RB1 (RB transcriptional corepressor 1) - Rat Genome Database

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Gene: RB1 (RB transcriptional corepressor 1) Sus scrofa
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Symbol: RB1
Name: RB transcriptional corepressor 1
RGD ID: 14078807
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); enzyme binding (ortholog); transcription factor binding (ortholog); INVOLVED IN apoptotic process (ortholog); cell division (ortholog); cell morphogenesis involved in neuron differentiation (ortholog); PARTICIPATES IN ceramide signaling pathway; G1/S transition pathway; RNA polymerase III transcription pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cyclin/CDK positive transcription elongation factor complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: retinoblastoma protein; retinoblastoma-associated protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,186,759 - 19,317,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,186,754 - 19,317,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,648,360 - 19,770,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
Autosomal Recessive Woolly Hair  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1  (ISO)
basal cell carcinoma  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 13q14 deletion syndrome  (ISO)
disease of cellular proliferation  (ISO)
ductal carcinoma in situ  (ISO)
embryonal carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
familial retinoblastoma  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
glioblastoma proneural subtype  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
hypotrichosis 8  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
intestinal pseudo-obstruction  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oligodendroglioma  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
retinoblastoma  (ISO)
seminoma  (ISO)
Sezary's disease  (ISO)
small cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
trilateral retinoblastoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IEA)
apoptotic process  (ISO)
cell differentiation  (IBA)
cell division  (IEA,ISO)
cell morphogenesis involved in neuron differentiation  (IBA,IEA,ISO)
cellular response to insulin stimulus  (ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
chondrocyte differentiation  (ISO)
digestive tract development  (IEA,ISO)
enucleate erythrocyte differentiation  (IEA,ISO)
G1/S transition of mitotic cell cycle  (ISO)
glial cell apoptotic process  (IEA,ISO)
hepatocyte apoptotic process  (IEA,ISO)
maintenance of mitotic sister chromatid cohesion  (IEA)
myoblast differentiation  (IEA)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (ISO)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IBA,IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (IEA)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myofibroblast differentiation  (IEA)
negative regulation of protein kinase activity  (IEA)
negative regulation of protein serine/threonine kinase activity  (ISO)
negative regulation of smoothened signaling pathway  (IEA,ISO)
negative regulation of tau-protein kinase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transcription involved in G1/S transition of mitotic cell cycle  (IEA)
negative regulation of transcription, DNA-templated  (ISO)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (ISO)
neuron maturation  (IEA,ISO)
neuron projection development  (IBA,IEA,ISO)
positive regulation of collagen fibril organization  (IEA)
positive regulation of extracellular matrix organization  (ISO)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of mitotic metaphase/anaphase transition  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription regulatory region DNA binding  (IEA,ISO)
protein localization to chromosome, centromeric region  (IEA)
Ras protein signal transduction  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of cell growth  (ISO)
regulation of cohesin loading  (IEA)
regulation of lipid kinase activity  (IEA)
regulation of mitotic cell cycle  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
sister chromatid biorientation  (IEA)
skeletal muscle cell differentiation  (IEA,ISO)
spermatogenesis  (ISO)
striated muscle cell differentiation  (IEA,ISO)
tissue homeostasis  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:25146601  


