LOC102167410 (5-formyltetrahydrofolate cyclo-ligase) - Rat Genome Database

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Gene: LOC102167410 (5-formyltetrahydrofolate cyclo-ligase) Sus scrofa
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Symbol: LOC102167410
Name: 5-formyltetrahydrofolate cyclo-ligase
RGD ID: 14089122
Description: ENCODES a protein that exhibits folic acid binding (ortholog); INVOLVED IN folic acid catabolic process (ortholog); glutamate metabolic process (ortholog); tetrahydrofolate interconversion (ortholog); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; ASSOCIATED WITH Bloom syndrome (ortholog); cleft lip (ortholog); cleft palate (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1748,717,518 - 48,873,492 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2754,276,934 - 54,313,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712  


Genomics

Comparative Map Data
LOC102167410
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1748,717,518 - 48,873,492 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2754,276,934 - 54,313,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1579,833,585 - 79,897,379 (-)EnsemblGRCh38hg38GRCh38
GRCh381579,843,547 - 79,897,285 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371580,135,889 - 80,189,627 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361577,924,373 - 77,976,425 (-)NCBINCBI36hg18NCBI36
Build 341577,924,374 - 77,976,395NCBI
Celera1557,073,628 - 57,125,676 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1556,894,007 - 56,947,724 (-)NCBIHuRef
CHM1_11580,252,880 - 80,306,583 (-)NCBICHM1_1
Mthfs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39989,093,243 - 89,122,278 (+)NCBIGRCm39mm39
GRCm39 Ensembl989,092,729 - 89,259,766 (+)Ensembl
GRCm38989,211,190 - 89,240,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl989,210,676 - 89,377,713 (+)EnsemblGRCm38mm10GRCm38
MGSCv37989,106,028 - 89,135,063 (+)NCBIGRCm37mm9NCBIm37
MGSCv36989,009,083 - 89,038,118 (+)NCBImm8
Celera988,839,126 - 88,843,217 (+)NCBICelera
Celera987,292,813 - 87,293,205 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
Mthfs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2889,729,498 - 89,801,998 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl896,564,877 - 96,614,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0896,564,877 - 96,614,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0896,071,796 - 96,121,086 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,058,605 - 94,108,277 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1894,078,059 - 94,127,729 (+)NCBI
Celera889,291,095 - 89,340,497 (+)NCBICelera
Cytogenetic Map8q31NCBI
Mthfs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955533720,255 - 756,893 (-)NCBIChiLan1.0ChiLan1.0
MTHFS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,480,935 - 57,514,836 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha360,139,116 - 60,173,501 (+)NCBI
ROS_Cfam_1.0357,913,790 - 57,950,014 (+)NCBI
UMICH_Zoey_3.1357,413,049 - 57,447,505 (+)NCBI
UNSW_CanFamBas_1.0357,620,059 - 57,654,466 (+)NCBI
UU_Cfam_GSD_1.0357,967,073 - 58,003,248 (+)NCBI
Mthfs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,976,748 - 120,116,548 (-)NCBI
SpeTri2.0NW_00493647137,910,856 - 37,964,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Mthfs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624941856,196 - 894,057 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 2 3
Low 2 2 3 2 23 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: XM_021098846   ⟹   XP_020954505
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1748,821,029 - 48,873,492 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098847   ⟹   XP_020954506
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1748,741,698 - 48,873,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098849   ⟹   XP_020954508
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1748,821,029 - 48,873,174 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098850   ⟹   XP_020954509
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1748,821,029 - 48,867,148 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098851   ⟹   XP_020954510
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1748,821,029 - 48,873,125 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098852   ⟹   XP_020954511
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1748,821,029 - 48,867,731 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098853   ⟹   XP_020954512
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1748,821,029 - 48,866,623 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002345772
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1748,717,518 - 48,873,450 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020954506   ⟸   XM_021098847
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020954505   ⟸   XM_021098846
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020954508   ⟸   XM_021098849
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020954510   ⟸   XM_021098851
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020954511   ⟸   XM_021098852
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020954509   ⟸   XM_021098850
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020954512   ⟸   XM_021098853
- Peptide Label: isoform X3
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038708 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070019249 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000054403 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000057831 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070031801 UniProtKB/TrEMBL
  ENSSSCP00070031816 UniProtKB/TrEMBL
  ENSSSCP00070031820 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000056095 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000063321 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070038012 UniProtKB/TrEMBL
  ENSSSCT00070038029 UniProtKB/TrEMBL
  ENSSSCT00070038035 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
  3.40.50.10420 UniProtKB/TrEMBL
InterPro Bcl2-like UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/TrEMBL
  Bcl2A1 UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/TrEMBL
  Blc2_fam UniProtKB/TrEMBL
  FTHF_cligase UniProtKB/TrEMBL
  FTHF_cligase-like_sf UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/TrEMBL
NCBI Gene LOC102167410 ENTREZGENE
PANTHER PTHR11256 UniProtKB/TrEMBL
  PTHR11256:SF10 UniProtKB/TrEMBL
  PTHR23407:SF1 UniProtKB/TrEMBL
Pfam 5-FTHF_cyc-lig UniProtKB/TrEMBL
  Bcl-2 UniProtKB/TrEMBL
PIRSF FTHF_cligase UniProtKB/TrEMBL
PRINTS BCL2FAMILY UniProtKB/TrEMBL
  BCL2RLATEDA1 UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/TrEMBL
  BH1 UniProtKB/TrEMBL
SMART BCL UniProtKB/TrEMBL
Superfamily-SCOP SSF100950 UniProtKB/TrEMBL
  SSF56854 UniProtKB/TrEMBL
TIGRFAMs MTHFS_bact UniProtKB/TrEMBL
UniProt A0A287BE62_PIG UniProtKB/TrEMBL
  A0A287BMU8_PIG UniProtKB/TrEMBL
  A0A4X1UP21_PIG UniProtKB/TrEMBL
  A0A4X1UP37_PIG UniProtKB/TrEMBL
  A0A4X1UT60_PIG UniProtKB/TrEMBL