LVRN (laeverin) - Rat Genome Database

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Gene: LVRN (laeverin) Sus scrofa
Analyze
Symbol: LVRN
Name: laeverin
RGD ID: 14063685
Description: ENCODES a protein that exhibits aminopeptidase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN peptide catabolic process (inferred); proteolysis (inferred); ASSOCIATED WITH autistic disorder (ortholog); familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aminopeptidase Q
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2120,117,653 - 120,193,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12120,117,584 - 120,193,728 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22125,024,882 - 125,099,597 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
extracellular space  (IBA)
membrane  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LVRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2120,117,653 - 120,193,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12120,117,584 - 120,193,728 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22125,024,882 - 125,099,597 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LVRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385115,962,475 - 116,027,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5115,962,454 - 116,027,619 (+)EnsemblGRCh38hg38GRCh38
GRCh375115,298,172 - 115,363,303 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365115,326,170 - 115,391,199 (+)NCBINCBI36Build 36hg18NCBI36
Celera5111,246,534 - 111,311,673 (+)NCBICelera
Cytogenetic Map5q23.1NCBI
HuRef5110,478,890 - 110,544,021 (+)NCBIHuRef
CHM1_15114,730,769 - 114,796,042 (+)NCBICHM1_1
T2T-CHM13v2.05116,474,883 - 116,539,987 (+)NCBIT2T-CHM13v2.0
Lvrn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391846,983,106 - 47,040,313 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1846,983,105 - 47,040,309 (+)EnsemblGRCm39 Ensembl
GRCm381846,848,826 - 46,907,246 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1846,850,038 - 46,907,242 (+)EnsemblGRCm38mm10GRCm38
MGSCv371847,009,693 - 47,065,100 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361846,975,376 - 47,030,777 (+)NCBIMGSCv36mm8
Celera1848,207,861 - 48,266,898 (+)NCBICelera
Cytogenetic Map18CNCBI
cM Map1824.84NCBI
Lvrn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,752,788 - 41,861,830 (+)NCBIGRCr8
mRatBN7.21839,606,047 - 39,675,247 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,607,722 - 39,675,165 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01840,858,828 - 40,957,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,883,224 - 40,953,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01840,527,597 - 40,601,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41841,091,421 - 41,159,543 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1837,857,623 - 37,926,884 (+)NCBICelera
Cytogenetic Map18q11NCBI
Lvrn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540835,761,884 - 35,822,443 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540835,761,737 - 35,823,550 (+)NCBIChiLan1.0ChiLan1.0
LVRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24111,206,823 - 111,277,019 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15109,360,445 - 109,426,347 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05111,316,857 - 111,381,594 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15117,113,730 - 117,178,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5117,113,730 - 117,178,849 (+)Ensemblpanpan1.1panPan2
LVRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1115,684,244 - 5,750,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl115,684,568 - 5,776,455 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha115,835,040 - 5,901,425 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0115,676,282 - 5,742,693 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl115,676,037 - 5,742,090 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1115,625,222 - 5,691,572 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,702,629 - 5,769,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0115,954,851 - 6,019,641 (+)NCBIUU_Cfam_GSD_1.0
Lvrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213128,423,731 - 128,506,695 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367421,124,524 - 1,206,008 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367421,124,286 - 1,207,439 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LVRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12319,243,593 - 19,317,447 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2319,244,673 - 19,321,208 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603459,087,464 - 59,166,687 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lvrn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247335,829,438 - 5,896,796 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247335,828,615 - 5,896,954 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LVRN
