OAZ1 (ornithine decarboxylase antizyme 1) - Rat Genome Database

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Gene: OAZ1 (ornithine decarboxylase antizyme 1) Sus scrofa
Analyze
Symbol: OAZ1
Name: ornithine decarboxylase antizyme 1
RGD ID: 14055863
Description: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jul 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AZ1; ornithine decarboxylase antizyme 1 short isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,293,147 - 76,296,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,293,142 - 76,296,626 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,854,941 - 76,858,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:16120325   PMID:17145712   PMID:17332016   PMID:17407547   PMID:22310384  


Genomics

Comparative Map Data
OAZ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,293,147 - 76,296,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,293,142 - 76,296,626 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,854,941 - 76,858,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OAZ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl192,269,509 - 2,273,490 (+)EnsemblGRCh38hg38GRCh38
GRCh38192,269,486 - 2,273,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37192,269,485 - 2,273,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,220,520 - 2,224,487 (+)NCBINCBI36hg18NCBI36
Build 34192,220,519 - 2,224,487NCBI
Celera192,203,699 - 2,207,665 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef192,040,604 - 2,044,469 (+)NCBIHuRef
CHM1_1192,269,120 - 2,273,087 (+)NCBICHM1_1
Oaz1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,662,490 - 80,665,124 (+)NCBIGRCm39mm39
GRCm39 Ensembl1080,662,490 - 80,665,124 (+)Ensembl
GRCm381080,826,656 - 80,829,290 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,826,656 - 80,829,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,289,401 - 80,292,035 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,229,785 - 80,232,414 (+)NCBImm8
Celera1081,845,454 - 81,848,088 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Oaz1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,883,855 - 8,886,315 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl78,883,851 - 8,886,310 (-)Ensembl
Rnor_6.0711,752,127 - 11,754,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,752,412 - 11,754,508 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,919,843 - 11,922,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,394,495 - 10,396,952 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,394,494 - 10,396,952 (-)NCBI
Celera77,067,977 - 7,070,437 (-)NCBICelera
RH 3.4 Map740.6RGD
Cytogenetic Map7q11NCBI
Oaz1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,871,418 - 5,874,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,871,418 - 5,874,200 (-)NCBIChiLan1.0ChiLan1.0
OAZ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1192,250,599 - 2,254,534 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,250,678 - 2,254,179 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0191,279,139 - 1,283,079 (+)NCBIMhudiblu_PPA_v0panPan3
OAZ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,769,317 - 56,770,921 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,769,319 - 56,770,930 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,564,657 - 56,567,316 (-)NCBI
ROS_Cfam_1.02057,502,449 - 57,505,111 (-)NCBI
UMICH_Zoey_3.12056,554,504 - 56,557,154 (-)NCBI
UNSW_CanFamBas_1.02057,039,687 - 57,042,333 (-)NCBI
UU_Cfam_GSD_1.02057,240,093 - 57,242,753 (-)NCBI
Oaz1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,473,746 - 216,478,014 (-)NCBI
SpeTri2.0NW_0049365881,356,769 - 1,361,037 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OAZ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,061,774 - 2,065,595 (+)NCBI
ChlSab1.1 Ensembl62,061,811 - 2,065,265 (+)Ensembl
Vero_WHO_p1.0NW_0236660816,645,566 - 6,649,397 (-)NCBI
Oaz1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,617,342 - 6,620,466 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001122994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_125342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF196332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK240353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK345239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BW967753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BW984205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU545195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EW617964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP089467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01080005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF831084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF831085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN180302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000014704   ⟹   ENSSSCP00000014307
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl276,293,147 - 76,296,659 (-)Ensembl
RefSeq Acc Id: NM_001122994   ⟹   NP_001116466
RefSeq Status: REVIEWED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1276,293,142 - 76,296,626 (-)NCBI
Sequence:
RefSeq Acc Id: NR_125342
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1276,293,142 - 76,296,626 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001116466   ⟸   NM_001122994
- UniProtKB: B2CR15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000014307   ⟸   ENSSSCT00000014704


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013460 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014307 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014704 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.60 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  ODC-AZ_1 UniProtKB/TrEMBL
  ODC_AZ UniProtKB/TrEMBL
  ODC_AZ_sf UniProtKB/TrEMBL
KEGG Report ssc:397034 UniProtKB/TrEMBL
NCBI Gene OAZ1 ENTREZGENE
PANTHER PTHR10279 UniProtKB/TrEMBL
  PTHR10279:SF8 UniProtKB/TrEMBL
Pfam ODC_AZ UniProtKB/TrEMBL
PROSITE ODC_AZ UniProtKB/TrEMBL
Superfamily-SCOP SSF55729 UniProtKB/TrEMBL
UniProt A0A5K1UXY4_PIG UniProtKB/TrEMBL
  B2CR15 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1S8I3 UniProtKB/TrEMBL
VGNC ID VGNC:98166 ENTREZGENE