MAPK9 (mitogen-activated protein kinase 9) - Rat Genome Database

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Gene: MAPK9 (mitogen-activated protein kinase 9) Sus scrofa
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Symbol: MAPK9
Name: mitogen-activated protein kinase 9
RGD ID: 14088820
Description: ENCODES a protein that exhibits ATP binding (ortholog); cysteine-type endopeptidase activator activity involved in apoptotic process (ortholog); JUN kinase activity (ortholog); INVOLVED IN cellular hyperosmotic response (ortholog); cellular response to amyloid-beta (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; FasL mediated signaling pathway; glypican signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Animal Disease Models (ortholog); arteriosclerosis (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); neuron projection (ortholog); INTERACTS WITH anthra[1,9-cd]pyrazol-6(2H)-one; cadmium dichloride; elemental selenium
Type: protein-coding
RefSeq Status: MODEL
Also known as: c-Jun N-terminal kinase 2; janus kinase 2; JNK2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,338,369 - 78,399,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,338,466 - 78,399,108 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,823,618 - 79,884,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular hyperosmotic response  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to cadmium ion  (IEA)
cellular response to growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to reactive oxygen species  (IEA)
cellular response to tumor necrosis factor  (ISO)
cellular response to UV  (ISO)
central nervous system development  (ISO)
intracellular signal transduction  (IBA)
JNK cascade  (IBA,ISO)
JUN phosphorylation  (IEA,ISO)
MAPK cascade  (IEA)
neuron development  (ISO)
neuron projection development  (ISO)
peptidyl-serine phosphorylation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cell morphogenesis involved in differentiation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of podosome assembly  (IEA,ISO)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (IEA)
positive regulation of transcription factor catabolic process  (IEA)
positive regulation of transcription, DNA-templated  (ISO)
protein localization to tricellular tight junction  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
protein targeting to mitochondrion  (ISO)
regulation of circadian rhythm  (IEA)
regulation of JNK cascade  (ISO)
regulation of protein ubiquitination  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to amine  (ISO)
response to cadmium ion  (ISO)
response to drug  (ISO)
response to mechanical stimulus  (ISO)
response to nerve growth factor  (ISO)
response to organic substance  (ISO)
response to toxic substance  (ISO)
response to water deprivation  (ISO)
rhythmic process  (IEA)

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA)
mitochondrion  (IEA,ISO)
neuron projection  (ISO)
nucleus  (IBA,ISO)
perikaryon  (ISO)

References
Additional References at PubMed
PMID:17159082   PMID:22279582   PMID:22424736  