2670 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1
Low 4 2 1 2 3 2
Below cutoff 3 1 1 5 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015539   ⟹   ENSSSCP00000015127
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2120,117,698 - 120,193,713 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000077876   ⟹   ENSSSCP00000068715
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2120,117,653 - 120,193,355 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000084028   ⟹   ENSSSCP00000067252
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2120,117,700 - 120,193,706 (+)Ensembl
RefSeq Acc Id: XM_003123852   ⟹   XP_003123900
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12120,117,586 - 120,193,728 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013995045   ⟹   XP_013850499
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12120,117,584 - 120,193,728 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013995046   ⟹   XP_013850500
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12120,118,245 - 120,193,728 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013850499   ⟸   XM_013995045
- Peptide Label: isoform X2
- UniProtKB: A0A5G2QQR1 (UniProtKB/TrEMBL),   A0A8D1XGG9 (UniProtKB/TrEMBL),   A0A8D1SX88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003123900   ⟸   XM_003123852
- Peptide Label: isoform X1
- UniProtKB: F1RLE3 (UniProtKB/TrEMBL),   A0A8D0S272 (UniProtKB/TrEMBL),   A0A480UYE2 (UniProtKB/TrEMBL),   A0A4X1U4I5 (UniProtKB/TrEMBL),   A0A8D1KU19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013850500   ⟸   XM_013995046
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000015127   ⟸   ENSSSCT00000015539
RefSeq Acc Id: ENSSSCP00000067252   ⟸   ENSSSCT00000084028
RefSeq Acc Id: ENSSSCP00000068715   ⟸   ENSSSCT00000077876
Protein Domains
Aminopeptidase N-like N-terminal   ERAP1-like C-terminal   Peptidase M1 membrane alanine aminopeptidase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014221 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025043107 UniProtKB/TrEMBL
  ENSSSCG00030061977 UniProtKB/TrEMBL
  ENSSSCG00035066964 UniProtKB/TrEMBL
  ENSSSCG00040072058 UniProtKB/TrEMBL
  ENSSSCG00045009929 UniProtKB/TrEMBL
  ENSSSCG00050042919 UniProtKB/TrEMBL
  ENSSSCG00055009078 UniProtKB/TrEMBL
  ENSSSCG00060008588 UniProtKB/TrEMBL
  ENSSSCG00065010554 UniProtKB/TrEMBL
  ENSSSCG00070014515 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015539 ENTREZGENE
  ENSSSCT00000015539.5 UniProtKB/TrEMBL
  ENSSSCT00000077876.2 UniProtKB/TrEMBL
  ENSSSCT00000084028 ENTREZGENE
  ENSSSCT00000084028.2 UniProtKB/TrEMBL
  ENSSSCT00025058412.1 UniProtKB/TrEMBL
  ENSSSCT00025058674.1 UniProtKB/TrEMBL
  ENSSSCT00025058917.1 UniProtKB/TrEMBL
  ENSSSCT00030086667.1 UniProtKB/TrEMBL
  ENSSSCT00030086695.1 UniProtKB/TrEMBL
  ENSSSCT00030086718.1 UniProtKB/TrEMBL
  ENSSSCT00035090291.1 UniProtKB/TrEMBL
  ENSSSCT00035090298.1 UniProtKB/TrEMBL
  ENSSSCT00035090307.1 UniProtKB/TrEMBL
  ENSSSCT00040099135.1 UniProtKB/TrEMBL
  ENSSSCT00040099255.1 UniProtKB/TrEMBL
  ENSSSCT00040099394.1 UniProtKB/TrEMBL
  ENSSSCT00045016822.1 UniProtKB/TrEMBL
  ENSSSCT00045016860.1 UniProtKB/TrEMBL
  ENSSSCT00045016896.1 UniProtKB/TrEMBL
  ENSSSCT00050058349.1 UniProtKB/TrEMBL
  ENSSSCT00050058354.1 UniProtKB/TrEMBL
  ENSSSCT00050058359.1 UniProtKB/TrEMBL
  ENSSSCT00055017750.1 UniProtKB/TrEMBL
  ENSSSCT00055017864.1 UniProtKB/TrEMBL
  ENSSSCT00055017986.1 UniProtKB/TrEMBL
  ENSSSCT00060010996.1 UniProtKB/TrEMBL
  ENSSSCT00060010998.1 UniProtKB/TrEMBL
  ENSSSCT00060011001.1 UniProtKB/TrEMBL
  ENSSSCT00065014022.1 UniProtKB/TrEMBL
  ENSSSCT00065014031.1 UniProtKB/TrEMBL
  ENSSSCT00065014036.1 UniProtKB/TrEMBL
  ENSSSCT00070028489.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/TrEMBL
  1.25.50.20 UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/TrEMBL
  2.60.40.1910 UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ERAP1-like_C_dom UniProtKB/TrEMBL
  M1_APN-typ UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/TrEMBL
KEGG Report ssc:100521657 UniProtKB/TrEMBL
NCBI Gene LVRN ENTREZGENE
PANTHER AMINOPEPTIDASE Q UniProtKB/TrEMBL
  PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/TrEMBL
Pfam ERAP1_C UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/TrEMBL
PRINTS ALADIPTASE UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF63737 UniProtKB/TrEMBL
UniProt A0A480UYE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U4I5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QQR1 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QX39_PIG UniProtKB/TrEMBL
  A0A8D0S272 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KU19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1SL87_PIG UniProtKB/TrEMBL
  A0A8D1SX88 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1XGG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1XH61_PIG UniProtKB/TrEMBL
  F1RLE3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89898 ENTREZGENE