Genomics

Comparative Map Data
RB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,186,759 - 19,317,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,186,754 - 19,317,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,648,360 - 19,770,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1348,303,744 - 48,599,436 (+)EnsemblGRCh38hg38GRCh38
GRCh381348,303,751 - 48,481,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371348,877,887 - 49,056,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,775,884 - 47,954,027 (+)NCBINCBI36hg18NCBI36
Build 341347,775,911 - 47,954,023NCBI
Celera1329,932,627 - 30,110,747 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,670,144 - 29,848,118 (+)NCBIHuRef
CHM1_11348,845,597 - 49,023,603 (+)NCBICHM1_1
Rb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,430,298 - 73,563,446 (-)NCBIGRCm39mm39
GRCm39 Ensembl1473,421,113 - 73,563,262 (-)Ensembl
GRCm381473,192,858 - 73,325,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,183,673 - 73,325,822 (-)EnsemblGRCm38mm10GRCm38
MGSCv371473,595,309 - 73,725,598 (-)NCBIGRCm37mm9NCBIm37
MGSCv361471,929,656 - 72,059,895 (-)NCBImm8
Celera1470,715,843 - 70,870,859 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.73NCBI
Rb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21548,371,295 - 48,502,473 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)Ensembl
Rnor_6.01555,081,582 - 55,209,060 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01558,804,731 - 58,931,886 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41553,828,881 - 53,962,099 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11553,844,684 - 53,977,640 (-)NCBI
Celera1548,020,828 - 48,147,805 (-)NCBICelera
Cytogenetic Map15q11NCBI
Rb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554311,960,661 - 2,124,576 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554311,960,765 - 2,124,576 (+)NCBIChiLan1.0ChiLan1.0
RB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11348,155,608 - 48,326,396 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1348,155,795 - 48,324,575 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01329,453,872 - 29,624,665 (+)NCBIMhudiblu_PPA_v0panPan3
RB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,061,621 - 3,204,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,063,239 - 3,257,726 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,090,617 - 3,235,458 (-)NCBI
ROS_Cfam_1.0223,143,918 - 3,320,581 (-)NCBI
UMICH_Zoey_3.1222,960,514 - 3,106,149 (-)NCBI
UNSW_CanFamBas_1.0223,023,421 - 3,169,707 (-)NCBI
UU_Cfam_GSD_1.0223,028,586 - 3,174,226 (-)NCBI
Rb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945158,103,473 - 158,265,512 (+)NCBI
SpeTri2.0NW_0049365651,596,227 - 1,746,706 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1326,220,783 - 26,393,671 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl326,220,803 - 26,394,546 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605717,512,606 - 17,688,151 (-)NCBIVero_WHO_p1.0
Rb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247486,358,588 - 6,533,217 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 3 5 2 19 1 3 3
Low 1 2 4 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010300   ⟹   ENSSSCP00000010032
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1119,186,759 - 19,317,690 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000039213   ⟹   ENSSSCP00000045843
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1119,186,759 - 19,317,690 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000066955   ⟹   ENSSSCP00000063068
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1119,186,759 - 19,317,690 (-)Ensembl
RefSeq Acc Id: NM_001285967   ⟹   NP_001272896
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11119,188,483 - 19,317,642 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992198   ⟹   XP_013847652
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11119,186,754 - 19,317,635 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001272896 (Get FASTA)   NCBI Sequence Viewer  
  XP_013847652 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFP48333 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013847652   ⟸   XM_013992198
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001272896   ⟸   NM_001285967
- UniProtKB: J7FNA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000045843   ⟸   ENSSSCT00000039213
RefSeq Acc Id: ENSSSCP00000010032   ⟸   ENSSSCT00000010300
RefSeq Acc Id: ENSSSCP00000063068   ⟸   ENSSSCT00000066955
Protein Domains
CYCLIN   DUF3452   RB_A   Rb_C


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009401 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070001033 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010032 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000045843 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063068 UniProtKB/TrEMBL
  ENSSSCP00070001849 UniProtKB/TrEMBL
  ENSSSCP00070001877 UniProtKB/TrEMBL
  ENSSSCP00070001885 UniProtKB/TrEMBL
  ENSSSCP00070001906 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010300 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000039213 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000066955 UniProtKB/TrEMBL
  ENSSSCT00070002206 UniProtKB/TrEMBL
  ENSSSCT00070002243 UniProtKB/TrEMBL
  ENSSSCT00070002252 UniProtKB/TrEMBL
  ENSSSCT00070002282 UniProtKB/TrEMBL
InterPro Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  RB_B UniProtKB/TrEMBL
  RB_C UniProtKB/TrEMBL
  RB_fam UniProtKB/TrEMBL
  RB_N UniProtKB/TrEMBL
KEGG Report ssc:100151828 UniProtKB/TrEMBL
NCBI Gene RB1 ENTREZGENE
PANTHER PTHR13742 UniProtKB/TrEMBL
Pfam DUF3452 UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  RB_B UniProtKB/TrEMBL
  Rb_C UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  DUF3452 UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  Rb_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniProt A0A287APH4_PIG UniProtKB/TrEMBL
  A0A4X1SI08_PIG UniProtKB/TrEMBL
  A0A4X1SI24_PIG UniProtKB/TrEMBL
  A0A4X1SII7_PIG UniProtKB/TrEMBL
  A0A4X1SJ47_PIG UniProtKB/TrEMBL
  A0A5G2QGX9_PIG UniProtKB/TrEMBL
  F1RK14_PIG UniProtKB/TrEMBL
  J7FNA4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92132 ENTREZGENE