Genomics

Comparative Map Data
MAPK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,338,369 - 78,399,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,338,466 - 78,399,108 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,823,618 - 79,884,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5180,233,143 - 180,292,099 (-)EnsemblGRCh38hg38GRCh38
GRCh385180,233,143 - 180,292,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375179,660,143 - 179,719,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,595,390 - 179,640,216 (-)NCBINCBI36hg18NCBI36
Build 345179,595,389 - 179,640,216NCBI
Celera5175,286,573 - 175,345,058 (-)NCBI
Cytogenetic Map5q35.3NCBI
HuRef5174,385,878 - 174,444,273 (-)NCBIHuRef
CHM1_15179,092,988 - 179,151,485 (-)NCBICHM1_1
Mapk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,737,558 - 49,777,248 (+)NCBIGRCm39mm39
GRCm39 Ensembl1149,737,578 - 49,777,248 (+)Ensembl
GRCm381149,846,728 - 49,886,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,846,751 - 49,886,421 (+)EnsemblGRCm38mm10GRCm38
MGSCv371149,660,253 - 49,699,923 (+)NCBIGRCm37mm9NCBIm37
MGSCv361149,690,177 - 49,729,521 (+)NCBImm8
Celera1154,408,836 - 54,448,385 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
Mapk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21034,169,661 - 34,211,138 (+)NCBI
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01035,333,859 - 35,374,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01035,105,633 - 35,147,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,353,486 - 35,384,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11035,354,534 - 35,385,368 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBICelera
Cytogenetic Map10q21NCBI
Mapk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408391,094 - 430,981 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955408391,094 - 430,638 (+)NCBIChiLan1.0ChiLan1.0
MAPK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15182,748,381 - 182,801,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5182,748,381 - 182,795,135 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05175,437,167 - 175,495,469 (-)NCBIMhudiblu_PPA_v0panPan3
MAPK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,443,528 - 1,480,501 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,443,547 - 1,478,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,491,213 - 1,542,807 (+)NCBI
ROS_Cfam_1.0111,400,469 - 1,452,082 (+)NCBI
UMICH_Zoey_3.1111,353,353 - 1,404,946 (+)NCBI
UNSW_CanFamBas_1.0111,451,386 - 1,502,976 (+)NCBI
UU_Cfam_GSD_1.0111,691,426 - 1,743,027 (+)NCBI
Mapk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,341,905 - 119,392,250 (+)NCBI
SpeTri2.0NW_004936739551,678 - 602,027 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK9
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,965,330 - 82,026,414 (-)NCBI
ChlSab1.1 Ensembl2381,963,899 - 82,013,659 (-)Ensembl
Mapk9
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473342,998,948 - 43,048,392 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 3 5 2 23 2 3 1
Low 7 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015303   ⟹   ENSSSCP00000014895
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,338,525 - 78,396,671 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000035631   ⟹   ENSSSCP00000029825
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,338,376 - 78,399,105 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053607   ⟹   ENSSSCP00000046017
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,338,376 - 78,399,105 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054897   ⟹   ENSSSCP00000046994
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,338,376 - 78,399,105 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000066864   ⟹   ENSSSCP00000062761
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,338,369 - 78,399,005 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069451   ⟹   ENSSSCP00000074278
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,338,502 - 78,383,727 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000089561   ⟹   ENSSSCP00000060506
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,339,611 - 78,399,103 (+)Ensembl
RefSeq Acc Id: XM_003354171   ⟹   XP_003354219
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,338,470 - 78,399,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005661439   ⟹   XP_005661496
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,338,500 - 78,399,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005661440   ⟹   XP_005661497
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,338,471 - 78,399,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005661441   ⟹   XP_005661498
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,338,466 - 78,399,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005661444   ⟹   XP_005661501
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,352,387 - 78,399,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013994862   ⟹   XP_013850316
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,352,406 - 78,399,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084316   ⟹   XP_020939975
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,352,387 - 78,399,108 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084317   ⟹   XP_020939976
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,352,406 - 78,399,108 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005661498   ⟸   XM_005661441
- Peptide Label: isoform X2
- UniProtKB: A0A287APM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003354219   ⟸   XM_003354171
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005661497   ⟸   XM_005661440
- Peptide Label: isoform X1
- UniProtKB: K7GPL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661496   ⟸   XM_005661439
- Peptide Label: isoform X1
- UniProtKB: K7GPL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661501   ⟸   XM_005661444
- Peptide Label: isoform X3
- UniProtKB: F1S5Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939975   ⟸   XM_021084316
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013850316   ⟸   XM_013994862
- Peptide Label: isoform X3
- UniProtKB: F1S5Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939976   ⟸   XM_021084317
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSSSCP00000046994   ⟸   ENSSSCT00000054897
RefSeq Acc Id: ENSSSCP00000014895   ⟸   ENSSSCT00000015303
RefSeq Acc Id: ENSSSCP00000060506   ⟸   ENSSSCT00000089561
RefSeq Acc Id: ENSSSCP00000029825   ⟸   ENSSSCT00000035631
RefSeq Acc Id: ENSSSCP00000074278   ⟸   ENSSSCT00000069451
RefSeq Acc Id: ENSSSCP00000062761   ⟸   ENSSSCT00000066864
RefSeq Acc Id: ENSSSCP00000046017   ⟸   ENSSSCT00000053607
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014010 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070026924 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014895 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000029825 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000046017 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000046994 UniProtKB/TrEMBL
  ENSSSCP00000060506 UniProtKB/TrEMBL
  ENSSSCP00000062761 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000074278 UniProtKB/TrEMBL
  ENSSSCP00070045763 UniProtKB/TrEMBL
  ENSSSCP00070045765 UniProtKB/TrEMBL
  ENSSSCP00070045766 UniProtKB/TrEMBL
  ENSSSCP00070045768 UniProtKB/TrEMBL
  ENSSSCP00070045769 UniProtKB/TrEMBL
  ENSSSCP00070045770 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015303 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000035631 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053607 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000054897 UniProtKB/TrEMBL
  ENSSSCT00000066864 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000069451 UniProtKB/TrEMBL
  ENSSSCT00000089561 UniProtKB/TrEMBL
  ENSSSCT00070053991 UniProtKB/TrEMBL
  ENSSSCT00070053993 UniProtKB/TrEMBL
  ENSSSCT00070053994 UniProtKB/TrEMBL
  ENSSSCT00070053996 UniProtKB/TrEMBL
  ENSSSCT00070053997 UniProtKB/TrEMBL
  ENSSSCT00070053998 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:396609 UniProtKB/TrEMBL
NCBI Gene MAPK9 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PRINTS JNKMAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287APM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A287ASQ5_PIG UniProtKB/TrEMBL
  A0A4X1VQA9_PIG UniProtKB/TrEMBL
  A0A4X1VQB4_PIG UniProtKB/TrEMBL
  A0A4X1VUS0_PIG UniProtKB/TrEMBL
  A0A4X1VVX0_PIG UniProtKB/TrEMBL
  A0A4X1VWV3_PIG UniProtKB/TrEMBL
  A0A4X1VWV8_PIG UniProtKB/TrEMBL
  A0A5G2QEQ3_PIG UniProtKB/TrEMBL
  A0A5G2QG50_PIG UniProtKB/TrEMBL
  A0A5G2RGU1_PIG UniProtKB/TrEMBL
  F1S5Q3 ENTREZGENE, UniProtKB/TrEMBL
  K7GPL0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90009 ENTREZGENE