TOP1 (DNA topoisomerase I) - Rat Genome Database

Name: TOP1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: TOP1 (DNA topoisomerase I) Sus scrofa

Analyze

Symbol:

TOP1

Name:

DNA topoisomerase I

RGD ID:

14050062

Description:

ENCODES a protein that exhibits ATP binding (ortholog); chromatin binding (ortholog); chromatin DNA binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to luteinizing hormone stimulus (ortholog); chromatin remodeling (ortholog); PARTICIPATES IN irinotecan pharmacodynamics pathway; irinotecan pharmacokinetics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); disease of cellular proliferation (ortholog); Disease Progression (ortholog); FOUND IN cytoplasm (ortholog); dense fibrillar component (ortholog); fibrillar center (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA topoisomerase 1; topoisomerase (DNA) I

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TOP1 (DNA topoisomerase I)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Top1 (topoisomerase (DNA) I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TOP1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Top1 (DNA topoisomerase I)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	43,710,290 - 43,799,700 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	43,710,270 - 43,799,700 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	49,135,554 - 49,193,582 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

disease of cellular proliferation (ISO)

Disease Progression (ISO)

focal epilepsy (ISO)

Liver Neoplasms (ISO)

Recurrence (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ regeneration (ISO)

cellular response to luteinizing hormone stimulus (ISO)

chromatin remodeling (ISO)

chromosome segregation (IBA)

circadian regulation of gene expression (ISO)

circadian rhythm (ISO)

DNA replication (IBA,ISO)

DNA topological change (IBA,IEA,ISO)

embryonic cleavage (ISO)

peptidyl-serine phosphorylation (ISO)

response to cAMP (ISO)

response to gamma radiation (ISO)

response to temperature stimulus (ISO)

response to xenobiotic stimulus (ISO)

rhythmic process (IEA)

rRNA transcription (ISO)

Cellular Component

chromosome (IEA)

cytoplasm (ISO)

dense fibrillar component (ISO)

fibrillar center (ISO)

male germ cell nucleus (ISO)

nuclear chromosome (ISO)

nucleolus (IBA,ISO)

nucleoplasm (ISO)

nucleus (IEA)

P-body (ISO)

perikaryon (ISO)

protein-DNA complex (ISO)

Molecular Function

ATP binding (ISO)

chromatin binding (ISO)

chromatin DNA binding (ISO)

DNA binding (IEA,ISO)

DNA binding, bending (ISO)

DNA topoisomerase activity (IEA)

DNA topoisomerase type I (single strand cut, ATP-independent) activity (IBA,IEA,ISO)

double-stranded DNA binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein serine/threonine kinase activity (ISO)

protein-containing complex binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

single-stranded DNA binding (ISO)

supercoiled DNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TOP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	43,710,290 - 43,799,700 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	43,710,270 - 43,799,700 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	49,135,554 - 49,193,582 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	41,028,822 - 41,124,487 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	41,028,822 - 41,124,487 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	39,657,462 - 39,753,127 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	39,090,876 - 39,186,541 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	39,090,875 - 39,186,541	NCBI
Celera	20	36,368,028 - 36,463,696 (+)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI
HuRef	20	36,395,468 - 36,491,177 (+)	NCBI		HuRef
CHM1_1	20	39,561,887 - 39,657,539 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	42,760,511 - 42,856,164 (+)	NCBI		T2T-CHM13v2.0

Top1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	160,487,901 - 160,564,684 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	160,487,808 - 160,564,684 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	160,645,897 - 160,722,764 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	160,645,888 - 160,722,764 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	160,471,633 - 160,548,500 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	160,337,671 - 160,414,152 (+)	NCBI		MGSCv36	mm8
Celera	2	166,577,915 - 166,654,823 (+)	NCBI		Celera
Cytogenetic Map	2	H2	NCBI
cM Map	2	80.96	NCBI

Top1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	169,713,195 - 169,796,330 (+)	NCBI		GRCr8
mRatBN7.2	3	149,293,469 - 149,376,618 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	149,293,403 - 149,376,623 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	153,107,309 - 153,188,513 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	161,606,688 - 161,687,898 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	159,345,818 - 159,427,549 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	156,635,688 - 156,717,686 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	156,642,464 - 156,717,686 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	162,865,335 - 162,947,076 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	151,428,931 - 151,512,884 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	151,334,966 - 151,418,920 (+)	NCBI
Celera	3	147,968,261 - 148,049,789 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Top1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	15,834,017 - 15,922,785 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	15,834,017 - 15,922,785 (-)	NCBI	ChiLan1.0	ChiLan1.0

