TACSTD2 (tumor associated calcium signal transducer 2)

Gene: TACSTD2 (tumor associated calcium signal transducer 2) Sus scrofa

Analyze

Symbol:

TACSTD2

Name:

tumor associated calcium signal transducer 2

RGD ID:

14062227

Description:

INVOLVED IN negative regulation of branching involved in ureteric bud morphogenesis (ortholog); negative regulation of cell motility (ortholog); negative regulation of epithelial cell migration (ortholog); ASSOCIATED WITH corneal dystrophy (ortholog); endometriosis (ortholog); gelatinous drop-like corneal dystrophy (ortholog); FOUND IN basal plasma membrane (ortholog); lateral plasma membrane (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

tumor-associated calcium signal transducer 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	153,859,482 - 153,861,492 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	153,859,488 - 153,861,508 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	141,453,653 - 141,455,459 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

corneal dystrophy (ISO)

endometriosis (ISO)

gelatinous drop-like corneal dystrophy (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of branching involved in ureteric bud morphogenesis (ISS)

negative regulation of cell motility (ISS)

negative regulation of epithelial cell migration (ISS)

negative regulation of ruffle assembly (ISS)

negative regulation of stress fiber assembly (ISS)

negative regulation of substrate adhesion-dependent cell spreading (ISS)

positive regulation of stem cell differentiation (IBA,IEA,ISO)

regulation of epithelial cell proliferation (ISO)

ureteric bud morphogenesis (ISO)

Cellular Component

basal plasma membrane (ISS)

extracellular space (IBA,IEA)

lateral plasma membrane (ISS)

membrane (IEA)

nucleus (IBA,IEA)

plasma membrane (ISO)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

TACSTD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	153,859,482 - 153,861,492 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	153,859,488 - 153,861,508 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	141,453,653 - 141,455,459 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TACSTD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	58,575,433 - 58,577,252 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	58,575,433 - 58,577,252 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	59,041,105 - 59,042,924 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	58,813,231 - 58,816,033 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	58,752,663 - 58,755,466	NCBI
Celera	1	57,324,947 - 57,327,018 (-)	NCBI		Celera
Cytogenetic Map	1	p32.1	NCBI
HuRef	1	57,151,670 - 57,153,741 (-)	NCBI		HuRef
CHM1_1	1	59,156,449 - 59,158,520 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	58,453,397 - 58,455,216 (-)	NCBI		T2T-CHM13v2.0

Tacstd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	67,511,043 - 67,512,806 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	67,511,046 - 67,512,780 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	67,534,059 - 67,535,822 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	67,534,062 - 67,535,796 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	67,484,053 - 67,485,816 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	67,463,640 - 67,465,374 (-)	NCBI		MGSCv36	mm8
Celera	6	69,652,700 - 69,654,464 (-)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI
cM Map	6	30.88	NCBI

Tacstd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	98,037,620 - 98,039,320 (-)	NCBI		GRCr8
mRatBN7.2	4	96,707,950 - 96,709,650 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	96,707,951 - 96,709,650 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	101,963,680 - 101,965,380 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	97,738,651 - 97,740,351 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	96,165,839 - 96,167,539 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	98,341,187 - 98,342,887 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	98,341,188 - 98,342,887 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	163,126,801 - 163,128,501 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	97,803,151 - 97,804,851 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	98,047,632 - 98,049,313 (-)	NCBI
Celera	4	91,374,254 - 91,375,954 (-)	NCBI		Celera
Cytogenetic Map	4	q31	NCBI

Tacstd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955464	1,282,989 - 1,284,785 (+)	NCBI	ChiLan1.0	ChiLan1.0

TACSTD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	168,269,077 - 168,271,255 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	167,421,430 - 167,423,741 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	57,838,661 - 57,841,444 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	59,544,868 - 59,547,207 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	59,545,625 - 59,546,596 (-)	Ensembl	panpan1.1		panPan2

TACSTD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	51,122,469 - 51,123,753 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	51,187,934 - 51,189,787 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	51,303,042 - 51,304,084 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	5	51,252,727 - 51,254,573 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	51,198,006 - 51,199,866 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	51,481,572 - 51,483,437 (+)	NCBI		UU_Cfam_GSD_1.0

Tacstd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	72,207,616 - 72,209,632 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936522	3,206,957 - 3,207,919 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936522	3,206,826 - 3,208,675 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TACSTD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	74,403,547 - 74,406,756 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	42,956,630 - 42,959,787 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tacstd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624862	1,721,030 - 1,722,780 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TACSTD2
44 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	nervous system	renal system	reproductive system	respiratory system
High
Medium				1			3	1
Low	1	2	1		3	2
Below cutoff	2		2		8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003127967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU929656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000004241 ⟹ ENSSSCP00000004146

