ANPEP (alanyl aminopeptidase, membrane) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: ANPEP (alanyl aminopeptidase, membrane) Sus scrofa
Analyze
Symbol: ANPEP
Name: alanyl aminopeptidase, membrane
RGD ID: 14087089
Description: ENCODES a protein that exhibits aminopeptidase activity (inferred); metallopeptidase activity (inferred); virus receptor activity (inferred); INVOLVED IN negative regulation of renal sodium excretion (ortholog); PARTICIPATES IN angiotensin IV signaling pathway; glutathione metabolic pathway; glutathione synthase deficiency pathway; ASSOCIATED WITH severe acute respiratory syndrome (ortholog); urinary bladder cancer (ortholog); FOUND IN brush border membrane (ortholog); endoplasmic reticulum-Golgi intermediate compartment (ortholog); extracellular exosome (ortholog); INTERACTS WITH 1,10-phenanthroline; bis(2-chloroethyl) sulfide; ethylenediaminetetraacetic acid
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: aminopeptidase M; aminopeptidase N; AP-M; AP-N; APN; gp130; microsomal aminopeptidase; pAPN; PEPN; porcine aminopeptidase N
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,351,083 - 55,373,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,351,081 - 55,373,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,240,144 - 60,262,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7cen-q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:1350661   PMID:1677324   PMID:1977382   PMID:2568950   PMID:3121301   PMID:6119979   PMID:7904801   PMID:7911642   PMID:7913510   PMID:8672129   PMID:8963385   PMID:8985407  
PMID:9634079   PMID:14681463   PMID:17145712   PMID:17634404   PMID:20074871   PMID:20643168   PMID:22083718   PMID:24023659   PMID:24663207   PMID:25681796   PMID:25787280   PMID:26044794  
PMID:26449746   PMID:26907329   PMID:27449937   PMID:28363778   PMID:30315482   PMID:33114247  


Genomics

Comparative Map Data
ANPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,351,083 - 55,373,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,351,081 - 55,373,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,240,144 - 60,262,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7cen-q21NCBI
ANPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1589,784,895 - 89,815,401 (-)EnsemblGRCh38hg38GRCh38
GRCh381589,784,895 - 89,814,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371590,328,126 - 90,358,119 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,129,130 - 88,159,076 (-)NCBINCBI36hg18NCBI36
Build 341588,129,130 - 88,150,938NCBI
Celera1566,730,914 - 66,760,859 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1566,440,812 - 66,470,613 (-)NCBIHuRef
CHM1_11590,169,132 - 90,199,097 (-)NCBICHM1_1
Anpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,471,551 - 79,497,958 (-)NCBIGRCm39mm39
GRCm38779,821,803 - 79,848,210 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,821,803 - 79,861,059 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,966,689 - 86,987,238 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,695,316 - 79,715,797 (-)NCBImm8
Celera777,221,100 - 77,243,027 (-)NCBICelera
Cytogenetic Map7D2NCBI
Anpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01141,561,364 - 141,604,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,561,334 - 141,604,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01142,522,426 - 142,565,721 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,600,751 - 135,619,208 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11135,679,156 - 135,697,614 (-)NCBI
Celera1125,830,648 - 125,849,086 (-)NCBICelera
Cytogenetic Map1q31NCBI
RH 3.4 Map11063.2RGD
Anpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,424,932 - 15,444,075 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,415,981 - 15,442,032 (+)NCBIChiLan1.0ChiLan1.0
ANPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11587,681,826 - 87,703,713 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,681,826 - 87,703,713 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01568,479,349 - 68,509,238 (-)NCBIMhudiblu_PPA_v0panPan3
ANPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl352,764,418 - 52,779,746 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1352,764,418 - 52,779,516 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Anpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648315,563,540 - 15,582,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103231162
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,324,094 - 8,354,491 (-)NCBI
ChlSab1.1 Ensembl298,323,797 - 8,346,581 (-)Ensembl
Anpep
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476816,840,743 - 16,856,158 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 1 2
Low 5 2 3 4 2 12 2 3
Below cutoff 11 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_214277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005653523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005653524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH008222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK345090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK346266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT737411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBZA01000041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01042368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ824547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF280271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF318789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU986724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX342854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z29522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000002072   ⟹   ENSSSCP00000002023
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,351,346 - 55,368,735 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000035626   ⟹   ENSSSCP00000029051
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,351,083 - 55,373,881 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000068880   ⟹   ENSSSCP00000066695
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,351,521 - 55,368,735 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000073917   ⟹   ENSSSCP00000063888
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,351,087 - 55,365,995 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000077115   ⟹   ENSSSCP00000063121
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,351,083 - 55,373,881 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086218   ⟹   ENSSSCP00000064055
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,351,083 - 55,373,881 (-)Ensembl
RefSeq Acc Id: NM_214277   ⟹   NP_999442
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1755,351,083 - 55,365,997 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005653523   ⟹   XP_005653580
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1755,351,081 - 55,373,855 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005653524   ⟹   XP_005653581
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1755,351,081 - 55,373,856 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098304   ⟹   XP_020953963
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1755,351,081 - 55,373,846 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005653581   ⟸   XM_005653524
- Peptide Label: isoform X2
- UniProtKB: K7GMF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005653580   ⟸   XM_005653523
- Peptide Label: isoform X2
- UniProtKB: K7GMF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953963   ⟸   XM_021098304
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999442   ⟸   NM_214277
- UniProtKB: P15145 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000063888   ⟸   ENSSSCT00000073917
RefSeq Acc Id: ENSSSCP00000066695   ⟸   ENSSSCT00000068880
RefSeq Acc Id: ENSSSCP00000002023   ⟸   ENSSSCT00000002072
RefSeq Acc Id: ENSSSCP00000029051   ⟸   ENSSSCT00000035626
RefSeq Acc Id: ENSSSCP00000064055   ⟸   ENSSSCT00000086218
RefSeq Acc Id: ENSSSCP00000063121   ⟸   ENSSSCT00000077115
Protein Domains
ERAP1_C   Peptidase_M1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001849 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070013489 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002023 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000029051 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063121 UniProtKB/TrEMBL
  ENSSSCP00000063888 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000064055 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000066695 UniProtKB/TrEMBL
  ENSSSCP00070021984 UniProtKB/TrEMBL
  ENSSSCP00070022037 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002072 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000035626 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000068880 UniProtKB/TrEMBL
  ENSSSCT00000073917 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000077115 UniProtKB/TrEMBL
  ENSSSCT00000086218 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070026461 UniProtKB/TrEMBL
  ENSSSCT00070026524 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397520 UniProtKB/Swiss-Prot
NCBI Gene ANPEP ENTREZGENE
Pfam ERAP1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALADIPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1U246_PIG UniProtKB/TrEMBL
  A0A4X1U2S4_PIG UniProtKB/TrEMBL
  A0A5G2QI26_PIG UniProtKB/TrEMBL
  A0A5G2QM04_PIG UniProtKB/TrEMBL
  A0A5G2QP78_PIG UniProtKB/TrEMBL
  A0A5G2QPR2_PIG UniProtKB/TrEMBL
  AMPN_PIG UniProtKB/Swiss-Prot
  F1SK03_PIG UniProtKB/TrEMBL
  K7GMF9 ENTREZGENE, UniProtKB/TrEMBL
  P15145 ENTREZGENE
  U5NEE3_PIG UniProtKB/TrEMBL
UniProt Secondary Q29242 UniProtKB/Swiss-Prot
VGNC ID VGNC:85362 ENTREZGENE