SIX3 (SIX homeobox 3) - Rat Genome Database

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Gene: SIX3 (SIX homeobox 3) Sus scrofa
Analyze
Symbol: SIX3
Name: SIX homeobox 3
RGD ID: 14056200
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN apoptotic process involved in development (ortholog); brain development (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH genetic disease (ortholog); holoprosencephaly (ortholog); holoprosencephaly 2 (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein SIX3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl395,521,334 - 95,525,436 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1395,521,330 - 95,527,004 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SIX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl395,521,334 - 95,525,436 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1395,521,330 - 95,527,004 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SIX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38244,941,702 - 44,946,071 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl244,941,702 - 44,946,071 (+)EnsemblGRCh38hg38GRCh38
GRCh37245,168,841 - 45,173,210 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36245,022,541 - 45,025,894 (+)NCBINCBI36Build 36hg18NCBI36
Build 34245,080,511 - 45,084,092NCBI
Celera245,007,709 - 45,011,888 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef244,885,400 - 44,910,885 (+)NCBIHuRef
CHM1_1245,098,943 - 45,103,122 (+)NCBICHM1_1
T2T-CHM13v2.0244,946,967 - 44,951,332 (+)NCBIT2T-CHM13v2.0
Six3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,921,036 - 85,933,619 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,921,036 - 85,936,730 (+)EnsemblGRCm39 Ensembl
GRCm381785,613,608 - 85,626,191 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1785,613,608 - 85,629,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv371786,020,174 - 86,025,531 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361785,529,160 - 85,532,488 (+)NCBIMGSCv36mm8
Celera1789,974,811 - 89,987,580 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.42NCBI
Six3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8614,791,937 - 14,796,365 (-)NCBIGRCr8
mRatBN7.269,039,017 - 9,043,336 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,036,434 - 9,053,301 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx69,326,170 - 9,330,489 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.069,635,567 - 9,639,890 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,156,148 - 9,160,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,886,730 - 8,891,094 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,886,591 - 8,889,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,778,756 - 8,815,903 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,981,995 - 9,019,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.169,015,373 - 9,019,374 (+)NCBI
Celera68,770,011 - 8,793,533 (-)NCBICelera
Cytogenetic Map6q12NCBI
Six3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544111,966,389 - 11,979,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544111,966,389 - 11,978,545 (+)NCBIChiLan1.0ChiLan1.0
SIX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21281,436,292 - 81,469,922 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A81,440,269 - 81,466,464 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A45,038,634 - 45,072,867 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A45,978,828 - 45,988,078 (+)NCBIpanpan1.1PanPan1.1panPan2
SIX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11047,332,875 - 47,369,359 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1047,332,888 - 47,343,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1047,190,442 - 47,227,035 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01048,209,368 - 48,245,952 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1048,209,335 - 48,244,622 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11047,917,957 - 47,954,541 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01048,207,086 - 48,217,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01048,389,961 - 48,426,595 (+)NCBIUU_Cfam_GSD_1.0
Six3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629235,674,153 - 35,677,974 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365087,104,066 - 7,107,597 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365087,103,578 - 7,106,588 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11462,278,124 - 62,292,942 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1462,278,461 - 62,281,127 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604549,599,060 - 49,626,248 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Six3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473826,380,088 - 26,394,252 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473826,379,172 - 26,391,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SIX3
35 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
nervous system
reproductive system
9 3 9 3

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021087568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000038965   ⟹   ENSSSCP00000035728
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl395,521,334 - 95,525,436 (-)Ensembl
RefSeq Acc Id: XM_021087568   ⟹   XP_020943227
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1395,521,330 - 95,527,004 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020943227 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000035728.2
RefSeq Acc Id: XP_020943227   ⟸   XM_021087568
- Sequence:
Ensembl Acc Id: ENSSSCP00000035728   ⟸   ENSSSCT00000038965
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039283 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000038965.3 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  SIX1_SD UniProtKB/TrEMBL
NCBI Gene SIX3 ENTREZGENE
PANTHER HOMEOBOX PROTEIN SIX UniProtKB/TrEMBL
  PTHR10390:SF31 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  SIX1_SD UniProtKB/TrEMBL
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A286ZW96_PIG UniProtKB/TrEMBL
VGNC ID VGNC:92894 ENTREZGENE