IDH2 (isocitrate dehydrogenase (NADP(+)) 2) - Rat Genome Database

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Gene: IDH2 (isocitrate dehydrogenase (NADP(+)) 2) Sus scrofa
Analyze
Symbol: IDH2
Name: isocitrate dehydrogenase (NADP(+)) 2
RGD ID: 14041463
Description: ENCODES a protein that exhibits isocitrate dehydrogenase (NADP+) activity (ortholog); isocitrate dehydrogenase activity (ortholog); magnesium ion binding (ortholog); INVOLVED IN 2-oxoglutarate metabolic process (ortholog); isocitrate metabolic process (ortholog); NADP biosynthetic process (ortholog); ASSOCIATED WITH 2-hydroxyglutaric aciduria (ortholog); acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); FOUND IN cytosol (inferred); mitochondrion (inferred); peroxisome (inferred); INTERACTS WITH 1,4-dithiothreitol; 3-oxalomalic acid; cadmium atom
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ICD-M; IDH; IDP; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)-specific ICDH; NADPH-specific isocitrate dehydrogenase; oxalosuccinate decarboxylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,651,606 - 55,681,426 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,654,298 - 55,675,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,539,333 - 60,549,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
mitochondrion  (IBA,IEA)
peroxisome  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:1627563   PMID:1869531   PMID:3624273   PMID:12207025   PMID:14512428   PMID:14681463   PMID:15975917   PMID:16785314  


Genomics

Comparative Map Data
IDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,651,606 - 55,681,426 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,654,298 - 55,675,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,539,333 - 60,549,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1590,083,045 - 90,102,477 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1590,083,045 - 90,102,504 (-)EnsemblGRCh38hg38GRCh38
GRCh381590,083,045 - 90,102,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371590,626,277 - 90,645,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,428,214 - 88,446,712 (-)NCBINCBI36hg18NCBI36
Build 341588,428,217 - 88,446,712NCBI
Celera1567,031,136 - 67,049,657 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1566,738,326 - 66,745,989 (-)NCBIHuRef
CHM1_11590,468,783 - 90,487,361 (-)NCBICHM1_1
Idh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,744,594 - 79,768,356 (-)NCBIGRCm39mm39
GRCm39 Ensembl779,744,594 - 79,765,140 (-)Ensembl
GRCm38780,094,845 - 80,118,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,094,846 - 80,115,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,239,732 - 87,260,236 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,968,359 - 79,988,834 (-)NCBImm8
Celera777,493,303 - 77,513,823 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.43NCBI
Idh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,038,644 - 134,057,969 (-)NCBI
Rnor_6.0 Ensembl1141,866,283 - 141,893,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01141,874,354 - 141,893,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01142,830,040 - 142,849,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,876,052 - 135,895,373 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1126,099,085 - 126,118,402 (-)NCBICelera
Cytogenetic Map1q31NCBI
Idh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,197,366 - 15,223,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541615,197,611 - 15,212,919 (+)NCBIChiLan1.0ChiLan1.0
IDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11587,972,883 - 87,991,270 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,972,889 - 87,991,276 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01568,771,050 - 68,790,523 (-)NCBIMhudiblu_PPA_v0panPan3
IDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,070,462 - 53,077,566 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,070,695 - 53,087,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,708,523 - 55,724,976 (-)NCBI
ROS_Cfam_1.0353,486,432 - 53,502,992 (-)NCBI
UMICH_Zoey_3.1353,006,922 - 53,023,434 (-)NCBI
UNSW_CanFamBas_1.0353,217,752 - 53,234,294 (-)NCBI
UU_Cfam_GSD_1.0353,558,279 - 53,574,816 (-)NCBI
Idh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,470,218 - 130,488,711 (+)NCBI
SpeTri2.0NW_00493648315,845,777 - 15,864,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103231165
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,633,429 - 8,650,744 (-)NCBI
ChlSab1.1 Ensembl298,633,715 - 8,650,657 (-)Ensembl
Idh2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476817,094,649 - 17,111,333 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 4 5 2 1 2 2 3
Low 1 3 22 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002075   ⟹   ENSSSCP00000002026
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,654,303 - 55,675,554 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000038437   ⟹   ENSSSCP00000057213
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,651,606 - 55,681,426 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000044124   ⟹   ENSSSCP00000036736
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl755,651,606 - 55,675,540 (-)Ensembl
RefSeq Acc Id: NM_001164007   ⟹   NP_001157479
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1755,654,298 - 55,675,571 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001157479 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA31089 (Get FASTA)   NCBI Sequence Viewer  
  P33198 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001157479   ⟸   NM_001164007
- Sequence:
RefSeq Acc Id: ENSSSCP00000036736   ⟸   ENSSSCT00000044124
RefSeq Acc Id: ENSSSCP00000002026   ⟸   ENSSSCT00000002075
RefSeq Acc Id: ENSSSCP00000057213   ⟸   ENSSSCT00000038437
Protein Domains
Iso_dh


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001852 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070013278 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002026 UniProtKB/TrEMBL
  ENSSSCP00000036736 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000057213 UniProtKB/TrEMBL
  ENSSSCP00070021486 UniProtKB/TrEMBL
  ENSSSCP00070021502 UniProtKB/TrEMBL
  ENSSSCP00070021509 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002075 UniProtKB/TrEMBL
  ENSSSCT00000038437 UniProtKB/TrEMBL
  ENSSSCT00000044124 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070025892 UniProtKB/TrEMBL
  ENSSSCT00070025908 UniProtKB/TrEMBL
  ENSSSCT00070025915 UniProtKB/TrEMBL
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Isocitrate_DH_NADP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene IDH2 ENTREZGENE
PANTHER PTHR11822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF IDH_NADP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IDH_IMDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs nadp_idh_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZYE6_PIG UniProtKB/TrEMBL
  A0A287BL23_PIG UniProtKB/TrEMBL
  A0A4X1TVW8_PIG UniProtKB/TrEMBL
  A0A4X1TYC2_PIG UniProtKB/TrEMBL
  A0A4X1U136_PIG UniProtKB/TrEMBL
  F1SK00_PIG UniProtKB/TrEMBL
  IDHP_PIG UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-16 IDH2  isocitrate dehydrogenase (NADP(+)) 2  IDH2  isocitrate dehydrogenase (NADP(+)) 2, mitochondrial  Symbol and/or name change 5135510 APPROVED