POLK (DNA polymerase kappa) - Rat Genome Database

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Pathways
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Gene: POLK (DNA polymerase kappa) Sus scrofa
Analyze
Symbol: POLK
Name: DNA polymerase kappa
RGD ID: 14066362
Description: ENCODES a protein that exhibits molecular adaptor activity (ortholog); INVOLVED IN DNA repair (ortholog); PARTICIPATES IN nucleotide excision repair pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 34 (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred); nuclear body (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl284,538,056 - 84,619,485 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1284,555,648 - 84,619,490 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2286,174,657 - 86,250,880 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nuclear body  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA)
site of DNA damage  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
POLK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl284,538,056 - 84,619,485 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1284,555,648 - 84,619,490 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2286,174,657 - 86,250,880 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38575,510,774 - 75,609,991 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl575,511,845 - 75,609,991 (+)EnsemblGRCh38hg38GRCh38
GRCh37574,807,716 - 74,905,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36574,843,337 - 74,930,889 (+)NCBINCBI36Build 36hg18NCBI36
Build 34574,843,336 - 74,930,889NCBI
Celera570,701,054 - 70,789,056 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef570,012,832 - 70,100,786 (+)NCBIHuRef
CHM1_1574,240,383 - 74,328,367 (+)NCBICHM1_1
T2T-CHM13v2.0575,992,960 - 76,091,061 (+)NCBIT2T-CHM13v2.0
Polk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391396,617,195 - 96,679,087 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1396,617,198 - 96,679,087 (-)EnsemblGRCm39 Ensembl
GRCm381396,480,687 - 96,542,579 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1396,480,690 - 96,542,579 (-)EnsemblGRCm38mm10GRCm38
MGSCv371397,250,644 - 97,312,440 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361397,581,388 - 97,643,184 (-)NCBIMGSCv36mm8
Celera13100,116,241 - 100,179,060 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.56NCBI
Polk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8229,556,831 - 29,616,960 (-)NCBIGRCr8
mRatBN7.2227,822,228 - 27,882,331 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl227,822,679 - 27,882,313 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx234,870,198 - 34,930,018 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0232,970,284 - 33,030,097 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0227,783,088 - 27,844,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0227,305,718 - 27,364,906 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,305,728 - 27,364,906 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0246,417,808 - 46,477,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,952,022 - 27,012,088 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1226,875,113 - 26,875,624 (-)NCBI
Celera223,868,651 - 23,928,707 (-)NCBICelera
Cytogenetic Map2q12NCBI
Polk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542525,161,222 - 25,228,524 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542525,164,749 - 25,228,064 (-)NCBIChiLan1.0ChiLan1.0
POLK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2439,701,845 - 39,789,856 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1537,855,476 - 37,944,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0539,700,659 - 39,788,727 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1540,313,114 - 40,365,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl540,311,526 - 40,401,003 (-)Ensemblpanpan1.1panPan2
POLK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1330,793,893 - 30,860,240 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl330,712,571 - 30,859,106 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha332,036,886 - 32,103,334 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0330,716,706 - 30,790,391 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl330,717,013 - 30,789,573 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1330,654,748 - 30,720,406 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0330,624,393 - 30,691,008 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,002,435 - 31,068,944 (-)NCBIUU_Cfam_GSD_1.0
Polk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213189,596,918 - 189,658,957 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365491,199,810 - 1,261,889 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1469,842,887 - 69,948,285 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl469,872,752 - 69,948,249 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604918,628,236 - 18,719,870 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249052,800,693 - 2,844,516 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249052,801,160 - 2,844,549 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in POLK
1586 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 2 2 2 1
Low 9 4 3 3 2 21 1 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015383   ⟹   ENSSSCP00000014975
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl284,538,056 - 84,616,932 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045937   ⟹   ENSSSCP00000051349
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl284,567,156 - 84,614,199 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000047573   ⟹   ENSSSCP00000041006
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl284,567,156 - 84,656,234 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000049282   ⟹   ENSSSCP00000049043
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl284,567,156 - 84,619,485 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000088207   ⟹   ENSSSCP00000073349
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl284,538,050 - 84,586,262 (+)Ensembl
RefSeq Acc Id: XM_021084453   ⟹   XP_020940112
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1284,555,648 - 84,619,490 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020940112 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000014975
  ENSSSCP00000014975.5
  ENSSSCP00000049043.2
  ENSSSCP00000051349.2
  ENSSSCP00005013041.1
  ENSSSCP00045001483.1
  ENSSSCP00060006261.1
Reference Protein Sequences
RefSeq Acc Id: XP_020940112   ⟸   XM_021084453
- UniProtKB: A0A8D1UIE3 (UniProtKB/TrEMBL),   A0A8D0IKN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000073349   ⟸   ENSSSCT00000088207
RefSeq Acc Id: ENSSSCP00000014975   ⟸   ENSSSCT00000015383
RefSeq Acc Id: ENSSSCP00000049043   ⟸   ENSSSCT00000049282
RefSeq Acc Id: ENSSSCP00000051349   ⟸   ENSSSCT00000045937
RefSeq Acc Id: ENSSSCP00000041006   ⟸   ENSSSCT00000047573
Protein Domains
UBZ4-type   UmuC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014082 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005013932 UniProtKB/TrEMBL
  ENSSSCG00045001239 UniProtKB/TrEMBL
  ENSSSCG00060012117 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015383 ENTREZGENE
  ENSSSCT00000015383.5 UniProtKB/TrEMBL
  ENSSSCT00000045937.2 UniProtKB/TrEMBL
  ENSSSCT00000049282.3 UniProtKB/TrEMBL
  ENSSSCT00005021823.1 UniProtKB/TrEMBL
  ENSSSCT00045002314.1 UniProtKB/TrEMBL
  ENSSSCT00060015939.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.810 UniProtKB/TrEMBL
  3.30.1490.100 UniProtKB/TrEMBL
  3.30.70.270 UniProtKB/TrEMBL
  3.40.1170.60 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro DNA/RNA_pol_sf UniProtKB/TrEMBL
  DNA_pol_Y-fam_lit_finger_sf UniProtKB/TrEMBL
  DNA_pol_Y-fam_little_finger UniProtKB/TrEMBL
  DNApol_IV UniProtKB/TrEMBL
  PolY_HhH_motif UniProtKB/TrEMBL
  Rev_trsase/Diguanyl_cyclase UniProtKB/TrEMBL
  UmuC UniProtKB/TrEMBL
  Znf_Rad18_put UniProtKB/TrEMBL
NCBI Gene POLK ENTREZGENE
PANTHER DNA POLYMERASE KAPPA UniProtKB/TrEMBL
  DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER UniProtKB/TrEMBL
Pfam IMS UniProtKB/TrEMBL
  IMS_C UniProtKB/TrEMBL
  IMS_HHH UniProtKB/TrEMBL
PIRSF DPol_eta UniProtKB/TrEMBL
PROSITE UMUC UniProtKB/TrEMBL
  ZF_UBZ4 UniProtKB/TrEMBL
SMART ZnF_Rad18 UniProtKB/TrEMBL
Superfamily-SCOP SSF100879 UniProtKB/TrEMBL
  SSF56672 UniProtKB/TrEMBL
UniProt A0A287AY23_PIG UniProtKB/TrEMBL
  A0A287B4Y4_PIG UniProtKB/TrEMBL
  A0A8D0IKN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UIE3 ENTREZGENE, UniProtKB/TrEMBL
  F1S2I2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91637 ENTREZGENE