LRRC8D (leucine rich repeat containing 8 VRAC subunit D) - Rat Genome Database

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Gene: LRRC8D (leucine rich repeat containing 8 VRAC subunit D) Sus scrofa
Analyze
Symbol: LRRC8D
Name: leucine rich repeat containing 8 VRAC subunit D
RGD ID: 14076952
Description: ENCODES a protein that exhibits volume-sensitive anion channel activity (ortholog); INVOLVED IN cyclic-GMP-AMP transmembrane import across plasma membrane (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); monoatomic ion channel complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine rich repeat containing 8 family member D; volume-regulated anion channel subunit LRRC8D
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,766,211 - 126,874,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,751,720 - 126,883,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,807,385 - 138,915,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LRRC8D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,766,211 - 126,874,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,751,720 - 126,883,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,807,385 - 138,915,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,821,032 - 89,936,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,821,014 - 89,936,611 (+)EnsemblGRCh38hg38GRCh38
GRCh37190,286,591 - 90,402,170 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36190,060,101 - 90,174,148 (+)NCBINCBI36Build 36hg18NCBI36
Build 34189,999,533 - 90,113,580NCBI
Celera188,532,275 - 88,647,680 (+)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef188,403,943 - 88,519,276 (+)NCBIHuRef
CHM1_1190,401,923 - 90,517,356 (+)NCBICHM1_1
T2T-CHM13v2.0189,664,217 - 89,779,829 (+)NCBIT2T-CHM13v2.0
Lrrc8d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,847,829 - 105,963,081 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5105,847,835 - 105,980,302 (+)EnsemblGRCm39 Ensembl
GRCm385105,699,963 - 105,815,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,699,969 - 105,832,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv375106,128,988 - 106,244,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365105,934,781 - 106,055,512 (+)NCBIMGSCv36mm8
Celera5102,815,568 - 102,929,479 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Lrrc8d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,335,114 - 4,411,549 (-)NCBIGRCr8
mRatBN7.2144,029,971 - 4,134,922 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,029,473 - 4,135,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,031,137 - 4,046,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0145,331,273 - 5,346,414 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,034,927 - 4,050,056 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,085,606 - 5,194,808 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,086,054 - 5,101,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,077,476 - 5,157,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,104,878 - 5,120,038 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1145,104,878 - 5,120,038 (-)NCBI
Celera144,193,278 - 4,208,420 (-)NCBICelera
Cytogenetic Map14p22NCBI
Lrrc8d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,237,651 - 4,240,227 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554234,237,263 - 4,360,352 (-)NCBIChiLan1.0ChiLan1.0
LRRC8D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,088,794 - 137,203,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11136,244,564 - 136,359,775 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,481,871 - 92,606,922 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,232,146 - 91,346,539 (+)NCBIpanpan1.1PanPan1.1panPan2
LRRC8D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1658,692,352 - 58,805,004 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl658,692,792 - 58,695,368 (-)NCBICanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha661,401,528 - 61,514,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0659,086,742 - 59,089,777 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl659,086,746 - 59,111,772 (-)NCBIROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl659,086,746 - 59,111,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1658,777,879 - 58,890,397 (-)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.0659,211,040 - 59,323,995 (-)NCBIUU_Cfam_GSD_1.0
Lrrc8d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505899,984,575 - 100,097,562 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365378,850,411 - 8,963,448 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365378,850,411 - 8,963,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,542,451 - 43,659,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2043,542,806 - 43,545,382 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603374,274,555 - 74,391,546 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc8d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247427,822,880 - 7,946,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247427,822,880 - 7,947,731 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LRRC8D
4715 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005663697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005663698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005663699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013997401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK391191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01011336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000051604   ⟹   ENSSSCP00000036043