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	153,859,482 - 153,861,492 (+)	Ensembl

RefSeq Acc Id:

XM_003127967 ⟹ XP_003128015

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	153,859,488 - 153,861,508 (+)	NCBI

Sequence:

show sequence

GTCGGGAGGAGACAGGCAGCCTCCACTCCCCTGATCCTATCGCTGGCGGCGCAAGGCGGGCCGG
GCCTTTCGTGGGACGGGACAGGACGGGGACCGGGGTGGGGGTGGTAGTGGTGCGGGATGTGTCA
CCCAAATACCAGCGAGTGAGTCGGCGGCCGAACCAGCCGGGCAGGTCCGGCGGAGTATAAGAGC
TGAAGGGAGCGGCGGGCGGCAGACGCCTGGAAACCATCCCAGACAGCGGAGCCCGAGCCCAGCG
GAGTCCCCAGCCCTCTCCAGTCCGCTCCGGGTTCGCGCTTCTCCGCCCCACCATGGCCCGGGGC
CCGGGCCTCGCGCTGCTGTCGTTGTCGCTGCTGCCGCCGCTCCTGCTGCTGGTGGCGGTGATCG
GCCACGCAGCCGCGCAGGACAACTGTACGTGCCCCACCAACAAGATGACCATGTGCGAAAGGAG
CGGCCCGGGCGGCCGCTGCCAGTGCCGCGCGCTCGGCTCAGGCCTGCTGGTCGACTGCTCCACG
CTCACGTCCAAGTGTCTGCTGCTCAAGGCGCGCATGAGCGCGTCCAAGAGCGGCCGCGCGCTGG
TGCGTCCGAGCGAGCACGCGCTCGTGGACAACGACGGCCTGTACGACCCGGATTGCGACCAGCA
GGGCAGCTTCAAGGCGCGCCAGTGCAACCAGACGTCCGTGTGCTGGTGCGTGAACTCGGTGGGC
GTGCGCCGCACCGACAAGGGCGACCAGAGCCTGCGCTGCGACGAGCTGGTGCGCACCCACCACA
TCCTCATCGACCTGCGCCACCGCCCGGACACCCGCGCCTTCAACCACTCGGACCTGGACGCCGA
GCTGCGGCGGCTCTTCCGGGAGCGCTACCTGCTGCACCCCAAGTTCGTGGCTGCAGTGCATTAC
GAGCACCCCACCATTCAGATCGAGCTGCAGCAGAACGCGTCGCAGAAGGCCGCCGGCGACGTGG
ACATCGCCGATGCAGCCTACTACTTCGAGAGGGACGTCAAGGGCGAGTCGGTGTTCCCTGGCCG
CGGCGGCCTAGACGTGCGCGTGCGCGGAGAGCCCCTGCTGCTGGAGCGGACGCTCATCTACTAC
CTGGACGAGAAGCCCCCCCAGTTCTCCATGAAGCGCCTCACCAGCGGCCTCATCGCCGTCATCG
TCGTGGTCGCGGTGGCCCTCGTCGCCGGCGTGGTTGTCCTGGTGGTTACCAACCGGAGGAAGTC
TGGGAAATACAAGAAGGTGGAGGTCAAGGAACTGGGGGAGATGAGAAAGGAACCGAGCTTGTAG
GTACCGGTGGGGCTGGGGTCCGGTGGGGGTATCAGATTTCAGCAAGGACCCAGACCCAAATGAG
TCATGCTTCTTGCTTGATTCTTGGCCCCAAGGGGACATTTCTCCTCCCAAGCCCCTGTCCCCCA
CCCACATGGCTACCAAATGTTAATAGATCCTATTCTCAGGGTCACCTCTCTTTCTGACTGCTCT
CCTGAAAGAAGCATTTCTAAAAACCCTTCCTTTTCAGTCCAACCAGAAACCTTATTGGAAGACT
AAGGGAAGTTTGGCATAGGGTTATGTATAAGAATCTAGTGTCTGTATGACAACCCAGCATCGTT
TACAAGTGACGCAATCGATGTTGAAGGCTTACATGCGTTTAGGTGGGAAACAGTGCTTTTACTG
ACTTGGGTTTAAGTTATTTGATTAGCTCCACTTGTATCGTGACCTTCCTGATGAGGAGTTTGCT
AATTGGGCCTGTATAGTATCCTTATTTACCATCGTTTGTATTACCGACCACACATATTCGTGTC
ACTGGGAAAGAAGCCTGTTTCAGCTGTTTCCTTTTAGATGTCTTTGTTGGAAGGCAGACTGTGG
CCCAGAAACTCAGCATCTGTTCTTCAGCTTGCCCTTCTTACAGCTGCTATTAGTAACGTTTCTT
TTGTAAAATGTTTGTACATAGGTTGTCTTTGATAATGCTGTTGTGATTTTTTAAAAACACGAAT
TTAATAAAAATATGGAAAAGACACAAACCAAAAAAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003128015	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000004146
	ENSSSCP00000004146.1
	ENSSSCP00015002038.1
	ENSSSCP00025003287.1
	ENSSSCP00030017250.1
	ENSSSCP00035040763.1
	ENSSSCP00040036417.1
	ENSSSCP00045036690.1
	ENSSSCP00050003698.1
	ENSSSCP00055016635.1
	ENSSSCP00065039686.1
	ENSSSCP00070031137.1