TOP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	46,769,898 - 46,866,351 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	46,762,969 - 46,859,450 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	37,368,606 - 37,464,649 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	38,468,197 - 38,563,842 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	38,468,452 - 38,562,652 (+)	Ensembl	panpan1.1		panPan2

TOP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	29,075,267 - 29,166,733 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	29,075,492 - 29,165,864 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	28,720,984 - 28,812,380 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	29,781,234 - 29,872,485 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	29,781,498 - 29,872,296 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	29,049,969 - 29,141,401 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	29,153,861 - 29,245,250 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	29,650,217 - 29,741,420 (+)	NCBI		UU_Cfam_GSD_1.0

Top1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	178,026,161 - 178,108,033 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	641,423 - 723,518 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	641,451 - 723,323 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	22,655,085 - 22,751,082 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	22,651,995 - 22,751,102 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	71,467,009 - 71,562,443 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Top1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624919	1,668,440 - 1,756,629 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624919	1,668,712 - 1,756,624 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TOP1
1388 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	6	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021078395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK345953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK347717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK348350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU062531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBZA01000678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01014387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000029351 ⟹ ENSSSCP00000023570

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	43,710,290 - 43,799,696 (+)	Ensembl

Ensembl Acc Id:

ENSSSCT00000092206 ⟹ ENSSSCP00000080330

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	43,769,569 - 43,799,692 (+)	Ensembl

Ensembl Acc Id:

ENSSSCT00000098245 ⟹ ENSSSCP00000074796

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	43,710,325 - 43,799,692 (+)	Ensembl

RefSeq Acc Id:

XM_021078395 ⟹ XP_020934054

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	17	43,710,270 - 43,799,700 (+)	NCBI

Sequence:

show sequence

TCTCTGACGTCAGCGACGTCTCATTTAAAAGCGGCCGCGCAGGCGCAGTGAGCCGAAATGCGAA
CTTAGGCTGTTACACAACTGCTGGGGTCTGCTCTCGCCTCCCGCCCGGCAGTCAGTCAGCGTCG
CCGCCGCTGTCGCCGCCTCAGCCTTACCGGGAGTCTCAGGCCCGCCCCGCCGACGTTTACTCGC
GCTTCCGGGAGCCTTCGGGAGCCTCCGGAAGCCCCTGTCCACCCGCACAGGCCGGTAGCGACCG
TCTGCGTCTCCTCGGCGCCCCTCGCCGCCCGCCGCACTCGCCACTCCTGCCGACATGAGTGGGG
ACCATCTCCACACCGATTCCCAGATCGAGGCGGATTTCCGACTGAATGATTCTCATAAACACAA
AGATAAACATAAAGATCGAGAACACCGGCACAAAGAACACAAGAAGGACAAGGAGAAGGACCGA
GAAAAGTCCAAGCATAGCAACAGTGAACATAAAGATTCTGAAAAGAAACACAAAGAGAAGGAGA
AAACCAAACACAAAGATGGAAGTTCAGAAAAGCATAAAGACAAACACAAAGACAGAGATAAGGA
AAAACGAAAGGAAGAAAAGATTAGAGCCTCTGGGGATGCAAAAATAAAAAAGGAGAAGGAGAAT
GGTTTCTCTAGTCCACCACGGATTAAAGATGAACCTGAAGATGATGGCTACTTTGCTCCTCCTA
AAGAGGATATAAAGCCATTAAAGAGACCTCGAGACGAAGATGATGCTGATTATAAGCCTAAGAA
AATTAAAACAGAAGATATCAAGAAAGAGAAGAAACGCAAACTGGAGGAAGAAGAGGACGGTAAA
TTGAAAAAAACCAAGAATAAGGATAAAGATAAAGATAAAAAAGTTCCTGAGCCAGATAGCAAGA
AAAAGAAGCCGAAGAAAGAAGAGGAACAGAAGTGGAAATGGTGGGAAGAAGAGCGCTATCCTGA
AGGCATCAAGTGGAAATTCCTAGAACATAAAGGTCCTGTATTTGCTCCACCATATGAACCTCTT
CCAGAGAGTGTCAAGTTTTACTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAAGAAG
TAGCTACGTTCTTTGCAAAAATGCTCGACCATGAATATACTACTAAAGAAATATTTAGGAAAAA
TTTCTTTAAAGACTGGAGAAAGGAAATGACCAATGAAGAGAAGAATATTATCACCAACCTAAGC
AAATGTGATTTTACCCAGATGAGCCAGTATTTCAAAGCCCAGTCAGAAGCTCGGAAACAGATGA
GCAAGGAAGAGAAACTGAAAATCAAAGAAGAGAATGAAAAATTACTAAAAGAATATGGCTTCTG
TATTATGGATAACCACAGAGAGAGGATTGCCAACTTCAAGATAGAACCTCCTGGACTTTTCCGT
GGCCGGGGCAACCACCCCAAAATGGGCATGCTAAAGAGACGGATCATGCCTGAGGATATAATCA
TCAACTGTAGCAAAGATGCCAAGGTTCCTTCTCCTCCCCCAGGACATAAATGGAAAGAGGTCCG
ACATGATAACAAGGTTACTTGGCTAGTCTCCTGGACAGAGAACATCCAAGGTTCCATTAAATAC
ATCATGCTGAATCCTAGCTCACGGATCAAGGGTGAGAAAGACTGGCAGAAATATGAGACTGCTC
GGCGGCTGAAGAAGTGTGTGGACAAGATCCGGAACCAGTATAGAGAAGACTGGAAGTCCAAAGA
GATGAAAGTCCGGCAGAGAGCTGTAGCCCTGTACTTCATTGACAAGCTTGCTCTGCGAGCAGGC
AATGAGAAGGAGGAAGGAGAAACCGCGGACACTGTGGGTTGCTGCTCGCTTCGTGTGGAGCACA
TTAACCTGCACCCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTCCTTGGGAAGGA
CTCAATCAGATACTATAACAAAGTCCCCGTTGAGAAACGAGTTTTTAAGAACTTACAGCTATTT
ATGGAGAATAAACAGCCTGAGGATGATCTTTTTGATAGACTCAATACTGGTATTCTAAATAAGC
ATCTTCAGGATCTCATGGAGGGCTTGACAGCCAAGGTGTTCCGTACATACAACGCTTCCATCAC
GCTACAACAGCAGCTAAAGGAACTCACAGCTCCTGATGAAAACATCCCAGCAAAGATCCTATCT
TATAACCGTGCCAACCGAGCTGTTGCAATTCTTTGTAACCATCAGAGGGCACCACCAAAAACTT
TTGAGAAGTCCATGATGAACTTGCAGACTAAGATTGATGCCAAGAAGGAACAGCTAGCAGATGC
GCGGAGAGACCTGAAAAGTGCTAAAGCTGATGCCAAGGTCCTAAAGGATGCAAAGACCAAGAAG
GTGGTAGAGTCAAAGAAAAAGGCCGTGCAGAGACTGGAGGAGCAGCTGATGAAGCTCGAAGTTC
AGGCCACAGACCGAGAGGAAAATAAACAAATTGCTTTGGGAACCTCCAAACTCAATTATCTGGA
CCCAAGGATCACCGTGGCTTGGTGCAAGAAATGGGGGGTCCCAATTGAGAAAATTTACAACAAA
ACCCAGCGGGAGAAGTTTGCCTGGGCCATCGACATGGCTGACGAGGACTATGAGTTCTAGCCAG
TCTTAAGGGGCAGGGTTCTGTGGAAAGGAACAGTGTGGTTGGGGAAGATGGATAAACTGTGAGC
CTCGCTTGCCCTCGCACCTGAGGGAAAGAGGCAGCAAGTCTTAAAAAACCAACATCTTTGAGAA
AAGATAAACCTGGAGATATTATAAGGGAGAGCTGAGCCAGTTGTCCTATGGACAACTTATTTAA
AAATATTTCAGATATCAAAATTCTAGCTGTATGATTTGTTTTGAATTTTGTTTTTATTTTCAAG
GGGTCAAGTGGATGGGAATTTGTCAGAGTTCTGCCAGGCAAATTCACTGTTTCACTGAAGCATT
TGGATTCTCTTAGCTACTGTATACGAAGTCCGATTATATTGGTGCGTTTTTACAGTTAGGGTTT
TGCAATAACTTCTATATTTTAATAGAAATGAATTCCTAAACTCCCCTCTCCCCCATTTCAGGAA
TTTAAAATTAAGTAGAACAAAAACCCAGCGCACCTGTTAAGAGTTGTCACTATTGTCATGGGAA
TCAATTTTCATTAAACTTGAAGCAGTTGTGACATTGGCAGTGTTTTGGTTCAGACACCTGTTAA
CAGAAAAGCATGATGGGAAAATATTTCCTGACTTGAGTGTTCCTTTTTAAATGTGAATTTTTAT
TTCTTTTTAATTATTTTAAAATATTTAAACCTTTTTCTTGATCTTAAAGATCGTGTAGATTGGG
GTTGGGGAGGGATGAGGGGTGAGCGAGTCTAAGGATAATGAAATAATCAGTGACTGAAACCATT
TTCCCATCATCCTTTGTTCTGAGCATTCTCTGTACCCTTTCAGATACCCATCTTTTTTCATTTT
AAACCCAAGTCTTTCACTTGAAAGATTTTATTGTATAAAAAGTTCCACAGGTCAATAAATTTAG
AGGAAAATGAGTATTTGGTCCAAAAAAAAAAAGGAAAAAAAAATCAAGATTTTAGGGCTTTTAT
TTTTTTTCTTTTGTAATTGTGTAAAAAATGGGGGGAAAACACATAAAAAGCAGAATTTTAATGT
GAAAACATTTTTTGCTATAATCATTAGTTTTAGAGGCATTGTTAGTATAGCGTGTGTGCAGAGT
CCATTTCCCACATCTTCCCTCAAGTATCTTCTATTTTTATCATGAATTCCCTTTTAATCAACTG
TAGGTTATTTAAAATAAATTCCTACAACTTAACGGAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020934054	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000023570
	ENSSSCP00000023570.2
	ENSSSCP00000074796.1
	ENSSSCP00000080330.1
	ENSSSCP00015028346.1
	ENSSSCP00025020977.1
	ENSSSCP00025020989.1
	ENSSSCP00030008568.1
	ENSSSCP00030008576.1
	ENSSSCP00035035407.1
	ENSSSCP00040034560.1
	ENSSSCP00040034605.1
	ENSSSCP00050010577.1
	ENSSSCP00050010584.1
	ENSSSCP00055037440.1
	ENSSSCP00060039544.1
	ENSSSCP00060039549.1
	ENSSSCP00065012209.1
	ENSSSCP00070017745.1
	ENSSSCP00070017775.1
GenBank Protein	JAG69090	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_020934054 ⟸ XM_021078395

