LDLRAD3 (low density lipoprotein receptor class A domain containing 3) - Rat Genome Database

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Gene: LDLRAD3 (low density lipoprotein receptor class A domain containing 3) Sus scrofa
Analyze
Symbol: LDLRAD3
Name: low density lipoprotein receptor class A domain containing 3
RGD ID: 14049258
Description: ENCODES a protein that exhibits amyloid-beta binding (inferred); INVOLVED IN receptor-mediated endocytosis (ortholog); regulation of protein processing (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); substance-related disorder (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: low-density lipoprotein receptor class A domain-containing protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl224,875,380 - 25,138,873 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1224,875,379 - 25,155,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2227,321,334 - 27,490,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LDLRAD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl224,875,380 - 25,138,873 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1224,875,379 - 25,155,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2227,321,334 - 27,490,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LDLRAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381135,944,062 - 36,232,136 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1135,943,981 - 36,232,136 (+)EnsemblGRCh38hg38GRCh38
GRCh371135,965,612 - 36,253,686 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361135,922,188 - 36,209,417 (+)NCBINCBI36Build 36hg18NCBI36
Celera1136,112,827 - 36,400,880 (+)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1135,664,007 - 35,952,047 (+)NCBIHuRef
CHM1_11135,964,057 - 36,251,263 (+)NCBICHM1_1
T2T-CHM13v2.01136,082,756 - 36,371,759 (+)NCBIT2T-CHM13v2.0
Ldlrad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392101,780,546 - 102,016,805 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2101,780,548 - 102,016,730 (-)EnsemblGRCm39 Ensembl
GRCm382101,950,201 - 102,186,460 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2101,950,203 - 102,186,385 (-)EnsemblGRCm38mm10GRCm38
MGSCv372101,790,358 - 102,026,534 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362101,751,042 - 101,987,199 (-)NCBIMGSCv36mm8
Celera2103,177,515 - 103,425,538 (-)NCBICelera
Cytogenetic Map2E2NCBI
cM Map254.11NCBI
Ldlrad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83108,694,528 - 108,936,330 (-)NCBIGRCr8
mRatBN7.2388,239,529 - 88,481,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl388,239,622 - 88,481,267 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx391,740,240 - 91,985,132 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03100,339,261 - 100,584,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0398,161,670 - 98,403,482 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0391,596,730 - 91,839,054 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl391,527,657 - 91,839,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0398,186,015 - 98,191,116 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0398,255,058 - 98,497,395 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4387,108,483 - 87,275,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1387,004,744 - 87,235,986 (-)NCBI
Celera387,346,492 - 87,586,796 (-)NCBICelera
Cytogenetic Map3q31-q32NCBI
Ldlrad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542210,206,460 - 10,375,940 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542210,206,498 - 10,382,573 (-)NCBIChiLan1.0ChiLan1.0
LDLRAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2938,165,014 - 38,452,213 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11138,169,674 - 38,456,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,917,271 - 36,204,509 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,870,059 - 36,079,093 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,791,899 - 36,076,358 (+)Ensemblpanpan1.1panPan2
LDLRAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11831,900,807 - 32,066,758 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1831,903,095 - 32,061,171 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1831,507,253 - 31,739,703 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01832,510,608 - 32,743,444 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1832,510,618 - 32,743,909 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11832,071,852 - 32,304,387 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01831,657,012 - 31,889,722 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,301,948 - 32,535,042 (-)NCBIUU_Cfam_GSD_1.0
Ldlrad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494728,980,701 - 29,221,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365332,105,197 - 2,263,675 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365332,105,844 - 2,263,621 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDLRAD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,017,428 - 29,317,531 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,017,115 - 29,317,476 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038126,151,759 - 126,439,918 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ldlrad3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476711,003,802 - 11,255,878 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476711,003,981 - 11,346,063 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LDLRAD3
12060 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5
Low 10 4 3 5 2 18 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014519   ⟹   ENSSSCP00000014126
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl224,875,384 - 25,138,864 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000062140   ⟹   ENSSSCP00000059070
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl224,875,380 - 25,138,873 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000080424   ⟹   ENSSSCP00000062989
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl225,000,742 - 25,138,826 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089111   ⟹   ENSSSCP00000061399
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl224,875,384 - 25,138,814 (-)Ensembl
RefSeq Acc Id: XM_021083183   ⟹   XP_020938842
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,118,829 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083184   ⟹   XP_020938843
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,118,837 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083185   ⟹   XP_020938844
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,138,874 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083186   ⟹   XP_020938845
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,138,865 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083187   ⟹   XP_020938846
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,155,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083189   ⟹   XP_020938848
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,138,633 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083190   ⟹   XP_020938849
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,065,798 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083191   ⟹   XP_020938850
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,137,395 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083192   ⟹   XP_020938851
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1224,875,379 - 25,138,865 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020938846   ⟸   XM_021083187
- Peptide Label: isoform X5
- UniProtKB: A0A8D2CCD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938844   ⟸   XM_021083185
- Peptide Label: isoform X3
- UniProtKB: A0A8D1PY71 (UniProtKB/TrEMBL),   A0A287BR09 (UniProtKB/TrEMBL),   A0A480MFG5 (UniProtKB/TrEMBL),   A0A8D1TI32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938851   ⟸   XM_021083192
- Peptide Label: isoform X6
- UniProtKB: A0A8D1PTV6 (UniProtKB/TrEMBL),   F1SHG2 (UniProtKB/TrEMBL),   A0A8D1MYK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938845   ⟸   XM_021083186
- Peptide Label: isoform X4
- UniProtKB: A0A8D1TI32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938848   ⟸   XM_021083189
- Peptide Label: isoform X5
- UniProtKB: A0A8D2CCD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938850   ⟸   XM_021083191
- Peptide Label: isoform X5
- UniProtKB: A0A8D2CCD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938843   ⟸   XM_021083184
- Peptide Label: isoform X2
- UniProtKB: A0A4X1SKP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938842   ⟸   XM_021083183
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SKP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938849   ⟸   XM_021083190
- Peptide Label: isoform X5
- UniProtKB: A0A8D2CCD8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000061399   ⟸   ENSSSCT00000089111
RefSeq Acc Id: ENSSSCP00000062989   ⟸   ENSSSCT00000080424
RefSeq Acc Id: ENSSSCP00000059070   ⟸   ENSSSCT00000062140
RefSeq Acc Id: ENSSSCP00000014126   ⟸   ENSSSCT00000014519


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013294 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005040895 UniProtKB/TrEMBL
  ENSSSCG00025052107 UniProtKB/TrEMBL
  ENSSSCG00030020008 UniProtKB/TrEMBL
  ENSSSCG00040022258 UniProtKB/TrEMBL
  ENSSSCG00050050507 UniProtKB/TrEMBL
  ENSSSCG00055006485 UniProtKB/TrEMBL
  ENSSSCG00060022919 UniProtKB/TrEMBL
  ENSSSCG00065058677 UniProtKB/TrEMBL
  ENSSSCG00070001617 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014519 ENTREZGENE
  ENSSSCT00000014519.5 UniProtKB/TrEMBL
  ENSSSCT00000062140 ENTREZGENE
  ENSSSCT00000062140.3 UniProtKB/TrEMBL
  ENSSSCT00000089111.2 UniProtKB/TrEMBL
  ENSSSCT00005065477.1 UniProtKB/TrEMBL
  ENSSSCT00005065544.1 UniProtKB/TrEMBL
  ENSSSCT00025071254.1 UniProtKB/TrEMBL
  ENSSSCT00025071314.1 UniProtKB/TrEMBL
  ENSSSCT00030027646.1 UniProtKB/TrEMBL
  ENSSSCT00040029846.1 UniProtKB/TrEMBL
  ENSSSCT00040029906.1 UniProtKB/TrEMBL
  ENSSSCT00040029940.1 UniProtKB/TrEMBL
  ENSSSCT00050068742.1 UniProtKB/TrEMBL
  ENSSSCT00050068748.1 UniProtKB/TrEMBL
  ENSSSCT00055012547.1 UniProtKB/TrEMBL
  ENSSSCT00055012575.1 UniProtKB/TrEMBL
  ENSSSCT00060031104.1 UniProtKB/TrEMBL
  ENSSSCT00060031109.1 UniProtKB/TrEMBL
  ENSSSCT00065080293.1 UniProtKB/TrEMBL
  ENSSSCT00070003041.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.400.10 UniProtKB/TrEMBL
InterPro LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
NCBI Gene LDLRAD3 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
SMART LDLa UniProtKB/TrEMBL
Superfamily-SCOP SSF57424 UniProtKB/TrEMBL
UniProt A0A287BR09 ENTREZGENE
  A0A480MFG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SKP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QBG6_PIG UniProtKB/TrEMBL
  A0A8D0KHB3_PIG UniProtKB/TrEMBL
  A0A8D0KI98_PIG UniProtKB/TrEMBL
  A0A8D1DUX6_PIG UniProtKB/TrEMBL
  A0A8D1DWP5_PIG UniProtKB/TrEMBL
  A0A8D1K673_PIG UniProtKB/TrEMBL
  A0A8D1MYK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1PTV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1PY71 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1TI32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2CCD8 ENTREZGENE, UniProtKB/TrEMBL
  F1SHG2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287BR09 UniProtKB/TrEMBL
VGNC ID VGNC:89672 ENTREZGENE