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,766,211 - 126,874,275 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000073793   ⟹   ENSSSCP00000068791
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,766,884 - 126,853,981 (-)Ensembl
RefSeq Acc Id: XM_005663697   ⟹   XP_005663754
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,874,307 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005663698   ⟹   XP_005663755
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,858,992 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005663699   ⟹   XP_005663756
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,882,338 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013997401   ⟹   XP_013852855
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,874,495 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090294   ⟹   XP_020945953
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,875,143 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090295   ⟹   XP_020945954
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,820,436 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090296   ⟹   XP_020945955
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,808,695 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090297   ⟹   XP_020945956
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,882,405 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090299   ⟹   XP_020945958
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,858,992 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090300   ⟹   XP_020945959
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,873,874 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090301   ⟹   XP_020945960
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,853,981 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090302   ⟹   XP_020945961
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,864,594 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090303   ⟹   XP_020945962
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,883,344 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020945962   ⟸   XM_021090303
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945956   ⟸   XM_021090297
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005663756   ⟸   XM_005663699
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945953   ⟸   XM_021090294
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013852855   ⟸   XM_013997401
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005663754   ⟸   XM_005663697
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945959   ⟸   XM_021090300
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945961   ⟸   XM_021090302
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945958   ⟸   XM_021090299
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005663755   ⟸   XM_005663698
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945960   ⟸   XM_021090301
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945954   ⟸   XM_021090295
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945955   ⟸   XM_021090296
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL),   A0A4X1U3K1 (UniProtKB/TrEMBL),   A0A8D1LG53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000068791   ⟸   ENSSSCT00000073793
Ensembl Acc Id: ENSSSCP00000036043   ⟸   ENSSSCT00000051604
Protein Domains
LRRC8 pannexin-like TM region


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025026593 UniProtKB/TrEMBL
  ENSSSCG00030018848 UniProtKB/TrEMBL
  ENSSSCG00035005256 UniProtKB/TrEMBL
  ENSSSCG00040062006 UniProtKB/TrEMBL
  ENSSSCG00045023592 UniProtKB/TrEMBL
  ENSSSCG00050014088 UniProtKB/TrEMBL
  ENSSSCG00055010942 UniProtKB/TrEMBL
  ENSSSCG00060018544 UniProtKB/TrEMBL
  ENSSSCG00065022717 UniProtKB/TrEMBL
  ENSSSCG00070014833 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000051604 ENTREZGENE
  ENSSSCT00000051604.2 UniProtKB/TrEMBL
  ENSSSCT00025035962.1 UniProtKB/TrEMBL
  ENSSSCT00025035997.1 UniProtKB/TrEMBL
  ENSSSCT00030026006.1 UniProtKB/TrEMBL
  ENSSSCT00030026012.1 UniProtKB/TrEMBL
  ENSSSCT00035006600.1 UniProtKB/TrEMBL
  ENSSSCT00035006606.1 UniProtKB/TrEMBL
  ENSSSCT00040084379.1 UniProtKB/TrEMBL
  ENSSSCT00040084422.1 UniProtKB/TrEMBL
  ENSSSCT00045040287.1 UniProtKB/TrEMBL
  ENSSSCT00050019000.1 UniProtKB/TrEMBL
  ENSSSCT00050019009.1 UniProtKB/TrEMBL
  ENSSSCT00055021484.1 UniProtKB/TrEMBL
  ENSSSCT00055021494.1 UniProtKB/TrEMBL
  ENSSSCT00060024888.1 UniProtKB/TrEMBL
  ENSSSCT00060024890.1 UniProtKB/TrEMBL
  ENSSSCT00065030219.1 UniProtKB/TrEMBL
  ENSSSCT00065030228.1 UniProtKB/TrEMBL
  ENSSSCT00070029113.1 UniProtKB/TrEMBL
  ENSSSCT00070029121.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRR_domain-containing UniProtKB/TrEMBL
  LRRC8_Pannexin-like UniProtKB/TrEMBL
KEGG Report ssc:100737439 UniProtKB/TrEMBL
NCBI Gene LRRC8D ENTREZGENE
PANTHER LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A UniProtKB/TrEMBL
  PTHR48051 UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  Pannexin_like UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A0A286ZWM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U3K1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1LG53 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:98088 ENTREZGENE