SPO11 (SPO11 initiator of meiotic double strand breaks)

Advanced Search (OLGA)

Gene: SPO11 (SPO11 initiator of meiotic double strand breaks) Sus scrofa

Analyze

Symbol:

SPO11

Name:

SPO11 initiator of meiotic double strand breaks

RGD ID:

14065310

Description:

ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); DNA topoisomerase activity (inferred); INVOLVED IN double-strand break repair involved in meiotic recombination (ortholog); homologous chromosome pairing at meiosis (ortholog); male meiosis I (ortholog); ASSOCIATED WITH spermatogenic failure 3 (ortholog); FOUND IN chromosome (inferred); chromosome, telomeric region (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

meiotic recombination protein SPO11; SPO11 initiator of meiotic double stranded breaks; SPO11 meiotic protein covalently bound to DSB homolog; SPO11 meiotic protein covalently bound to DSB-like protein; sporulation protein, meiosis-specific, SPO11

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	57,730,675 - 57,745,875 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	57,730,676 - 57,745,875 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	64,894,962 - 64,910,090 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

spermatogenic failure 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

double-strand break repair involved in meiotic recombination (IEA,ISO)

homologous chromosome pairing at meiosis (IEA,ISO)

male meiosis I (IEA,ISO)

meiotic DNA double-strand break formation (IBA,IEA)

meiotic DNA double-strand break processing (IBA)

meiotic telomere clustering (IEA,ISO)

oogenesis (IEA,ISO)

ovarian follicle development (IEA,ISO)

protein localization to chromosome (IEA,ISO)

reciprocal meiotic recombination (IBA,IEA,ISO)

sexual reproduction (IEA)

spermatid development (IEA,ISO)

synaptonemal complex assembly (IEA,ISO)

Cellular Component

chromosome (IEA)

chromosome, telomeric region (IEA)

nuclear chromosome (IBA)

nucleus (IEA)

Molecular Function

ATP binding (IEA)

DNA binding (IBA,IEA)

DNA topoisomerase activity (IEA)

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SPO11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	57,730,675 - 57,745,875 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	57,730,676 - 57,745,875 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	64,894,962 - 64,910,090 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPO11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	57,329,803 - 57,343,993 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	57,329,803 - 57,343,994 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	55,904,859 - 55,919,049 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	55,338,238 - 55,352,456 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	55,338,237 - 55,352,455	NCBI
Celera	20	52,645,068 - 52,659,286 (+)	NCBI		Celera
Cytogenetic Map	20	q13.31	NCBI
HuRef	20	52,686,790 - 52,701,008 (+)	NCBI		HuRef
CHM1_1	20	55,805,942 - 55,820,160 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	59,107,550 - 59,121,740 (+)	NCBI		T2T-CHM13v2.0

Spo11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	172,819,172 - 172,835,369 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	172,819,493 - 172,835,369 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	172,977,379 - 172,993,576 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	172,977,700 - 172,993,576 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	172,805,343 - 172,819,077 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	172,622,784 - 172,636,504 (+)	NCBI		MGSCv36	mm8
MGSCv36	2	174,209,775 - 174,223,792 (+)	NCBI		MGSCv36	mm8
Celera	2	178,918,642 - 178,957,539 (+)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	95.64	NCBI

Spo11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	182,173,615 - 182,189,273 (+)	NCBI		GRCr8
mRatBN7.2	3	161,755,299 - 161,770,930 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	161,757,519 - 161,770,925 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	165,571,645 - 165,582,906 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	174,070,591 - 174,081,852 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	171,812,404 - 171,823,665 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	170,991,573 - 171,008,226 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	170,994,038 - 171,013,185 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	177,058,150 - 177,081,041 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	163,842,817 - 163,854,067 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	163,746,748 - 163,759,641 (+)	NCBI
Celera	3	160,953,190 - 160,964,440 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Spo11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	2,088,144 - 2,103,385 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	2,088,144 - 2,103,385 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPO11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	63,080,959 - 63,095,174 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	63,074,078 - 63,088,293 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	53,669,128 - 53,684,328 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	54,948,664 - 54,962,908 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	54,948,661 - 54,963,384 (+)	Ensembl	panpan1.1		panPan2

