PLA2G12B (phospholipase A2 group XIIB) - Rat Genome Database

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Gene: PLA2G12B (phospholipase A2 group XIIB) Sus scrofa
Analyze
Symbol: PLA2G12B
Name: phospholipase A2 group XIIB
RGD ID: 14071447
Description: ENCODES a protein that exhibits calcium ion binding (inferred); phospholipase A2 activity (inferred); INVOLVED IN cholesterol homeostasis (ortholog); low-density lipoprotein particle remodeling (ortholog); triglyceride homeostasis (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: group XIIB secretory phospholipase A2-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,753,727 - 75,778,800 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,754,525 - 75,778,933 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,819,851 - 81,844,252 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:17407547   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLA2G12B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,753,727 - 75,778,800 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,754,525 - 75,778,933 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,819,851 - 81,844,252 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G12B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,934,762 - 72,954,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,934,762 - 72,954,806 (-)EnsemblGRCh38hg38GRCh38
GRCh371074,694,520 - 74,714,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,364,944 - 74,384,516 (-)NCBINCBI36Build 36hg18NCBI36
Build 341074,364,943 - 74,384,516NCBI
Celera1067,980,077 - 67,999,649 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,688,779 - 68,708,351 (-)NCBIHuRef
CHM1_11074,976,668 - 74,996,240 (-)NCBICHM1_1
T2T-CHM13v2.01073,806,140 - 73,826,184 (-)NCBIT2T-CHM13v2.0
Pla2g12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,239,242 - 59,257,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,239,482 - 59,257,798 (+)EnsemblGRCm39 Ensembl
GRCm381059,403,420 - 59,421,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,403,660 - 59,421,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv371058,866,433 - 58,884,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,799,042 - 58,817,333 (+)NCBIMGSCv36mm8
Celera1060,503,964 - 60,522,245 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.54NCBI
Pla2g12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,910,620 - 27,931,734 (+)NCBIGRCr8
mRatBN7.22027,369,196 - 27,389,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,370,266 - 27,388,743 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02028,989,440 - 29,007,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,989,491 - 29,007,968 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,793,778 - 30,812,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,813,714 - 28,832,140 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pla2g12b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,694,496 - 18,719,337 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,694,496 - 18,723,311 (+)NCBIChiLan1.0ChiLan1.0
PLA2G12B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,111,134 - 85,130,164 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,116,402 - 85,135,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,482,065 - 69,502,398 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,946,072 - 71,965,616 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,946,506 - 71,965,482 (-)Ensemblpanpan1.1panPan2
PLA2G12B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,539,909 - 23,561,211 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,541,258 - 23,561,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,678,362 - 23,699,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,826,379 - 23,847,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,827,748 - 23,847,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,725,146 - 23,746,673 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,924,120 - 23,945,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,279,156 - 24,300,450 (-)NCBIUU_Cfam_GSD_1.0
Pla2g12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,579,733 - 57,604,031 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,072,486 - 6,096,791 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,072,487 - 6,096,791 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G12B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,311,609 - 58,335,286 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,312,500 - 58,336,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,907,588 - 18,935,677 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g12b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,653,698 - 6,680,489 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247546,653,307 - 6,680,063 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G12B
695 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
mesenchyme
mesoderm
renal system
7 5 2 2

Sequence


Ensembl Acc Id: ENSSSCT00000011263   ⟹   ENSSSCP00000010971
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1475,753,727 - 75,778,800 (-)Ensembl
RefSeq Acc Id: NM_001243338   ⟹   NP_001230267
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11475,754,531 - 75,778,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005671053   ⟹   XP_005671110
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11475,754,525 - 75,778,927 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005671054   ⟹   XP_005671111
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11475,754,525 - 75,778,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005671055   ⟹   XP_005671112
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11475,754,525 - 75,778,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021071880   ⟹   XP_020927539
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11475,754,525 - 75,778,933 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020927539   ⟸   XM_021071880
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005671112   ⟸   XM_005671055
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005671111   ⟸   XM_005671054
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005671110   ⟸   XM_005671053
- Peptide Label: isoform X1
- UniProtKB: A0A8D0IF95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230267   ⟸   NM_001243338
- Peptide Label: precursor
- UniProtKB: F1SU77 (UniProtKB/TrEMBL),   A0A4X1T5X7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000010971   ⟸   ENSSSCT00000011263


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010291 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015019445 UniProtKB/TrEMBL
  ENSSSCG00025076562 UniProtKB/TrEMBL
  ENSSSCG00030074875 UniProtKB/TrEMBL
  ENSSSCG00035066998 UniProtKB/TrEMBL
  ENSSSCG00040009270 UniProtKB/TrEMBL
  ENSSSCG00045005739 UniProtKB/TrEMBL
  ENSSSCG00050021838 UniProtKB/TrEMBL
  ENSSSCG00055019645 UniProtKB/TrEMBL
  ENSSSCG00060032179 UniProtKB/TrEMBL
  ENSSSCG00065015277 UniProtKB/TrEMBL
  ENSSSCG00070006821 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011263 ENTREZGENE
  ENSSSCT00000011263.5 UniProtKB/TrEMBL
  ENSSSCT00015025662.1 UniProtKB/TrEMBL
  ENSSSCT00025106078.1 UniProtKB/TrEMBL
  ENSSSCT00030105200.1 UniProtKB/TrEMBL
  ENSSSCT00030105201.1 UniProtKB/TrEMBL
  ENSSSCT00035090335.1 UniProtKB/TrEMBL
  ENSSSCT00035090344.1 UniProtKB/TrEMBL
  ENSSSCT00040012003.1 UniProtKB/TrEMBL
  ENSSSCT00045009550.1 UniProtKB/TrEMBL
  ENSSSCT00050029436.1 UniProtKB/TrEMBL
  ENSSSCT00055038445.1 UniProtKB/TrEMBL
  ENSSSCT00060043553.1 UniProtKB/TrEMBL
  ENSSSCT00065020292.1 UniProtKB/TrEMBL
  ENSSSCT00070013094.1 UniProtKB/TrEMBL
  ENSSSCT00070013099.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro PLA2G12 UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100152597 UniProtKB/TrEMBL
NCBI Gene PLA2G12B ENTREZGENE
PANTHER GROUP XIIB SECRETORY PHOSPHOLIPASE A2-LIKE PROTEIN UniProtKB/TrEMBL
  PTHR12824 UniProtKB/TrEMBL
Pfam PLA2G12 UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A0A4X1T5X7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0IF95 ENTREZGENE
  A0A8D0YAX2_PIG UniProtKB/TrEMBL
  F1SU77 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91489 ENTREZGENE