FOXC1 (forkhead box C1) - Rat Genome Database

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Gene: FOXC1 (forkhead box C1) Sus scrofa
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Symbol: FOXC1
Name: forkhead box C1
RGD ID: 14088630
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN artery morphogenesis (ortholog); blood vessel development (ortholog); blood vessel diameter maintenance (ortholog); ASSOCIATED WITH aniridia (ortholog); anterior segment dysgenesis (ortholog); anterior segment dysgenesis 3 (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: forkhead box protein C1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7837,171 - 838,805 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17837,088 - 840,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,037,165 - 1,039,040 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IBA)
artery morphogenesis  (IEA,ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
brain development  (ISO)
camera-type eye development  (IEA,ISO)
cardiac muscle cell proliferation  (IEA,ISO)
cell differentiation  (IBA)
cell migration  (ISO)
cell population proliferation  (ISO)
cellular response to chemokine  (ISO)
cellular response to epidermal growth factor stimulus  (IEA)
cerebellum development  (IEA)
chemokine-mediated signaling pathway  (IEA)
collagen fibril organization  (IEA,ISO)
embryonic heart tube development  (IEA,ISO)
endochondral ossification  (IEA)
eye development  (ISO)
germ cell migration  (IEA,ISO)
glomerular epithelium development  (IEA)
glycosaminoglycan metabolic process  (IEA,ISO)
heart development  (ISO)
heart morphogenesis  (ISO)
in utero embryonic development  (IEA,ISO)
kidney development  (ISO)
lacrimal gland development  (IEA,ISO)
lymph vessel development  (IEA,ISO)
maintenance of lens transparency  (IEA)
mesenchymal cell development  (ISO)
mesenchymal cell differentiation  (ISO)
negative regulation of angiogenesis  (IEA)
negative regulation of apoptotic process involved in outflow tract morphogenesis  (IEA,ISO)
negative regulation of lymphangiogenesis  (IEA)
negative regulation of mitotic cell cycle  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
neural crest cell development  (IEA,ISO)
Notch signaling pathway  (IEA,ISO)
odontogenesis of dentin-containing tooth  (IEA)
ossification  (ISO)
ovarian follicle development  (IEA,ISO)
paraxial mesoderm formation  (IEA,ISO)
positive regulation of core promoter binding  (IEA)
positive regulation of DNA binding  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of hematopoietic progenitor cell differentiation  (ISO)
positive regulation of hematopoietic stem cell differentiation  (IEA)
positive regulation of keratinocyte differentiation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of organ growth  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (ISO)
skeletal system development  (ISO)
somitogenesis  (IEA)
ureteric bud development  (IEA,ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
vascular endothelial growth factor signaling pathway  (IEA)
ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)

Cellular Component
cytosol  (IEA)
heterochromatin  (IEA)
nucleoplasm  (IEA)
nucleus  (ISO)

References

Genomics

Comparative Map Data
FOXC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7837,171 - 838,805 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17837,088 - 840,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,037,165 - 1,039,040 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOXC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl61,609,915 - 1,613,897 (+)EnsemblGRCh38hg38GRCh38
GRCh3861,609,915 - 1,613,897 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3761,610,150 - 1,614,132 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3661,555,680 - 1,559,131 (+)NCBINCBI36hg18NCBI36
Build 3461,555,679 - 1,557,341NCBI
Celera62,838,909 - 2,842,360 (+)NCBI
Cytogenetic Map6p25.3NCBI
HuRef61,480,597 - 1,483,685 (+)NCBIHuRef
CHM1_161,612,575 - 1,616,026 (+)NCBICHM1_1
Foxc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391331,990,629 - 31,994,618 (+)NCBIGRCm39mm39
GRCm39 Ensembl1331,990,616 - 31,996,459 (+)Ensembl
GRCm381331,806,646 - 31,810,635 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1331,806,633 - 31,812,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv371331,898,515 - 31,902,504 (+)NCBIGRCm37mm9NCBIm37
MGSCv361331,814,111 - 31,818,100 (+)NCBImm8
Celera1332,016,470 - 32,020,494 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.52NCBI
Foxc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21732,631,379 - 32,635,361 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1732,633,142 - 32,634,803 (-)Ensembl
Rnor_6.01733,947,501 - 33,951,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1733,947,506 - 33,951,484 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01735,833,707 - 35,837,690 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41739,026,186 - 39,030,163 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1732,190,633 - 32,194,475 (-)NCBICelera
Cytogenetic Map17p12NCBI
FOXC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v061,429,051 - 1,433,180 (+)NCBIMhudiblu_PPA_v0panPan3
FOXC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha352,065,990 - 2,069,716 (+)NCBI
ROS_Cfam_1.0352,012,278 - 2,015,999 (+)NCBI
UMICH_Zoey_3.1351,987,281 - 1,991,006 (+)NCBI
UNSW_CanFamBas_1.0352,008,542 - 2,012,243 (+)NCBI
UU_Cfam_GSD_1.0353,344,191 - 3,347,919 (+)NCBI
FOXC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11770,533,048 - 70,536,555 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1770,534,821 - 70,536,476 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660441,552,589 - 1,556,578 (+)NCBIVero_WHO_p1.0
Foxc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475623,060,065 - 23,062,407 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 2 1 1
Below cutoff 1 2 1 1 11 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000037866   ⟹   ENSSSCP00000035002
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7837,171 - 838,805 (+)Ensembl
RefSeq Acc Id: XM_005665529   ⟹   XP_005665586
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.17837,088 - 840,593 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005665586 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005665586   ⟸   XM_005665529
- Sequence:
RefSeq Acc Id: ENSSSCP00000035002   ⟸   ENSSSCT00000037866
Protein Domains
Fork-head


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070003483 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000035002 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070005340 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000037866 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070006553 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Fork_head_dom UniProtKB/TrEMBL
  FoxC1 UniProtKB/TrEMBL
  TF_fork_head_CS_1 UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene FOXC1 ENTREZGENE
PANTHER PTHR11829:SF68 UniProtKB/TrEMBL
Pfam Forkhead UniProtKB/TrEMBL
PRINTS FORKHEAD UniProtKB/TrEMBL
PROSITE FORK_HEAD_1 UniProtKB/TrEMBL
  FORK_HEAD_2 UniProtKB/TrEMBL
  FORK_HEAD_3 UniProtKB/TrEMBL
SMART SM00339 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A286ZTP3_PIG UniProtKB/TrEMBL
  A0A4X1SSE9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88197 ENTREZGENE