SMTN (smoothelin) - Rat Genome Database

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Gene: SMTN (smoothelin) Sus scrofa
Analyze
Symbol: SMTN
Name: smoothelin
RGD ID: 14051226
Description: INVOLVED IN negative regulation of systemic arterial blood pressure (ortholog); positive regulation of cardiac muscle contraction (ortholog); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); FOUND IN filamentous actin (inferred); microtubule organizing center (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: smoothelin-B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,879,317 - 47,902,698 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,879,317 - 47,902,700 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,990,987 - 51,014,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SMTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,879,317 - 47,902,698 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,879,317 - 47,902,700 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,990,987 - 51,014,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,064,118 - 31,104,624 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,064,105 - 31,104,757 (+)EnsemblGRCh38hg38GRCh38
GRCh372231,460,104 - 31,500,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,807,305 - 29,830,609 (+)NCBINCBI36Build 36hg18NCBI36
Build 342229,801,858 - 29,825,163NCBI
Celera2215,277,437 - 15,300,741 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,439,094 - 14,462,417 (+)NCBIHuRef
CHM1_12231,437,118 - 31,460,447 (+)NCBICHM1_1
T2T-CHM13v2.02231,527,653 - 31,568,123 (+)NCBIT2T-CHM13v2.0
Smtn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,467,522 - 3,489,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,467,523 - 3,490,612 (-)EnsemblGRCm39 Ensembl
GRCm38113,517,522 - 3,539,292 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,517,523 - 3,540,612 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,417,525 - 3,439,295 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,417,526 - 3,439,242 (-)NCBIMGSCv36mm8
Celera114,008,414 - 4,030,184 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.47NCBI
Smtn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,622,223 - 82,644,525 (-)NCBIGRCr8
mRatBN7.21478,398,595 - 78,420,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,397,778 - 78,420,886 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,839,785 - 82,862,070 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,079,891 - 84,102,176 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,525,655 - 80,547,941 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,755,141 - 83,776,871 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,755,142 - 83,776,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,443,088 - 84,464,813 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01480,301,566 - 80,303,230 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,160,580 - 84,182,869 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,179,725 - 84,202,043 (-)NCBI
Celera1477,311,041 - 77,333,331 (-)NCBICelera
Cytogenetic Map14q21NCBI
Smtn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554555,273,602 - 5,297,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554555,271,615 - 5,294,151 (+)NCBIChiLan1.0ChiLan1.0
SMTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22341,036,635 - 41,060,211 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,735,328 - 43,758,712 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02212,105,016 - 12,128,365 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,942,889 - 29,966,256 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,942,895 - 29,966,256 (+)Ensemblpanpan1.1panPan2
SMTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,085,356 - 24,108,005 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,085,382 - 24,108,540 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,955,752 - 23,978,245 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,468,412 - 24,490,906 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,468,434 - 24,490,906 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12624,171,777 - 24,194,301 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,433,828 - 24,456,302 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,495,094 - 24,517,587 (+)NCBIUU_Cfam_GSD_1.0
Smtn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118117,005,130 - 117,028,133 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936755264,570 - 289,260 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936755264,635 - 285,668 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,972,812 - 13,996,124 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,974,686 - 13,999,061 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,123,501 - 112,146,815 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smtn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247477,559,026 - 7,585,154 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247477,559,364 - 7,582,080 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SMTN
226 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 4 2 2 1 3
Low 6 2 3 3 1 23 2 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010974   ⟹   ENSSSCP00000010688
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,879,317 - 47,902,693 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000080926   ⟹   ENSSSCP00000072429
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,879,317 - 47,902,698 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000081382   ⟹   ENSSSCP00000061698
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,879,319 - 47,902,694 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085253   ⟹   ENSSSCP00000073743
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,885,374 - 47,902,694 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000088256   ⟹   ENSSSCP00000060408
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,891,866 - 47,902,691 (+)Ensembl
RefSeq Acc Id: NM_001244360   ⟹   NP_001231289
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11447,879,317 - 47,902,700 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001231289   ⟸   NM_001244360
- UniProtKB: A0A480JJK2 (UniProtKB/TrEMBL),   A0A4X1VBW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000060408   ⟸   ENSSSCT00000088256
RefSeq Acc Id: ENSSSCP00000010688   ⟸   ENSSSCT00000010974
RefSeq Acc Id: ENSSSCP00000072429   ⟸   ENSSSCT00000080926
RefSeq Acc Id: ENSSSCP00000073743   ⟸   ENSSSCT00000085253
RefSeq Acc Id: ENSSSCP00000061698   ⟸   ENSSSCT00000081382
Protein Domains
Calponin-homology (CH)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010017 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005030774 UniProtKB/TrEMBL
  ENSSSCG00015081070 UniProtKB/TrEMBL
  ENSSSCG00025064294 UniProtKB/TrEMBL
  ENSSSCG00030021812 UniProtKB/TrEMBL
  ENSSSCG00035039534 UniProtKB/TrEMBL
  ENSSSCG00040006055 UniProtKB/TrEMBL
  ENSSSCG00045003420 UniProtKB/TrEMBL
  ENSSSCG00050077144 UniProtKB/TrEMBL
  ENSSSCG00055007291 UniProtKB/TrEMBL
  ENSSSCG00060071914 UniProtKB/TrEMBL
  ENSSSCG00065031752 UniProtKB/TrEMBL
  ENSSSCG00070022816 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010974.5 UniProtKB/TrEMBL
  ENSSSCT00000080926.2 UniProtKB/TrEMBL
  ENSSSCT00000081382 ENTREZGENE
  ENSSSCT00000081382.2 UniProtKB/TrEMBL
  ENSSSCT00000085253.2 UniProtKB/TrEMBL
  ENSSSCT00000088256.2 UniProtKB/TrEMBL
  ENSSSCT00005048981.1 UniProtKB/TrEMBL
  ENSSSCT00005049020.1 UniProtKB/TrEMBL
  ENSSSCT00005049051.1 UniProtKB/TrEMBL
  ENSSSCT00005049087.1 UniProtKB/TrEMBL
  ENSSSCT00005049095.1 UniProtKB/TrEMBL
  ENSSSCT00005049157.1 UniProtKB/TrEMBL
  ENSSSCT00005049177.1 UniProtKB/TrEMBL
  ENSSSCT00005049209.1 UniProtKB/TrEMBL
  ENSSSCT00015110507.1 UniProtKB/TrEMBL
  ENSSSCT00025089083.1 UniProtKB/TrEMBL
  ENSSSCT00030030321.1 UniProtKB/TrEMBL
  ENSSSCT00035052546.1 UniProtKB/TrEMBL
  ENSSSCT00040008122.1 UniProtKB/TrEMBL
  ENSSSCT00045005715.1 UniProtKB/TrEMBL
  ENSSSCT00050106271.1 UniProtKB/TrEMBL
  ENSSSCT00055014576.1 UniProtKB/TrEMBL
  ENSSSCT00060098600.1 UniProtKB/TrEMBL
  ENSSSCT00065043082.1 UniProtKB/TrEMBL
  ENSSSCT00070045402.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
InterPro CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  SMTN UniProtKB/TrEMBL
NCBI Gene SMTN ENTREZGENE
PANTHER CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED UniProtKB/TrEMBL
  SMOOTHELIN UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  Smoothelin UniProtKB/TrEMBL
PROSITE PS50021 UniProtKB/TrEMBL
SMART SM00033 UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/TrEMBL
UniProt A0A480J3M1_PIG UniProtKB/TrEMBL
  A0A480JJK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A481BA85_PIG UniProtKB/TrEMBL
  A0A4X1V9Q5_PIG UniProtKB/TrEMBL
  A0A4X1VBW0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QI59_PIG UniProtKB/TrEMBL
  A0A5G2QQ45_PIG UniProtKB/TrEMBL
  A0A5G2R5C2_PIG UniProtKB/TrEMBL
  A0A5G2R8Z1_PIG UniProtKB/TrEMBL
  A0A8D0JXS5_PIG UniProtKB/TrEMBL
  A0A8D1BSR4_PIG UniProtKB/TrEMBL
  A0A8D1PZR7_PIG UniProtKB/TrEMBL
  A0A8D1Y9L7_PIG UniProtKB/TrEMBL
  F1RPD7_PIG UniProtKB/TrEMBL
UniProt Secondary A0A8D0JXU7 UniProtKB/TrEMBL
  A0A8D0QK57 UniProtKB/TrEMBL
  A0A8D1GMP1 UniProtKB/TrEMBL
VGNC ID VGNC:93267 ENTREZGENE