GCLM (glutamate-cysteine ligase modifier subunit) - Rat Genome Database

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Gene: GCLM (glutamate-cysteine ligase modifier subunit) Sus scrofa
Analyze
Symbol: GCLM
Name: glutamate-cysteine ligase modifier subunit
RGD ID: 14055570
Description: ENCODES a protein that exhibits glutamate-cysteine ligase activity (ortholog); glutamate-cysteine ligase catalytic subunit binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN aging (ortholog); apoptotic mitochondrial changes (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; glutamic acid/glutamate metabolic pathway; ASSOCIATED WITH berylliosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Liver Injury (ortholog); FOUND IN glutamate-cysteine ligase complex (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; glyphosate
Type: protein-coding
RefSeq Status: MODEL
Also known as: glutamate--cysteine ligase regulatory subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4123,371,193 - 123,390,135 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14123,371,198 - 123,390,130 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,017,027 - 135,035,890 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
GCLM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4123,371,193 - 123,390,135 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14123,371,198 - 123,390,130 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,017,027 - 135,035,890 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCLM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl193,885,199 - 93,909,456 (-)EnsemblGRCh38hg38GRCh38
GRCh38193,885,199 - 93,910,370 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,350,755 - 94,374,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,178 - 94,147,600 (-)NCBINCBI36hg18NCBI36
Build 34194,064,610 - 94,087,033NCBI
Celera192,606,277 - 92,628,698 (-)NCBI
Cytogenetic Map1p22.1NCBI
HuRef192,473,642 - 92,495,998 (-)NCBIHuRef
CHM1_1194,467,558 - 94,489,979 (-)NCBICHM1_1
Gclm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,039,206 - 122,060,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl3122,039,206 - 122,064,381 (+)Ensembl
GRCm383122,245,487 - 122,267,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,245,557 - 122,270,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,948,510 - 121,969,566 (+)NCBIGRCm37mm9NCBIm37
MGSCv363122,237,614 - 122,258,670 (+)NCBImm8
MGSCv363122,610,732 - 122,631,895 (+)NCBImm8
Celera3128,652,324 - 128,663,438 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
Gclm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22210,347,482 - 210,367,537 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2210,347,482 - 210,367,535 (+)Ensembl
Rnor_6.02225,827,504 - 225,847,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,827,504 - 225,847,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,862,903 - 243,883,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,895,434 - 218,915,491 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12218,858,495 - 218,878,551 (+)NCBI
Celera2202,777,122 - 202,797,150 (+)NCBICelera
Cytogenetic Map2q41NCBI
Gclm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423782,468 - 805,384 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423782,468 - 805,384 (+)NCBIChiLan1.0ChiLan1.0
GCLM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1195,278,665 - 95,298,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,278,665 - 95,297,893 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0196,548,850 - 96,573,273 (-)NCBIMhudiblu_PPA_v0panPan3
GCLM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1655,204,602 - 55,244,217 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,930,482 - 57,952,133 (+)NCBI
ROS_Cfam_1.0655,598,315 - 55,619,977 (+)NCBI
UMICH_Zoey_3.1655,278,061 - 55,299,711 (+)NCBI
UNSW_CanFamBas_1.0655,263,100 - 55,284,829 (+)NCBI
UU_Cfam_GSD_1.0655,715,747 - 55,737,399 (+)NCBI
LOC101977655
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058103,569,105 - 103,591,072 (-)NCBI
SpeTri2.0NW_0049365375,356,914 - 5,378,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCLM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12039,339,948 - 39,359,980 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2039,339,908 - 39,359,430 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603378,685,244 - 78,710,789 (-)NCBIVero_WHO_p1.0
Gclm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247423,713,275 - 3,746,219 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 6 3 1 2 23 2 1
Low 4 4 4 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000061853   ⟹   ENSSSCP00000040673
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4123,371,193 - 123,390,135 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000067689   ⟹   ENSSSCP00000071697
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4123,371,565 - 123,390,135 (+)Ensembl
RefSeq Acc Id: XM_001926378   ⟹   XP_001926413
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14123,371,198 - 123,390,130 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001926413 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001926413   ⟸   XM_001926378
- Sequence:
RefSeq Acc Id: ENSSSCP00000040673   ⟸   ENSSSCT00000061853
RefSeq Acc Id: ENSSSCP00000071697   ⟸   ENSSSCT00000067689
Protein Domains
Aldo_ket_red


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037549 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070013145 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000040673 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000071697 UniProtKB/TrEMBL
  ENSSSCP00070021252 UniProtKB/TrEMBL
  ENSSSCP00070021258 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061853 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000067689 UniProtKB/TrEMBL
  ENSSSCT00070025632 UniProtKB/TrEMBL
  ENSSSCT00070025638 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro Gclm UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100153977 UniProtKB/TrEMBL
NCBI Gene GCLM ENTREZGENE
PANTHER PTHR13295 UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A287AA47_PIG UniProtKB/TrEMBL
  A0A4X1TV88_PIG UniProtKB/TrEMBL
  A0A4X1U0N2_PIG UniProtKB/TrEMBL
  A0A5G2RBY0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88387 ENTREZGENE