FCHO2 (FCH and mu domain containing endocytic adaptor 2) - Rat Genome Database

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Gene: FCHO2 (FCH and mu domain containing endocytic adaptor 2) Sus scrofa
Analyze
Symbol: FCHO2
Name: FCH and mu domain containing endocytic adaptor 2
RGD ID: 14054269
Description: ENCODES a protein that exhibits identical protein binding (ortholog); phosphatidylinositol binding (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN membrane invagination (ortholog); protein localization to plasma membrane (ortholog); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN clathrin-coated vesicle (ortholog); presynaptic endocytic zone membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-BAR domain only protein 2; FCH domain only 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl282,101,343 - 82,248,821 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1282,101,283 - 82,248,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2283,869,528 - 83,956,906 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
FCHO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl282,101,343 - 82,248,821 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1282,101,283 - 82,248,410 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2283,869,528 - 83,956,906 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FCHO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38572,956,041 - 73,090,522 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl572,956,041 - 73,090,522 (+)EnsemblGRCh38hg38GRCh38
GRCh37572,251,868 - 72,386,349 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36572,287,655 - 72,422,105 (+)NCBINCBI36Build 36hg18NCBI36
Celera568,147,183 - 68,281,688 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef567,457,697 - 67,591,999 (+)NCBIHuRef
CHM1_1571,684,573 - 71,818,938 (+)NCBICHM1_1
T2T-CHM13v2.0573,437,124 - 73,571,849 (+)NCBIT2T-CHM13v2.0
Fcho2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391398,859,914 - 98,953,085 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1398,859,911 - 98,951,957 (-)EnsemblGRCm39 Ensembl
GRCm381398,723,406 - 98,816,577 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1398,723,403 - 98,815,449 (-)EnsemblGRCm38mm10GRCm38
MGSCv371399,493,361 - 99,585,404 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361399,823,567 - 99,915,303 (-)NCBIMGSCv36mm8
Celera13102,384,562 - 102,476,173 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.16NCBI
Fcho2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8231,813,356 - 31,916,471 (-)NCBIGRCr8
mRatBN7.2230,079,143 - 30,181,639 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,080,962 - 30,181,241 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,142,108 - 37,242,707 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,236,463 - 35,337,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0230,049,355 - 30,149,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0228,927,918 - 29,029,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl228,926,107 - 29,029,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,110,537 - 48,211,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4229,349,477 - 29,451,434 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera226,114,535 - 26,214,094 (-)NCBICelera
Cytogenetic Map2q12NCBI
Fcho2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542527,506,660 - 27,632,983 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542527,506,645 - 27,632,983 (-)NCBIChiLan1.0ChiLan1.0
FCHO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2442,224,615 - 42,363,411 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1540,378,249 - 40,519,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0542,223,201 - 42,361,317 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1542,822,190 - 42,958,619 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl542,824,621 - 42,958,565 (-)Ensemblpanpan1.1panPan2
FCHO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1255,905,497 - 56,011,395 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl255,905,520 - 56,009,131 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha252,856,825 - 52,977,919 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0256,405,588 - 56,526,744 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl256,405,494 - 56,526,744 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,465,325 - 53,587,071 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0254,233,789 - 54,354,882 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0255,124,469 - 55,245,831 (+)NCBIUU_Cfam_GSD_1.0
Fcho2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213187,276,731 - 187,403,801 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365493,455,172 - 3,565,558 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365493,455,172 - 3,565,507 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCHO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1467,289,172 - 67,430,622 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl467,301,984 - 67,428,194 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604916,057,428 - 16,198,003 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcho2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249052,029,808 - 2,140,721 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249052,027,709 - 2,139,312 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FCHO2
3037 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 15 2 3 3
Low 2 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026067   ⟹   ENSSSCP00000026999
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl282,101,343 - 82,248,825 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000041247   ⟹   ENSSSCP00000047988
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl282,101,333 - 82,248,408 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000047233   ⟹   ENSSSCP00000034772
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl282,101,283 - 82,248,413 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054977   ⟹   ENSSSCP00000036636
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl282,101,343 - 82,248,825 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000061003   ⟹   ENSSSCP00000045743
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl282,101,343 - 82,248,821 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069771   ⟹   ENSSSCP00000066408
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl282,101,343 - 82,248,821 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000073706   ⟹   ENSSSCP00000068954
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl282,101,283 - 82,248,404 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000083762   ⟹   ENSSSCP00000070328
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl282,101,381 - 82,248,406 (+)Ensembl
RefSeq Acc Id: XM_013994888   ⟹   XP_013850342
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1282,101,295 - 82,248,410 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084437   ⟹   XP_020940096
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1282,101,295 - 82,248,410 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084438   ⟹   XP_020940097
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1282,101,283 - 82,248,410 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020940097   ⟸   XM_021084438
- Peptide Label: isoform X2
- UniProtKB: A0A287ANV0 (UniProtKB/TrEMBL),   A0A8D0YRG6 (UniProtKB/TrEMBL),   A0A8D0MUA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940096   ⟸   XM_021084437
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SLM1 (UniProtKB/TrEMBL),   A0A8D0MUA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013850342   ⟸   XM_013994888
- Peptide Label: isoform X3
- UniProtKB: A0A5G2QND3 (UniProtKB/TrEMBL),   A0A8D0TER0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000036636   ⟸   ENSSSCT00000054977
RefSeq Acc Id: ENSSSCP00000068954   ⟸   ENSSSCT00000073706
RefSeq Acc Id: ENSSSCP00000070328   ⟸   ENSSSCT00000083762
RefSeq Acc Id: ENSSSCP00000047988   ⟸   ENSSSCT00000041247
RefSeq Acc Id: ENSSSCP00000026999   ⟸   ENSSSCT00000026067
RefSeq Acc Id: ENSSSCP00000045743   ⟸   ENSSSCT00000061003
RefSeq Acc Id: ENSSSCP00000066408   ⟸   ENSSSCT00000069771
RefSeq Acc Id: ENSSSCP00000034772   ⟸   ENSSSCT00000047233
Protein Domains
F-BAR   MHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000022661 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005012906 UniProtKB/TrEMBL
  ENSSSCG00015016739 UniProtKB/TrEMBL
  ENSSSCG00025070714 UniProtKB/TrEMBL
  ENSSSCG00030036835 UniProtKB/TrEMBL
  ENSSSCG00035011335 UniProtKB/TrEMBL
  ENSSSCG00040072333 UniProtKB/TrEMBL
  ENSSSCG00045003117 UniProtKB/TrEMBL
  ENSSSCG00050027351 UniProtKB/TrEMBL
  ENSSSCG00055001744 UniProtKB/TrEMBL
  ENSSSCG00060012434 UniProtKB/TrEMBL
  ENSSSCG00065017282 UniProtKB/TrEMBL
  ENSSSCG00070002166 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061003 ENTREZGENE
  ENSSSCT00000061003.3 UniProtKB/TrEMBL
  ENSSSCT00000069771.2 UniProtKB/TrEMBL
  ENSSSCT00005021226.1 UniProtKB/TrEMBL
  ENSSSCT00005021265.1 UniProtKB/TrEMBL
  ENSSSCT00005021327.1 UniProtKB/TrEMBL
  ENSSSCT00005021375.1 UniProtKB/TrEMBL
  ENSSSCT00005021413.1 UniProtKB/TrEMBL
  ENSSSCT00005021502.1 UniProtKB/TrEMBL
  ENSSSCT00005021594.1 UniProtKB/TrEMBL
  ENSSSCT00015022250.1 UniProtKB/TrEMBL
  ENSSSCT00015022425.1 UniProtKB/TrEMBL
  ENSSSCT00025097145.1 UniProtKB/TrEMBL
  ENSSSCT00025097540.1 UniProtKB/TrEMBL
  ENSSSCT00025097872.1 UniProtKB/TrEMBL
  ENSSSCT00025098258.1 UniProtKB/TrEMBL
  ENSSSCT00030051255.1 UniProtKB/TrEMBL
  ENSSSCT00030051295.1 UniProtKB/TrEMBL
  ENSSSCT00030051317.1 UniProtKB/TrEMBL
  ENSSSCT00030051352.1 UniProtKB/TrEMBL
  ENSSSCT00035014226.1 UniProtKB/TrEMBL
  ENSSSCT00035014232.1 UniProtKB/TrEMBL
  ENSSSCT00035014236.1 UniProtKB/TrEMBL
  ENSSSCT00035014246.1 UniProtKB/TrEMBL
  ENSSSCT00040099553.1 UniProtKB/TrEMBL
  ENSSSCT00045005013.1 UniProtKB/TrEMBL
  ENSSSCT00045005056.1 UniProtKB/TrEMBL
  ENSSSCT00050036818.1 UniProtKB/TrEMBL
  ENSSSCT00050036842.1 UniProtKB/TrEMBL
  ENSSSCT00055003171.1 UniProtKB/TrEMBL
  ENSSSCT00055003235.1 UniProtKB/TrEMBL
  ENSSSCT00060016292.1 UniProtKB/TrEMBL
  ENSSSCT00060016378.1 UniProtKB/TrEMBL
  ENSSSCT00060016402.1 UniProtKB/TrEMBL
  ENSSSCT00065022969.1 UniProtKB/TrEMBL
  ENSSSCT00065023005.1 UniProtKB/TrEMBL
  ENSSSCT00070004026.1 UniProtKB/TrEMBL
  ENSSSCT00070004048.1 UniProtKB/TrEMBL
  ENSSSCT00070004071.1 UniProtKB/TrEMBL
  ENSSSCT00070004092.1 UniProtKB/TrEMBL
  ENSSSCT00070004137.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  Mu homology domain, subdomain B UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  AP2_Mu_C_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH_dom UniProtKB/TrEMBL
  FCHo2 UniProtKB/TrEMBL
  MHD UniProtKB/TrEMBL
  Muniscin_C UniProtKB/TrEMBL
NCBI Gene FCHO2 ENTREZGENE
PANTHER PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 UniProtKB/TrEMBL
  PTHR23065:SF8 UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  muHD UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  MHD UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF49447 UniProtKB/TrEMBL
UniProt A0A287ANV0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SLM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SLP1_PIG UniProtKB/TrEMBL
  A0A4X1SLS0_PIG UniProtKB/TrEMBL
  A0A4X1SLS8_PIG UniProtKB/TrEMBL
  A0A4X1SMV1_PIG UniProtKB/TrEMBL
  A0A5G2QND3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0IFX5_PIG UniProtKB/TrEMBL
  A0A8D0IG61_PIG UniProtKB/TrEMBL
  A0A8D0IKB9_PIG UniProtKB/TrEMBL
  A0A8D0IRS9_PIG UniProtKB/TrEMBL
  A0A8D0LIK1_PIG UniProtKB/TrEMBL
  A0A8D0MUA9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0MW19_PIG UniProtKB/TrEMBL
  A0A8D0TER0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0YRG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1LZT5_PIG UniProtKB/TrEMBL
  A0A8D1UIH9_PIG UniProtKB/TrEMBL
  A0A8D1XV67_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88066 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 FCHO2  FCH and mu domain containing endocytic adaptor 2  FCHO2  FCH domain only 2  Symbol and/or name change 5135510 APPROVED