- UniProtKB:

I3LHM3 (UniProtKB/TrEMBL), A0A0B8RT23 (UniProtKB/TrEMBL), A0A8D0P994 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGDHLHTDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKEKDREKSKHSNSEHKDSEKKHK
EKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKIRASGDAKIKKEKENGFSSPPRIKDEPEDDGYF
APPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLKKTKNKDKDKDKKVPEP
DSKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPK
AEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQSEAR
KQMSKEEKLKIKEENEKLLKEYGFCIMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPE
DIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKY
ETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLR
VEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGI
LNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAP
PKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVLKDAKTKKVVESKKKAVQRLEEQLMK
LEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYE
F

hide sequence

Ensembl Acc Id:

ENSSSCP00000023570 ⟸ ENSSSCT00000029351

Ensembl Acc Id:

ENSSSCP00000080330 ⟸ ENSSSCT00000092206

Ensembl Acc Id:

ENSSSCP00000074796 ⟸ ENSSSCT00000098245

Protein Domains

DNA topoisomerase I eukaryotic-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000007355	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015053165	UniProtKB/TrEMBL
	ENSSSCG00025035967	UniProtKB/TrEMBL
	ENSSSCG00030013985	UniProtKB/TrEMBL
	ENSSSCG00035063291	UniProtKB/TrEMBL
	ENSSSCG00040058809	UniProtKB/TrEMBL
	ENSSSCG00050018779	UniProtKB/TrEMBL
	ENSSSCG00055023831	UniProtKB/TrEMBL
	ENSSSCG00060066982	UniProtKB/TrEMBL
	ENSSSCG00065022418	UniProtKB/TrEMBL
	ENSSSCG00070011018	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000029351	ENTREZGENE
	ENSSSCT00000029351.4	UniProtKB/TrEMBL
	ENSSSCT00000092206.1	UniProtKB/TrEMBL
	ENSSSCT00000098245.1	UniProtKB/TrEMBL
	ENSSSCT00015070756.1	UniProtKB/TrEMBL
	ENSSSCT00025049036.1	UniProtKB/TrEMBL
	ENSSSCT00025049054.1	UniProtKB/TrEMBL
	ENSSSCT00030019231.1	UniProtKB/TrEMBL
	ENSSSCT00030019244.1	UniProtKB/TrEMBL
	ENSSSCT00035085091.1	UniProtKB/TrEMBL
	ENSSSCT00040079933.1	UniProtKB/TrEMBL
	ENSSSCT00040080007.1	UniProtKB/TrEMBL
	ENSSSCT00050025430.1	UniProtKB/TrEMBL
	ENSSSCT00050025444.1	UniProtKB/TrEMBL
	ENSSSCT00055046938.1	UniProtKB/TrEMBL
	ENSSSCT00060091431.1	UniProtKB/TrEMBL
	ENSSSCT00060091445.1	UniProtKB/TrEMBL
	ENSSSCT00065029841.1	UniProtKB/TrEMBL
	ENSSSCT00070021456.1	UniProtKB/TrEMBL
	ENSSSCT00070021487.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.41	UniProtKB/TrEMBL
	1.10.132.10	UniProtKB/TrEMBL
	2.170.11.10	UniProtKB/TrEMBL
InterPro	DNA_brk_join_enz	UniProtKB/TrEMBL
	DNA_topo_DNA_db_N_dom1	UniProtKB/TrEMBL
	DNA_topo_DNA_db_N_dom2	UniProtKB/TrEMBL
	TopoI	UniProtKB/TrEMBL
	TopoI_AS	UniProtKB/TrEMBL
	TopoI_C_dom	UniProtKB/TrEMBL
	TopoI_cat_a-hlx-sub_euk	UniProtKB/TrEMBL
	TopoI_cat_a/b-sub_euk	UniProtKB/TrEMBL
	TopoI_cat_euk	UniProtKB/TrEMBL
	TopoI_DNA-bd_euk	UniProtKB/TrEMBL
	TopoI_DNA-bd_euk_N_sf	UniProtKB/TrEMBL
	TopoI_euk	UniProtKB/TrEMBL
	Topoisomer_I_DNA-bd	UniProtKB/TrEMBL
	Topoisomerase_IB	UniProtKB/TrEMBL
NCBI Gene	TOP1	ENTREZGENE
PANTHER	DNA TOPOISOMERASE 1	UniProtKB/TrEMBL
	DNA TOPOISOMERASE I	UniProtKB/TrEMBL
Pfam	Topo_C_assoc	UniProtKB/TrEMBL
	Topoisom_I	UniProtKB/TrEMBL
	Topoisom_I_N	UniProtKB/TrEMBL
PRINTS	EUTPISMRASEI	UniProtKB/TrEMBL
PROSITE	TOPOISOMERASE_I_EUK	UniProtKB/TrEMBL
SMART	TOPEUc	UniProtKB/TrEMBL
Superfamily-SCOP	Eukaryotic DNA topoisomerase I, dispensable insert domain	UniProtKB/TrEMBL
	SSF56349	UniProtKB/TrEMBL
	SSF56741	UniProtKB/TrEMBL
UniProt	A0A0B8RT23	ENTREZGENE
	A0A4X1TR46_PIG	UniProtKB/TrEMBL
	A0A4X1TR88_PIG	UniProtKB/TrEMBL
	A0A8D0P994	ENTREZGENE, UniProtKB/TrEMBL
	A0A8W4F6H8_PIG	UniProtKB/TrEMBL
	A0A8W4FPT3_PIG	UniProtKB/TrEMBL
	I3LHM3	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:104084	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB