 - 568,452 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18543,281 - 568,437 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAEA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8543,291 - 568,452 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18543,281 - 568,437 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAEA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,289,891 - 1,340,137 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,289,887 - 1,340,147 (+)EnsemblGRCh38hg38GRCh38
GRCh3741,283,679 - 1,333,925 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,273,672 - 1,323,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 3441,273,542 - 1,323,721NCBI
Celera41,215,633 - 1,265,565 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,250,956 - 1,301,457 (+)NCBIHuRef
CHM1_141,282,541 - 1,333,721 (+)NCBICHM1_1
T2T-CHM13v2.041,288,439 - 1,338,753 (+)NCBIT2T-CHM13v2.0
Maea
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,492,916 - 33,530,638 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,492,853 - 33,530,640 (+)EnsemblGRCm39 Ensembl
GRCm38533,335,572 - 33,373,294 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,335,509 - 33,373,296 (+)EnsemblGRCm38mm10GRCm38
MGSCv37533,678,221 - 33,715,943 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36533,652,467 - 33,689,370 (+)NCBIMGSCv36mm8
Celera530,814,826 - 30,852,569 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.55NCBI
Maea
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,581,784 - 81,615,246 (-)NCBIGRCr8
mRatBN7.21477,357,261 - 77,390,683 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1477,357,264 - 77,390,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,808,960 - 81,842,384 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,049,511 - 83,082,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,494,839 - 79,528,263 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,664,248 - 82,697,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,664,249 - 82,697,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01483,349,564 - 83,383,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41483,124,774 - 83,158,198 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11483,127,164 - 83,160,588 (+)NCBI
Celera1476,276,552 - 76,309,970 (-)NCBICelera
Cytogenetic Map14q21NCBI
Maea
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514689,868 - 722,779 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955514689,867 - 722,779 (+)NCBIChiLan1.0ChiLan1.0
MAEA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v231,621,007 - 1,673,967 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan141,586,767 - 1,640,160 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,432,848 - 1,485,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,335,508 - 1,366,448 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,315,810 - 1,366,448 (+)Ensemblpanpan1.1panPan2
MAEA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,679,084 - 62,718,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,682,538 - 62,718,071 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha365,198,239 - 65,234,415 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0363,157,007 - 63,193,190 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1362,648,983 - 62,685,136 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,852,407 - 62,888,598 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0363,211,815 - 63,248,001 (-)NCBIUU_Cfam_GSD_1.0
Maea
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,257,773 - 68,294,743 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,959,465 - 21,996,937 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647721,959,465 - 21,996,395 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAEA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,425,276 - 47,473,618 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,425,185 - 47,473,626 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,765,578 - 3,816,123 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Maea
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,934,569 - 25,968,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,934,569 - 25,968,726 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAEA
333 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 10 4 3 3 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000042592   ⟹   ENSSSCP00000053279
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8543,291 - 572,636 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000056477   ⟹   ENSSSCP00000044808
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8543,330 - 568,452 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081683   ⟹   ENSSSCP00000060126
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8543,291 - 568,428 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082873   ⟹   ENSSSCP00000061190
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8543,291 - 572,636 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000104663   ⟹   ENSSSCP00000080905
