ANK2 (ankyrin 2) - Rat Genome Database
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Gene: ANK2 (ankyrin 2) Sus scrofa
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Symbol: ANK2
Name: ankyrin 2
RGD ID: 14039402
Description: ENCODES a protein that exhibits ATPase binding (ortholog); enzyme binding (ortholog); ion channel binding (ortholog); INVOLVED IN atrial cardiac muscle cell action potential (ortholog); atrial cardiac muscle cell to AV node cell communication (ortholog); atrial septum development (ortholog); ASSOCIATED WITH aniridia (ortholog); ankyrin-B-related cardiac arrhythmia (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); FOUND IN A band (ortholog); basolateral plasma membrane (ortholog); costamere (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: ankyrin-2
Orthologs:
Homo sapiens (human) : ANK2 (ankyrin 2)  HGNC  Alliance
Mus musculus (house mouse) : Ank2 (ankyrin 2, brain)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ank2 (ankyrin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ank2 (ankyrin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ANK2 (ankyrin 2)
Canis lupus familiaris (dog) : ANK2 (ankyrin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ank2 (ankyrin 2)
Chlorocebus sabaeus (African green monkey) : ANK2 (ankyrin 2)
Heterocephalus glaber (naked mole-rat) : Ank2 (ankyrin 2)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.18109,306,793 - 109,661,970 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28117,345,572 - 117,559,478 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrial cardiac muscle cell action potential  (ISO)
atrial cardiac muscle cell to AV node cell communication  (ISO)
atrial septum development  (ISO)
cardiac muscle contraction  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular protein localization  (ISO)
nervous system development  (ISO)
paranodal junction assembly  (ISO)
positive regulation of calcium ion transmembrane transporter activity  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cation channel activity  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of potassium ion transmembrane transporter activity  (ISO)
positive regulation of potassium ion transport  (ISO)
protein localization  (ISO)
protein localization to cell surface  (ISO)
protein localization to endoplasmic reticulum  (ISO)
protein localization to M-band  (ISO)
protein localization to organelle  (ISO)
protein localization to plasma membrane  (ISO)
protein localization to T-tubule  (ISO)
protein stabilization  (ISO)
regulation of atrial cardiac muscle cell action potential  (ISO)
regulation of AV node cell action potential  (ISO)
regulation of calcium ion transmembrane transporter activity  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of cardiac muscle cell membrane potential  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (ISO)
regulation of cation channel activity  (ISO)
regulation of heart rate  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of SA node cell action potential  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
response to methylmercury  (ISO)
SA node cell action potential  (ISO)
SA node cell to atrial cardiac muscle cell communication  (ISO)
signal transduction  (IEA)
T-tubule organization  (ISO)
ventricular cardiac muscle cell action potential  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
ANK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.18109,306,793 - 109,661,970 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28117,345,572 - 117,559,478 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4112,818,032 - 113,384,221 (+)EnsemblGRCh38hg38GRCh38
GRCh384112,705,622 - 113,383,736 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374113,739,239 - 114,304,896 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364114,190,319 - 114,524,337 (+)NCBINCBI36hg18NCBI36
Celera4111,031,065 - 111,596,545 (+)NCBI
Cytogenetic Map4q25-q26NCBI
HuRef4109,467,190 - 110,033,212 (+)NCBIHuRef
CHM1_14113,715,710 - 114,281,305 (+)NCBICHM1_1
Ank2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393126,715,256 - 127,293,996 (-)NCBI
GRCm383126,921,607 - 127,500,347 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3126,921,612 - 127,499,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv373126,624,525 - 126,701,370 (-)NCBIGRCm37mm9NCBIm37
MGSCv363126,913,629 - 126,990,474 (-)NCBImm8
Celera3133,394,159 - 133,470,953 (-)NCBICelera
Cytogenetic Map3G2NCBI
cM Map356.07NCBI
Ank2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02231,224,643 - 231,522,655 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2231,226,949 - 231,648,122 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02250,573,979 - 250,869,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42224,182,431 - 224,501,751 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12224,228,885 - 224,376,051 (-)NCBI
Celera2207,699,846 - 207,902,141 (-)NCBICelera
Cytogenetic Map2q42NCBI
Ank2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,624,413 - 14,076,261 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545713,624,590 - 13,938,427 (-)NCBIChiLan1.0ChiLan1.0
ANK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14115,760,071 - 116,446,170 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4115,967,106 - 116,443,905 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04105,315,776 - 105,882,506 (+)NCBIMhudiblu_PPA_v0panPan3
ANK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3232,671,281 - 33,141,036 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13232,484,196 - 33,143,295 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ank2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365633,520,195 - 4,170,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl760,938,523 - 61,175,519 (+)Ensembl
ChlSab1.1760,487,776 - 61,174,351 (+)NCBI
Ank2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248386,490,434 - 7,023,945 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 3 2 23
Low 10 3 5 2 3 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: XM_021100703   ⟹   XP_020956362
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18109,306,793 - 109,661,970 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020956362 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020956362   ⟸   XM_021100703
- Sequence:
Protein Domains
ANK_REP_REGION   Death   ZU5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009125 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000009731 UniProtKB/TrEMBL
  ENSSSCP00000047594 UniProtKB/TrEMBL
  ENSSSCP00000064712 UniProtKB/TrEMBL
  ENSSSCP00000068222 UniProtKB/TrEMBL
  ENSSSCP00000073958 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009992 UniProtKB/TrEMBL
  ENSSSCT00000040372 UniProtKB/TrEMBL
  ENSSSCT00000070046 UniProtKB/TrEMBL
  ENSSSCT00000070597 UniProtKB/TrEMBL
  ENSSSCT00000078836 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Ankyrin_UPA UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  ZU5_dom UniProtKB/TrEMBL
NCBI Gene ANK2 ENTREZGENE
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  UPA_2 UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  DEATH_DOMAIN UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  ZU5 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
UniProt A0A287AUI5_PIG UniProtKB/TrEMBL
  A0A5G2QRQ7_PIG UniProtKB/TrEMBL
  A0A5G2R203_PIG UniProtKB/TrEMBL
  A0A5G2R9I6_PIG UniProtKB/TrEMBL
  F1S146_PIG UniProtKB/TrEMBL