GATA4 (GATA binding protein 4) - Rat Genome Database

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Gene: GATA4 (GATA binding protein 4) Sus scrofa
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Symbol: GATA4
Name: GATA binding protein 4
RGD ID: 14058998
Description: ENCODES a protein that exhibits transcription cis-regulatory region binding; chromatin binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN positive regulation of transcription, DNA-templated; atrial septum morphogenesis (ortholog); atrial septum primum morphogenesis (ortholog); ASSOCIATED WITH 46,XY sex reversal 3 (ortholog); alcohol use disorder (ortholog); Animal Disease Models (ortholog); FOUND IN nucleus; chromatin (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: transcription factor GATA-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1414,858,159 - 14,939,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11414,858,470 - 14,938,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,046,527 - 16,126,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IEA)
atrial septum morphogenesis  (ISO)
atrial septum primum morphogenesis  (ISO)
atrial septum secundum morphogenesis  (IEA)
atrioventricular canal development  (ISO)
atrioventricular valve formation  (ISO)
atrioventricular valve morphogenesis  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac muscle tissue development  (ISO)
cardiac muscle tissue regeneration  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cardiac septum development  (ISO)
cell fate commitment  (IBA)
cell growth involved in cardiac muscle cell development  (ISO)
cell-cell signaling  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic heart tube anterior/posterior pattern specification  (ISO)
embryonic heart tube development  (ISO)
embryonic morphogenesis  (ISO)
endocardial cushion development  (IEA,ISO)
endoderm formation  (ISO)
epithelial cell fate commitment  (ISO)
gastrulation with mouth forming second  (ISO)
heart development  (ISO)
heart looping  (ISO)
heart morphogenesis  (ISO)
in utero embryonic development  (ISO)
intestinal epithelial cell differentiation  (IEA,ISO)
lung lobe formation  (ISO)
male gonad development  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of connective tissue replacement  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of oxidative stress-induced cell death  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cardioblast differentiation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (IMP,ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of gene expression  (ISO)
regulation of protein kinase B signaling  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transcription, DNA-templated  (ISO)
response to estrogen  (ISO)
response to mechanical stimulus  (ISO)
response to retinoic acid  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (IEA)
seminiferous tubule development  (ISO)
Sertoli cell differentiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
SMAD protein signal transduction  (ISO)
spermatogenesis  (ISO)
transdifferentiation  (ISO)
tube morphogenesis  (ISO)
ventricular cardiac muscle tissue development  (ISO)
ventricular septum development  (ISO)
wound healing  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:12533404   PMID:15059951   PMID:18653717   PMID:20739664  


Genomics

Comparative Map Data
GATA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1414,858,159 - 14,939,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11414,858,470 - 14,938,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,046,527 - 16,126,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GATA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl811,676,959 - 11,760,002 (+)EnsemblGRCh38hg38GRCh38
GRCh38811,676,935 - 11,760,002 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37811,534,444 - 11,617,511 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,599,162 - 11,654,918 (+)NCBINCBI36hg18NCBI36
Build 34811,599,161 - 11,654,918NCBI
Celera810,690,994 - 10,746,848 (+)NCBI
Cytogenetic Map8p23.1NCBI
HuRef810,492,698 - 10,548,485 (+)NCBIHuRef
CHM1_1811,627,233 - 11,683,005 (+)NCBICHM1_1
Gata4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,436,363 - 63,509,161 (-)NCBIGRCm39mm39
GRCm39 Ensembl1463,436,371 - 63,509,141 (-)Ensembl
GRCm381463,198,914 - 63,271,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,198,922 - 63,271,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv371463,817,752 - 63,864,097 (-)NCBIGRCm37mm9NCBIm37
MGSCv361462,153,032 - 62,199,370 (-)NCBImm8
Celera1460,962,648 - 61,008,982 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
Gata4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21537,459,601 - 37,531,291 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1537,459,601 - 37,505,636 (-)Ensembl
Rnor_6.01546,386,703 - 46,458,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,151,497 - 50,197,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,472,793 - 42,519,569 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11542,488,492 - 42,535,269 (-)NCBI
Celera1537,143,928 - 37,189,874 (-)NCBICelera
RH 3.4 Map15261.71RGD
Cytogenetic Map15p12NCBI
Gata4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540352,987,644 - 53,029,267 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540352,958,318 - 53,029,267 (+)NCBIChiLan1.0ChiLan1.0
GATA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v087,442,921 - 7,526,731 (-)NCBIMhudiblu_PPA_v0panPan3
GATA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,126,172 - 26,211,474 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,127,853 - 26,182,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,784,428 - 26,835,191 (-)NCBI
ROS_Cfam_1.02526,280,507 - 26,366,154 (-)NCBI
UMICH_Zoey_3.12526,235,249 - 26,286,037 (-)NCBI
UNSW_CanFamBas_1.02526,131,847 - 26,182,607 (-)NCBI
UU_Cfam_GSD_1.02526,283,313 - 26,334,650 (-)NCBI
Gata4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049435,165,238 - 5,177,602 (-)NCBI
SpeTri2.0NW_0049366753,408,549 - 3,420,828 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.187,348,145 - 7,432,574 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl87,349,660 - 7,400,562 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605235,034,077 - 35,087,089 (+)NCBIVero_WHO_p1.0
Gata4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475825,278,878 - 25,319,317 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system respiratory system
High
Medium 2 1
Low 1 1
Below cutoff 3 2 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000031727   ⟹   ENSSSCP00000027951
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1414,858,159 - 14,939,941 (+)Ensembl
RefSeq Acc Id: NM_214293   ⟹   NP_999458
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11414,888,653 - 14,935,712 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005657268   ⟹   XP_005657325
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11414,883,653 - 14,938,156 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013990297   ⟹   XP_013845751
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11414,858,470 - 14,938,156 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013990298   ⟹   XP_013845752
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11414,873,486 - 14,938,156 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013990299   ⟹   XP_013845753
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11414,883,658 - 14,938,156 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013845751   ⟸   XM_013990297
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013845752   ⟸   XM_013990298
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005657325   ⟸   XM_005657268
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013845753   ⟸   XM_013990299
- Peptide Label: isoform X2
- UniProtKB: I3LUZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999458   ⟸   NM_214293
- UniProtKB: Q8MIM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000027951   ⟸   ENSSSCT00000031727
Protein Domains
GATA-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000022383 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000027951 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031727 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.50.10 UniProtKB/TrEMBL
InterPro GATA_N UniProtKB/TrEMBL
  TF_GATA_4/5/6 UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/TrEMBL
  Znf_GATA UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report ssc:397555 UniProtKB/TrEMBL
NCBI Gene GATA4 ENTREZGENE
PANTHER PTHR10071 UniProtKB/TrEMBL
Pfam GATA UniProtKB/TrEMBL
  GATA-N UniProtKB/TrEMBL
PIRSF TF_GATA_4/5/6 UniProtKB/TrEMBL
PRINTS GATAZNFINGER UniProtKB/TrEMBL
PROSITE GATA_ZN_FINGER_1 UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/TrEMBL
SMART ZnF_GATA UniProtKB/TrEMBL
UniProt I3LUZ9 ENTREZGENE, UniProtKB/TrEMBL
  Q8MIM5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88365 ENTREZGENE