SPO11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	42,345,595 - 42,360,851 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	42,345,547 - 42,384,481 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	41,593,229 - 41,608,456 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	43,211,094 - 43,226,379 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	43,211,048 - 43,250,014 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	42,296,075 - 42,311,271 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	42,435,814 - 42,451,039 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	43,093,993 - 43,109,232 (+)	NCBI		UU_Cfam_GSD_1.0

Spo11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	183,108,577 - 183,122,976 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936530	183,271 - 197,335 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936530	183,271 - 197,549 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPO11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	6,778,442 - 6,792,736 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	6,778,985 - 6,792,643 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	54,840,590 - 54,854,921 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spo11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	23,784,298 - 23,800,168 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	23,784,362 - 23,800,127 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SPO11
462 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	22	3	2	5	14	12	22	3	6	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005673040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021077177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR956362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ239911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000008214 ⟹ ENSSSCP00000007995

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	57,730,749 - 57,745,875 (+)	Ensembl

Ensembl Acc Id:

ENSSSCT00000075218 ⟹ ENSSSCP00000073803

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	57,730,675 - 57,745,875 (+)	Ensembl

RefSeq Acc Id:

NM_001105313 ⟹ NP_001098783

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	17	57,730,749 - 57,745,875 (+)	NCBI

Sequence:

show sequence

CAGGGACTGGCCGTAGTTGTGTTCGTGGAGATTGTTTTCGCAGTTGGTCGTCATGGCCTTTGCG
CCCAGGGGGCCTAAGGCCTCGTTCTTCGATGTGTTGGACCAGCACCGGGCTTCCCTGCTGGCCT
CCCTGAGGAGAGGCGGAGGGGAGCCGGCGGGCGGGGGGACACGCCTGGCCTCTAGATTTGAAGA
TTCTGTGGGCCTTCACATGGTATCTCATTGTACCACAAGAAAAATCAAAAGTGATTCACCAAAA
TCAGTTAAAAATTTTGCACTAATTCTTAAAATATTGTCCATGATATATAAATTAGTACAGAGCA
ACACTTACGCAACCAAAAGAGACATATATTACACTGACAGCCAACTCTTTGGTAACCAGACTGT
TGTGGACAATATCATCAATGATGTTTCCTGTATGTTGAAAGTGCCGAGGAGGAGTCTACACATA
TTCTCTACATCAAAAGGTTTAATTGCTGGCAACTTAAGGTATATAGAGGAAGACGGCACCAAGG
TGAATTGTGCATGTGCAACCGCTGTTGCTGTGCCATCCAATATTCAAGGAATTTGGAATTTAAT
TACAGATGCGAAATTTCTGTTAATTGTAGAAAAAGATGCGACATTTCAGAGACTCCTGGATGAC
AATTTTTGCAACAAAATGTCTCCGTGCATCATGGTTACGGGAAAGGGAGTACCTGATCTGAACA
CAAGACTTTTAGTCAAGAAGCTTTGGGACACATTTCACATTCCTGTGTTCACTCTTGTCGATGC
TGATCCACACGGCATAGAAATAATGTGCATCTATAAGTATGGCTCCATGGCTATGTCTTTTGAA
GCACATAATCTCACAGTTCCAGCTATTAGATGGCTTGGTCTCCTCCCTTCTGATATCAAAAGAC
TAAATATACCAAAAGGTACTTTAATTCCACTGACAAAACGAGACCAAATGAAACTTGACAGCAT
TCTAAAGAGACCTTATGTTGCTTGCCAACCATTTTGGAGAAAAGAAATGGAAATCATGGCAGAC
TCTAAAATGAAGGCAGAGATTCAAGCTTTGACCTTCCTCTCATCAGATTATCTTTCCAGAGTGT
ACTTACCCAACAAATTAAAATTTGGAGGTTGGATATAAAAATATATCAGACTATATCTTGTGAT
TGCAAGAGGCTTTCCATGAGTTTTGTTTGCAGCAGTAGATACTGTTGTGGAAAGAATGTGTATG
CTTAATTTTATAGAGAGAAAATAAAATAATTTTCCATTGTATTTTTTTAAATGTTGTACTCTAA
CTTTCTTTAGAAGGCTTTATTTTATCCCTCTTTGTAGAGAGTTGCTTCTATCCCATGTTCTAAA
GTTAATCGTAGAAGAGTGTGTGTAATTTTGACTTTTACATTGTATTTTAGAAAATTATTCTACA
CGTCATCAAAGTCTACAGATATATTTTATCTACTTTCTACATACAATTAATGTTAAGGCATGAA
GTATCTTATTAATAACAAAAAAATGATAGCCTAAACTTGACAGGTTGCAAATGAATTATAGTGT
CTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGTCTTTTTGCCATTTCTTGGGCTGCTCCCGCAGC
ATATGGAGGTTCCCAGGCTAGGGGTCCAATCGGAGCTGTAGCTGCCAGCCTGTGCCAGAGGCAC
AGCAACGTGGGATCCGAGCCGCATCTGCAACCTACACCACAGCTCACGGCAACGCCGGATCGTT
AACCCACTGAGCAAGGGCAGGGATCGAACCCGCAACCTCATGGTTCCTAGTCGGATTCGTTAAC
CACTGCGCCACGACGGGAACTCCATAGTGTCTTCTTAATTTCAACCATTGCAGCAGTTTCTTCT
TTACTACATTTTTCTTTGCCTTCGTAGTATCGGGGTCATACCACATTCACTCACCGAGACAATC
AGTAATGTTTATTATGAATAAATATTTGGGCTGATGTCG

hide sequence

RefSeq Acc Id:

XM_005673040 ⟹ XP_005673097

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	17	57,730,676 - 57,745,173 (+)	NCBI

Sequence:

show sequence

GCCGCCCCGCCCCCTCCAGAAAAAACGCGGGAAAGACGCCTTGGACCCTACACGGACGCGCGCT
GTGTGCAGGCAGGGACTGGCCGTAGTTGTGTTCGTGGAGATTGTTTTCGCAGTTGGTCGTCATG
GCCTTTGCGCCCAGGGGGCCTAAGGCCTCGTTCTTCGATGTGTTGGACCAGCACCGGGCTTCCC
TGCTGGCCTCCCTGAGGAGAGGCGGAGGGGAGCCGGCGGGCGGGGGGACACGCCTGGCCTCTAG
TTCTGAGGTGCTTTCTTCTATAGAAAATATCATCCAAGACGTAATCACAAGCTTGGCAAGAAAT
GAAGCTCCTGCATTCACAATAGAAAATAGATCAAGCTGGGAAAATATAAAATTTGAAGATTCTG
TGGGCCTTCACATGGTATCTCATTGTACCACAAGAAAAATCAAAAGTGATTCACCAAAATCAGT
TAAAAATTTTGCACTAATTCTTAAAATATTGTCCATGATATATAAATTAGTACAGAGCAACACT
TACGCAACCAAAAGAGACATATATTACACTGACAGCCAACTCTTTGGTAACCAGACTGTTGTGG
ACAATATCATCAATGATGTTTCCTGTATGTTGAAAGTGCCGAGGAGGAGTCTACACATATTCTC
TACATCAAAAGGTTTAATTGCTGGCAACTTAAGGTATATAGAGGAAGACGGCACCAAGGTGAAT
TGTGCATGTGCAACCGCTGTTGCTGTGCCATCCAATATTCAAGGAATTTGGAATTTAATTACAG
ATGCGAAATTTCTGTTAATTGTAGAAAAAGATGCGACATTTCAGAGACTCCTGGATGACAATTT
TTGCAACAAAATGTCTCCGTGCATCATGGTTACGGGAAAGGGAGTACCTGATCTGAACACAAGA
CTTTTAGTCAAGAAGCTTTGGGACACATTTCACATTCCTGTGTTCACTCTTGTCGATGCTGATC
CACACGGCATAGAAATAATGTGCATCTATAAGTATGGCTCCATGGCTATGTCTTTTGAAGCACA
TAATCTCACAGTTCCAGCTATTAGATGGCTTGGTCTCCTCCCTTCTGATATCAAAAGACTAAAT
ATACCAAAAGGTACTTTAATTCCACTGACAAAACGAGACCAAATGAAACTTGACAGCATTCTAA
AGAGACCTTATGTTGCTTGCCAACCATTTTGGAGAAAAGAAATGGAAATCATGGCAGACTCTAA
AATGAAGGCAGAGATTCAAGCTTTGACCTTCCTCTCATCAGATTATCTTTCCAGAGTGTACTTA
CCCAACAAATTAAAATTTGGAGGTTGGATATAAAAATATATCAGACTATATCTTGTGATTGCAA
GAGGCTTTCCATGAGTTTTGTTTGCAGCAGTAGATACTGTTGTGGAAAGAATGTGTATGCTTAA
TTTTATAGAGAGAAAATAAAATAATTTTCCATTGTA

hide sequence

RefSeq Acc Id:

XM_021077177 ⟹ XP_020932836

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	17	57,730,676 - 57,745,173 (+)	NCBI

Sequence:

show sequence

GCCGCCCCGCCCCCTCCAGAAAAAACGCGGGAAAGACGCCTTGGACCCTACACGGACGCGCGCT
GTGTGCAGGCAGGGACTGGCCGTAGTTGTGTTCGTGGAGATTGTTTTCGCAGTTGGTCGTCATG
GCCTTTGCGCCCAGGGGGCCTAAGGCCTCGTTCTTCGATGTGTTGGACCAGCACCGGGCTTCCC
TGCTGGCCTCCCTGAGGAGAGGCGGAGGGGAGCCGGCGGGCGGGGGGACACGCCTGGCCTCTAG
TTCTGAGGTGCTTTCTTCTATAGAAAATATCATCCAAGACGTAATCACAAGCTTGGCAAGAAAT
GAAGCTCCTGCATTCACAATAGAAAATAGATCAAGCTGGGAAAATATAAAATTTGAAGATTCTG
TGGGCCTTCACATGGTATCTCATTGTACCACAAGAAAAATCAAAAGTGATTCACCAAAATCAGT
TAAAAATTTTGCACTAATTCTTAAAATATTGTCCATGATATATAAATTAGTACAGAGCAACACT
TACGCAACCAAAAGAGACATATATTACACTGACAGCCAACTCTTTGGTAACCAGACTGTTGTGG
ACAATATCATCAATGATGTTTCCTGTATGTTGAAAGTGCCGAGGAGGAGTCTACACATATTCTC
TACATCAAAAGGTTTAATTGCTGGCAACTTAAGGTATATAGAGGAAGACGGCACCAAGGTGAAT
TGTGCATGTGCAACCGCTGTTGCTGTGCCATCCAATATTCAAGGAATTTGGAATTTAATTACAG
ATGCGAAATTTCTGTTAATTGTAGAAAAAGATGCGACATTTCAGAGACTCCTGGATGACAATTT
TTGCAACAAAATGTCTCCGTGCATCATGGTTACGGCTATGTCTTTTGAAGCACATAATCTCACA
GTTCCAGCTATTAGATGGCTTGGTCTCCTCCCTTCTGATATCAAAAGACTAAATATACCAAAAG
GTACTTTAATTCCACTGACAAAACGAGACCAAATGAAACTTGACAGCATTCTAAAGAGACCTTA
TGTTGCTTGCCAACCATTTTGGAGAAAAGAAATGGAAATCATGGCAGACTCTAAAATGAAGGCA
GAGATTCAAGCTTTGACCTTCCTCTCATCAGATTATCTTTCCAGAGTGTACTTACCCAACAAAT
TAAAATTTGGAGGTTGGATATAAAAATATATCAGACTATATCTTGTGATTGCAAGAGGCTTTCC
ATGAGTTTTGTTTGCAGCAGTAGATACTGTTGTGGAAAGAATGTGTATGCTTAATTTTATAGAG
AGAAAATAAAATAATTTTCCATTGTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001098783	(Get FASTA)	NCBI Sequence Viewer
	XP_005673097	(Get FASTA)	NCBI Sequence Viewer
	XP_020932836	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABD04435	(Get FASTA)	NCBI Sequence Viewer
	CAN13250	(Get FASTA)	NCBI Sequence Viewer
	CAN13251	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000007995
	ENSSSCP00000007995.1
	ENSSSCP00000073803
	ENSSSCP00000073803.1
	ENSSSCP00015002616.1
	ENSSSCP00015002620.1
	ENSSSCP00025046143.1
	ENSSSCP00025046176.1
	ENSSSCP00030025029.1
	ENSSSCP00030025043.1
	ENSSSCP00035023793.1
	ENSSSCP00035023795.1
	ENSSSCP00040004545.1
	ENSSSCP00040004550.1
	ENSSSCP00045022560.1
	ENSSSCP00045022625.1
	ENSSSCP00050023608.1
	ENSSSCP00050023610.1
	ENSSSCP00055014235.1
	ENSSSCP00055014277.1
	ENSSSCP00060023894.1
	ENSSSCP00060023897.1
	ENSSSCP00065042833.1
	ENSSSCP00065042836.1
	ENSSSCP00070030858.1
	ENSSSCP00070030861.1

RefSeq Acc Id:	XP_005673097 ⟸ XM_005673040
- Peptide Label:	isoform X1
- UniProtKB:	A5GFN5 (UniProtKB/TrEMBL), A0A4X1UNI4 (UniProtKB/TrEMBL), A0A8D1VGG4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFAPRGPKASFFDVLDQHRASLLASLRRGGGEPAGGGTRLASSSEVLSSIENIIQDVITSLAR NEAPAFTIENRSSWENIKFEDSVGLHMVSHCTTRKIKSDSPKSVKNFALILKILSMIYKLVQSN TYATKRDIYYTDSQLFGNQTVVDNIINDVSCMLKVPRRSLHIFSTSKGLIAGNLRYIEEDGTKV NCACATAVAVPSNIQGIWNLITDAKFLLIVEKDATFQRLLDDNFCNKMSPCIMVTGKGVPDLNT RLLVKKLWDTFHIPVFTLVDADPHGIEIMCIYKYGSMAMSFEAHNLTVPAIRWLGLLPSDIKRL NIPKGTLIPLTKRDQMKLDSILKRPYVACQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVY LPNKLKFGGWI hide sequence

RefSeq Acc Id:	XP_020932836 ⟸ XM_021077177
- Peptide Label:	isoform X2
- UniProtKB:	A0A8D1VGG4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFAPRGPKASFFDVLDQHRASLLASLRRGGGEPAGGGTRLASSSEVLSSIENIIQDVITSLAR NEAPAFTIENRSSWENIKFEDSVGLHMVSHCTTRKIKSDSPKSVKNFALILKILSMIYKLVQSN TYATKRDIYYTDSQLFGNQTVVDNIINDVSCMLKVPRRSLHIFSTSKGLIAGNLRYIEEDGTKV NCACATAVAVPSNIQGIWNLITDAKFLLIVEKDATFQRLLDDNFCNKMSPCIMVTAMSFEAHNL TVPAIRWLGLLPSDIKRLNIPKGTLIPLTKRDQMKLDSILKRPYVACQPFWRKEMEIMADSKMK AEIQALTFLSSDYLSRVYLPNKLKFGGWI hide sequence

RefSeq Acc Id:

NP_001098783 ⟸ NM_001105313

- UniProtKB:

A5GFN4 (UniProtKB/TrEMBL), A0A4X1UQN6 (UniProtKB/TrEMBL), A0A8D1VES4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAFAPRGPKASFFDVLDQHRASLLASLRRGGGEPAGGGTRLASRFEDSVGLHMVSHCTTRKIKS
DSPKSVKNFALILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDVSCMLKVPRR
SLHIFSTSKGLIAGNLRYIEEDGTKVNCACATAVAVPSNIQGIWNLITDAKFLLIVEKDATFQR
LLDDNFCNKMSPCIMVTGKGVPDLNTRLLVKKLWDTFHIPVFTLVDADPHGIEIMCIYKYGSMA
MSFEAHNLTVPAIRWLGLLPSDIKRLNIPKGTLIPLTKRDQMKLDSILKRPYVACQPFWRKEME
IMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI

hide sequence

Ensembl Acc Id:

ENSSSCP00000073803 ⟸ ENSSSCT00000075218

Ensembl Acc Id:

ENSSSCP00000007995 ⟸ ENSSSCT00000008214

Protein Domains

Meiosis-specific protein Spo11 Spo11/DNA topoisomerase VI subunit A N-terminal Topoisomerase 6 subunit A/Spo11 TOPRIM

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000007502	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015004703	UniProtKB/TrEMBL
	ENSSSCG00025075370	UniProtKB/TrEMBL
	ENSSSCG00030039319	UniProtKB/TrEMBL
	ENSSSCG00035044568	UniProtKB/TrEMBL
	ENSSSCG00040009305	UniProtKB/TrEMBL
	ENSSSCG00045019092	UniProtKB/TrEMBL
	ENSSSCG00050041050	UniProtKB/TrEMBL
	ENSSSCG00055009208	UniProtKB/TrEMBL
	ENSSSCG00060041249	UniProtKB/TrEMBL
	ENSSSCG00065071093	UniProtKB/TrEMBL
	ENSSSCG00070018712	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000008214	ENTREZGENE
	ENSSSCT00000008214.2	UniProtKB/TrEMBL
	ENSSSCT00000075218	ENTREZGENE
	ENSSSCT00000075218.2	UniProtKB/TrEMBL
	ENSSSCT00015006343.1	UniProtKB/TrEMBL
	ENSSSCT00015006347.1	UniProtKB/TrEMBL
	ENSSSCT00025103997.1	UniProtKB/TrEMBL
	ENSSSCT00025104045.1	UniProtKB/TrEMBL
	ENSSSCT00030054805.1	UniProtKB/TrEMBL
	ENSSSCT00030054834.1	UniProtKB/TrEMBL
	ENSSSCT00035059214.1	UniProtKB/TrEMBL
	ENSSSCT00035059218.1	UniProtKB/TrEMBL
	ENSSSCT00040012082.1	UniProtKB/TrEMBL
	ENSSSCT00040012097.1	UniProtKB/TrEMBL
	ENSSSCT00045032592.1	UniProtKB/TrEMBL
	ENSSSCT00045032677.1	UniProtKB/TrEMBL
	ENSSSCT00050055636.1	UniProtKB/TrEMBL
	ENSSSCT00050055638.1	UniProtKB/TrEMBL
	ENSSSCT00055018078.1	UniProtKB/TrEMBL
	ENSSSCT00055018143.1	UniProtKB/TrEMBL
	ENSSSCT00060055919.1	UniProtKB/TrEMBL
	ENSSSCT00060055924.1	UniProtKB/TrEMBL
	ENSSSCT00065097707.1	UniProtKB/TrEMBL
	ENSSSCT00065097716.1	UniProtKB/TrEMBL
	ENSSSCT00070036903.1	UniProtKB/TrEMBL
	ENSSSCT00070036906.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	3.40.1360.10	UniProtKB/TrEMBL
InterPro	Meiosis_Spo11	UniProtKB/TrEMBL
	Meiotic_Spo11	UniProtKB/TrEMBL
	Spo11/TopoVI_A	UniProtKB/TrEMBL
	Spo11/TopoVI_A_N	UniProtKB/TrEMBL
	Spo11/TopoVI_A_sf	UniProtKB/TrEMBL
	TOPRIM_Topo6A/Spo11	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	ssc:100125974	UniProtKB/TrEMBL
NCBI Gene	SPO11	ENTREZGENE
PANTHER	MEIOTIC RECOMBINATION PROTEIN SPO11	UniProtKB/TrEMBL
	PTHR10848	UniProtKB/TrEMBL
Pfam	SPO11_like	UniProtKB/TrEMBL
	TOP6A-Spo11_Toprim	UniProtKB/TrEMBL
	TP6A_N	UniProtKB/TrEMBL
PRINTS	SPO11HOMOLOG	UniProtKB/TrEMBL
	TOP6AFAMILY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56726	UniProtKB/TrEMBL
UniProt	A0A4X1UNI4	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1UQN6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1VES4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1VGG4	ENTREZGENE, UniProtKB/TrEMBL
	A5GFN4	ENTREZGENE, UniProtKB/TrEMBL
	A5GFN5	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:95514	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-05-22	SPO11	SPO11 initiator of meiotic double strand breaks	SPO11	SPO11 initiator of meiotic double stranded breaks	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar