UROC1 (urocanate hydratase 1) - Rat Genome Database
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Gene: UROC1 (urocanate hydratase 1) Sus scrofa
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Symbol: UROC1
Name: urocanate hydratase 1
RGD ID: 14048438
Description: ENCODES a protein that exhibits urocanate hydratase activity (inferred); INVOLVED IN histidine catabolic process to glutamate and formamide (inferred); histidine catabolic process to glutamate and formate (inferred); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; ASSOCIATED WITH Ataxia (ortholog); hepatocellular carcinoma (ortholog); intellectual disability (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: urocanase domain containing 1; urocanate hydratase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,590,776 - 53,637,714 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,592,763 - 53,634,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,628,304 - 58,665,410 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
UROC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,590,776 - 53,637,714 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,592,763 - 53,634,214 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,628,304 - 58,665,410 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UROC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3126,481,166 - 126,517,773 (-)EnsemblGRCh38hg38GRCh38
GRCh383126,481,166 - 126,517,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373126,200,008 - 126,236,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363127,682,814 - 127,719,284 (-)NCBINCBI36hg18NCBI36
Build 343127,682,821 - 127,719,292NCBI
Celera3124,624,832 - 124,661,450 (-)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3123,580,466 - 123,616,232 (-)NCBIHuRef
CHM1_13126,163,023 - 126,199,631 (-)NCBICHM1_1
Uroc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39690,310,221 - 90,341,533 (+)NCBIGRCm39mm39
GRCm38690,333,239 - 90,364,551 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl690,333,284 - 90,364,551 (+)EnsemblGRCm38mm10GRCm38
MGSCv37690,283,283 - 90,314,545 (+)NCBIGRCm37mm9NCBIm37
MGSCv36690,298,810 - 90,330,055 (+)NCBImm8
Celera692,226,993 - 92,258,298 (+)NCBICelera
Cytogenetic Map6D1NCBI
Uroc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04122,244,744 - 122,276,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4122,244,711 - 122,276,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04186,786,121 - 186,817,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44124,591,873 - 124,622,726 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4111,769,716 - 111,800,721 (+)NCBICelera
Cytogenetic Map4q34NCBI
Uroc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542121,732,262 - 21,765,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542121,734,910 - 21,765,754 (-)NCBIChiLan1.0ChiLan1.0
UROC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13130,845,588 - 130,882,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3130,846,775 - 130,882,119 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03123,530,644 - 123,569,337 (-)NCBIMhudiblu_PPA_v0panPan3
UROC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl20678,073 - 717,141 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.120676,624 - 717,109 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Uroc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936898583,802 - 600,305 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UROC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2254,499,487 - 54,535,862 (+)Ensembl
ChlSab1.12254,497,373 - 54,536,295 (+)NCBI
Uroc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477372,871 - 107,686 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system musculoskeletal system nervous system reproductive system
High
Medium 1
Low 12
Below cutoff 1 1 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002042   ⟹   ENSSSCP00000001993
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,590,871 - 53,634,198 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000055408   ⟹   ENSSSCP00000041064
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,605,998 - 53,637,709 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000059821   ⟹   ENSSSCP00000058578
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,590,876 - 53,637,714 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071108   ⟹   ENSSSCP00000064429
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,590,776 - 53,634,998 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071947   ⟹   ENSSSCP00000060317
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,605,998 - 53,637,709 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000080824   ⟹   ENSSSCP00000074574
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,590,876 - 53,637,714 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000091639   ⟹   ENSSSCP00000069572
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,590,876 - 53,637,714 (+)Ensembl
RefSeq Acc Id: NM_001244219   ⟹   NP_001231148
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,597,100 - 53,634,206 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098106   ⟹   XP_020953765
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,595,267 - 53,634,214 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098107   ⟹   XP_020953766
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,592,763 - 53,634,214 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098108   ⟹   XP_020953767
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,595,611 - 53,634,214 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098109   ⟹   XP_020953768
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,598,584 - 53,634,214 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098110   ⟹   XP_020953769
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,598,545 - 53,634,214 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020953766   ⟸   XM_021098107
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020953765   ⟸   XM_021098106
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020953767   ⟸   XM_021098108
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001231148   ⟸   NM_001244219
- UniProtKB: A0A287BPN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953769   ⟸   XM_021098110
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020953768   ⟸   XM_021098109
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000074574   ⟸   ENSSSCT00000080824
RefSeq Acc Id: ENSSSCP00000001993   ⟸   ENSSSCT00000002042
RefSeq Acc Id: ENSSSCP00000058578   ⟸   ENSSSCT00000059821
RefSeq Acc Id: ENSSSCP00000041064   ⟸   ENSSSCT00000055408
RefSeq Acc Id: ENSSSCP00000069572   ⟸   ENSSSCT00000091639
RefSeq Acc Id: ENSSSCP00000064429   ⟸   ENSSSCT00000071108
RefSeq Acc Id: ENSSSCP00000060317   ⟸   ENSSSCT00000071947
Protein Domains
Urocanase   Urocanase_C   Urocanase_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001823 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070014993 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001993 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000041064 UniProtKB/TrEMBL
  ENSSSCP00000058578 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000060317 UniProtKB/TrEMBL
  ENSSSCP00000064429 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000069572 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000074574 UniProtKB/TrEMBL
  ENSSSCP00070024649 UniProtKB/TrEMBL
  ENSSSCP00070024658 UniProtKB/TrEMBL
  ENSSSCP00070024668 UniProtKB/TrEMBL
  ENSSSCP00070024688 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002042 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000055408 UniProtKB/TrEMBL
  ENSSSCT00000059821 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000071108 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000071947 UniProtKB/TrEMBL
  ENSSSCT00000080824 UniProtKB/TrEMBL
  ENSSSCT00000091639 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070029564 UniProtKB/TrEMBL
  ENSSSCT00070029575 UniProtKB/TrEMBL
  ENSSSCT00070029587 UniProtKB/TrEMBL
  ENSSSCT00070029610 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10730 UniProtKB/TrEMBL
InterPro Urocanase UniProtKB/TrEMBL
  Urocanase_C UniProtKB/TrEMBL
  Urocanase_central_sf UniProtKB/TrEMBL
  Urocanase_CS UniProtKB/TrEMBL
  Urocanase_N UniProtKB/TrEMBL
  Urocanase_Rossmann-like UniProtKB/TrEMBL
  Urocanase_sf UniProtKB/TrEMBL
KEGG Report ssc:100157217 UniProtKB/TrEMBL
NCBI Gene UROC1 ENTREZGENE
PANTHER PTHR12216 UniProtKB/TrEMBL
Pfam Urocanase UniProtKB/TrEMBL
  Urocanase_C UniProtKB/TrEMBL
  Urocanase_N UniProtKB/TrEMBL
PIRSF Urocanate_hydrat UniProtKB/TrEMBL
PROSITE UROCANASE UniProtKB/TrEMBL
Superfamily-SCOP SSF111326 UniProtKB/TrEMBL
UniGene Ssc.44750 ENTREZGENE
UniProt A0A287AAZ5_PIG UniProtKB/TrEMBL
  A0A287BPN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A480TLP6_PIG UniProtKB/TrEMBL
  A0A4X1U4S4_PIG UniProtKB/TrEMBL
  A0A4X1U718_PIG UniProtKB/TrEMBL
  A0A4X1U940_PIG UniProtKB/TrEMBL
  A0A4X1U9M7_PIG UniProtKB/TrEMBL
  A0A5G2QKB4_PIG UniProtKB/TrEMBL
  A0A5G2QPV4_PIG UniProtKB/TrEMBL
  A0A5G2RF41_PIG UniProtKB/TrEMBL
  A0A5G2RHD0_PIG UniProtKB/TrEMBL
  F1RMH5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:94733 ENTREZGENE