DDX53 (DEAD-box helicase 53) - Rat Genome Database

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Gene: DDX53 (DEAD-box helicase 53) Sus scrofa
Analyze
Symbol: DDX53
Name: DEAD-box helicase 53
RGD ID: 14082802
Description: ENCODES a protein that exhibits ATP binding (inferred); helicase activity (inferred); hydrolase activity (inferred); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); nephrotic syndrome (ortholog); FOUND IN cytosol (ortholog); intracellular membrane-bounded organelle (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DEAD box protein 53
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X19,164,076 - 19,169,280 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X20,433,746 - 20,435,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DDX53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X19,164,076 - 19,169,280 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X20,433,746 - 20,435,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDX53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X22,999,960 - 23,003,589 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX22,999,960 - 23,003,589 (+)EnsemblGRCh38hg38GRCh38
GRCh37X23,018,077 - 23,021,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X22,928,008 - 22,930,127 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX27,139,644 - 27,141,763 (+)NCBICelera
Cytogenetic MapXp22.11NCBI
HuRefX20,758,982 - 20,760,816 (+)NCBIHuRef
CHM1_1X23,049,405 - 23,051,533 (+)NCBICHM1_1
T2T-CHM13v2.0X22,583,485 - 22,587,114 (+)NCBIT2T-CHM13v2.0
Ddx53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555093,352,639 - 3,354,949 (+)NCBIChiLan1.0ChiLan1.0
DDX53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X24,796,165 - 24,805,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X24,800,247 - 24,809,354 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X15,600,945 - 15,603,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X22,976,616 - 22,978,738 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX22,976,707 - 22,978,602 (+)Ensemblpanpan1.1panPan2
DDX53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X18,776,178 - 18,778,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X18,712,683 - 18,734,605 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X18,769,309 - 18,771,552 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X18,788,344 - 18,790,589 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X18,829,437 - 18,851,359 (+)NCBIUU_Cfam_GSD_1.0
Ddx53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X11,719,403 - 11,722,005 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366241,436,134 - 1,438,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDX53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X21,480,981 - 21,483,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX21,481,264 - 21,483,162 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605623,339,153 - 23,342,474 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddx53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248298,122,795 - 8,124,988 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DDX53
42 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system
High
Medium
Low 1 4
Below cutoff 1 3 16

Sequence


Reference Sequences
RefSeq Acc Id: XM_021080573   ⟹   XP_020936232
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X19,164,076 - 19,169,280 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020936232 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000012954
  ENSSSCP00000012954.2
  ENSSSCP00025017290.1
  ENSSSCP00035014084.1
  ENSSSCP00045022382.1
  ENSSSCP00065000073.1
  ENSSSCP00070039355.1
Reference Protein Sequences
RefSeq Acc Id: XP_020936232   ⟸   XM_021080573
- UniProtKB: A0A4X1V8W4 (UniProtKB/TrEMBL),   F1SQ03 (UniProtKB/TrEMBL),   A0A8D0RTW0 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
DEAD-box RNA helicase Q   Helicase ATP-binding   Helicase C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012169 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025029873 UniProtKB/TrEMBL
  ENSSSCG00035026906 UniProtKB/TrEMBL
  ENSSSCG00045019006 UniProtKB/TrEMBL
  ENSSSCG00065000435 UniProtKB/TrEMBL
  ENSSSCG00070023397 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013311 ENTREZGENE
  ENSSSCT00000013311.5 UniProtKB/TrEMBL
  ENSSSCT00025040607.1 UniProtKB/TrEMBL
  ENSSSCT00035035524.1 UniProtKB/TrEMBL
  ENSSSCT00045032321.1 UniProtKB/TrEMBL
  ENSSSCT00065000474.1 UniProtKB/TrEMBL
  ENSSSCT00070046649.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  KH_dom UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/TrEMBL
NCBI Gene DDX53 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE DBP3 UniProtKB/TrEMBL
  ATP-DEPENDENT RNA HELICASE DDX53-RELATED UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  KH_1 UniProtKB/TrEMBL
PROSITE DEAD_ATP_HELICASE UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  KH_TYPE_1 UniProtKB/TrEMBL
  Q_MOTIF UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
  SM00322 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF54791 UniProtKB/TrEMBL
UniProt A0A4X1V8W4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0RTW0 ENTREZGENE, UniProtKB/TrEMBL
  F1SQ03 ENTREZGENE, UniProtKB/TrEMBL