DPYD (dihydropyrimidine dehydrogenase) - Rat Genome Database
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Gene: DPYD (dihydropyrimidine dehydrogenase) Sus scrofa
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Symbol: DPYD
Name: dihydropyrimidine dehydrogenase
RGD ID: 14070176
Description: ENCODES a protein that exhibits dihydropyrimidine dehydrogenase (NADP+) activity; flavin adenine dinucleotide binding; FMN binding; INVOLVED IN aging (ortholog); circadian rhythm (ortholog); CMP catabolic process (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); Breast Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DHPDHase; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase; DPD
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4119,931,458 - 120,712,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24131,845,556 - 132,550,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:1544906   PMID:1901022   PMID:2319593   PMID:8083224   PMID:8373446   PMID:9860876   PMID:11988088   PMID:20831907  


Genomics

Comparative Map Data
DPYD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4119,931,458 - 120,712,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24131,845,556 - 132,550,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl197,077,743 - 97,995,000 (-)EnsemblGRCh38hg38GRCh38
GRCh38197,077,743 - 97,921,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,543,299 - 98,386,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,315,887 - 98,159,203 (-)NCBINCBI36hg18NCBI36
Build 34197,255,322 - 98,098,600NCBI
Celera195,797,301 - 96,640,303 (-)NCBI
Cytogenetic Map1p21.3NCBI
HuRef195,664,181 - 96,508,076 (-)NCBIHuRef
CHM1_1197,659,318 - 98,502,216 (-)NCBICHM1_1
Dpyd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393118,355,758 - 119,226,573 (+)NCBIGRCm39mm39
GRCm39 Ensembl3118,355,778 - 119,226,573 (+)Ensembl
GRCm383118,562,109 - 119,432,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3118,562,129 - 119,432,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv373118,265,096 - 119,135,836 (+)NCBIGRCm37mm9NCBIm37
MGSCv363118,554,182 - 119,424,922 (+)NCBImm8
Celera3124,970,410 - 125,843,833 (+)NCBICelera
Cytogenetic Map3G1NCBI
Dpyd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22206,609,043 - 207,474,982 (+)NCBI
Rnor_6.0 Ensembl2221,823,687 - 222,694,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02221,823,692 - 222,694,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02239,874,415 - 240,000,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02240,072,322 - 240,744,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42214,931,901 - 215,818,809 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12214,894,962 - 215,781,871 (+)NCBI
Celera2199,080,477 - 199,932,183 (+)NCBICelera
Cytogenetic Map2q41NCBI
Dpyd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554352,007,185 - 2,766,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554352,007,185 - 2,800,907 (-)NCBIChiLan1.0ChiLan1.0
DPYD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1198,457,934 - 99,300,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,736,145 - 100,576,663 (-)NCBIMhudiblu_PPA_v0panPan3
DPYD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl651,814,573 - 52,580,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1651,789,786 - 52,564,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dpyd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365371,660,461 - 2,439,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12035,376,738 - 36,215,388 (+)NCBI
ChlSab1.1 Ensembl2035,377,266 - 36,215,679 (+)Ensembl


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 2 3 2 1 3
Low 2 20 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007532   ⟹   ENSSSCP00000007333
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4120,086,228 - 120,712,462 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054080   ⟹   ENSSSCP00000035249
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4119,931,458 - 120,712,462 (+)Ensembl
RefSeq Acc Id: NM_214044   ⟹   NP_999209
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021088696   ⟹   XP_020944355
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14120,152,723 - 120,712,458 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999209 (Get FASTA)   NCBI Sequence Viewer  
  XP_020944355 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA57475 (Get FASTA)   NCBI Sequence Viewer  
  CAM12688 (Get FASTA)   NCBI Sequence Viewer  
  CAX21653 (Get FASTA)   NCBI Sequence Viewer  
  Q28943 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999209   ⟸   NM_214044
- Peptide Label: precursor
- UniProtKB: Q28943 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_020944355   ⟸   XM_021088696
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000035249   ⟸   ENSSSCT00000054080
RefSeq Acc Id: ENSSSCP00000007333   ⟸   ENSSSCT00000007532
Protein Domains
4Fe-4S ferredoxin-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006878 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070012273 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000007333 UniProtKB/TrEMBL
  ENSSSCP00000035249 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070019893 UniProtKB/TrEMBL
  ENSSSCP00070019903 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007532 UniProtKB/TrEMBL
  ENSSSCT00000054080 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070024045 UniProtKB/TrEMBL
  ENSSSCT00070024056 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1060.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4Fe4S_Fe-S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4Fe4S_Fe_S_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPD_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helical_ferredxn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397109 UniProtKB/Swiss-Prot
NCBI Gene DPYD ENTREZGENE
Pfam DHO_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer4_20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 4FE4S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4FE4S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46548 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs pyrD_sub1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZUI1_PIG UniProtKB/TrEMBL
  A0A4X1TWU6_PIG UniProtKB/TrEMBL
  A0A4X1TWV6_PIG UniProtKB/TrEMBL
  DPYD_PIG UniProtKB/Swiss-Prot
  F1S550_PIG UniProtKB/TrEMBL
  Q28943 ENTREZGENE
VGNC ID VGNC:98787 ENTREZGENE