GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D) - Rat Genome Database

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Gene: GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D) Sus scrofa
Analyze
Symbol: GRIN2D
Name: glutamate ionotropic receptor NMDA type subunit 2D
RGD ID: 14080383
Description: ENCODES a protein that exhibits glutamate binding (ortholog); glutamate-gated receptor activity (ortholog); ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN adult locomotory behavior (ortholog); cellular response to L-glutamate (ortholog); detection of mechanical stimulus involved in sensory perception of pain (ortholog); ASSOCIATED WITH brain disease (ortholog); developmental and epileptic encephalopathy 46 (ortholog); Developmental Disease (ortholog); FOUND IN glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog); NMDA selective glutamate receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutamate receptor ionotropic, NMDA 2D
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,806,174 - 53,848,789 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,809,590 - 53,849,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,570,829 - 49,613,106 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GRIN2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,806,174 - 53,848,789 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,809,590 - 53,849,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,570,829 - 49,613,106 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,393,668 - 48,444,931 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,393,668 - 48,444,931 (+)EnsemblGRCh38hg38GRCh38
GRCh371948,896,925 - 48,948,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,589,944 - 53,640,000 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,589,943 - 53,639,205NCBI
Celera1945,763,381 - 45,813,433 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,278,762 - 45,328,386 (+)NCBIHuRef
CHM1_11948,900,198 - 48,950,044 (+)NCBICHM1_1
T2T-CHM13v2.01951,387,832 - 51,439,100 (+)NCBIT2T-CHM13v2.0
Grin2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,481,307 - 45,520,708 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,481,307 - 45,527,802 (-)EnsemblGRCm39 Ensembl
GRCm38745,831,883 - 45,871,194 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,831,883 - 45,878,378 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,087,853 - 53,122,051 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,700,822 - 45,734,609 (-)NCBIMGSCv36mm8
Celera741,296,635 - 41,330,798 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.54NCBI
Grin2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,443,317 - 105,483,400 (-)NCBIGRCr8
mRatBN7.2196,306,871 - 96,346,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,308,365 - 96,344,793 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,694,508 - 101,730,941 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,166,494 - 110,202,933 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,456,865 - 103,493,298 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,819,068 - 101,859,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,820,461 - 101,856,881 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,899,446 - 102,935,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,308,548 - 96,345,931 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,386,658 - 96,424,042 (-)NCBI
Celera190,560,875 - 90,597,451 (-)NCBICelera
Cytogenetic Map1q22NCBI
Grin2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555592,042,723 - 2,080,706 (-)NCBIChiLan1.0ChiLan1.0
GRIN2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,496,831 - 54,550,701 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,423,033 - 56,477,035 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,392,258 - 45,447,004 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11953,989,734 - 54,038,371 (+)NCBIpanpan1.1PanPan1.1panPan2
GRIN2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,821,853 - 107,853,411 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,822,716 - 107,849,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,344,687 - 107,375,906 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,347,785 - 108,379,031 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,347,734 - 108,379,883 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,013,073 - 108,045,131 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,660,406 - 107,692,469 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,496,256 - 108,532,686 (-)NCBIUU_Cfam_GSD_1.0
Grin2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934920,898,056 - 20,928,675 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,515,928 - 2,546,429 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,512,777 - 2,546,865 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,650,458 - 41,707,024 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,656,334 - 41,706,030 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,434,159 - 21,490,139 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin2d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,362,046 - 5,392,973 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,362,046 - 5,392,988 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GRIN2D
466 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system hemolymphoid system nervous system reproductive system respiratory system
High
Medium
Low 10
Below cutoff 2 3 10 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003474   ⟹   ENSSSCP00000003391
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl653,806,174 - 53,848,789 (+)Ensembl
RefSeq Acc Id: XM_021094673   ⟹   XP_020950332
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1653,809,590 - 53,849,535 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020950332   ⟸   XM_021094673
- UniProtKB: A0A8D0QZ93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000003391   ⟸   ENSSSCT00000003474
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003133 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025016471 UniProtKB/TrEMBL
  ENSSSCG00030053578 UniProtKB/TrEMBL
  ENSSSCG00035050524 UniProtKB/TrEMBL
  ENSSSCG00045014389 UniProtKB/TrEMBL
  ENSSSCG00050074853 UniProtKB/TrEMBL
  ENSSSCG00055027267 UniProtKB/TrEMBL
  ENSSSCG00060068259 UniProtKB/TrEMBL
  ENSSSCG00065038836 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003474 ENTREZGENE
  ENSSSCT00000003474.5 UniProtKB/TrEMBL
  ENSSSCT00025022159.1 UniProtKB/TrEMBL
  ENSSSCT00030074758.1 UniProtKB/TrEMBL
  ENSSSCT00035067329.1 UniProtKB/TrEMBL
  ENSSSCT00045024561.1 UniProtKB/TrEMBL
  ENSSSCT00050102473.1 UniProtKB/TrEMBL
  ENSSSCT00055054004.1 UniProtKB/TrEMBL
  ENSSSCT00060093178.1 UniProtKB/TrEMBL
  ENSSSCT00065053073.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2300 UniProtKB/TrEMBL
  Periplasmic binding protein-like II UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/TrEMBL
  Ionotropic_Glu_rcpt UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
  Solute-binding_3/MltF_N UniProtKB/TrEMBL
NCBI Gene GRIN2D ENTREZGENE
PANTHER GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D UniProtKB/TrEMBL
  IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/TrEMBL
Pfam ANF_receptor UniProtKB/TrEMBL
  Lig_chan UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/TrEMBL
  SBP_bac_3 UniProtKB/TrEMBL
PRINTS NMDARECEPTOR UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/TrEMBL
  PBPe UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/TrEMBL
  SSF53822 UniProtKB/TrEMBL
UniProt A0A8D0QZ93 ENTREZGENE, UniProtKB/TrEMBL
  F1RL86_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88686 ENTREZGENE