RefSeq Acc Id:

XP_003128015 ⟸ XM_003127967

- UniProtKB:

F1S7A4 (UniProtKB/TrEMBL), A0A8D1BAJ3 (UniProtKB/TrEMBL), A0A4X1UM49 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARGPGLALLSLSLLPPLLLLVAVIGHAAAQDNCTCPTNKMTMCERSGPGGRCQCRALGSGLLV
DCSTLTSKCLLLKARMSASKSGRALVRPSEHALVDNDGLYDPDCDQQGSFKARQCNQTSVCWCV
NSVGVRRTDKGDQSLRCDELVRTHHILIDLRHRPDTRAFNHSDLDAELRRLFRERYLLHPKFVA
AVHYEHPTIQIELQQNASQKAAGDVDIADAAYYFERDVKGESVFPGRGGLDVRVRGEPLLLERT
LIYYLDEKPPQFSMKRLTSGLIAVIVVVAVALVAGVVVLVVTNRRKSGKYKKVEVKELGEMRKE
PSL

hide sequence

RefSeq Acc Id:

ENSSSCP00000004146 ⟸ ENSSSCT00000004241

Protein Domains

Thyroglobulin type-1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000003832	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015003987	UniProtKB/TrEMBL
	ENSSSCG00025006208	UniProtKB/TrEMBL
	ENSSSCG00030026934	UniProtKB/TrEMBL
	ENSSSCG00035071557	UniProtKB/TrEMBL
	ENSSSCG00040061442	UniProtKB/TrEMBL
	ENSSSCG00045030973	UniProtKB/TrEMBL
	ENSSSCG00050006302	UniProtKB/TrEMBL
	ENSSSCG00055010729	UniProtKB/TrEMBL
	ENSSSCG00065066091	UniProtKB/TrEMBL
	ENSSSCG00070018898	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000004241	ENTREZGENE
	ENSSSCT00000004241.2	UniProtKB/TrEMBL
	ENSSSCT00015005255.1	UniProtKB/TrEMBL
	ENSSSCT00025008237.1	UniProtKB/TrEMBL
	ENSSSCT00030037637.1	UniProtKB/TrEMBL
	ENSSSCT00035096751.1	UniProtKB/TrEMBL
	ENSSSCT00040083586.1	UniProtKB/TrEMBL
	ENSSSCT00045052758.1	UniProtKB/TrEMBL
	ENSSSCT00050008607.1	UniProtKB/TrEMBL
	ENSSSCT00055021036.1	UniProtKB/TrEMBL
	ENSSSCT00065090696.1	UniProtKB/TrEMBL
	ENSSSCT00070037251.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.800.10	UniProtKB/TrEMBL
InterPro	EPCAM-Trop-2_C	UniProtKB/TrEMBL
	EPCAM/Trop-2	UniProtKB/TrEMBL
	EpCAM_N	UniProtKB/TrEMBL
	Thyroglobulin_1	UniProtKB/TrEMBL
	Thyroglobulin_1_sf	UniProtKB/TrEMBL
KEGG Report	ssc:100510966	UniProtKB/TrEMBL
NCBI Gene	TACSTD2	ENTREZGENE
PANTHER	PTHR14168	UniProtKB/TrEMBL
	TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER 2	UniProtKB/TrEMBL
Pfam	EPCAM-Trop-2_C	UniProtKB/TrEMBL
	EpCAM_N	UniProtKB/TrEMBL
	Thyroglobulin_1	UniProtKB/TrEMBL
PROSITE	THYROGLOBULIN_1_1	UniProtKB/TrEMBL
	THYROGLOBULIN_1_2	UniProtKB/TrEMBL
SMART	SM00211	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57610	UniProtKB/TrEMBL
UniProt	A0A4X1UM49	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1BAJ3	ENTREZGENE, UniProtKB/TrEMBL
	F1S7A4	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:93704	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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