NPC1L1 (NPC1 like intracellular cholesterol transporter 1) - Rat Genome Database

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Gene: NPC1L1 (NPC1 like intracellular cholesterol transporter 1) Sus scrofa
Analyze
Symbol: NPC1L1
Name: NPC1 like intracellular cholesterol transporter 1
RGD ID: 14065017
Description: ENCODES a protein that exhibits myosin V binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to sterol depletion (ortholog); cholesterol biosynthetic process (ortholog); cholesterol homeostasis (ortholog); ASSOCIATED WITH arteriosclerosis (ortholog); Experimental Diabetes Mellitus (ortholog); Hypercholesterolemia (ortholog); FOUND IN brush border membrane (ortholog); spanning component of plasma membrane (ortholog); INTERACTS WITH ezetimibe; simvastatin
Type: protein-coding
RefSeq Status: MODEL
Also known as: Niemann-Pick C1-like protein 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,726,894 - 50,757,649 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,726,854 - 50,757,676 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,630,239 - 55,657,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ezetimibe  (EXP)
simvastatin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21051527  


Genomics

Comparative Map Data
NPC1L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,726,894 - 50,757,649 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,726,854 - 50,757,676 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,630,239 - 55,657,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPC1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl744,512,535 - 44,541,315 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl744,512,535 - 44,541,330 (-)EnsemblGRCh38hg38GRCh38
GRCh38744,512,440 - 44,541,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37744,552,134 - 44,580,929 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,518,659 - 44,547,439 (-)NCBINCBI36hg18NCBI36
Build 34744,325,376 - 44,354,154NCBI
Celera744,651,139 - 44,679,899 (-)NCBI
Cytogenetic Map7p13NCBI
HuRef744,436,243 - 44,465,023 (-)NCBIHuRef
CHM1_1744,556,489 - 44,585,261 (-)NCBICHM1_1
CRA_TCAGchr7v2744,591,658 - 44,620,428 (-)NCBI
Npc1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,161,011 - 6,180,245 (-)NCBIGRCm39mm39
GRCm39 Ensembl116,161,013 - 6,180,143 (-)Ensembl
GRCm38116,211,011 - 6,230,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,211,013 - 6,230,143 (-)EnsemblGRCm38mm10GRCm38
MGSCv37116,111,014 - 6,130,248 (-)NCBIGRCm37mm9NCBIm37
MGSCv36116,111,461 - 6,130,126 (-)NCBImm8
Celera116,693,602 - 6,712,842 (-)NCBICelera
Cytogenetic Map11A1NCBI
Npc1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21481,071,448 - 81,091,113 (-)NCBI
Rnor_6.0 Ensembl1486,345,953 - 86,560,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01486,345,946 - 86,560,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01487,307,372 - 87,319,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01487,516,291 - 87,523,225 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1479,954,434 - 79,974,086 (-)NCBICelera
Cytogenetic Map14q21NCBI
Npc1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,528,423 - 7,547,720 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,528,452 - 7,547,714 (+)NCBIChiLan1.0ChiLan1.0
NPC1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1745,296,365 - 45,324,692 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl745,297,271 - 45,324,692 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0745,227,289 - 45,256,094 (-)NCBIMhudiblu_PPA_v0panPan3
NPC1L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,311,494 - 2,327,591 (-)NCBI
ROS_Cfam_1.01614,518,743 - 14,550,434 (+)NCBI
UNSW_CanFamBas_1.01614,165,465 - 14,181,751 (+)NCBI
UU_Cfam_GSD_1.01614,146,247 - 14,162,328 (+)NCBI
Npc1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,222,063 - 100,240,594 (-)NCBI
SpeTri2.0NW_00493647819,434,557 - 19,452,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPC1L1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,129,413 - 14,163,916 (+)NCBI
ChlSab1.1 Ensembl2114,130,767 - 14,163,907 (+)Ensembl
Npc1l1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247407,590,041 - 7,609,574 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system nervous system
High
Medium 2
Low 3
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018228   ⟹   ENSSSCP00000017736
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1850,726,922 - 50,757,649 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000078642   ⟹   ENSSSCP00000073588
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1850,726,894 - 50,735,632 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085914   ⟹   ENSSSCP00000073628
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1850,727,897 - 50,757,649 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000088341   ⟹   ENSSSCP00000069617
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1850,726,922 - 50,757,649 (+)Ensembl
RefSeq Acc Id: XM_005673340   ⟹   XP_005673397
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11850,726,854 - 50,757,676 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005673397 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005673397   ⟸   XM_005673340
- Sequence:
RefSeq Acc Id: ENSSSCP00000073588   ⟸   ENSSSCT00000078642
RefSeq Acc Id: ENSSSCP00000069617   ⟸   ENSSSCT00000088341
RefSeq Acc Id: ENSSSCP00000073628   ⟸   ENSSSCT00000085914
RefSeq Acc Id: ENSSSCP00000017736   ⟸   ENSSSCT00000018228
Protein Domains
SSD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016746 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070016200 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000017736 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000069617 UniProtKB/TrEMBL
  ENSSSCP00000073588 UniProtKB/TrEMBL
  ENSSSCP00000073628 UniProtKB/TrEMBL
  ENSSSCP00070026589 UniProtKB/TrEMBL
  ENSSSCP00070026597 UniProtKB/TrEMBL
  ENSSSCP00070026601 UniProtKB/TrEMBL
  ENSSSCP00070026605 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018228 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000078642 UniProtKB/TrEMBL
  ENSSSCT00000085914 UniProtKB/TrEMBL
  ENSSSCT00000088341 UniProtKB/TrEMBL
  ENSSSCT00070031896 UniProtKB/TrEMBL
  ENSSSCT00070031905 UniProtKB/TrEMBL
  ENSSSCT00070031910 UniProtKB/TrEMBL
  ENSSSCT00070031913 UniProtKB/TrEMBL
InterPro NPC1-like UniProtKB/TrEMBL
  NPC1_N UniProtKB/TrEMBL
  Ptc/Disp UniProtKB/TrEMBL
  SSD UniProtKB/TrEMBL
NCBI Gene NPC1L1 ENTREZGENE
Pfam NPC1_N UniProtKB/TrEMBL
  Patched UniProtKB/TrEMBL
  Sterol-sensing UniProtKB/TrEMBL
PROSITE SSD UniProtKB/TrEMBL
TIGRFAMs 2A060601 UniProtKB/TrEMBL
UniProt A0A4X1U9V5_PIG UniProtKB/TrEMBL
  A0A4X1UC92_PIG UniProtKB/TrEMBL
  A0A4X1UCA7_PIG UniProtKB/TrEMBL
  A0A4X1UFA4_PIG UniProtKB/TrEMBL
  A0A5G2QXL8_PIG UniProtKB/TrEMBL
  A0A5G2R8J1_PIG UniProtKB/TrEMBL
  A0A5G2R8N3_PIG UniProtKB/TrEMBL
  F1SSH5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90842 ENTREZGENE