LRRC8D (leucine rich repeat containing 8 VRAC subunit D) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: LRRC8D (leucine rich repeat containing 8 VRAC subunit D) Sus scrofa
Analyze
Symbol: LRRC8D
Name: leucine rich repeat containing 8 VRAC subunit D
RGD ID: 14076952
Description: ENCODES a protein that exhibits volume-sensitive anion channel activity (ortholog); INVOLVED IN anion transmembrane transport (ortholog); cyclic-GMP-AMP transmembrane import across plasma membrane (ortholog); FOUND IN integral component of membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: leucine rich repeat containing 8 family member D; volume-regulated anion channel subunit LRRC8D
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,766,211 - 126,874,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,751,720 - 126,883,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,807,385 - 138,915,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
LRRC8D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,766,211 - 126,874,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,751,720 - 126,883,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,807,385 - 138,915,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl189,821,014 - 89,936,611 (+)EnsemblGRCh38hg38GRCh38
GRCh38189,821,014 - 89,936,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37190,286,591 - 90,402,170 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36190,060,101 - 90,174,148 (+)NCBINCBI36hg18NCBI36
Build 34189,999,533 - 90,113,580NCBI
Celera188,532,275 - 88,647,680 (+)NCBI
Cytogenetic Map1p22.2NCBI
HuRef188,403,943 - 88,519,276 (+)NCBIHuRef
CHM1_1190,401,923 - 90,517,356 (+)NCBICHM1_1
Lrrc8d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,847,829 - 105,963,081 (+)NCBIGRCm39mm39
GRCm39 Ensembl5105,847,835 - 105,980,302 (+)Ensembl
GRCm385105,699,963 - 105,815,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,699,969 - 105,832,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv375106,128,988 - 106,244,234 (+)NCBIGRCm37mm9NCBIm37
MGSCv365105,934,781 - 106,055,512 (+)NCBImm8
Celera5102,815,568 - 102,929,479 (+)NCBICelera
Cytogenetic Map5E5NCBI
Lrrc8d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2144,029,971 - 4,134,922 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl144,029,473 - 4,135,877 (-)Ensembl
Rnor_6.0145,085,606 - 5,194,808 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,086,054 - 5,101,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,077,476 - 5,157,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,104,878 - 5,120,038 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1145,104,878 - 5,120,038 (-)NCBI
Celera144,193,278 - 4,208,420 (-)NCBICelera
Cytogenetic Map14p22NCBI
Lrrc8d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,237,651 - 4,240,227 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554234,237,263 - 4,360,352 (-)NCBIChiLan1.0ChiLan1.0
LRRC8D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1191,232,146 - 91,346,539 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0192,481,871 - 92,606,922 (+)NCBIMhudiblu_PPA_v0panPan3
LRRC8D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1658,692,352 - 58,805,004 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl658,692,792 - 58,695,368 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha661,401,528 - 61,514,644 (-)NCBI
Lrrc8d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505899,984,575 - 100,097,562 (+)NCBI
SpeTri2.0NW_0049365378,850,411 - 8,963,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,542,451 - 43,659,465 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2043,542,806 - 43,545,382 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603374,274,555 - 74,391,546 (+)NCBIVero_WHO_p1.0
Lrrc8d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247427,822,880 - 7,947,731 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 1 5 11 2 1 3
Low 2 2 2 2 12 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005663697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005663698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005663699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013997401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021090303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK391191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01011336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000051604   ⟹   ENSSSCP00000036043
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,766,211 - 126,874,275 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000073793   ⟹   ENSSSCP00000068791
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,766,884 - 126,853,981 (-)Ensembl
RefSeq Acc Id: XM_005663697   ⟹   XP_005663754
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,874,307 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005663698   ⟹   XP_005663755
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,858,992 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005663699   ⟹   XP_005663756
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,882,338 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013997401   ⟹   XP_013852855
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,874,495 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090294   ⟹   XP_020945953
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,875,143 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090295   ⟹   XP_020945954
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,820,436 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090296   ⟹   XP_020945955
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,808,695 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090297   ⟹   XP_020945956
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,882,405 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090299   ⟹   XP_020945958
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,858,992 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090300   ⟹   XP_020945959
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,873,874 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090301   ⟹   XP_020945960
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,853,981 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090302   ⟹   XP_020945961
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,864,594 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021090303   ⟹   XP_020945962
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,751,720 - 126,883,344 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020945962   ⟸   XM_021090303
- Sequence:
RefSeq Acc Id: XP_020945956   ⟸   XM_021090297
- Sequence:
RefSeq Acc Id: XP_005663756   ⟸   XM_005663699
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945953   ⟸   XM_021090294
- Sequence:
RefSeq Acc Id: XP_013852855   ⟸   XM_013997401
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005663754   ⟸   XM_005663697
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945959   ⟸   XM_021090300
- Sequence:
RefSeq Acc Id: XP_020945961   ⟸   XM_021090302
- Sequence:
RefSeq Acc Id: XP_020945958   ⟸   XM_021090299
- Sequence:
RefSeq Acc Id: XP_005663755   ⟸   XM_005663698
- UniProtKB: A0A286ZWM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020945960   ⟸   XM_021090301
- Sequence:
RefSeq Acc Id: XP_020945954   ⟸   XM_021090295
- Sequence:
RefSeq Acc Id: XP_020945955   ⟸   XM_021090296
- Sequence:
RefSeq Acc Id: ENSSSCP00000068791   ⟸   ENSSSCT00000073793
RefSeq Acc Id: ENSSSCP00000036043   ⟸   ENSSSCT00000051604
Protein Domains
Pannexin_like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070014833 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000036043 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000068791 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070024276 UniProtKB/TrEMBL
  ENSSSCP00070024282 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000051604 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000073793 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070029113 UniProtKB/TrEMBL
  ENSSSCT00070029121 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRC8_Pannexin-like UniProtKB/TrEMBL
KEGG Report ssc:100737439 UniProtKB/TrEMBL
NCBI Gene LRRC8D ENTREZGENE
Pfam LRR_8 UniProtKB/TrEMBL
  Pannexin_like UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
UniProt A0A286ZWM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U3K1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:98088 ENTREZGENE