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8543,291 - 568,428 (+)Ensembl
RefSeq Acc Id: XM_021100884   ⟹   XP_020956543
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18543,281 - 568,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100885   ⟹   XP_020956544
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18543,281 - 568,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100887   ⟹   XP_020956546
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18543,281 - 568,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021100888   ⟹   XP_020956547
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18543,281 - 568,437 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002346522
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18543,281 - 568,437 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002346523
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18543,281 - 568,437 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002346524
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18547,423 - 568,437 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020956543   ⟸   XM_021100884
- Peptide Label: isoform X1
- UniProtKB: A0A8D1TZX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020956546   ⟸   XM_021100887
- Peptide Label: isoform X3
- UniProtKB: A0A287ALN2 (UniProtKB/TrEMBL),   A0A4X1T340 (UniProtKB/TrEMBL),   A0A481D2J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020956544   ⟸   XM_021100885
- Peptide Label: isoform X2
- UniProtKB: A0A8D1QE58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020956547   ⟸   XM_021100888
- Peptide Label: isoform X4
- UniProtKB: A0A480VEA9 (UniProtKB/TrEMBL),   A0A4X1T3D5 (UniProtKB/TrEMBL),   A0A4X1T3F4 (UniProtKB/TrEMBL),   A0A5G2Q8D4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000053279   ⟸   ENSSSCT00000042592
RefSeq Acc Id: ENSSSCP00000044808   ⟸   ENSSSCT00000056477
RefSeq Acc Id: ENSSSCP00000060126   ⟸   ENSSSCT00000081683
RefSeq Acc Id: ENSSSCP00000061190   ⟸   ENSSSCT00000082873
RefSeq Acc Id: ENSSSCP00000080905   ⟸   ENSSSCT00000104663
Protein Domains
CTLH   RING-Gid-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032304 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025053771 UniProtKB/TrEMBL
  ENSSSCG00030054464 UniProtKB/TrEMBL
  ENSSSCG00035077586 UniProtKB/TrEMBL
  ENSSSCG00040072365 UniProtKB/TrEMBL
  ENSSSCG00045012869 UniProtKB/TrEMBL
  ENSSSCG00050003914 UniProtKB/TrEMBL
  ENSSSCG00055010620 UniProtKB/TrEMBL
  ENSSSCG00060054338 UniProtKB/TrEMBL
  ENSSSCG00065068689 UniProtKB/TrEMBL
  ENSSSCG00070005844 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000056477 ENTREZGENE
  ENSSSCT00000056477.2 UniProtKB/TrEMBL
  ENSSSCT00000081683.1 UniProtKB/TrEMBL
  ENSSSCT00000104663 ENTREZGENE
  ENSSSCT00000104663.1 UniProtKB/TrEMBL
  ENSSSCT00025073664.1 UniProtKB/TrEMBL
  ENSSSCT00025074247.1 UniProtKB/TrEMBL
  ENSSSCT00030075934.1 UniProtKB/TrEMBL
  ENSSSCT00030076012.1 UniProtKB/TrEMBL
  ENSSSCT00035106058.1 UniProtKB/TrEMBL
  ENSSSCT00040099923.1 UniProtKB/TrEMBL
  ENSSSCT00040099974.1 UniProtKB/TrEMBL
  ENSSSCT00045021912.1 UniProtKB/TrEMBL
  ENSSSCT00045022023.1 UniProtKB/TrEMBL
  ENSSSCT00045022051.1 UniProtKB/TrEMBL
  ENSSSCT00045022104.1 UniProtKB/TrEMBL
  ENSSSCT00050005325.1 UniProtKB/TrEMBL
  ENSSSCT00055020813.1 UniProtKB/TrEMBL
  ENSSSCT00055020873.1 UniProtKB/TrEMBL
  ENSSSCT00055020943.1 UniProtKB/TrEMBL
  ENSSSCT00055020986.1 UniProtKB/TrEMBL
  ENSSSCT00060074073.1 UniProtKB/TrEMBL
  ENSSSCT00065094310.1 UniProtKB/TrEMBL
  ENSSSCT00065094313.1 UniProtKB/TrEMBL
  ENSSSCT00070011182.1 UniProtKB/TrEMBL
  ENSSSCT00070011197.1 UniProtKB/TrEMBL
  ENSSSCT00070011220.1 UniProtKB/TrEMBL
InterPro CRA_dom UniProtKB/TrEMBL
  CTLH/CRA UniProtKB/TrEMBL
  CTLH_C UniProtKB/TrEMBL
  Fyv10_fam UniProtKB/TrEMBL
  LisH UniProtKB/TrEMBL
  ZF_RING_GID UniProtKB/TrEMBL
NCBI Gene MAEA ENTREZGENE
PANTHER PTHR12170 UniProtKB/TrEMBL
  PTHR12170:SF2 UniProtKB/TrEMBL
Pfam CLTH UniProtKB/TrEMBL
PROSITE CTLH UniProtKB/TrEMBL
  LISH UniProtKB/TrEMBL
  ZF_RING_GID UniProtKB/TrEMBL
SMART CRA UniProtKB/TrEMBL
  CTLH UniProtKB/TrEMBL
  LisH UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A287ALN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A480VEA9 ENTREZGENE, UniProtKB/TrEMBL
  A0A481D2J0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T340 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T3D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T3F4 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2Q8D4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1H858_PIG UniProtKB/TrEMBL
  A0A8D1H910_PIG UniProtKB/TrEMBL
  A0A8D1QE58 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1TZX6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89943 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-25 MAEA  macrophage erythroblast attacher, E3 ubiquitin ligase  MAEA  macrophage erythroblast attacher  Symbol and/or name change 5135510 APPROVED